D'Cosmix

Dr.
Priti Vaidyanathan
Sabinsa Europe GmbH
16 April 2015
In-Cosmetics 2015
Sabinsa Corporation | Confidential | www.sabinsa.com
What is DCosmix?
DCosmix is the outcome of over 2 decades of
unrivalled competence of the Sabinsa research team to
pioneer and innovate, novel dermaceuticals from
natural sources.
DCosmix is an intelligent fusion of science and
performance.
DCosmix caters to the broad palette of applications in
the Cosmeceutical and Personal care range.
Why DCosmix ?
Provides innovative solutions to create unique formulations.
Helps unravel multiple facets with the powerhouse of
synergistic naturals.
Brings balance to your search of novelty in formulations.
Offers solutions to the boundless challenges that your
formulations face.
Helps your products stand out in the fiercely competitive
market.
Positively influences the ease of formulations.
Uplifts the spirit of formulationsNaturally !
DCosmix Application Focus.

Skin firming
Skin regeneration
Skin hydration
Skin protection
Skin calming
Skin nourishing
Skin energizing
Skin lightening
Skin brightening
Skin conditioning
Skin de-stress
Hair growth
Hair fall control
Hair conditioning
DCosmix Range
DCosmix Range
Blend
Broad range of application
1 AgeLess Complex DCx Skin firming, Skin regeneration

2 AcNil DCx
Anti-acne, Skin protection, Skin calming
3 CosmeVit DCx
Skin conditioning, Skin energizing, Skin

lightening and Skin de-stress
4 DermaSoothe DCx
Skin conditioning, Skin calming
5 DerMoist DCx
Skin hydration, Skin nourishing
6 DHeal DCx
Skin protection, Skin calming
7 KeraCon DCx
Hair growth, Hair fall control
8 MelaLite DCx
Skin lightening, Skin brightening
AgeLess Complex DCx

1. AgeLess Complex DCx

AgeLess Complex DCx effective ingredients
that offer pro-active protection against time
and
environmental
aggression
and
synergistically help to repair, rejuvenate and
condition the skin naturally!!
Ageless Complex DCx Ingredient Rationale

Barley Beta Glucans - Recognized for their role in maintaining collagen
balance, it helps protect the integrity of the skin matrix
N-Acetyl Glucosamine Maintains the natural reserve of skin moisture
Niacinamide - Clinically validated to balance skin moisture and manage
hyperpigmentation. It inhibits melanosome transfer to keratinocytes
pTeroWhite - Known for its melanogensis inhibition potential
Tocopheryl Acetate- Cell membrane protectant and potent antioxidant
Cosmoperine - Patented and proven dermal penetration enhancer
Cosmoperine U.S Patent No. 6,849,645. Japanese Patent No. JP4098985. Great Britain Patent No. GB2380675
Ageless Complex DCx In vitro study

Activity
Result
Anti-collagenase activity
13.56% inhibition at 1000 g/ml
Anti-elastase activity
11.5% inhibition at 1000 g/ml
10
AgeLess Complex DCx - Deliverables

Efficient control of wrinkles
Increase collagen formation
Enhance elasticity of the skin
Promote evenness of skin tone
11
AgeLess Complex DCx - Suggested Usage and Dosage

Range
Anti aging
Anti Wrinkle
After Suncare
Dosage Form
Cream
Translucent Serum
Cream
Cream, Lotion
Dose
1-3 %
1-3%
0.5-2%
1-2%
12
AcNil DCx
13
2. AcNil DCx
AcNil DCx provides an effective nutrient
composite offering a multi-pronged approach
to acne management by addressing different
skin concerns such as P acne activity,
inflammation, irritation and increase sebum
secretion.
14
Causes of acne
Some of the common causes of acne
Growth and multiplication of acne causing
bacterium Propionibacterium acnes.
Higher
levels
of
the
hormone
Dihydrotestosterone by the activity of the
enzyme 5-alpha reductase.
Increase in androgens during puberty and
adolescence which in turn, triggers an
enlargement of the sebaceous glands.
15
AcNil DCx Ingredient Rationale

Monolaurin - A produce from Cocus nucifera with proven antiacne benefits
Olive oil Contains natural squalene and affords skin soothing benefits
Policosanol Clinically evaluated to reduce sebum production
Coleus Oil Potent antimicrobial
Aloe vera Clinically validated to promote wound healing and soothing
Niacinamide - Clinically validated to manage depigmentation and acne
breakouts. It inhibits melanosome transfer to keratinocytes
Zinc Monomethionine Improves skin immunity
Ginger SCFE 20%- Anti-inflammtory, Antimicrobial
Mandelic acid- Mild exfoliate and anti acne
Policosanol U.S Patent No. 7,217,546. Indian Patent No. IN229695.
16
AcNil DCx In vitro Antimicrobial activity
Inhibitory activity against P acnes bacteria

Minimal Inhibitory Concentration 500 g/ml
17
AcNil DCx - Deliverables

Reduce sebum production
Inhibit P. acnes proliferation
Minimize recurrence of acne break outs
Reduce inflammation
Diminish acne scars
18
AcNil DCx - Suggested Usage and Dosage

Range
Anti-Acne
Dosage Form
Cream
Gel (Spot applicator)
Creamy Face Wash
Face pack
Dose
2-5%
4-6%
2-4%
2-3%
19
CosmeVit DCx
20
3. CosmeVit DCx
CosmeVit DCx is a power house of skin
nutrients that supports a healthy and glowing
skin with a multifaceted approach to skin
lightening, skin moisturizing and skin
protection.
CosmeVit DCx is generally recommended for
use in combination with core actives intended
for the specific application.
21
CosmeVit DCx - Ingredient Rationale

Retinol / Vitamin A - Effective as an antioxidant, skin-cell regulator and
helps skin repair
Vitamin E acetate - Stable form of Vitamin E, acts as a cell membrane
protectant
Niacinamide / Vitamin B3 Clinically validated to manage hyper
pigmentation and moisture balance. It inhibits melanosome transfer to
keratinocytes
Vitamin F - Linoleic acid and Linolenic acids well recognized to promote
skin vitality
Ascorbyl glucoside - Stabilized form of Vitamin C with antioxidant benefits
22
CosmeVit DCx - Deliverables

Nourishes skin with vital nutrients to make it
bright and radiant
Protects skin against harmful UV radiation
production
Visibly lightens complexion
Evens out skin tone
23
CosmeVit DCx - Suggested Usage and Dosage

Range
Skin lightening
Depigmentation
Anti-aging
Anti-Wrinkle
Anti-acne
After Sun-care
Hair Care
Dosage Form
Dose
Cream, Lotion, Translucent Serum 0.5-1%

Cream
1-2%
Cream, Translucent Serum
1-2%
Cream
0.5-2%
Cream, Face Wash
0.5-1%
Creams and Lotions
0.5-1%
Creams
0.3-0.5%
24
CosmeVit DCx used in commercial formulation

Johara PhytoBright Skin Lightening Range
25
DermaSoothe DCx
26
4. DermaSoothe DCx
Dermasoothe DCx is a composite of potent
ingredients to replenish the skins natural
moisture reserves and placate the skin
naturally.
27
DermaSoothe DCx - Ingredient Rationale

Allantoin A proven moisturizing, healing, anti-irritating, soothing
nutrient
N-Acetyl Glucosamine Helps preserve the natural moisture reserves of
the skin
CovaFresh IV - Water soluble Menthyl lactate to offer cooling effects
Chamomile extract Proven anti-irritant phytonutrients
Olive oil Skin soothing oil
28
DermaSoothe DCx - Deliverables

Soothe and calm the skin
Moisturizes to restore visibly healthier skin
Helps calm minor skin itch / irritations
29
DermaSoothe DCx - Usage and Dosage

Range
After Suncare
Soothing - Calamine
Skin Care
Hair Care
Dosage Form
Lotion, cream
Lotion
Shave and After shave cream or
Translucent Gel
Leave on Hair cream
Dose
1-3%
1-3%
2-3%
2-3%
30
DermaSoothe DCx used in commercial

formulation Glenmarks Elosmooth
31
DerMoist DCx
32
5. DerMoist DCx
DerMoist DCx is a balanced composite of
proven nutrients that help to gently calm
sensitive skin while keeping it moist,
nourished and healthy.
33
DerMoist DCx - Ingredient Rationale

Cococin CG - Supports skin hydration and rejuvenation
Dexapanthenol Helps maintain hydration balance
Hyaluronic acid- Potent moisturizer and humectant for dry skin
Zinc Gluconate Boosts skin immunity
Jojoba Oil - Affords a protective sheath to the skin
Cococin U.S Patent No. 7,300,682 & 8,247,003. European Patent No. EP1341547.
New Zealand Patent No. NZ598630. and NZ600307. Eurasian Patent No. EA20368
34
DerMoist DCx Human User Study
*After using DerMoist DCx 3% Moisturizing Cream for 4 weeks by 20 volunteers (6 men and 14 women), during a
study conducted by an independent agency
35
DerMoist DCx - Deliverables

Affords hydration of skin
Moderate and modulate sebum production
Improve skin immunity
Support skin rejuvenation
36
DerMoist DCx - Usage and Dosage

Range
Anti-acne
Anti-aging
Day Care
Skin conditioning
Dosage Form
Cream, Face Wash

Cream, Serum
Creams, Lotions
Creams, Lotions
Dose
5-15%
5-10%
3-5%
2-5%
37
DHeal DCx
38
6. DHeal DCx
DHeal DCx is a scientifically validated
composite of natural nutrients that provide a
healing touch and soothe the skin while
protecting it from microbial infections.
39
DHeal DCx - Ingredient Rationale

Cococin CG - Supports skin hydration and promotes wound healing
Centellin CG Wound and scar management
1,2 Diols Antimicrobial, hydration support
Chamomile extract Proven anti-irritant phytonutrients
Aloe vera Clinically validated to promote wound healing and soothing
Allantoin A proven moisturizing, healing, anti-irritating, soothing nutrient
Betaine Monohydrate - Helps strengthen skin barrier and maintain waterbalance of the skin
40
DHeal DCx - In vitro study

Activity
Result
MTT cell proliferation assay 24.15% cell proliferation at 50 g/ml

SRB cell proliferation assay
21.50% cell proliferation at 50 g/ml
41
DHeal DCx - Deliverables

Promotes cell renewal and restores skin vitality
Helps reduce inflammation
Stimulates collagen production
Prevents microbial infection
Provides antioxidant support
Gently nourishes the skin
42
DHeal DCx - Usage and Dosage

Range
Cuts/Burns & Wounds

Cleansers
Skin conditioning
Dosage Form
Cream
Face wash
Hand wash
Creams, Lotions
Dose
3-5%
2-4%
3-5%
2-5%
43
KeraCon DCx
44
7. KeraCon DCx
KeraCon DCx is composed of ingredients which
helps to strengthen hair, promote hair growth
and keeps the hair healthy and soft.
45
KeraCon DCx - Ingredient Rationale

Cococin CG - Helps promote hair growth while moisturizing the scalp
Barley Beta Glucans - Helps to improve the hair vitality and protect it from
environmental stressors
Caffeine A phosphodiesterase inhibitor, helps prevent hair loss and also
promotes hair growth
Betaine Monohydrate - Increase the moisture content of the hair, protects
the scalp and produces brighter hair gloss
Trehalose Moisture retention property
46
KeraCon DCx - In vitro study

Activity
Result
MTT cell proliferation assay 22.35% cell proliferation at 50 g/ml

SRB cell proliferation assay
26.00% cell proliferation at 50 g/ml
47
KeraCon DCx - Deliverables

Strengthens hair shaft
Protects from hair shaft damage
Protects hair from environmental stressors
48
KeraCon DCx - Usage and Dosage

Range
Hair care
Dosage Form
Hair conditioner
Shampoo
Conditioning Creams
Gels
Dose
5-8%
2-5%
1-2%
1-2%
49
MelaLite DCx
50
8. MelaLite DCx
MelaLite DCx is a natural composite of melanin
suppressors that helps to lighten the skin tone and
eliminate pigmentation problems.
51
MelaLite DCx - Ingredient Rationale

SabiWhite - Clinically proven to be a safe and effective alternative to
Hydroquinone for its skin lightening property
pTeroWhite - Potent melanogenesis inhibitor, UV protectant
Licorice Extract 40% CA Potential tyrosinase and melanogenesis

inhibitor
Tetrahydrocurcuminoids (SabiWhite) U.S Patent No. 6,653,327. European Patent No. EP1171144
& EP1328263. New Zealand Patent No. NZ514884. Australian Patent No. AU2006235807
52
MelaLite DCx - In vitro study

Skin lightening potential of MelaLite DCx vs Kojic acid
IC50 (g/ml)
100
80
MelaLite DCx
100
Kojic Acid
60
40
20
0
3.62
Tyrosinase inhibition
10.19
Melanogenesis inhibition
Lower the IC50 value, higher the activity

53
MelaLite DCx Human User Study
Users also reported an improvement in skin clarity, skin tone and glow
on using MelaLite DCx cream.
*After using MelaLite DCx 1% Skin Lightening Cream for 4 weeks by 20 volunteers (10 men and 10 women), during a
study conducted by an independent agency
54
MelaLite DCx - Deliverables

Improves fairness to the skin
Supports an even skin tone
Nourishes skin to make it bright and radiant
Protects skin against harmful UV radiation
55
MelaLite DCx - Usage and Dosage

Range
Skin lightening
Depigmentation
Anti-aging
Sun care
After suncare
Dosage Form
Cream,Lotion,Serum
Cream
Cream, Serum
Cream, Lotions
Cream, Lotion
Dose
3-5%
5-8%
1-3%
1-2%
3-5%
56
DCosmix Application Areas.

Application Focus
Skin firming
Skin regeneration
Skin conditioning
Skin hydration
Skin protection
Skin calming
Skin nourishing
DCosmix
AgeLess Complex DCx

AgeLess Complex DCx
CosmeVit DCx, DermaSoothe DCx
DerMoist DCx
AcNil DCx, DHeal DCx
DermaSoothe DCx, DHeal DCx, AcNil DCx
DerMoist DCx
Contd.,
57
DCosmix Application Areas.

Application Focus
Skin energizing
Skin lightening
Skin brightening
Skin de-stress
Hair growth
Hair fall control
DCosmix
CosmeVit DCx
MelaLite DCx, CosmeVit DCx
MelaLite DCx
CosmeVit DCx
KeraCon DCx
KeraCon DCx
58
DCosmix
DCosmix is an intelligent integration of science and
performance.
DCosmix is suitable for use in a broad range of dosage
forms that include creams, lotions, gels, serums, tonics
and more.
DCosmix The formulators choice
59
www.sabinsa.com
participating members of:
THANK YOU
60

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Sabinsa Corporation | Confidential | www.sabinsa.com

DCosmix Application Focus.

Sabinsa Corporation | Confidential | www.sabinsa.com

Sabinsa Corporation | Confidential | www.sabinsa.com

Broad range of application

1 AgeLess Complex DCx Skin firming, Skin regeneration

Anti-acne, Skin protection, Skin calming

Skin conditioning, Skin energizing, Skin

Skin conditioning, Skin calming

Skin hydration, Skin nourishing

Skin protection, Skin calming

Hair growth, Hair fall control

Skin lightening, Skin brightening

Sabinsa Corporation | Confidential | www.sabinsa.com

AgeLess Complex DCx

1. AgeLess Complex DCx

Sabinsa Corporation | Confidential | www.sabinsa.com

Ageless Complex DCx Ingredient Rationale

Ageless Complex DCx In vitro study

13.56% inhibition at 1000 g/ml

11.5% inhibition at 1000 g/ml

Sabinsa Corporation | Confidential | www.sabinsa.com

AgeLess Complex DCx - Deliverables

Sabinsa Corporation | Confidential | www.sabinsa.com

AgeLess Complex DCx - Suggested Usage and Dosage

Sabinsa Corporation | Confidential | www.sabinsa.com

Sabinsa Corporation | Confidential | www.sabinsa.com

Sabinsa Corporation | Confidential | www.sabinsa.com

AcNil DCx Ingredient Rationale

AcNil DCx In vitro Antimicrobial activity

Inhibitory activity against P acnes bacteria

Sabinsa Corporation | Confidential | www.sabinsa.com

AcNil DCx - Deliverables

Sabinsa Corporation | Confidential | www.sabinsa.com

AcNil DCx - Suggested Usage and Dosage

Sabinsa Corporation | Confidential | www.sabinsa.com

CosmeVit DCx - Ingredient Rationale

CosmeVit DCx - Deliverables

Sabinsa Corporation | Confidential | www.sabinsa.com

CosmeVit DCx - Suggested Usage and Dosage

Cream, Lotion, Translucent Serum 0.5-1%

Sabinsa Corporation | Confidential | www.sabinsa.com

CosmeVit DCx used in commercial formulation

Sabinsa Corporation | Confidential | www.sabinsa.com

Sabinsa Corporation | Confidential | www.sabinsa.com

DermaSoothe DCx - Ingredient Rationale

Sabinsa Corporation | Confidential | www.sabinsa.com

DermaSoothe DCx - Deliverables

Sabinsa Corporation | Confidential | www.sabinsa.com

DermaSoothe DCx - Usage and Dosage

Sabinsa Corporation | Confidential | www.sabinsa.com

DermaSoothe DCx used in commercial

Sabinsa Corporation | Confidential | www.sabinsa.com

Sabinsa Corporation | Confidential | www.sabinsa.com

DerMoist DCx - Ingredient Rationale

DerMoist DCx Human User Study

DerMoist DCx - Deliverables

Sabinsa Corporation | Confidential | www.sabinsa.com

DerMoist DCx - Usage and Dosage

Cream, Face Wash

Sabinsa Corporation | Confidential | www.sabinsa.com

Sabinsa Corporation | Confidential | www.sabinsa.com

DHeal DCx - Ingredient Rationale

D'Cosmix

D'Cosmix