Schedule Lecture of Human Genetics (MAB4161/ 2 sks)

Biology Dept. UB, Odd Semester, Year 2015-2016

Day: Monday
week
Lerning
Outcome
1 start Understand
on
basic concepts
7.9.20 of human
15
genetics
2
Understand
Mendelian
inheritance
patterns of the
different types
of inheritance
patterns of
human disease.
3-4

Understand
multigenic
inheritance
patterns.

Focus study

13:55 15:40
Topics

Basic concepts of
human genetics

Role of lecture

Identify and
Compare a
Mendelian
inheritance
pattern of
different types of
inheritance
patterns of human
disease

Mendelian
inheritance pattern
of human disease
Types of
inheritance patterns
of human disease

Identify a
multigenic
inheritance pattern.

Mapping and
characterizing
simple genetic
disease

Subtopics
-

Room:
Learning
Leacturer
methods
Lecture and
discussion

Mendel law, single

gene and
polygenetics factors
Sex-linked,
multifactorial and
maternal inheritance

Presentation,
Lecture and
discussion

Mapping disease
genes, diseaseassociated
mutations, diseases

Presentation,
Lecture and
discussion

WN

Presentation,
Lecture and

Basic concepts of
human genetics

associated with a
gene loss-function
effect, nuclear and

5-6

Understand

Identifify Gene-

Mapping and

mitochondrial
genome mutations,
Evolution of a
gene cluster and
divergence of
function
Genomics for the

Geneenvironment
interaction
in
behavior related
Genomics to the
study
of
complex
diseases

environment
interaction in
behavior related
Genomics to the
study of complex
diseases

characterizing
complex genetic
diseases

6-8

Understand the
current research
into epigenetic
and
transgeneration
al inheritance.

Explain the basics

of epigenetic and
transgenerational
inheritance.

Sex, prions, and

epigenetics

9-10

Understand
how to interpret
data from a
genome-wide
association
(GWA) study
and
Genetic
Testing

Analyze data
from genomewide association
studies.

Genome-wide
association (GWA)
study and Genetic
Testing

study of complex
diseases, genetic
study of type 2
diabetes and
obesity, Geneenvironment
interaction in
behavior,
pharmacogenetics
Epigenetic
inheritance of
chromatin states /
Role of DNA
methylation in
human
disease,dysregulati
on of the histone
modification
machinery,
transgenerational
epigenetic
inheritance, sex
determination,
prion diseases
Genome-wide
association (GWA)
study
Type, across the
life span (prenatal,
pediatric and
adult), technology,
molecular, clinical
and ethical

discussion

Presentation,
Lecture and
discussion

WN

Presentation,
Lecture and
discussion

WN

11-12

Understand
Chromosomal
and
genomic
disorders

13

Understand the
potential
implications of
personalized
and genomic
medicine

14-15

Understand
some of the
ethical issues
facing genomic
researchers.

perspectives
Identify
Chromosomal and Mechanisms and
Chromosomal and genomic disorders
maternal age
genomic disorders
influence the
origin of
aneuploidy in
humans,
mechanisms
causing these
aberrations, fragile
X syndrome
Natural
genetics
Pharcogenenomic
Explain the
and/or
potential benefits resources: the
Nutrigenomic:
potential
benefits
and
Bioactive
and
risks/challenges
compound,
risks/challenges
of genomic
phytopharmaca,
medicine.
functional food for
Explain some of the
ethical challenges
raised by the
prevalence of
genomic data

Medical genetics
and the associated
ethical, legal, and
social implications

Lecturer: F (Prof. Fatchiyah, PhD) and WN (Prof. Wolfgang Nellen)

healthy controlling
Ethical clearance
Inform consent
ELSI for medical
research based on
samples of human
or animal model

Presentation,
Lecture and
discussion

Presentation,
Lecture and
discussion

Presentation,
Lecture and
discussion

Daftar Pustaka
Rick Lewis. 2011. Basic Human Genetics. Routledge Taylor & Francis group, NY ISBN-10:
0415579864 ISBN-13: 978-0415579865,
Ricki Lewis. 2011. Human Genetics concepts and application. McGraw-Hill Education; 10
edition ISBN-13: 978-0073525303, ISBN-10: 0073525308 or ISBN: 007246268x
Tom Strachan & Andrew Read.2003. Human Molecular genetics. Garland Science; 3 edition.
ISBN-10: 0815341822 ISBN-13: 978-0815341826
Julian Knight.2009. Human Genetic Diversity. Oxford Univrsity Press. London.
Robert Nussbaum, Roderick R. McInnes, and Huntington F Willard. 2007. Genetics in Medicine,
7th Edition. Sounders. ISBN: 9781416030805