Name Of Drug

General Action

Indication

Contraindication

Side Effects

Adverse Effects

1.) Oxytocin

Endogenous
hormone with
uterine stimulant
properties and
vasopressive and
antidiuretic effects.

Initiation or
improvement of
uterine contractions
to achieve early
vaginal delivery for
maternal or fetal
reasons (IV); as
adjunctive therapy
in the management
of inevitable or
incomplete abortion
(IV); stimulation of
uterine contractions
during third stage
of labor (IV);
stimulation
reinforcement of
labor, as in selected
cases of uterine
inertia (IV); control
of postpartum
bleeding or
hemorrhage (IV,
IM); induction of
labor in patients
with a medical
indication for the
initiation of labor
(eg, Rh problems,
maternal diabetes,
preeclampsia at or
near term) when in
the best interest of
mother and fetus or
when membranes

Hypersensitivity to
the drug; significant
cephalopelvic
disproportion;
inadequate,
undeliverable fetal
position; obstetric
emergencies in
which surgical
intervention is
preferred; cases of
fetal distress in
which delivery is
not imminent;
prolonged use in
uterine inertia or
severe toxemia;
hypertonic or
hyperactive uterine
patterns; when
adequate uterine
activity fails to
achieve satisfactory
response; when
vaginal delivery is
contraindicated (eg,
invasive cervical
carcinoma, active
herpes genitalis,
total placenta
previa, vasa previa,
prolapse of the
cord).

GenitourinaryRupture of uterus,
increased tone of
uterine muscle.
Fetus or neonateJaundice; abnormal
heart rhythm, slow
heart beat, brain,
brain damage,
seizure, eye
bleeding, low Apgar
score. (Activity,
Pulse, Grimace,
Appearance, and
Respiration).
Mother- Low blood
pressure, fast heart
rate, nasal
irritation, runny
nose, tears
(following nasal
admin); uterine
bleeding, violent
contractions,
increased tone of
uterus and spasm,
nausea, vomiting.
Heart- Premature
ventricular
contractions,
hypertensive
episodes.
GastrointestinalNausea and
vomiting.

Cardiovascular
Maternal reactions
include cardiac
arrhythmias,
premature
ventricular
contractions,
hypertensive
episodes; fetal or
neonatal reactions
include
bradycardia,
premature
ventricular
contractions, other
arrhythmias.
CNS
Fetal or neonatal
reactions include
permanent CNS or
brain damage and
seizures.
EENT
Fetal or neonatal
reactions include
retinal hemorrhage.
GI
Maternal reactions
include nausea and
vomiting.
Genitourinary
Maternal reactions
include rupture of
uterus, uterine
hypertonicity.

Nursing
Responsibilities
*Start flowcharts to
record maternal BP,
and other vital
signs, I&O ratio,
weight, strength,
duration, and
frequency of
contractions as well
as fetal heart tone
and rate, before
instituting
treatment.
*Monitor I&O during
labor. If patient is
receiving drug by
prolonged IV
infusion, watch for
symptoms of water
intoxication. Report
changes in
alertness and
orientation and
changes in I & O
*Stop the drug
immediately if the
uterus contracts
excessively or the
fetus is in distress.
Intra muscular
administration is
not regularly used
due to
unpredictable
effects of this
medication.

are prematurely
ruptured and
delivery is indicated
(IV).

2.) Ranitidine

Histamine-2
blockers

Reducing the
amount of acid your
stomach produces.

Kidney disease,
liver disease, or
porphyria.

MetabolicNutritional- Water
intoxication with
convulsion, coma,
and death.
MiscellaneousSevere allergic
reactions, absence
of fibrinogen in the
plasma that could
be fatal, blood clot
in pelvic region.
Leukopenia,
granulocytopenia,
and
thrombocytopenia,
gynecomastia,
impotence, and loss
of libido in male
patients

Hepatic
Fetal or neonatal
reactions include
jaundice.

Constipation,
nausea/vomiting,
diarrhea, abdominal
pain, and rare
reports of
pancreatitis.

Do not use it for

prolonged periods
in resistant uterine
inertia, severe preeclampsia
(hypertension), or
severe CV
disorders, hyper
hydration.