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LMethylfolate,Methylfolate,5MTHF,L5MTHF.Whymanyvariations?

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LMethylfolate,Methylfolate,5MTHF,L5MTHF.Whatisthe

L-Methylfolate, Methylfolate, 5-MTHF, L-5MTHF. What is the Difference!?


by Dr Lynch on April 5, 2012 in MTHFR Mutations
10

653

Those with MTHFR mutations scan labels, read websites or listen to their doctors rattle of conflicting terms
for a nutrient they really need.
Understanding which form of methylfolate is best must be clear.
Why all the confusion?
Because there are so many different terms used for methylfolate.
By the end, you will understand everything you need to know about methylfolate.
More significantly you will understand how to pick the right form of methylfolate.
Terms often used for methylfolate are:
Methylfolate
L-MTHF
L-Methylfolate
L-Methylfolate Calcium
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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D-Methylfolate
D-5-Methylfolate
Levomefolic Acid
Metafolin
5-MTHF
5-Methylfolate
5-Methyltetrahydrofolate
L-5-MTHF
L-5-Methyltetrahydrofolate
6(S)-5-MTHF
6(S)-5-Methyltetrahydrofolate
6(R)-5-MTHF
6(R)-5-methyltetrahydrofolate
Quatrefolic
Are these forms of methylfolate all the same?
No.
Are any of these forms of methylfolate the same?
Yes. The same forms are grouped together here. These forms are synonymous with each other:
1. L-5-MTHF = L-5-Methyltetrahydrofolate = 6(S)-L-MTHF = 6(S)-L-Methyltetrahydrofolate
Good forms which are well absorbed
2. L-Methylfolate Calcium = Metafolin = Levomefolic Acid
Good forms which are all well absorbed
3. D-5-MTHF = D-5-Methyltetrahydrofolate = 6(R)-L-MTHF = 6(R)-L-Methyltetrahydrofolate
Avoid these (learn why soon)
Then what are the other forms of methylfolate?
The other forms of methylfolate may or may not be 99% pure biologically active methylfolate.
5-MTHF
5-Methylfolate
5-Methyltetrahydrofolate
How come these may or may not be 99% pure biologically active methylfolate?
These forms do not specify the L form (or 6(S) form) of methylfolate; therefore, you do not know what you
are ingesting.
The forms of methylfolate not specifying L or 6(S) likely contain more than 1% of the D form of methylfolate.
What is the difference between D and L forms of Methylfolate?
In organic chemistry, one learns compounds may have the exact same molecular formula and sequence of
bonded atoms but differ three dimensionally. These compounds are known as steroisomers.[1]
There are two common forms of sterioisomers:
1. Enantiomers:
mirror images of each other, such as our hands.
same physical properties
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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may have different biological effects


2. Diastereoisomers:
not mirror images of each other
rarely have same physical properties
have different biological effects
Methylfolate has stereoisomers in the form of diastereoisomers.
The forms of methylfolate that are biologically active are:
L forms
6(S) forms
L-5 forms
Metafolin
L-Methylfolate Calcium
Levomefolic Acid
Quatrefolic
The forms of methylfolate that are NOTbiologically active are:
D forms
6(R) forms
The forms of methylfolate that may or may not be biologically active are the:
forms which do not specify L, 6(S) or trademarked name of Metafolin
5-MTHF
5-methylfolate
5-methyltetrahydrofolate
From the package insert of Metanx, a prescription drug using biologically active Metafolin[2]:
L-methylfolate or 6(S)-5-methyltetrahydrofolate [6(S)-5-MTHF], is the primary biologically active
diastereoisomer of folateand the primary form of folate in circulation.It is also the form which is
transported across membranes into peripheral tissues,particularly across the blood brain barrier.In the cell,
6(S)-5-MTHF is used in the methylation of homocysteine to form methionine and tetrahydrofolate (THF).THF
is the immediate acceptor of one carbon units for the synthesis of thymidine-DNA, purines (RNA and DNA)
and methionine.About 70% of food folate and cellular folate is comprised of 6(S)-5-MTHF. Folic acid, the
synthetic form of folate, must undergo enzymatic reduction by methylenetetrahydrofolate reductase (MTHFR)
to become biologically active.Genetic mutations of MTHFR result in a cells inability to convert folic acid to
6(S)-5-MTHF.
Metafolin (L-methylfolate calcium) is a substantially diastereoisomerically pure source of L-methylfolate
containing not more than 1% D-methylfolate which results in not more than 0.03 milligrams of Dmethylfolate inMetanx
D-methylfolate or 6(R)-5-methyltetrahydrofolate [6(R)-5-MTHF] is the other diastereoisomer of folate. Studies
administering doses of 2.5 mg per day or higher resulted in plasma protein binding of D-methylfolate higher
than L-methylfolate causing a significantly higher renal clearance of L-methylfolate when compared to Dmethylfolate.Further, D-methylfolate is found to be stored in tissues in the body, mainly in the liver. Dmethylfolate is not metabolized by the body and has been hypothesized to inhibit regulatory enzymes related
to folate and homocysteine metabolism and reduces the bioavailability of L-methylfolate.
Example of why all this is important to know
A supplement company has a supplement called, 5-MTHF
Lets say this supplement states it contains 10 mg of 5-MTHF.
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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One assumes this contains 10 mg of biologically active L-methylfolate.


Dont assume.
The likelihood of it containing 99% of the biologically active form of L-methylfolate is slim to
none.
Why?
Prescription drugs such as Deplin contain 99% active L-methylfolate as Metafolin. Deplin provides two
potencies of L-methylfolate: 7.5 mg and a 15 mg
This much L-methylfolate is VERY potent and must be prescribed by a physician.
Merck does not allow any supplement company to provide more than 1 mg of their L-methylfolate in a
stand-alone supplement. If L-methylfolate, as Metafolin, is included in a formula along with other
nutrients, then a maximum of 800 mcg is allowed.
What amount of this 10 gram 5-MTHF supplement actually contains the biologically active Lmethylfolate?
It is not known without requesting a lab report.

READPREVIOUSPOST:

Ten Day Transformation Between Mother and Child

Therearetwopeopleclosetomethatcannotha
goodtimeineachother'spresence.Oneisan...

The likelihood of it containing a significant amount of the inactive D form of methylfolate is high.
Remember, the D form of methylfolate is undesirable and actually may reduce the bioavailability of Lmethylfolate.
What to do?
Two things:
1. Request a prescription from their physician to obtain drugs containing Metafolin.
2. Look for supplements specifying the amount of active L-methylfolate.
Drugs containing Metafolin are:
Metanx
Deplin
Cerefolin
CerefolinNAC
Neevo
NeevoDHA
Supplements with Methylfolate
One must carefully evaluate supplements specifying the use of Metafolin, Quatrefolic or the L form.
If the supplement does not specify on the label that it uses Metafolin, Quartrefolic or the L form
of methylfolate, then it is not recommended to use without first inquiring directly to the
manufacturer. A manufacturer may have named their product as 5-MTHF and use the pure L
form of methylfolate; however, one must inquire to be certain.
Quatrefolic: What is this?
This is a new form of methylfolate that uses glucosamine instead of calcium to bind the L-methylfolate.
Quatrefolic is also a quality form of L-methylfolate.
Key Points about Methylfolate:
1. Not all methylfolate is the same
2. The D form of methylfolate actually is undesired and should be avoided
3. The L form of methylfolate is the desired form
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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4. There are many names for the same thing. Understand them.
___________________
Supplements using the pure form of L-Methylfolate
Seeking Health uses purely the L-methylfolate as Metafolin.
You may find over-the-counter L-methylfolate as Metafolin here in these select Seeking Health
supplements.

10

653

5mthf,l5mthf,Lmethylfolate,methylfolate
TenDayTransformationBetweenMotherandChild
RecurrentMiscarriageCauses:LookBeyondtheWoman

ViewComments(97)
SubmitAComment

1.
LauraApril26,2012at6:40pm#

Reply

ThankyoufortheworkyouredoingtohelpthoseofuswithMTHFRandrepeated
miscarriages!IvebeentakingGardenofLifesRawOneforWomenmultivitamin.Itlists
Folate800mcg.Wouldthatbeanacceptableform?WehaveacallouttoGardenofLife,
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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buthaventheardbackyet.IjustfoundoutthatImpregnant,andtryingtowadethroughthe
informationtofigureoutwhattodoasfarasaprenatalandBvitamins.IamhetroforC677t.
Ivehadfourmiscarriages.Threesecondtrimester,andoneatnineweeks.Ihave6healthy
children,butmylastthreepregnanciesweremiscarried,andthisistheonlypossiblecause
thatwasfound.Ialsohavehashimotos.Ihaveuppedmysynthroiddoseandamnowon
heparin.ImplanningonorderingthesublingualB12w/Methylfolate.
LauraApril29,2012at6:03pm#

Reply

DearDr.Lynch,
IamheteroforMTHFR,C677Tallele.Ihavea13yroldsonwhoisdiagnosedwith
ADHD,Autism/Aspergers(veryhighfunctioning),severeasthma,allergies,
autoantibodiestofolate(Dr.EdwardQuadrostest),hypothyroid,immunedysfunction,
mitochondrialdysfunctioncomplexes1&3,andhasbeenidentifiedrecentlybyhis
neurologistashavingsignificantproblemswithmethylation.
Heiscurrentlyon25mgofLeucovorindaily.Within3monthshisbinocularvision
defectsresolved.Thisyearinschool(afternearlyayearonleucovorin,hisreading
comprehensionhasimprovedgreatlytogradelevel(truelyamazing).Hetakesmany
supplementstoomanytolisthereallprescribedbyhisDAN!Doctorandhis
neurologist.IputhimonanoralIgGsupplementduetochronicillnessesenabledby
LowIgGandlowneutrophils(notlowenoughtoqualifyforIVIG).Hehasalso
demonstratedlowIgM.SincestartingtheoralIgGlastsumer,hishealthhasbeen
muchbetter.HealsogetsB12(methylcolbalaminshotsevery3days.
IamconsideringhavinghimtestedforMTHFRmutations.IstheLeucovorinthebest
formoffolateforhim?
Myownhealthissuesareendometriosis,hypothyoid,prematureovarianfailure,
chronichives,keratoconusandothercollagenrelatedproblems.
Thanksinadvance!
Laura
MelissaJune11,2012at6:09pm#

Reply

Laura,
Dontknowifthisisappropriatepostingetiquetteorhowwecouldgetintouch
andstillmaintaineveryonesprivacy,butplease,ifitspossible,couldyoutell
mewhoyourDANdoc/Neurologistis?Theysoundamazing,andgood
Neurologists,especially,seemnotoriouslydifficulttocomebyespeciallyones
thatmayunderstandthewholecerebralfolatemetabolismissues,methylation
polymorhisms,etc.Ihaveasonwhohas,forthemostpart,recoveredfrom
autism,butcontinuetodoresearchforhimandmymyriad,lifelong,vague
healthissues.IndoingsoIhaverecentlyputsomeGIANTpuzzlepieces
togetherregardingmyextendedfamilyshealthhistoryandreallywanttowork
withsomeoneknowledgable.Iwillcontinuetodigintothis(amazinga
Godsend)website,hopefullycontactDr.Ben,butyourpoststruckachordandI
thoughtIdreachout,momtomom.Also,dyingtofindouthowtogetDr.
quadrostestcantseemtofindit?Whodidyoufindtodoit?Pleasehelp!
Thanksinadvance
Melissa
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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DrBenJune11,2012at7:01pm# Reply

Melissa
IwillbemakingDrQuadrostestavailablesoononmywebsite.Itisan
importanttesttoevaluate.
Askingfordoctorreferralsfromeachotherisperfectlyfineand
encouragedpleasepostdirectlyinthecomments
DesOctober7,2012at4:21pm#
JustanIMPORTANTFYI:manyoftheBrandsyoulistedsuchas
NEEVO,containSoyLecithin(MSG)andTitaniumDioxide
Toxicwheningestedonadailybasis
LauraJune11,2012at9:32pm#

Reply

Dr.RichardFryeismysonsNeurologist.HeisatArkansasChildrens
Hospital.Justmovedandnotseeingpatientsyet.Wellworththetimefor
anyparentofanautisticchild.
Dr.BryanJepsonwasmysonsDANDr.Unfortunately,heisnolonger
seeingpatients.HehasanexcellentbookcalledChangingTheCourseof
Autism,though.
Feelfreetoemailme@lauc174@aol.com
SherrieLineCoilNovember14,2012at11:56pm#
myNeurologistinDavis,CaliforniaisEricHassid,M.D.ofInstitute
ofRestorativeHealthafunctionalNeurology,AntiAgingand
RegenerativeMedicineclinic.
HetestedmeandIamcompoundheterozygousforthemutations.
Amnowtaking5MTHFandhavingIVtreatments.
Itisareleiftohavesomeanswersandaroadlesstraveledtotake
myjourney
Sherrie
2.
JenniferJuly27,2012at6:02pm#

Reply

HiDr.Ben,
Firstofall,Idliketosaythankyouforallofyourresponsestomyquestionsandeveryone
elsesyouareprovidinguswithsomuchgoodinformation!
IhaveaquestionregardingthePrenatalPromultivitaminmadebyDesignsforHealth.Isaw
itmentionedonanotherpostasapotentiallygoodoption.Inlookingattheiringredientlist,I
seeitsfolateisablendcalledNatureFolate(atrademarkblend).ThenIsawonanotherpost
thatyousaidnaturefolateisnotanadequatetypeoffolateforMTHFR.Arethesetwoterms
referringtothesameentity?Iftheyarethesame,doyoufeelthePrenatalProisnotagood
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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option?
Thankssomuch,
Jennifer
3.
prasadAugust6,2012at12:19pm# Reply

whatisprofalacticuseofl5,methyltetrahydrofolate?
4.
JenniferAugust13,2012at9:48pm#

Reply

HiDr.Ben,
Inmyquesttofindagoodprenatalvitamin,ImadeaninquirytoDesignsforHealth,after
seeingitlistedononeofyourposts.Iaskedspecificallywhattypeofmethylfolatetheyused
(theycalltheirfolateblendNatureFolate,whichIthoughtIhadreadsomewhereonhere
thatitwasnotagoodtype).ThisistheresponseIreceivedfromthem:
Iaskedourproductdevelopmentmanagertohelpansweryourquestion.
Hisrepliedwiththefollowinginformation:NatureFolateisablendofthenaturalSformof
both5Methyland5Formyltetrahydofolate.Theamountsofeachisproprietaryinformation.

WouldyouconsiderthistobeanacceptableformofmethylfolateforaheterozygousC677T
personlikemyself?
Thankyouforyouradvice,
Jennifer
PatDecember31,2013at7:22pm#

Reply

Jennifer,didyoueverygetaresponsetothisquestion?Iaminterestedtoknowthis
also.
5.
LatoriaSeptember1,2012at2:02pm#

Reply

Iwasonlineresearching5MTHFandcameacrossthispage.Ihavea5yearoldsonwho
wasdiagnosedwithautismatage2.Forthepast3months,wehavebeenslowlyintroducing
supplementsrecommendedbyhisDANspecialist.Followingtestingwefoundthatmyson
wouldbenefitfrom:Calciumcitrate,DPPIVdigestiveenzyme,SuperNuTheraliquid
multivitamin,VSL#3morningandProBioGoldatdinner,Speak(whichcontainsvitaminE,
omega3,GLA,andvitaminK),LGlutamine,AlphaKetoglutaricacid,EsterCantifungals
goldensealandgrapefruitseedextract(whichwerotateeveryfourweeks),UvaUrsifor2
weekperiodsandswitchtoOregongrapeextractforsixweeks,androtatetheBiofilm
strippersInterfaseandNattokinaseeveryfourweeks.Wehaveyettointroduce,AcetylL
Carnitine,LMethylFolate,5HTP,LipoceuticalGlutathione,NacetylLcysteine,and
TransferFactorSensitive/MultiImmunewhichbringsmetomyresearchtoday.Ofthese
newsupplements,Iwillbeintroducingonetodayandwouldappreciateanyinputyou
viewerscanoffer.ThissitehashelpedmeunderstandthedifferencesinFolatesupplements,
butIquestionifmysonhasagoodbrand.Mysontakesabrandcontaining1,000mcgFolate
(asMetafolinL5methyltetrahydrofolate).Iwouldappreciateanyadvice/infoyoucould
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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provideDr.Ben.
6.
AnnSeptember21,2012at4:01pm#

Reply

Ihavea5MTHFproductthatis10mgderivedfrom5methyltetrahydrofolate20mg.Ijust
askedthemanufactureraboutthe6Svs6Rcomposition,andhereistheirreply:
10mg(6S)5MTHFand10mg(6R)5MTHF.Asstatedonthelabel,weuse20mgtotal
racemic(50/50)5MTHFtoyield10mg(6S)5MTHF.
ThanksDrLynchforyourpost.Thisproductisgoinginthetrash.
MarieDecember21,2012at7:23pm#

Reply

Ann,istheproductyoumentionbyMetabolicMaintenance?Ihaveseveralbottles
withthesameingredients.
Dr.Ben,isitokaytogivethisfolicacidtosomeonewhodoesnothavetheMTHFR
genemutation,orisitbetternottouseitatall?
Also,IhaveaproductbyJigsawcalledActivatedBw/SRT.ItsanactivatedB
complexwithQuatrefolic5MTHFin200mcg.Doyouknowanythingaboutthis
supplement?Imwonderingifitssafetotake.
7.
MegJanuary6,2013at2:36am#

Reply

Hi,
Thankssomuchforwritingthis.
Iam30yrsoldandhaveMTHFRandLeidenFactor5.IsitacceptabletotaketheNew
ChapterPrenatal(ithasfolate)plusoneoftheseekinghealthsLmethylfolates?
AlsodoesathyroidissuehaveanythingtodowithMTHFR?
Thankssomuch
8.
SharonMarch11,2013at1:09am#

Reply

Dr.Ben,
IhaveahomozygousMTHR667tdefectmynaturopathhasmeonThorneLaboratories5
MTHFtheactiveingredientisnotlistedasanLoraDmethyltetrahydrofolate.Doyou
knowifthisbrandhasthemostbioavailableformsthatyousuggestinyourwritings?
Thankyou
9.
BecApril11,2013at11:35pm#

Reply

Folate(asQuatrefolic[6S]5methyltetrahydrofolicacidequivalentto1.6mgof[6S]5
methyltetrahydrofolicacid
Notsureificanpostspecificbrandsbutifoundthisonewiththeabovestatedingredients
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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andamwonderingiffolinicacidisokaytotakeforMTHFRhomozygous.
FruitbatDecember13,2013at8:12am#

Reply

HowmuchQuatrefolicisequivalentto1.6mgof[6S]5methyltetrahydrofolicacid?
MeganDecember1,2014at1:18am#

Reply

Ialsohaveasupplementwiththeseexactingredients.Didyoufindananswertothis
question?
Michael_DowdyDecember29,2014at8:48pm#

Reply

HelloMegan.Ivelookedfortheanswer.Tomethemuchmoreseriousquestion
isCanthebodyproduce5DMTHFwhenitseesthewrongmolecule?
5MTHFhasbothbutexactlywhathappenstothewrongonewhichisin5MTHF
stillseemstobenotfullyknownorunderstood.5DMTHFisgoingtohave
differentpropertiesthan5LMTHFandtoxicityissomethingIthinkislikely.
Thalidomideisanexampleofwhatcangowrongwhentheresachiralproblem.
http://www.chirality.org/homepage.htm

10.
jslim180April19,2013at8:38pm#

Reply

Imtaking4,500mgofCysteineHCLperday.Theprotocolalsocallsfor400mcgofFolate
perday.IwouldliketouseL5MTHFinstead.HowdoIfigureouthowmuchIneedtake?
11.
KarenJuly20,2013at2:46pm#

Reply

HiDr.Lynch,
IsfolateinamultivitaminasbroccolithesameasfolateinabcomplexasMetafolin,L5
MTHF?Thereisamultivitaminwith4,000mcgoffolateasbroccoliandabcomplexwith
400mcgoffolateasMetafolin,L5MTHF.Thoughthedosageforthemultivitaminismuch
higher,isitasaferbettostartwithsincethesourceoffolateisnaturalfoods?Pleaseadvise,
thankyou.
Karen
DrBenJuly21,2013at12:19am# Reply

HiKaren
Idcallthesupplementmanufacturerandask.
MybetisitismostlikelyaformofTHForfolinicacidandnotmethylfolate.
Iliketoknowexactlywhichformsoffolateoneisgetting.Foodformsmaybegreat
butIpreferknowingwhatIandmyclientsaresupplementingwithexactly.
Theneatingfolaterichfoodsonyourownisgreat.
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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12.
ZachAugust1,2013at2:08am#

Reply

HiDr.Ben.
Firstoff,thankyouforalltheworkthatyoudo.Clearlyitshighlyvaluabletoallthose
strugglingwiththeseissues.
Justacoupleofquickquestions.Ivetaken5MTHFasawaytoaugmentmycurrentSNRI
(Pristiq)andtobehonestIfeltquitegood.Iwastaking1mgperdayinthemorning.ONthe
3rddayIhadsomemildinsomniaandmuscleachesintheshoulders/upperback.4thday,I
actuallypulledsomethinginmyupperback,whichseemedtobeduetomuscleweakness.
Ivereadabouttakingniacintocombatthesideeffectsofthe5mthf,butshouldIcontinue
withthe5mthfregimenandjustincludeniacindaily?Shouldtheniacinbetakenatacertain
timeorjustasneeded?
13.
RyanAugust22,2013at1:14am#

Reply

Is(6S)5methyltetrahydrofolategood?Mysupplementincludes800mcgaday.Ima
doubleheterozygote.
DrLynchAugust22,2013at8:25am# Reply

HelloRyanyesabsolutely.ItisagreatformofmethylfolatewhichIalsouse.
RyanAugust22,2013at9:21am#

Reply

Is800mcgenough?Ihaventyetbeenabletoseeadoctor,butuntilthen,what
canIdo?ImtakingtheCountryLifeCoenzymeBComplex,butIdontknow
howtotellifitsworking.
14.
JaimeMichaelsAugust28,2013at5:07pm#

Reply

HiDr.Lynch,IamreallyconfusedabouttheBComplexSeekingHealthsells.Itlistsfor
folate:5methyltetrahydrofolatewhichisaquestionableformyoudontrecommend.Whydo
yousupportthisproduct?Andwhydonttheyusethemetafolinform?AlsoIreadthat
QuatrefolicismuchbetterabsorbedthanMetafolinwhatdoyouthink?Thanksforallyour
incredibleinformation!
DrLynchAugust29,2013at12:44am# Reply

HiJaime
TheBComplexprovidedbySeekingHealthoffersthe5methyltetrahydrofolateas
MetafolinwhichisL5MTHF.
QuatrefolicisabitbetterabsorbedfromwhatIamfindingaswell.Wehaveswitched
outfromMetafolintoQuatrefolicinour:
Prenatal
ActiveB12withL5MTHF
HomocysteXPlus
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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WewillcontinuetomovefromMetafolintoQuatrefolic.
Thedifferencesareminimaloverall.Ihaveotherreasonsfromswitchingfrom
MetafolintoQuatrefolicanditdoesnotrelatetoabsorptionorquality.Justapersonal
preference.
RachelFebruary25,2014at4:45pm#

Reply

HiDr.Lynch,
CouldyoupleaseelaboratefurtheronwhyyouareswitchingfromMetafolinto
Quatrefolic,evenifitisjustpersonalpreference.
Ihaveswitchedbackandforthbetweenthetwoformsmyself.Idontknowifit
isplaceboeffectthatMetafolinseemstoworkslightlybetterforme.
Also,Ihavespenthoursresearchingwhichofthetwoformsisbetter,anditis
frustratingnottofindaclearanswerotherthanthatQuatrefolicisthenewer,
nextgeneration.
Thankyouforyourresponse!
DrLynchFebruary25,2014at8:09pm# Reply

Rachel
Theswitchwasforafewreasons:
betterabsorption(slightly)
preferthenoncalciumboundmethylfolate
BothareverygoodformsofmethylfolateIthinkthedifferencesarevery
slight.
ThedifferenceyoufeelmaybethatQuatrefolicisactuallystrongerthan
MetafolintrytakinglessQuatrefoliccomparedtoMetafolindonttake
theequalamount.Seeifthathelps.Youmaybetakingtoomuch
methylfolatewhentakingQuatrefoliccomparedtoMetafolindueto
improvedabsorption.
15.
CarikerCSeptember25,2013at3:15pm#

Reply

Thankyousomuchforthisdetailedandclearinformation
16.
FruitbatDecember13,2013at8:39am#

Reply

Canyougiveanyadviceontherelativeavailablefolateinthedifferentacceptable
supplementforms?
IaskbecauseofwonderingaboutthesituationofswitchingfromL5MTHF(Metafolin)to
Quatrefolic.Ihavereadcontradictoryadviceelsewhereaboutadjustingthedosageof
QuatrefolicbothupanddownrelativetotheMetafolin.Wouldbegreattoknowyour
thoughtsonthis.
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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Manythanks
17.
GaryDecember29,2013at3:03pm#

Reply

Dr.Lynch,
Doyouknowifthereisaconnectionbetweenfolacinandhistamine?Istartedusingthe
SolgarMetafolinwhichseemstorestorelibidowheneverythingelsehasfailed.Allmy
hormonelabslooknormal,andImwonderingifIcouldbehistapenic
18.
CarieFebruary18,2014at9:19pm#

Reply

Hi,Dr.Lynch!
Thanksforallyourinfofromyourresearch.
Mymultiforwomenover40islistedasFolate(500mcgasCalciumFolinateand500mcgas
LMethyltetrahydrofolatefromL5MethyltetrahydrofolinicAcid,Glucosaminesalt)1mg.
IheardyourwebinarwithDrChristiansonthathypothyroidpatientsareverylikelytohave
theMTHFRmutation.Ihavebeenavoidingsyntheticfolicacidasaresult.
WouldthisCalciumFolinatebesafe.Thanks.
DrLynchFebruary18,2014at9:49pm# Reply

HelloCarie
YescalciumfolinatecanbeveryusefulasitsupportsDNAbaseproduction.
MethylfolatesupportsSAMeproductionandhomocysteinerecycling.
SincetheMethioninesynthaseenzymeissopicky,itisbest,inmyopinion,tosupport
peoplewithfolinicacidabitaswell.
Ifyouarefeelinggoodandyourdoctoragrees,thenshouldbegoodtogo.
JoshAugust1,2014at5:55pm#

Reply

Dr.Lynch,
IfirstwanttocommendandthankyouforprovidingresourcesaboutMTHFR
andthehardworkandeffortyouareputtingintotheefforttospreadawareness.
Idohaveonefollowupquestionbasedonthispost.
Thesupplement(aThorneproduct)thatIamtakingtohelpmyownhealth
issueshasL5MethyltetrahydrofolatefromL5MethyltetrahydrofolicAcid,
GlucosamineSalt.IsthisthesamethingastheQuatrefolicyoudiscussedinyour
post?
Ifnot,isthisformoffolatestilleffective(bioavailable)forhelpingwith
MTHFRissues?
Thankyousomuch!
Bestregards,
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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Josh
19.
AlexFebruary22,2014at5:16am#

Reply

HiDr.Lynch.Thankyouforallyoudo.Theinformationonyourwebsitehashelpedme
identifythatIhaveaMTHFRmutationandIvebeenworkingwithmyprimarycare
physicianandtakingaqualitymethylfolatesupplement.
Inthisarticle,youmentionsteroisomersandhowweneedacertaintypeofmethylfolateto
makesurewegettherightform.Imwonderingifthereareothervitamins/mineral
supplementsthatcouldalsohavenonactive,undesirableforms.
Itakeavarietyofsupplements,andamcuriousifthereareinactiveformsofothernutrients
B12/methylcobalamin,B6/P5P,etc.
Thankyou!
20.
SimonMarch16,2014at4:22pm#

Reply

DearDr.Ben,
IwaswonderingaboutthepotencybioavailabilityofLmethylfolateasMetafolin,orwhats
usedinDeplinvsQuatrefolic.IfQuatrefolicisjustaspotent(ormore)asyousuggest,mg.
vsmg.whyisQuatrefolicalotlessexpensive?
Thanks!
Simon
21.
ChrisApril26,2014at10:03pm#

Reply

Dr.Lynch,
ImheterozygousA1298C.Thepersonwhodiagnosedmeandorderedthelabtestingisa
verywellreadnursepractitionerandshehasacompounddiagnosisherself.Shewantsmeto
goonDeplinandB12(methylcobalaminform).Ifoundanaffordableandgoodformulation
ofmethylcobalaminthatIlike.Unfortunatelyasyouknow,DeplinisVERYexpensive,Istill
cantfigurewhyitissoexpensiveotherthanMerktookoutapatentonitandthereisonly
oneauthorizedgenericthatischeaperbutstillexpensive.Iaskedheraboutseveralother
productsthatappeartobelegitimatetomeandaremuchmoreaffordable.Shewenttoa
conferenceofsortsformedicalprofessionalsandafterwardssaid,Therearenoproductsthat
canbetakeninplaceofDeplinorthegenericLMethyfolateCalciummadeby
BreckenridgeNowIhaveahardtimeswallowingthatandIhavemydoubtsaboutthat
statement.
Ihavelookedatyourguidelinesaboveaswellasinyourintroductoryvideoatthehomepage
ofmthfr.net.Ihavetirelesslylookedforotherproductswithmethylfolateandtheyarealso
expensive(likeDeplin),illegitimateformsofmethylfolate,orarentthedosemyNPwants
meon.
Ihavefoundseveralproducts(seelinksbelow)calledMethylPro.Themethylfolateseemsto
meetyourguidelinesandcriteriaforthegoodform.TheygettheirmethylfolatefromGnosis
S.p.A.TheyhavebothQuatrefolicandExtrafolateS(bothregisteredtrademarks).Im
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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17/7/2015

LMethylfolate,Methylfolate,5MTHF,L5MTHF.Whymanyvariations?

lookingatthe10mgdose.ItlookslikeitsbasedinSisters,Oregon.
http://www.methylpro.com

Myquestionstoyouare:
1.Aretheselegitimateformsofmethylfolate?
2.KnowingIalreadytakeB12,whichMethylProproduct,assumingthesearelegitimate,
wouldyourecommend(ExtrafolateS,Quatrefolic,Quatrefolic+cofactors)?
Ifyouwouldlikethereishelpfulnarrativeabouttheirproductsandasectiononhowit
comparestoDeplin:http://www.methylpro.com/more_info
Onanothernote,IguessGnosisinthepasthadalabelingproblemwiththeExtrafolateS
(seehttp://www.gnosisbio.com/pdf/Corrective%20advertising%20letter%20for%20Extrafolate%20&%20ExtrafolateS.pdf)
however,itappearstheyhavecorrectedthisundercourtorder.
Ireallyappreciateanyguidanceyoucanofferonthismattertome.Ialsoappreciatethe
wealthofinformationyouhavehereandthatitisfreetoallsothattheymaybettertheir
health.
22.
ChrisMay3,2014at8:46pm#

Reply

IforgottomentionImcurrentlyonGabapentin,Doxepin,andmethylcobalamin.
KimHildrethJune27,2015at3:02am# Reply

ChrisIfoundyourpostsearchingGabapentinandDoxepinIamtryingtohelpmy
niecewithherMTHFRandsheisonthatsamedrugcombo.Iwaswonderingifyou
havefoundawinningsupplementcombo.Youcanemailmeatkim@drugtestyourteen.com.
Thanks!
23.
ValMay15,2014at7:21pm# Reply

HelloDr.Lynch,
Myunderstandingisthat{6S}L5MTHFisprocessedfromfolicacid.Itisasynthetic
formoffolateandthatFormaldehydeisusedinthedistillationprocesstoobtainthisformof
folate.Couldyoupleaseclarifyallofthis!!!Ofcoursemyconcernisinthepossibilityof
ingestinganyformaldehyderesidue.
ManyThanks,
Valerie
24.
SucramdwMay20,2014at2:24am#

Reply

SowhatdoesitmeanforthiswholefoodsWomansmultitohaverealFolateas100%
Organic??http://www.herbalprovider.com/WholefoodWomensMultiOrganic
ThankYou!!
25.
MichelleMay21,2014at2:03am#
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

Reply

15/31

17/7/2015

LMethylfolate,Methylfolate,5MTHF,L5MTHF.Whymanyvariations?

SeekingHealthKidsOptimalMultivitaminlistsFolateas5methyltetrahydrofolate.It
doesntspecifyDorLanddoesntmentionMetafolin.Youputthattypeonyour
questionablelist.
26.
DaleJune12,2014at9:56pm#

Reply

WhatdoyouthinkabouttheuseofRheumate?
27.
rexAugust1,2014at7:40pm#

Reply

Iwashopingthatyouwouldhavereferencestoyourstatementsaboutthebiologicalactivity
andeffectivenessofthevariousformsoffolicacidsothatIcansharethisinfomywifes
physician.SoIwentontoPubMed.comandtypedfolicacidandl5methyltetrahydrofolate
inthesearchsection.TherearemanystudiesshowingthatL5MTHFsupplementsare
effective.Somesaythatitisbetteroratleastthesameasageneralformoffolicacid
supplementation.Obviously,L5MTHFwouldbefarsuperiorforthosewhohaveissueswith
folicacid.hereare3articlesthatIfoundregardingL5MTHFeffectiveness:
1:PietrzikK,BaileyL,ShaneB.FolicacidandL5methyltetrahydrofolate:
comparisonofclinicalpharmacokineticsandpharmacodynamics.ClinPharmacokinet.
2010Aug49(8):53548.doi:10.2165/1153299000000000000000.Review.PubMed
PMID:20608755.
2:AkogluB,SchrottM,BolouriH,JaffariA,KutscheraE,CasparyWF,FaustD.
ThefolicacidmetaboliteL5methyltetrahydrofolateeffectivelyreducestotal
serumhomocysteinelevelinorthotopiclivertransplantrecipients:a
doubleblindplacebocontrolledstudy.EurJClinNutr.2008Jun62(6):796801.
Epub2007May23.PubMedPMID:17522618.
3:VennBJ,GreenTJ,MoserR,MannJI.Comparisonoftheeffectoflowdose
supplementationwithL5methyltetrahydrofolateorfolicacidonplasma
homocysteine:arandomizedplacebocontrolledstudy.AmJClinNutr.2003
Mar77(3):65862.PubMedPMID:12600857.
28.
CatherineAugust11,2014at1:16pm#

Reply

Hi,Dr.Lynch.Thankyousomuchforexplainingaboutthedifferentformsoffolate.Ifthe
genericequivalentofDeplin15mg(LMethylfolateCalciummanufacturedbyVirtus)states
ithaslessthan1%ofDmethylfolate,isthissafetotakeforsomeonewhoiscompound
heterozygousMTHFR?Ihadplannedtotake1/4ofthetabletdailyalongwithmethylb12.
HavingjustlearnedabouttheharmfuleffectsofDmethylfolateonyourwebsite,Iamnot
surewhattodo.Thisstuffcostalotofmoney,butshouldIthrowitinthetrash?Canyou
pleaseadvise?Thankyousomuch!!
29.
AdrianAugust20,2014at2:11pm#

Reply

Myquestionisdoesanyonenoticearecurringthemeherewiththecompaniesmanufacturing
thesesupplements?VeryfewthatIhavefoundhaveactuallybeenworthmuch.
Isufferfrommilddepressionandhavehadverybadexperienceswithantidepressants.They
actuallymakethedepressionworse.Ihaveagreatdoctorthoughwhotestedmygenesand
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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17/7/2015

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foundseveraltraitsthatpredisposemetodepressionandnotrespondingtoserotonin
reuptakeinhibitors.HesaidthatIwaslackingcertainchemicalsthathelpedmetoabsorb
folicacid.Hetoldmethatitwasnecessarytohavetheproperamountoffolicacidinorder
formybodytocreateserotonin,dopamineandotherchemicalsthathelpedonesmoodsand
depression.HeputmerightonLMethylfolateCalciumandsaidthathewantedtogiveita
try.Withinafewweeks,Iwasfeelingabitbetter.WithinafewmonthsIwashappierin
generalthanIhaveeverbeen.Great!Iwasabletogetexcitedaboutfunthingsthatwere
comingupandremainstableeveninbadtimes.
Mygirlfriendsuffersfromsimilarsymptomsoflightdepression.HerdoctorputsheronAnti
depressantsandshegetsworsejustlikeIdid.ShecanseewhattheDeplinhasdoneforme.
ShegoestoherdoctortoaskaboutLMethylfolateandhetellsherthatsheiscrazy.Heups
herdosageofantidepressantandshegetsevenworse.Idiscussthiswithmydoctorwho
unfortunatelydoesnotacceptmygirlfriendsinsurance.Hecantbelievethatherdoctorwont
justtrytheDeplin.ThemoreIhavereaduponthisthough,themoreIhavefoundthatthere
areLOTSofdoctorsouttherewhorefusetotryLMethylfolate.Whyisthis?Peopleare
beingforcedtofindalternativesontheinternetandotherplacesthatarenowherenearas
effectiveastheprescription.Thesecompaniesaregettingrichanddoingnogoodfortheir
patients.
WhyaredoctorssoafraidtoleavetheconfinesofconventionalAntidepressantsandtry
somethingthatismostlynatural?WearenthippiestryingtobeAllNaturaljustfortheheck
ofit.Thisvitaminreallydoessomegood.Especiallywhenyoucangetthepurestform
possible.Ijustdontknowwhysomanyaresoagainsthelpingusobtainthat.
MydoctorisretiringsoonandIhavebeenlefttofindanewdoctor.Alotofthesenew
doctorswouldputmeonjustaboutanychemicalthatIwant,butthesecondthatImention
theDeplintheyhavealltoldmeNo,JusttakeB12oryoucanbuysupplementsonline
thathasfolateinitHUH!?!?!?!
Iamaskingyouforasimplethinghere.LMethylfolateCalcium.Howaboutsome
OXYCODONEDoc?SurethingAdrian,butImnotwritingaprescriptionforL
MethylfolateWhatswrongwiththispicture?
30.
NatashaAugust20,2014at2:47pm#

Reply

HiDr,soheregoeslongstoryshortIhavesufferedfromsensorialneuropathyand
anxietysincemyplasticsurgeryprocedure5monthsago.Ihavebeentestedforeverything
imaginableandnothingtoexplaintheneuropathysomyNeurohadmetakeMetanx.WhenI
startedresearchingthedrugmedicationafterexperiencingitching,dizziness,andirritabilityI
startedreadingaboutMTHFR.IhadmyPCPtestmeforitandfoundoutImhomozygous
C677t.ItriedtoquittheMetanxandexperimentwithCountryLifeCoenzymeBComplex
(anxiety,itchiness),GardenofLifeKindOrganicWomensOnceaDay(instantNiacinlike
reactionofredanditchyflush),RealFoodOrganicsPrenatalDaily(anxiet,itchiness),
SeekingHealthOptimalMultivitaminChewable(dizziness,depression,anxiety).Even
takingsupplementsformyneuropathysuchasacetyllcarnitinebackfiredbygivingme
dizzinessandanxietyfor23days.Ihavebeenjuicingforabout2monthsandnoticedthat
addingthespinachmakesmeitchy!ThereforeIamnowdowntojusttakingmyVitaminD
andOmega3supplementsandjuicing.Noneofmydoctorsareknowledgableenoughabout
myMTHFRtohelpme.SomeonesuggestedthatanaddedingredientintheMetanxis
causingtheitchingandbeingoffofitsolongwithmyMTHFRissueisnotaddressingthe
neuropathy.Ihavenoticedfeelingmoreneuropathylately.Couldyourecommendadoctor
formetoseeintheMiamiReathatcanhelpmegetontrack?
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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31.
DebAugust23,2014at1:39am#

Reply

Iamlookingforfoodsthathavetheactiveformoffolate,myhusbandhasoneofthe
MTHFRdefectsandmydaughterhasboth.mLookingfornaturalfoodsourcetosupplement
theirdiets.IliveonafarmandifIcanplantberriesthathavethiswillgrowmyownBut
needtoknowifALLberrieshavetheactiveformIhavebeentoldblackberriesand
raspberriesdo,justnotsureaboutstrawberriesandblueberries.oranyothertypesofberries.
Anyhelpwouldbeappreciated.
DrLynchAugust26,2014at6:45am# Reply

FolatecomesfromtherootfolarIbelievewhichmeansleaves.Eatanythinggreen
andthatwillprovideyoualotoffolatesespeciallyiftheyareuncooked.
MaraSeptember7,2014at6:37pm#

Reply

Wouldorganicfolatebetoleratedaswellasthegoodformsoffolatefor
someonewithMTHFRandCOMT?Orcoulditstillcauseovermethylation.Ive
beentakinganorganicwholefoodmultivitamin(KindOrganics),whichsay
theirfolate(800mcg)isfromorganiclemon,butIvebeenfeelingabitoff.
DebSeptember10,2014at2:57pm#

Reply

DrLynch,canyouexplainsomethingtome?
Husbandhas:c677tmutationisheterozygousa1298cwasnegative
Daughterhas:c677tmutationisheterozygousa1298cisheterozygous
IwastoldIhavenomutations
Iwouldhaveexpectedtohaveatleast1298c
DrLynchSeptember11,2014at6:49am# Reply

Deb
WhichlabcompanydidtheMTHFRtesting?Consider
http://www.23andMe.comforallthreeofyouIdorecommendit.Readthis:
http://mthfr.net/mthfrtestoptionsoralswabbloodtestorsaliva/2013/06/26/

32.
SamanthaMcRorieSeptember8,2014at2:40am#

Reply

IuseaThorneMultiBproducteasiestformetogetinCanadaasIcangetitfrommy
naturopathandIdonthavetopayshipping.
Ihave2oftheirmultiBsrightnow.Ononelabelitsays:Folate(L5Methyltetrahydrofolic
acid)whichIdonotseeonyourlist.YesithastheLandthe5butwhywoulditsayfolic
acidattheend?
TheotherproductsaysFolicAcid(5Methyltetrahydrofolate).Sothisonedoesnthavethe
L.IamveryconfusedbyallofthisandwanttobesureIamusingthecorrectfolatesinceI
amheterozygousforC677T.
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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Doyouhaveanyadviceonthis?
DrLynchSeptember9,2014at6:10pm# Reply

YouneedtohavetheLformorthe6Sform.Iftheyarenotstatingthis,itmaybe
racemicmeaningthattherearetwoformsinthereofmethylfolate.Oneofthoseforms
isabsorbedandusedbyyourbodyandtheotheroneisnot.
DebSeptember11,2014at3:36pm#

Reply

Husbandanddaughterhadblooddrawn,sentoftoClinicalPathologyLabs,Inc.
whomtheDrofficeuses.Minewasdonebycheekswab.Itwasdonebya
company,DNASTATPharmacogenomicTestingServices.
Wouldyouexpectmothertohaveoneorthesedefectsifchildhasbothand
fatheronlyhasone?
33.
MaraSeptember11,2014at4:52pm#

Reply

Wouldorganicfolatebetoleratedaswellasthegoodformsoffolateforsomeonewith
MTHFRandCOMT?Orcoulditstillcauseovermethylation.Ivebeentakinganorganic
wholefoodmultivitamin(KindOrganics),whichsaytheirfolate(800mcg)isfromorganic
lemon,butIvebeenfeelingabitoff.
34.
ingNovember13,2014at6:47pm#

Reply

Ijustwantedtoaddmyexperiencewithdifferentbrands
Itriedthree.Onlyoneworkedforme.
JarrowQuatrefolichadnoeffectatall.
Solgarmetafolinworkedforsomeaspectsofmyhealthbutcausedirritability.
Thorne5MthfExtrafolateS(usesGnosisS.p.A.sL5Methyltetrahydrofolate)works
beautifullywithaddedbenefitsonmoodandsleep.
Canyoutellmewhyyousayallactiveformsworkthesamewhenclearlyallthesedifferent
activeformsworkdifferentlyforme?
CanyoucommentonExtrafolateS,ImconcernedoversomethingsIvereadaboutit.
thanksmuch
DrLynchNovember14,2014at7:31am# Reply

Goodpoints.
Theyshouldworkthesamebutclearlytheydonotwithyou.
Italsodependsonthequalityofthemanufacturerhowdotheyhandletheraw
material,howdotheencapsulateit,storeit,howfresh,howsealit,deliverysystem?
Mycompany,http://www.SeekingHealth.comisswitchingtoallGnosisQuatrefolicandmost
ofourproductscurrentlyusethat.
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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IamnotsureaboutExtrafolateSbutmyfirstthoughtisthattheyusecalciumsaltvs
glucosaminesaltlikeMetafolin.AlsoitmayberacemicIamnotsureofthe
percentageofeachisomer.
ingNovember15,2014at9:19pm#

Reply

ThankyouDrLynchforyourresponse.
IhavedonemoreresearchandseemsGnosisextrafolatesisnotrecemicfrom
theirwebsite:
extrafolateSisthecalciumsaltof(6S)5methyltetrahydrofolate,andis
suitableasafoodingredient.
theyalsomakeextrafolatethecalciumsaltof(6R,S)5methyltetrahydrofolic
acid.
Ihavefoundthatthequatrefolicformofmethylfolategivesmemanyofthe
negativesymptomslistedassideeffectsonyourwebsite.Formepersonally
irritiblity,anxiety,racingheart,achingmuscles,weakmuscles,backpain)
whereasextrafolatesgivesmeonlyexcellentresultswithaddedbenefitson
sleepandmood.
Ihavefoundmanypeopleonlinecommentingthatthishasbeentheirexperience
aswellwithquatrefolicandwouldaskyoutoconsidersellingasupplementthat
containsextrafolatesasanalternativetothosewhocannottoleratequatrefolic.
HadItriedquatrefolicfirstIwouldnothavebelievedthatmethylfolatetherapy
wasformeandbasedonthenegativereactionswouldnothavecontinued
supplementationnorwouldIhavetriedadifferentformofmethylfolatebecause
mostwebsitesclaimallactiveformofmethylfolateworkthesame.
Thankfullymyfirsttrywithamethylfolatesupplementwaswithabrandthat
usesextrapolatesandIhadnosideeffectsandcouldtellrightawaythatitwas
indeedworkingformysymptoms.
IfearmanypeoplewhomaybeintolerantlikeIwasmaytryquatrefolicfirst
sinceitiswhatyouandmanyotherwebsitesareendorsingbasedonthefactthat
itisthelatest/fourthgenerationformofmethylfolateandmaygiveupbasedon
negativesymptoms,andnotconsideranotherform/brandofmethylfolate.
Ifeellikemethylfolateintheformofextrafolateshasgivenmebackmylife
andIwouldhateforsomeonelikemyselftomissoutonlytonothavefoundthe
rightformofmethylfolatethatworksfortheirpersonalchemisty.
Iwouldlovetoknowwhatyouthinkaboutmypersonalexperienceandwould
loveforanarticletobewritenforthoselikeme.
Thankyouverymuchforyourresponseandconsideration!
ingNovember18,2014at8:30pm#

Reply

edit..
metafolin(solgarbrand)wascausingnegativesymptomsnotquatrefolic.
Howeverquatrefolic(Jarrow)hasnobeneficialeffectformeunlikelike
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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extrapolates.
Sorryforthemixup.
JeffNovember20,2014at7:31pm#
Hiing,
SinceyouvetriedvariousformsofactivemethylfolateIm
wonderingifyouhaveevertakenmultipleformsofactive
methylfolatesimultaneouslyonadailybasis?
Doyouknowiftheeffectivenessofthefolateisadverselyaffected
orarethereanysafetyconcernsyoudhavewithtakingmultiple
formsofmethylfolate?
Implanningontakingthesetwosupplementswhentheyarrive:
L5MTHF1000fromtheSeekingHealthcompany.
andBComplex#12fromThorneResearch.
Thereis200mcg.ofL5MethyltetrahydrofolicAcid,Glucosamine
Saltand
200mcg.ofCalciumFolinateineachoftheBComplexcapsulesby
ThorneResearch.
AND
1,000mcg.ofQuatrefolic(6S)5methyltetrahydrofolate,
glucosaminesaltcontainedintheSeekingHealthL5MTHF
capsules.
Thankyouverymuch!
JeffNovember20,2014at3:39am#

Reply

Hello,
Imsogladtohavefoundthisexcellentsite.MyphysiciansuspectedthatImay
haveMTHFRmutationsandorderedthebloodlabtest.Ijustreceivedmytest
resultsbackwhichshowthatIhaveboththeC677T&A1298Cmutations.
Imsuretheresalotoffactorsthataffectthisquestion,butImwonderingwhat
isagoodgeneralstartingdoseof5MTHFforsomeonelikemewithboth
mutations?
IorderedL5MTHF1000fromyourSeekingHealthcompany.
IalsoorderedBComplex#12fromThorneResearch.
Ineedtoknowifthesethreedifferentformsoffolatearesafetotaketogether?
Thereis200mcg.ofL5MethyltetrahydrofolicAcid,GlucosamineSaltand200
mcg.ofCalciumFolinateineachofmyBComplexcapsulesbyThorne
Research.
IthenplanontakingyourL5MTHF1000fromSeekingHealthwhich
contains1,000mcg.ofFolatefromQuatrefolic(6S)5methyltetrahydrofolate,
glucosaminesaltintheSeekingHealthL5MTHFcapsules.
Mydoctorwantstoprescribemealarge15mgstartingdoseoffolate,butafter
readingalittleofthewealthofinformationonthissiteitsoundslikethismaybe
waytoomuchwithahighprobabilityofcausingadversesideeffects.
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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Idsureappreciateyourinputontherecommendedstartingdoseandtothe
effectivenessandsafetyoftakingthemultipleformsoffolateIlisted.
Thanksinadvanceforyourinput,Iappreciateitverymuch!
35.
BridgetNovember14,2014at9:30pm#

Reply

Dr.Lynch,canyouexplainthedifferencebetweenjustplainfolateandmethylfolate?(I
understandthedifferencebetweenfolateandfolicacid.)Iamtakinganorganic,rawvegan
vitaminformulathatlistsfolateasoneoftheingredients.ButIamalsotakinga
supplementthatsays(6S5)5MethyltetrahydrolicAcid.AfiendsaysIshouldnttakethe
vitaminwiththefolatebecauseitcouldinterferewithmetabolizingthemethylfolate.Thank
youforyourreply.
36.
PamelaNovember27,2014at2:18am#

Reply

Dr.Lynch,
Thankuforyourremarkableinformation.MyMDactuallyrecommendeditsinceIwas
diagnosedwithheterozygousA1298c/A1298c.WediscussedthemethylationPlusthatshe
recommends.ButwhenIaskedforaprescriptioninstead,shesaidtherewasnyoneavailable
inadosesmallenough.Shementioned300or400mcg.IguessImwonderingifyoumay
knowofonethatshemightnot.ShealsomentionthemethylationpluswilltakecareofmyB
2,6,&9deficienciesallatonceinsteadofhavingtotakeseparatepills.Ihaveverygood
prescriptioninsurance.&wouldrathegothatrouteifpossibleduetofinances.Willthisbea
lifelongrequirementorwould/coulditresolvewiththecandidairradication?
Thankyou
37.
JuditB.January1,2015at10:31pm#

Reply

DearDr.Lynch!
IamMTHFRC677Thomozygotes.Ihavepolyneuropathiawithaverylatestageofchronic
lymedisease(+otherlotsofsymptoms).Ihavebeenveryillformanyyears.Ihavedonea
Nutrahackerhealthinfofrommy23andmetest.IamHungarianandreallycantimagine
whocouldhelpme.Iam27yearsold.
IwouldliketoaskyouwhatkindoffolateshouldItakeifNutrahackerreportsmetoavoid
folinicacidandmethyldonors!(methylB12too).IalsohavethreekindofCOMTgeneand
rs6922269,rs1801133,rs1805087,rs1802059,rs1801394,rs7946,rs7925545,rs234706.
Ahugeproblemisnervepain.IhavetriedtakingTurmeric(300mg600mg),butthepain
increasedinsupportablysoIhavefinishedtakingit.
Ijustwantyoutohelpmealittlebit.
Thankyouverymuchinadvance:JuditB.
38.
SherryGoekeJanuary8,2015at3:11pm#

Reply

DrLynch,
Whataboutfolateinwholefoodbasedvitamins,andmorespecificallyGardenofLiferaw
vitamins?
IhavebeenunabletotoleratemediumchaintriglyceridesinSeekingHealthproducts.
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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LMethylfolate,Methylfolate,5MTHF,L5MTHF.Whymanyvariations?

Thankyouforyourresponse.
DrLynchJanuary9,2015at9:06am# Reply

Sherryiftheydontspecifywhichformoffolateitis,thenIwouldnttrustit.
Mediumchaintriglyceridesarederivedfromcoconutoilandtheamountisveryvery
small.Areyousurethatstheproblem?
39.
suzanJanuary14,2015at7:01am#

Reply

Hi!Thankyouforthisarticleitisveryhelpful!Ihavebeendiagnosedwithmthfr
homozygousc677..Iamfindingithardtofindmethylfolate,canIsupplementwithfolate(
pillnotjustnaturally)andifyeswhatisthedosage?Forfolateormethylfolate.Wouldreally
appreciatesomeinsight!Whereiamfromitseemslimetheydontreallyconsidermthfrasa
problem!Ihaveexperiencedalready2miscarriagessoiwanttogetitrightthistime.Thanks
inadvance.
40.
sowmyaJanuary20,2015at8:04pm#

Reply

DearDr.BenLynch
CouldyouexplaintomewhendoesoneuseL5MTHForitsvariousformsmentioned,
versusLeucovorin?Iunderstandthatlackof5mtfcausesCerebalFolatedeficiency,butthey
supplementitwithLeucovorin,Iamtryingtounderstand,whatmatterswhere?Thankyou
DrLynchJanuary21,2015at10:49pm# Reply

ImnotsurewhytheyusefolinicacidvsMTHFinthosestudies.
Cost?
AsfarasIknow,folinicacidisneededtoproduceDNAbasesandMTHFisneeded
formethylationthegeneraloverviewanyhowtheydootherthingsaswellbut
thosearethetwomajorones.
Neurotransmittersneedmethylationtobeformedandeliminatedthemajorones
Ineedtoresearchfurtheriffolinicacidplaysarolespecificallyasfolinicacidin
neurotransmission.Atthispoint,IamnotawareofthatbutIcouldbejustignoranton
thematter.
SowmyaJanuary22,2015at8:31am#

Reply

DearDr.Lynch
Igottheanswerfromsomeofthemomswhoareworkingtowardshealing
childrenwithautismlikeme,fromwhatIunderstood,Leucovorinwouldbe
convertedtoL5MTHFhoweverifyouhavemutationsetc,thentheconversion
wouldbeaffectedorsloweddown..hereiswhatsomeoneanswered,Iamsharing
itincasesomeoneelsewouldbeinterestedtoknow..Leucovorindoesnotcontain
methylgroupsandthus,thisformdoesnotparticipatedirectlyinthemethyl
cycle.However,itisavaluableplayeringeneratingpyramidinesanditcanbe
transformedinto5MTHF.Ofcourse,thisisbestaccomplishedifachilddoes
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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nothaveanMTHFrpolymorphisminwhichthatenzymeislessefficient.The
MTHFreductasewillstilltransformLeucovorininto5MTHF,albeitsomewhat
slower.Thiscanbeespeciallyhinderedbyhomozygouspolymorphisminthat
particulargene.
Folinicacid(INN)orleucovorin(USAN),generallyadministeredascalciumor
sodiumfolinate(orleucovorincalcium/sodium),..Folinicacidisa5formyl
derivativeoftetrahydrofolicacid.Itisreadilyconvertedtootherreducedfolic
acidderivatives(e.g.,tetrahydrofolate),and,thus,hasvitaminactivitythatis
equivalenttothatoffolicacid.However,sinceitdoesnotrequiretheactionof
dihydrofolatereductaseforitsconversion,itsfunctionasavitaminisunaffected
byinhibitionofthisenzymebydrugssuchasmethotrexate.
Folinicacid,therefore,allowsforsomepurine/pyrimidinesynthesistooccurin
thepresenceofdihydrofolatereductaseinhibition,sothatsomenormalDNA
replicationandRNAtranscriptionprocessescanproceed.
Deplinisatradenamefor5MTHF.Folaproisalsothesamething,butinalow
OTCdose,i.e.,800mcg/tab.Deplinistheprescriptionversionofthisandmy
understandingofthisisthatitismuchhigherinmilligramsratherthan
micrograms.Thisisdoeshavemethylgroupsattached.Itistheonlyformthat
partakesdirectlyintheMetcycle.ThisonecanovercometheMTHFreductase
blockadeifitispresent.
thankyouforalltheinputs,itreallybringsinsomuchknowledgeandsomuch
hopethatiftherearesolutionstoproblemsandwecansomewayhelpour
childrentoleadanormallife!
BestWishes
SowmyaFesenbeck
41.
ZachMarch15,2015at5:08pm#

Reply

Dr.Lynch,
AftercountlesshoursofeducatingmyselfaboutL5MethyfolateandB12(Methyl,
Hydroxy),Iwanttopersonallythankyouforyourdedicationtohelpingothers.Itgiveshope
tothoseofuswhohavesufferedwithchronicdepression&anxietyovertheyearswithout
anysuccesstotypicalSSRItreatments.Iwishmoredoctorsandmentalhealthprofessionals
wereawareofthisasanalternativetreatmentwhenantidepressantssimplydonotworkin
somepeople,suchasmyself.Thereishopeinfeelingnormalagain.
Zach
DrLynchMarch21,2015at5:01am# Reply

HiZach
Mypleasure!Iampleasedtoherethatthisinformationishelpingyou.
Dolisten/watchthisaswellmayprovidesomemoreusefulinfo
http://www.seekinghealth.org/gift

Keepgettingbetter!
42.
ZoriApril11,2015at11:09am#
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

Reply
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LMethylfolate,Methylfolate,5MTHF,L5MTHF.Whymanyvariations?

Hello,DrBen.Ithankyousomuchforyourwork?
Canyoutellmewhetherfolateas(6S)5methyltetrahydrofolicacid,isthesameasfolate
asQuatrefolic(6S)5methyltetrahydrofolate?
43.
AmandaApril14,2015at9:22pm#

Reply

Thankyousomuchforthiswebsiteandalltheinformation!Iwasdiagnosedwith
hypothyroidismandPCOSin2009justbeforewehadourfirstdaughterwhowasstillborn.
ThenwegotpregnantwithourseconddaughterwiththehelpofClomidwhichisalsowhat
weusedforourfirstpregnancy.In2010iwasdiagnosedwithMTHFRafterthestillbirthof
ourfirstdaughterandIwastoldtotake4mgoffolicacid.Nowwearetryingtoconceive
againandtheClomidisntworkingatallImnotovulating.TheonlythingIhavedone
differentistakingthefolicacidandIcanthelpbutthinkthisisourissue!Couldthefolic
acidbetheculpritformyanovulationandcausingtheclomidtonotworkthistimewhenit
workedwithbothofourotherpregnancies?WhatshouldIbetakinginplaceofthefolic
acid?Thankyousomuch!
AronApril24,2015at9:49pm#

Reply

HiAmanda,
Dr.BenisaHUGEproponentofgettingridorallformsoffolicacid(manmadeform)
insupplementationandfortifiedfoods.Herecentlycreatedabriefoverviewofthe
differencesbetweenfolicacidandfolate(foundinnature)(https://www.youtube.com/watch?
v=oZzR1NMg0hM).Inshort,thereisreallynoreasontobetakingfolicacid.
Thereisalsoapostonprenatalsupplementationthatyoumightfindinteresting:
http://mthfr.net/prenatalsupplementationoptimizingyourfuturechild/2012/01/20/

Hopethishelps!
44.
TerriMaxwellMay5,2015at4:32pm#

Reply

MydrprescribedMethylfolate3MGeveryday,Iwenttotheherbstoreandthegaveme
MethylationCompletebyNeuroBiologix.Isthisthesame.3.2mg
45.
DebbieMay5,2015at10:34pm#

Reply

Sorryaboutthetypos.MydaughterrecentlywasdiagnosedwiththeMTHFRgeneproblem
andhasbeentakingFolateasL5Methyltetrahydrofolateandmanyofherlupuslike
symptomshaveabated.ThankGOD.
Irecentlywastold,ashermom,toalsobegintakingitandIwonderifthisproductiswhat
theysayitis.SwansonHealthProductshasaFolateproductthatislabeledas:Folate(as
Quatrefolic[6S]5methyltetrahydrofolicacidequivalentto1.6mgof[6S]5
methyltetrahydrofolicacid,glucosaminesalt).
MyquestionisThisislistedasfolicacidinsteadoffolate.Isthataproblem?Isthereany
differencebetweenthe2?
AronMay8,2015at7:33pm#

http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

Reply

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LMethylfolate,Methylfolate,5MTHF,L5MTHF.Whymanyvariations?

HiDebbieImgladtohearthatyourdaughterssymptomshaveabated.Thenaming
conventionscanbeveryconfusing!Therearemanyformsoffolates,whichisa
generalterm.Inthiscase,thisparticularSwansonproductisusingfolateas
Quatrefolic,whichisthesameformofhighlybioavailablefolatethatDr.Benhasused
inhisownformulations.Folicacidisthesyntheticformthatisnotasbioavailableand
potentiallyharmfulinthosewithMTHFRgenemutations.SeeDr.Benspostonthis
verytopic:http://mthfr.net/folicacidawarenessweek2014wantawarenesshereyougo/2014/01/08/.
Allthebest!
46.
EstherMay22,2015at3:43am#

Reply

Isthisok?
Folate(as(6S)N5methyltetrahydrofolicacidcalciumsalt(molarequivalentto600mcgof
folicacid)andfolicacid,USP400mcg)
Itispartofaprescriptionforironduetopregnancyanemia.InprescriptiondrugFeriva
DrLynchMay26,2015at10:58pm# Reply

Idontbelieveanyoneshouldtakefolicacid.
Idontseewhywecannotusemoreactiveformsoffolatefolinicacidand
methylfolatearetheactiveforms.
Folicacidisfarfromactive.
Pleasetalkwithyourdoctoraboutusingmoreactiveformsoffolate
Lookatthefolateonthelabelhereinthisprenatalvitamin:
http://www.seekinghealth.com/optimalprenatal240vegetariancapsulesseekinghealth.html

Itshowstheactiveformsoffolate.
Youcanusethatasanexample.
Alsolearningmoreaboutfolateisimportantpleasereviewhttp://www.seekinghealth.org/gift
Thankyou
47.
SaraJune14,2015at6:55pm#

Reply

HiDr.lynch.Iamnearly30w2copiesofthe1298cmutation.Ihavehadseveral
miscarriagesandturneduppositiveforthisaftertransferringageneticallynormalembryo
viaIVFandsufferingablightedovum.MydocprescribedfoolguardbutItakeThornes
basicprenatal(1000mcgfolate)and400mcgofmethylfolate.ivebeendoingsosince
Oct/Novish.Iamnowpregnantagainandwillbe6weekstomorrow.Imnotsureifthisone
willmakeit,butduetoasuspectedsubchorionichematoma(confirmed),Ihadanearlyscan
at5weeks3daysandsawasacandyolksac,soalreadybetterthanlasttime.Afterdoing
researchtoday,Isawthatmyversionofthemutationmayonlyabsorb10%ofthefolateI
take.ImwonderingwhetherIreallyneed4000mcg?AndwhetherIshouldupmyvitamins
orfolatethroughfood.Thatisalotofgreensmoothies.Thankyou.
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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LMethylfolate,Methylfolate,5MTHF,L5MTHF.Whymanyvariations?

Dr.AronJune15,2015at10:11pm#

Reply

HiSaraUppingyourintakeofvitaminsandmethylfolatethroughfoodisusuallythe
idealwaytogettheseessentialnutrientsplusmanyotheressentialvitamins,
minerals,andantioxidants.Leafygreensaregreatbecausetheycontainmethylfolate
plus100+otherformsoffolate!Illassume4000mcgwasatypoandyouare
wonderingabout400mcg.400mcgisnotalotofmethylfolate.Iliketotellpatients
thattheyshouldaverage57cupsofvegetablesperdaymakingsuretoeatarainbow
ofcolors.Colorsrepresentdifferentnutrientsandeatingarainbowwillmakesureyou
getasmuchasyoucanfromfood.Supplementationmakesupthedifference.
YoumightfindDr.Bensprenatalsupplementationarticlehelpful:http://mthfr.net/prenatal
supplementationoptimizingyourfuturechild/2012/01/20/

Pleasekeepusupdatedonyourprogress!
Allthebest,
Dr.Aron
48.
DominiqueJune22,2015at11:51pm#

Reply

Hello,
Iwasjustwondering,ifasupplementjustsaysfolate,isthatacceptable?Thankyou.
Dr.AronJune23,2015at6:22am#

Reply

Dominiquethereareover150+formsoffolate.Themostcommonforminmost
supplementsissyntheticfolicacid.Itsimportanttoknowspecificallywhichform.

1. MTHFRNovember5,2012
[]IfoundthissitetobeanexpertresourceonMTHFRGeneMutations:mthfr.net[]
2. ThesupplementsAugust13,2013
[]folateisgenerallysafeandhelpfulandmostpeoplebenefitfrom3mgperday.Iuse
theactiveformfromSolgarbecausesomepeopledontconvertwellfromfolicacid.Ason
FDCmemberputit[]
3. MyMethMTHFRLiving August21,2013
[]evenseeninpersonthemoreinsidioussubstancethatdrivesthatprogram.Imtalking
aboutmethylatedBvitaminshere,whicharecrucialtoconqueringMTHFR.Imnot
planningontellingyouhowtodoseinthis[]
4. Tinnitus:Treatments,Causes,Genetics,Metabolism,andLOUDNOISES|MetabolicGiant
September4,2013
[]AccordingtoDr.BenLynch,peopleinterestedinactivefolateshouldpurchaseL
Methylfolate(seeadetailedexplanationofwhichtypeoffolatetobuyhere).Youalsowant
http://mthfr.net/lmethylfolatemethylfolate5mthf/2012/04/05/

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LMethylfolate,Methylfolate,5MTHF,L5MTHF.Whymanyvariations?

tobecarefulwithcopperastoomuchcanalsobeaproblem,especiallyifyouhave[]
5. HaveMTHFR?HowToAvoidFolicAcidInFoodMTHFRLiving September29,2013
[]formofB12)andB6.IfyouhaveMTHFRyouwanttheactiveformsofthesevitamins,
whichmeansspecifictypesofmethylfolateinsteadofFolicAcid(seethelinkedarticle
beforepurchasingactiveB9supplements),[]
6. (FAQ)FrequentlyAskedQuestionsMTHFRLiving June13,2014
[]foodslikebread,flour,processedfoods,conventionalpastas,etc.Dr.Lynchtalksabout
thedifferentformsoffolatehere.Itisimportanttorememberthatyouwanttohavean
adequateintakeofB12aswellinaformyou[]
7. TheEpigeneticEpidemic|MichaelChad(StayatHomeDad)October26,2014
[]chlorine.SupplementwithSAM.ConsultwithanMTHFRknowledgeabledoctorand
figureoutwhichmethylfolateisrightfor[]
8. WhyYourPrenatalFolicAcidMightNotBeEnoughJanuary5,2015
[]Lmethyltetrahydrofolate.Thereisanicewriteupaboutthedifferentsupplemental
formsoffolatehere.Beaware,however,thatsomepeoplecanexperiencesideeffectsfrom
methylatedfolatebecause[]
9. Peelingbacklayersoftheonion|journeyforourbaby May12,2015
[]FairhavenHealthOvaBoost(containsCoQ10,2000mgMyoInositol,melatonin,100IU
VitaminE,AlphaLipoicAcid,GrapeseedExtract,and400mcgFolate(thereisadifference
betweenFolicAcidandFolate!!Additionally,thereisadifferencebetweenvarioustypesof
Folate.)[]

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