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Email: alvaneenennaam@ucdavis.edu
Twitter: @BioBeef
http://animalscience.ucdavis.edu/animalbiotech
Van Eenennaam 12/8/2015
BreedingMethod:
SelectiveBreeding
GenomicSelection
Mutagenesis(ENU)
GeneKnockout(ES)
Geneticengineering
Sterileinsecttechnique
Cloning
GeneEditing
Species
Research
Millionsof
Mice/Laboratory
Rodents/Zebrafish
VanEenennaam12/8/2015
Biomedical
Products
Pharma
products
Pigs
Rabbit
Ruconest
Goat ATryn,
spidersilk
Xenotransplantation
Cattle polyclonal
humanantibodies
Pets
GloFish
Micropigs
PestControl
TseTse fly
sleepingsickness
Mosquitoes
malariaresistance
Moths
agriculturalpest
control
Agriculture
AquAdvantageSalmon
fastgrowth
PolledHolsteins
Diseaseresistance
Improvedproductquality
Decreaseenvironmental
footprint
Singlegenderoffspring
AnimalGenomicsandBiotechnologyEducation
Some participants expressed a preference for use of geneticallymodified (GM) animals over ENU mutagenesis, based on the
belief that the former involves less pain and improves both the
accuracy and efficiency of the animal models
Ormandy, E.H., C.A. Schuppli, and D.M. Weary. 2012. Factors Affecting Peoples Acceptance of
the Use of Zebrafish and Mice in Research. ATLA 321-333.
Van Eenennaam 12/8/2015
MethodUsed:
SelectiveBreeding
GenomicSelection
Mutagenesis(ENU)
GeneKnockout(ES)
Geneticengineering
Sterileinsecttechnique
Cloning
GeneEditing
Species
Research
Millionsof
Mice/Laboratory
Rodents
VanEenennaam12/8/2015
Biomedical
Products
Pharma
Products
Pigs
Rabbit
Ruconest
Goat ATryn,
spidersilk
Xenotransplantation
Cattle polyclonal
humanantibodies
Pets
GloFish
Micropigs
PestControl
TseTse fly
sleepingsickness
Mosquitoes
malariaresistance
Moths
agriculturalpest
control
Agriculture
AquAdvantageSalmon
fastgrowth
PolledHolsteins
Diseaseresistance
Improvedproductquality
Decreaseenvironmental
footprint
Singlegenderoffspring
AnimalGenomicsandBiotechnologyEducation
GLOFISH
Species:Tetras,DaniosandBarbs
Breedingmethod:GeneticEngineering
Purpose:Pet
Purpose
Shouldwekeeppets?
Doesthetraitimpactfish?
Shouldwebreedanimals
tobepets?
Species
Doesbreedingmethod
hurtfish?
Isthisafoodspecies?
Dotheyposean
environmental
hazard?
Governance?
VanEenennaam12/8/2015
Doesbreedingmethod
posenewrisks?
Howelseisthistrait
achievedinpetfish?
Breeding
Method
AnimalGenomicsandBiotechnologyEducation
MethodUsed:
SelectiveBreeding
GenomicSelection
Mutagenesis(ENU)
GeneKnockout(ES)
Geneticengineering
Sterileinsecttechnique
Cloning
GeneEditing
Species
Research
Millionsof
Mice/Laboratory
Rodents
VanEenennaam12/8/2015
Biomedical
Products
Pharma
Products
Pigs
Rabbit
Ruconest
Goat ATryn,
spidersilk
Xenotransplantation
Cattle polyclonal
humanantibodies
Pets
GloFish
Micropigs
PestControl
TseTse fly
sleepingsickness
Mosquitoes
malariaresistance
Moths
agriculturalpest
control
Agriculture
AquAdvantageSalmon
fastgrowth
PolledHolsteins
Diseaseresistance
Improvedproductquality
Decreaseenvironmental
footprint
Singlegenderoffspring
AnimalGenomicsandBiotechnologyEducation
AquAdvantagesalmon
Species:Atlanticsalmon
Breedingmethod:GeneticEngineering
Purpose:Agriculture/Foodanimal
Purpose
Shouldweeatfish?
Shouldwefarmraisesalmon?
Doesthetraitimpactfishhealth?
Aretherehealthrisksfromeating
fastgrowingfish?
Species
Doesbreedingmethod
hurtfish?
Isthisafoodspecies?
Dotheyposean
environmental
hazard?
Governance?
VanEenennaam12/8/2015
Doesbreedingmethod
posenewrisks?
Canthisphenotypebe
achievedwithother
breedingmethods?
Hasitalready?
Breeding
Method
AnimalGenomicsandBiotechnologyEducation
MethodUsed:
SelectiveBreeding
GenomicSelection
Mutagenesis(ENU)
GeneKnockout(ES)
Geneticengineering
Sterileinsecttechnique
Cloning
GeneEditing
Species
Photocredit:CornellAllianceforScience
Research
Millionsof
Mice/Laboratory
Rodents
VanEenennaam12/8/2015
Biomedical
Products
Pharma
Products
Pigs
Rabbit
Ruconest
Goat ATryn,
spidersilk
Xenotransplantation
Cattle polyclonal
humanantibodies
Pets
GloFish
Micropigs
PestControl
TseTse fly
sleepingsickness
Mosquitoes
malariaresistance
Moths
agriculturalpest
control
Agriculture
AquAdvantageSalmon
fastgrowth
PolledHolsteins
Diseaseresistance
Improvedproductquality
Decreaseenvironmental
footprint
Singlegenderoffspring
AnimalGenomicsandBiotechnologyEducation
HornlessHolstein
Species:Bos taurus
Breedingmethod:Geneediting
Purpose:Agriculture/Foodanimal
Photocredit:CornellAllianceforScience
Purpose
Shouldweeatbeef?
Doeshornlessimpactcattle
health?
Aretherehealthrisksfrompolled
cattle?
Species
Doesbreedingmethod
hurtcattle?
Isthisafoodspecies?
Dotheyposean
environmental
hazard?
Governance?
VanEenennaam12/8/2015
Doesbreedingmethod
posenewrisks?
Canthisphenotypebe
achievedwithother
breedingmethods?
Hasitalready?
Inbreeding?
Breeding
Method
AnimalGenomicsandBiotechnologyEducation
Method Used:
SelectiveBreeding
GenomicSelection
Mutagenesis(ENU)
GeneKnockout(ES)
Geneticengineering
Sterileinsecttechnique
Cloning
GeneEditing
Research
Millionsof
Mice/Laboratory
Rodents
VanEenennaam12/8/2015
Biomedical
Products
Pharma
Products
Pigs
Rabbit
Ruconest
Goat ATryn,
spidersilk
Xenotransplantation
Cattle polyclonal
humanantibodies
Pets
GloFish
Micropigs
PestControl
TseTse fly
sleepingsickness
Mosquitoes
malariaresistance
Moths
agriculturalpest
control
Agriculture
AquAdvantageSalmon
fastgrowth
PolledHolsteins
Diseaseresistance
Improvedproductquality
Decreaseenvironmental
footprint
Singlegenderoffspring
AnimalGenomicsandBiotechnologyEducation
Researchinmice
Species:Musmusculus
Breedingmethod:ENUmutagenesis/Knockout/GE
Purpose:Research
Shouldweperform
Purpose
researchonanimals?
Doesbreedingmethodimpact
health?
Aretherenonanimalsubstitutes
toreduceexperimentalnumbers?
Species
Doesbreedingmethod
hurtthemice?
Isthisafoodspecies?
Dotheyposean
environmental
hazard?
Governance?
VanEenennaam12/8/2015
Doesbreedingmethod
posenewrisks?
Canthisphenotypebe
achievedwithother
breedingmethods?
Hasitalready?
Breeding
Method
AnimalGenomicsandBiotechnologyEducation
Mouse x mutagenesis/genetic
engineering/KO x research
MethodUsed:
SelectiveBreeding
GenomicSelection
Mutagenesis(ENU)
GeneKnockout(ES)
Geneticengineering
Sterileinsecttechnique
Cloning
GeneEditing
Species
Research
Millionsof
Mice/Laboratory
Rodents
VanEenennaam12/8/2015
Biomedical
Products
Pharma
Products
Pigs
Rabbit
Ruconest
Goat ATryn,
spidersilk
Xenotransplantation
Cattle polyclonal
humanantibodies
Pets
GloFish
Micropigs
PestControl
TseTse fly
sleepingsickness
Mosquitoes
malariaresistance
Moths
agriculturalpest
control
Agriculture
AquAdvantageSalmon
fastgrowth
PolledHolsteins
Diseaseresistance
Improvedproductquality
Decreaseenvironmental
footprint
Singlegenderoffspring
AnimalGenomicsandBiotechnologyEducation
Conclusion
There are many ethical issues associated with the use of animals
in general, the use of animals for research purposes, animal
welfare, and the intentional development and use of genetically
modified animals for research purposes
http://animalscience.ucdavis.edu/animalbiotech
Van Eenennaam 12/8/2015