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Structure of DNA
DNA and RNA are made up of nucleotides
(Polymers)
(Monomers)
A nucleotide has a sugar, a phosphate
group, and a nitrogen containing base.
Ribosome
Translation
We need a means of getting the correct
amino acid in the correct sequence. For
this we use one more type of RNA :
transfer RNA (tRNA).
tRNA is a single strand of RNA that is
folded into the shape of a clover. It has an
anticodon that matches the codon on the
mRNA, and a spot for holding the amino
acid that matches the codon.
Elongation
Termination
When the ribosome reads one of the stop
codons, there is no matching tRNA.
Instead, a protein called a release factor
binds to the stop codon, the polypeptide is
cut from the last tRNA, and the
polypeptide (protein) is released into the
ctyoplasm, where other proteins will help
fold it.
Mutations
A mutation is a permanent, inheritable
change in the DNA.
To be passed on to the next generation,
this mutation must be present in the
gametes (eggs or sperm).
Mutations
Mutations can be as small as a change in
one base a point mutation
Mutations can be small sections of DNA,
entire genes or large pieces of
chromosomes that are moved from one
place to another by transposons.
Entire chromosomes may be duplicated
(Down syndrome 3 copies of
chromosome 21) or lost.
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Causes of mutations
Occur naturally
Due to mutagens:
Radiation
Toxic chemicals
Viruses