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1 / 1 point

A70yearoldwomanisstartingonanacidicdrug.Thenurseisawarethatfoodand
nutrientintakecanaffectdrugexcretionbychangingtheurinarypH.Aboutwhichof
thefollowingwillthenursequestionthepatientconcerningherdiet?
Question options:

a)

b)

c)

d)

Chapter 10:

Question 2

Theintakeoffoodshighinprotein

Theuseofgrapefruit

Theamountofmeatandvegetables

Theintakeofsodium

C. A diet that is rich in meat or vegetables can

affect pH. Thus, the patient needs to keep this in check.
(pg. 133).

0.75 / 1 point

Whattypesofmedicationcanpassthroughthebloodbrainbarrierortheplacenta?
Selectallthatapply.
Question options:

a) Watersolublemedications

b) Medicationsunboundtoprotein

c) Ionizedmedications

d) Lipophilicmedications

A, B. D. Only drugs that are lipophilic,

unbound to protein, and water-soluble are
able to cross the placenta and blood-brain
barrier. Drugs can't be ionized, not protein
bound, and lipophilic in order to cross the
placenta (pg. 46)

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1
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Question 3

Theprocessthatlargelydeterminesserumdruglevels,adverseeffects,andother
importantaspectsofdrugtherapyisknownas:
Question options:

a)

Systemiceffect

b)

Drugdistribution

c)

Drugclearance

d)

Bioavailability

B. Drug distribution can determine serum drug levels, adverse

effects, and other important aspect of drug therapy because it is how
much of the drug is in your system.
Question 4
1/1
point

Whichofthefollowingisakeyprocesswithdrugexcretion?
Question options:

a)

Activetransport

b)

Passivediffusion

c)

Proteinbinding

d)

Filtration

A. Key Process in drug excretion is active transport as it goes through

the renal system for drugs to be excreted. (pg. 50)

Question 5

0.5 / 1 point

Whichfactorswilldecreasetherateofdrugabsorption?Selectallthatapply.
Question options:

a)

Higherdrugconcentrationinthecirculatorysystem

b)

Increasedbloodflowrate

c) Adiseasethataltersthestomachandsmallintestinelining

d) Druggivenbyasubcutaneousrouteversusanintramuscularroute

C,D. There are several factors that can affect drug absorption. If the
stomach and small intestine lining is affected then it will cause a
decrease in drug absorption because those are the areas where a lot of
absorption takes place. Increased blood flow will increase drug
1/
absorption. A higher concentration can increase absorption but
1
intramuscular absorption is actually more rapid than subcutaneous
poi
absorption (pg. 43).
nt

Question 6

Themostseriousallergicresponseiscalledanaphylaxis.Whichofthefollowing
patientsexhibitpossiblesymptomsofanaphylaxis?Selectallthatapply.

Question options:

a)

b)

Teresahaslaryngealedemaandpale,coolskin

Mr.Devhasrednessalloverhisbody

c) Mrs.Vilmahasmarkedhypotensionandexperiencesconvulsions

d) Mr.Johnhasbeenshowingsignsofacuterespiratorydistress
A, C, D. All the signs of anaphylaxis include hypotension, convulsions,
constriction of bronchial smooth muscles, vasodilation, increased
vascular permeability, acute respiratory distress, laryngeal edema, and
pale, cool skin but redness all over is not commonly seen (pg. 60).
Question 7

0 / 1 point

Whatdoesthelipidsolubilityofthedruginfluence?
Question options:

a)

Scheduleofdosing

b)

Dosageofthedrug

c)

Absorptionofthedrug

d)

Distributionofthedrug

C. Lipid solubility affects absorption but altering absorption. Drugs

that are more lipid soluble are absorbed more rapidly than others (pg.
43).

Question 8

0 / 1 point

Howwouldthedosageofapartlyproteinbounddrugbealteredifanotherdrug
havingahigherattractiontoalbuminthanthefirstdrugisadministered?
Question options:

a)

Thedosageofthefirstdrugmayhavetobeincreased

b)

Thedosageofthefirstdrugmayhavetobedecreased

c) Thedosageoftheseconddrugmayhavetobeincreased

d)

Thedosagesofboththefirstandtheseconddrugsshouldbereduced
equally

#8. B. The dosage of the first drug will need to be decreased because
unbound forms of the drug are more active and thus will need to be
decreased since the second drug has a greater affinity (pg. 98).

Question 9

Onereasonitisimportantforyourphysiciantoknowwhatdrugsyouaretakingis
thatduringaphaseofpharmacokineticsasignificantdrugdruginteractioncanoccur
resultinginonedrugstimulatingorblockingthemetabolismoftheotherdrug.What
phasecanthisoccurin?
Question options:

a)

Biotransformation

b)

Distribution

c)

Absorption

d)

Excretion

A. Biotransformation is also called metabolism and this is the phase

where drugs are metabolized so it is also when there is drug to drug
interaction (pg. 46).
Question 10

1 / 1 point

Asthenursecaringforapatientwhohasbeendiagnosedwithhypoalbuminemia,
whicheffectdoyouknowwilloccurifyouadministeradrugthatishighlyprotein
bound?
Question options:

a) Increasedrateofexcretionofthedrug,causingthedrugtobelesseffective

b) Increasedrateofdistributionofthedrug,leadingtotoxicity

c) Decreasedrateofmetabolism,whichwilldelaytheonsetofthedrug

d) Increasedrateofabsorptionofthedrug,leadingtotoxicity

B. Increased rate of distribution of the drug because you are making the drug able
to bind to protein allowing them to be more easily distributed throughout the body.
If there was no protein, then it would be slower rate of absorption and distribution.