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Pagets disease can be confused with other skin conditions such as eczema, dermatitis and psoriasis,
because they can look very similar. This can make Pagets disease difficult to diagnose.
Pagets disease usually affects the nipple first and then the surrounding tissue, whereas other skin
conditions usually affect the areola (the dark area of skin around the nipple) first, and then spread into the
nipple.
Several tests may be carried out to diagnose Pagets disease of the breast. They may include the following.
Ultrasound scan
A gel is spread on the breast and a small device that emits sound waves is rubbed over the area. A
computer then converts these sound waves into a picture of the breast tissue. This test is painless and
takes just a few minutes.
A gel is spread on the breast and a small device that emits sound waves is rubbed over the area. The
echoes are converted into a picture of the breast tissue by a computer. This test is painless and takes just a
few minutes.
Biopsy
This is the main test for cancer cells below the skin surface. A small sample of skin and underlying breast
tissue is taken and sent to the laboratory to be examined under a microscope. A local anaesthetic is usually
given to numb the area first. The biopsy may be taken at the same time as an ultrasound to ensure that it's
taken from the correct area.
Surgery
The type of operation you have will depend on how much the breast is affected. Your surgeon and breast
care nurse will explain more about the type of operation that is best for your individual situation.
Usually an operation to remove all of the breast (a mastectomy) is done if the cancer affects a wide area, or
if there's DCSI in different parts of the breast. Some women may have a new breast shape formed (breast
reconstruction) at the same time as the mastectomy. But this may not be suitable for everyone, and breast
reconstruction can be done later when treatment is finished.
Some women may have an operation to remove the affected breast tissue along with some surrounding
normal tissue and also the nipple and areola (called breast-conserving surgery). This may be possible if
there's only a small area of cancer and the surgeon thinks the appearence of your breast will still be good
after surgery.
If you have an invasive cancer, your breast surgery will usually include removing some or all of the lymph
nodes in your armpit.
Radiotherapy
Radiotherapy treats cancer by using high energy x-rays to destroy the cancer cells, while doing as little
harm as possible to the healthy cells.
You will usually have radiotherapy to the remaining breast tissue after breast-conserving surgery. Its given to
reduce the risk of the cancer coming back in the breast. If the cancer is invasive, some women who have a
mastectomy may be given radiotherapy to the chest afterwards.
Radiotherapy is given as a series of short daily sessions, usually Monday-Friday, with a rest at weekends.
Each treatment takes 10-15 minutes. A course of radiotherapy for breast cancer usually lasts three weeks
and is given to you as an outpatient.
Your doctor or nurse will discuss the treatment and possible side effects with you. The skin in the treatment
area may become red or sore, or if you are dark skinned, it may become darker. Youll be given advice on
how to look after your skin. Youre likely to feel tired during treatment and this may continue for a month or
two after it. Get plenty of rest, but balance this with gentle, regular exercise, such as short walks, which will
give you more energy.
Side effects usually gradually disappear once your treatment has finished. You can read more about
radiotherapy in our section on radiotherapy.
Hormonal therapy
Some breast cancer cells have oestrogen receptors on their surfaces. This is called oestrogen receptor
positive (ER positive) breast cancer. Oestrogen is a hormone produced in the body. It can encourage some
breast cancer cells to grow.
If you have ER positive breast cancer, you'll be prescribed hormonal therapy to reduce the risk of cancer
coming back and to protect the other breast. You usually have it for up to five years. There are different types
of hormonal therapy and they work in different ways. Some hormonal therapies reduce the amount of
oestrogen in the body, while others prevent oestrogen from reaching the cancer cells.
Drugs such as tamoxifen, anastrozole, letrozole (Femara) or exemestane (Aromasin) may be used.
Your doctor or breast care nurse will give you more information about the hormonal therapy you'll be having
and any possible side effects it may have.
Chemotherapy
Chemotherapy is the use of anti-cancer (cytotoxic) drugs to destroy cancer cells. It's not used to treat an
underlying DCIS, but it may be given if the cancer is invasive.
You will have the chemotherapy drugs given by injection into a vein (intravenously) or as tablets.
Chemotherapy into the vein is given as a session of treatment, usually over a few hours. This is followed by a
rest period of a few weeks, which allows your body to recover from any side effects of the treatment.
Side effects of chemotherapy can often be well controlled by medicines and usually improve when treatment
is over. Some of the side effects the drugs may cause are increased risk of infection, tiredness, feeling sick
(nausea) and hair loss.
Always let your doctor or nurse know about any side effects you have. There are usually ways in which they
can be controlled or improved.
Our section on chemotherapy discusses the treatment and its side effects in more detail. We also have
information on individual chemotherapy drugs.
Trastuzumab (Herceptin)
Herceptin is one of a new group of drugs called monoclonal antibodies. Monoclonal antibodies are
sometimes called targeted therapies because they work by targeting specific proteins (receptors) on the
surface of cells.
Some breast cancer cells have too much of a protein called HER2 (human epidermal growth factor 2) on
their surface. The extra HER2 receptors stimulate the cancer cells to divide and grow. Herceptin locks on to
the HER2 protein. This blocks the receptor and stops the cells from dividing and growing.
the HER2 protein. This blocks the receptor and stops the cells from dividing and growing.
Herceptin only works in women who have cancer with high levels of the HER2 protein (HER2 positive breast
cancer), which you will be tested for. It can be used to treat early breast cancer or breast cancer that's
spread (secondary breast cancer).
Herceptin can affect the way the heart works so you will have tests to check the health of your heart first.
Herceptin is usually given once every three weeks for a year. You may have it with chemotherapy or after
chemotherapy has finished. Its given as a drip (infusion) into a vein in your hand or arm. Side effects can
include flu-like symptoms, diarrhoea and headaches, but these tend to be mild.
Research trials
Research into treatments for breast cancer are ongoing. Cancer specialists use clinical trials to assess new
treatments. Before any trial is allowed to take place, an ethics committee must approve it and agree that it's
in the interest of patients.
You may be invited to take part in a clinical trial. Your doctor must discuss the treatment with you so that
you have a full understanding of the trial and what it involves. You may decide not to take part, or to withdraw
from a trial at any stage. You'll then receive the best standard treatment available.
Your feelings
You may have many different emotions, including anger, resentment, guilt, anxiety and fear. These are all
normal reactions and are part of the process many people go through in trying to come to terms with their
condition.
Everyone has their own way of coping with difficult situations. Some people find it helpful to talk to family or
friends, while others prefer to seek help from people outside their situation. Some people prefer to keep their
feelings to themselves. There is no right or wrong way to cope, but help is there if you need it. Our cancer
support specialists can give you information about counselling in your area.
You may find it helpful to talk things over with your doctor or nurse, or with one of our . Family members and
close friends can also offer support.
We make every effort to ensure that the information we provide is accurate and up-to-date but it should not be
relied upon as a substitute for specialist professional advice tailored to your situation. So far as is permitted by
law, Macmillan does not accept liability in relation to the use of any information contained in this publication or
third party information or websites included or referred to in it.
Macmillan Cancer Support, registered charity in England and Wales (261017), Scotland (SC039907) and the
Isle of Man (604). A company limited by guarantee, registered in England and Wales company number
2400969. Isle of Man company number 4694F. Registered office: 89 Albert Embankment, London SE1 7UQ.