Académique Documents
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Reproductive health: WHO definition indicates that reproductive health refers to a state of complete physical,
mental, and social well-being..; Reproductive health implies that people are able to have a responsible, satisfying, and
safe sex life. This means access to effective, affordable, and acceptable methods of fertility regulation, health services
for safe pregnancies and deliveries, prevent and treatment for reproductive diseases and tumors, and health care
around and after menopause
Essential amino acids: Those amino acids we cannot make, so we must get them from the foods we eat, are known
as essential amino acids. The nine essential amino acids for human adults that must be obtained from the diet are
histidine, isoleucine, leucine,lysine, methionine, phenylalanine, threonine, tryptophan, valine.
Nonessential amino acids: The body can make about half of the amino acids for itself, when it has the needed parts
nitrogen to form the amine group and backbone fragments, which are derived from carbohydrate or fat.; The non
essential aminoacidsalso important in nutrition: Alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid,
glutamine, glycine, proline, serine, tyrosine.
kilocarlories (kcal) and kilojoules (kJ) : Measure energy in kilocalories (kcal) : Traditionally used in nutrition
science.; What most think of as a calorie is really a kilocalorie.; kcal = amount of energy needed to raise the
temperature of 1 kg of water by 10C.; Measure energy in kilojoules (kJ) : International unit for energy of any form.;
1kcal = 4.18 KJ, or1KJ = 0.239 kcal
Premenopause : As the endocrine function of ovary becomes weak step by step and this process is different
between individuals, perimenopause starts after 40 commonly and lasts for 2 ~ 4 years.; premature ovarian failure
( POF ). In puerperium, mother takes on the important task to feed and take care of the newborn, at the same time to
recover herself.
Growth : An increase in size of body.
Development : Increased complexity of function
Growth velocity : Growth velocity is the rate of change in size over time.; Velocity is the speed the child travels
along the road.
Learning : It is a process that human or animals receive information from the external environment via their nervous
system, which would affect their own behaviors.
Memory : It is a neural process that the obtained information or experiences were stored and extracted in the brain.
Starting regulation : The working capacity of the cerebral cortex is at a low level at the beginning, then increase
gradually with processing.
Dominant excited areas : Among a large number of stimulus in the environment, our nerve center would only focus
on a few stimulations (the strongest, most important stimulation which accord with our purposes and desires) and the
corresponding areas of brain would be excited.; Those excited areas in brain are called dominant excited areas.
Dynamic stereotype : When suffered conditioned stimulus inside or outside the body repeatedly, the related neural
circuits would fix relatively in the cerebral cortex. This process is called dynamic stereotype.
Mosaic Activities : When we change the types of activities, excited areas of brain would change accordingly.
Excited or suppressed areas, work or rest areas in cerebral cortex would exchange in spatial structure, functional
orientation, and time allocation.
Protective Inhibition : Concept : Once the brain is overloaded, the cerebral cortex would enter into inhibition state as
feedback.; Hygiene significance : Consumption Recovery working ability .; Consumption Recovery
working ability .; Early fatigue Working excessive fatigue.; Rest recovery.
Terminal Motivation : After a long time work, the excitability in cerebral cortex reduces gradually. However, when
brain perceives the signal of coming to an end, the excitability of cerebral cortex would have a transient increase
reflexly.; Depending on: extent of excitability decreased, stored energy, individual learning attitude, emotional state at
that time.
Defatiguation: It is also called chronic fatigue..; Its a pathological condition that caused by long time overloading,
and cant restore with a short break.
Defatiguation: Defatigation can not be used as the basis hygiene standard to establish a learning load.; Prevent it.
Tiredness : Its a subjective feeling of fatigue or defatigation.; Mechanism Protective inhibition.; Performance
Dizziness, brain swelling, malaise, lethargy, insomnia, irritability, muscle relaxants, feel cold in head but hot in limbs.
Benzene: Colorless, sweet odor, evaporates quickly & highly flammable liquid.Benzene is an aromatic hydrocarbon
chemical consisting of six atoms each of carbon and hydrogen arranged in a ring structure (C6H6).Molecular formula:
C6H6.; Melting point: 5.5C.; Boiling point: 80.1 C.; Flash point: -11 C .; Explosion limits: 1.3-7.1%
Solubility: slightly soluble in water; very soluble in organic solvents and oil.; Odour threshold: 1-1.5ppm
Aplastic Anaemia: Lack of white blood cells: increased infections, bone or joint pain and discomfort, and
feverishness.; Lack of platelets: excessive bleeding, a tendency to bruise easily, and a delay in healing.; Lack of red
blood cells: tiredness, a very pale complexion, and shortness of breath.
Tertiary prevention*: Methods to reduce negative impact of existent disease by restoring function and reducing
disease-related complications.; Eg: Prevent complications of diabetes.
Byssinosis: An occupational respiratory disease associated with inhalation of cotton, flax, or hemp dust and
characterized initially by chest tightness, shortness of breath, and cough, and eventually by irreversible lung disease.
Called also brown lung, brown lung disease, mill fever.Grain workers lung is a type of byssinosis . It can appear in
people who work with grains.
Primary prevention*: Methods to avoid occurrence of disease.; Most population-based health promotion efforts
are of this type.; Eg: breast feeding hand washing vaccines.
Secondary prevention*: Methods to diagnose and treat existent disease in early stages before it causes significant
morbidity.;Eg: screening.
Tertiary prevention*: Methods to reduce negative impact of existent disease by restoring function and reducing
disease-related complications.; Eg: Prevent complications of diabetes.
Toxicology : A branch of biology, chemistry, and medicine (more specifically pharmacology) concerned with the
study of the adverse effects of chemicals on living organisms.
Paracelsus: All substances are poisons; there is none which is not a poison. The right dose differentiates a poison
from a remedy. Paracelsus (1493-1541).
Toxin: Toxic substance are produced by biological systems .; Such as : plants, animals, fungi or bacteria.
Zeralanone, produced by mold.
Toxicant*: Toxic substance are produced by or are a by-product of anthropogenic activities.Such as : Dioxin
(TCDD) B(a)p.
Inhalation: Chemicals in the air are breathed in through the mouth or nose.; Gases & vapors are absorbed through
the lungs directly into the bloodstream.: The size of dust particles or mist droplets can affect where the chemical
settles in the respiratory tract.
Ingestion/Swallowing*: Chemicals that are swallowed are absorbed in the digestive tract.;Chemicals can rub off
dirty hands and contaminate food, drinks or tobacco products.; Chemicals in the air can settle on food or drink and be
swallowed.
Additive Effect: The combined effect of the two chemicals is equal to the sum of the effects of each agent given
alone. This is the most commonly observed effect when two chemicals are given together (2 + 2 = 4).
Synergist Effect: Occurs when the combined effects of two chemicals are much greater than the sum of the effects
of each agent given alone.CCl4 and ethanol are hepatotoxic alone but when given together produce much more liver
injury than the mathematical sum of their individual effects (2 + 2 = 20).Smoking and asbestos exposure is another
example.Cocaine use with alcohol use is a third example.
Potentiation: Occurs when one compound does not have a toxic effect on a certain organ or system but when added
to another chemical makes that chemical much more toxic.
CCl4 is hepatotoxic, isopropanol is not hepatotoxic, when given together the effect of CCl4 is more than expected (0
+ 2 = 10).
Antagonism: Occurs when two chemicals administered together interfere with each others action. Antagonistic
interactions are very often desirable in toxicology and are the basis of many antidotes (2 + (-2) = 0).
Functional antagonism : Occurs when two chemicals counterbalance each other by producing opposite effects on
the same physiological function.benzodiazepines is an anticonvulsant.
Chemical antagonism: Is a chemical reaction between two compounds that produces a less toxic product. Example
= a chelator and a metal.
Dispositional antagonism: Occurs when the disposition of a chemical is altered so that the concentration and/or
duration of the chemical at the target organ are diminished. Ex. Metabolism is increased Excretion is increased,
therefore half-life is decreased.; Change pH value of urine.
Receptor antagonism: Occurs when two chemicals that bind to the same receptor produce less of an effect when
given together than the addition of their separate parts. Receptor antagonists are often termed blockers.naloxone
---morphine.
Tolerance: A state of decreased responsiveness to a toxic effect of a chemical resulting from prior exposure to that
chemical or to a structurally related chemical.CCl4 decrease the formation of reactive metabolite (hepatotoxic)
Dose: Similar to drugs effectiviness , drugs toxicity e.g. lethality (mortality) also shows dose-response
relationship, typical S-shape curve.LD50 (the dosage of a substance that kills 50% of the animals over a set period of
time following an acute exposure). Amount of exposure to an agent.
Biomarker: A biomarker, or biological marker, generally refers to a measured characteristic which may be used as
an indicator of some biological state or condition.
Tolerable daily intake (TDI):The TDI is an estimate of the amout of a substance in food or drinking
water,expressed on a body weight basis (mg/kg or g/kg of body weight), that can be ingested daily over a lifetime
without appreciable health risk.
Acceptable daily intake (ADI): Are established for food additives and pesticide residues that occur in food for
necessary technological purpose or plant protection reasons.
No-observed-adverse-effect level (NOAEL): The NOAEL is defined as the highest dose or concentration of a
chemical in a single study, found by experiment or observation, that causes no detectable adverse health effect.
Whenever possible, The NOAEL is based on long-term studies, preferably of ingestion in drinking water.
Lowest-observed-adverse effect level (LOAEL): LOAEL is the lowest observed dose or concentration of a
substance at which there is a detectable adverse health effect. When LOAEL is used instead of NOAEL ,an additional
uncertainty factor is normally used.
Hormesis: (from Greek hrmsis "rapid motion, eagerness," from ancient Greek hormein "to set in motion, impel,
urge on") is the term for generally favorable biological responses to low exposures to toxins and other stressors.
In toxicology, hormesis is a dose response phenomenon characterized by a low dose stimulation, high dose inhibition,
resulting in either a J-shaped or an inverted U-shaped dose response.
Response: The reaction to the dose.; For example, eating one green apple may be just fine but eating five green
apples at one time may produce a very undesirable response.
Hazard: The possibility that an agent can cause harm .
Exposure: Contact with an agent
Risk: The probability of harm or adverse effect (injury, disease, death) following exposure to an agent.
Nutrition: The science of foods and the nutrients they contain.; Also consider the action of these foods and the
nutrients in the body.; Foods contain nutrients and are derived from plant or animal sources.; Nutrients are used by
the body to provide energy and to support growth, maintenance and repair of body tissues.; More than 40 nutrients
identified today. Providing nutrients for optimal health, unbalanced diet increases non-communicable diseases risk;
Nonessential nutrients: body can make from other nutrients ingested.; Examples:Cholesterol.; Some amino acids
and fatty acids.; Some bioactive food components from plants and animals..;The body can make about half of the
amino acids for itself, when it has the needed partsnitrogen to form the amine group and backbone fragments,
which are derived from carbohydrate or fat
Organic nutrients - contain carbon.; Carbohydrates.; Lipids.; Proteins .; Vitamins
Inorganic nutrients - do not contain carbon.; Minerals.; Water.
Macronutrients: Need in relatively large amounts.; Carbohydrates, lipids, proteins.
Energy-yielding nutrients: Carbohydrates (except fibers).; Fats .; Proteins
Non-energy-yielding nutrients : Vitamins.; Minerals.; Water.; Dietary fibers.
Estimated Average Requirements(EAR) : Intake amount that appears to meet the needs of 50% of the population.;
Age, gender, condition based.; Set after review of many research studies.\
Adequate Intake (AI): AI = average amount of the nutrient that a group of healthy people consume.; AI is set when
there isnt enough research to set an estimated average requirement (EAR) or RDA.; Examples: Calcium, Vitamin D,
water, fibre.
Tolerable Upper Intake Level (UL): Maximum daily amount of nutrient that appears safe for most healthy people
Intake above the UL is associated with toxicity symptoms.; Most often see with overuse of supplements or intake of
many fortified foods.
Energy density - Measure of the kcal per gram of food.;
Complimentary action*: Incomplete proteins can be mixed together to make a complete protein.; Cereal
grains+legumes, legumes+seeds (nuts) .
Subfertility / Infertility: Infertility is a worldwide issue in reproductive health.; In view of the World Health
Organization's definition of health, the psychological and social consequences of infertility simply cannot be ignored.
Obesity and reproductive health.; Prevention for infertility is difficult and does not help the couple seeking medical
advice for infertility, whereas efficient treatment for infertility is time consuming, expensive and often unsuccessful..;
assisted reproductive technology (ART).; in vitro fertilization and embryo transfer IVF-ET).
Three regularities of growth : Continuous, series of distinct stages process.; Imbalance development of different
systems and organs.; Individual difference.
Thermic effect of food : The thermic effect of food is proportional to the food energy taken in and is usually
estimated at 10% of energy intake.
Reproductive health care : Reproductive health care is defined as the constellation of methods, techniques and
services that contribute to reproductive health and well-being by preventing and solving reproductive health
problems.
Regularies of growth:Continuous, series of distinct stages process.; Imbalance development of different systems
and organs.; Individual difference(Influenced by genetic & environmental factors)
Physical growth : Indicators of physical growth.; Growth of the skeletal system.; Growth of the dental system
Oxygen carrier: Bound into the protein hemoglobin in the red blood cells, iron helps transport oxygen from lungs
to tissues.
Iron-deficiency anemia (IDA): Characterized by weakness, tiredness, apathy, headaches, increased
sensitivity to cold, and a paleness.
Energy yielding Non- nutrient : Alcohol :7 kcal/gram.; Non-nutrient because it interferes with growth, maintenance
and repair of the body.; Alcohols metabolites are harmful.
Beriberi : Beriberi is caused by the deficiency of vitamin-B1.; Wet Beriberi (characterized with heart
failure and edema).; Dry Beriberi (characterized with polyneuritis)
Menopausal syndrome: Women will have mental responses in different degrees such as dysphasia, sadness,
characteristic and behavior changes, even depression.; The increase of bone absorption can cause fracture of
bone, even osteoporosis..; Hormone replacement therapy ( HRT)
Complete proteins: Most animal products, such as fish, chicken, beef, pork, eggs, milk, cheese, yogurt, and
soy as well, contain all of the essential amino acids. (High quality proteins).
Incomplete proteins: Plant foods, such as rice, wheat, oats, corn, may be low or lacking in one or more of the
amino acids.
LONG ANSWERS:
Main indicators of physical growth
(a).Weight : Total weight of the organs, tissues (bones, muscles and fat) and body fluid.; To evaluate recent
nutritional status.;
----Normal term infant:
Age
Weight(kg)
Increment (kg)
Icrement (kg/y)
At birth
3
3m
6
3
12 m
9
3
6
24 m
12
3
3
>2y ~ Puberty
2
Growth Patterns of Weight : First growth spurt: first year of life.; Different growth rate in different age.;
Speed of weight increment is slowing down with age.;Formulae: 3~12months: weight(kg)=(age month
+9)/2
(b).Height(Length): < 3 years Supine Length.; >3 years Stand Height.
----Normal term infant :
Age
Weight(kg)
Increment (kg)
Increment (kg/y)
At birth
50
3m
61~62
11~12
12 m
75
12~13
25
24 m
85
10
10
>2y ~ Puberty
5~7
Growth Pattern of height/length: First growth spurt: first year of life.; Different growth rate in different age
(c).Crown-rump Length/Sitting height : < 3 years Supine Crown rump length.; > 3 years Sit Sitting
height
(d)Head Circumference : Is related with the growth of brain and skull
----Normal term infant :
Age
H.C(cm)
Increment (cm)
At birth
34
3m
40
6
12 m
46
6
24 m
48
2
5y
50
2
15y
53~54
3~4
Abnormality of H.C: Small ----- Cerebral dysplasia, Microcephaly.; Increase too fast ----- Hydrocephalus
(e).Chest Circumference: Be related with the development of the thorax and lungs.
----Normal term infant:
Age
C.C(cm)
H.C(cm)
At birth
32
34
1y
46
46
2y
49
48
>2y~Puberty :CC-HC(cm)=Age(year)-1
Summary:
New born
3m
12 m
24 m
2~10 years
Length (cm)
50
61~62
75
85
Age 7+70
Weight (kg)
3
6
9
12
Age 2+8
HC (cm)
34
36
46
48
15 y:53~54
CC (cm)
32
46
CC- HC=Age - 1
Equalization phase:
Give the same intensity
reaction to any stimulation
Hygience significance: Its a critical limit of learning load.; Take actions to relieve fatigue.; Prevent fatigue to
defatigation.
Defatiguation: Concept: It is also called chronic fatigue.; Its a pathological condition that caused by long time
overloading, and cant restore with a short break.; Mechanism: A long time overloading.
Performance : Appearance: pale skins, weakness, malaise, hesitant, hand tremor in sometimes. Working
ability: speed decline, and error increase.; Mental status: indifference, anxiety or depression, low mood, crying for
no reason.; Psychological function declined: inattention, bad memory, and obstacles in logical thinking,
imagination, judgment and reasoning analysis.; Academic record: decline.; Subjective feelings: dizziness,
headache, insomnia, lethargy, loss of appetite, indigestion and even neurastheni.
Hygiene significance
Defatigation can not be used as the basis hygiene standard to establish a learning load.
Prevent it.
Tiredness : Concept : Its a subjective feeling of fatigue or defatigation.; Mechanism: Protective inhibition.
Performance : Dizziness, brain swelling, malaise, lethargy, insomnia, irritability, muscle relaxants, feel cold in
head but hot in limbs.; Hygiene significance: Pay attention to:The tiredness subjective feelings are developing
into real fatigue.; Those who are fatigue without tiredness.
Sick Feeling
I.
Primary Prevention
Action taken to avoid or remove the cause of
a health problem n an individual or a
population before it arises.Includes health
promotion and specific protection
(eg. Immunization)
II.
Secondary Prevention
Actionn taken to detect a health problem at an
early stage in an individual or a population,
thereby facilitating cure, or reducing or
preventing it spreading or its long- term effects
(eg. Methods, screening, case finding, and early
diagnosis)
IV.
III.
Quaternary Prevention
Tertiaruy Prevention
Quaternary Prevention: Action taken to
Action taken to reduce the chronic effects of a
Identify patient at a risk of overmedicalisation, Health problemin an individual or a population
To protect him from new medical invasion, and By minimizing the functional impairment
to suggest to him intervensions, which are
Consequent to the acute or chronic health
ethically acceptable.
Problems.
(eg: prevent complications of diabetes ).
Includes rehabilitation
Energy-Yielding Nutrients
A).Carbohydrates: C, H, O ; Categories: Sugar: simple sugars.; Starch: made from chains of small
sugars, when these chains are broken down during digestion, we get energy.;Fibers: do not provide calories
because human bodies do not break fiber down during digestion.; Functions: 4 kcal/gram.; Bodys primary
source of energy ( use as glucose in the blood).; Brains only source of energy.; Stores are limited ~12-24 hours
(in liver and muscle as glycogen).; Recommended carbohydrates intake : Energy provided by carbohydrates
should account for 55%~65% of total energy; Starchy foods and dietary fibers-rich foods are the better choices
rather than sugary foods.; Carbohydrates-rich foods: Sugary foods: candy, cake, sugary drinks; Plant foods
like cereals, bread, rice, pasta, potatoes and corn are good sources of starch. These starchy foods give us important
vitamins and minerals, too. ; Dietary fibers-rich foods: Whole grains, vegetables and fruits.
B).Fats: C, H, O.; Categories: Triglycerides (fats and oils): Every triglyceride contains one molecule of
glycerol and three fatty acids. Fatty acids may be saturated or unsaturated. Phospholipids: The best-known
phospholipid is lecithin.; Sterols: compounds with a multiple-ring structure, the most famous sterol is cholesterol.
Classifying by degree of unsaturation : Saturated fatty acid: fully loaded with hydrogen atoms and contains only
single bonds between its carbon atoms.; Monounsaturated fatty acid: with one double bond in the molecule.
Polyunsaturated fatty acid: has two or more carbon-to-carbon double bonds.; Functions : 9 kcal/gram.;
Bodys alternate source of energy.; Needed to carry and store essential fat-soluble vitamins, like vitamins A and
D .; Excess energy intake can be stored as fats in the body. Stores are unlimited!; Recommended fats intake:
Keep total fat intake between 25%~30% of total energy needs..; Make sure most fats coming from sources of
PUFAs and MUFAs, such as fish, nuts, and vegetable oils..; Fats food sources: Cooking oils and fats: vegetable
oils are more healthy than animal fats added in cooking.; Fats we cannot see: a lot of fat is hidden in foods that we
eat as snacks or prepared meals. Cholesterol (1): Cholesterol is needed by our bodies for our cells, nerves and
brain. It is also important in forming hormones and enzymes.; Non-essential: Our bodies can make cholesterol. We
get cholesterol from the foods we eat, too.; Cholesterol (2): Adverse effects of too much cholesterol: the blood
cholesterol level increases. The higher our blood cholesterol, the higher our chances of developing heart disease. ;
Food sources: animal products, e.g. fish, eggs, chicken, milk, beef or cheese. Animal brain tissue contains the
highest level.
C).Proteins: C, H, O, N ; What are proteins made of? : Amino acids: molecule with amine and acid
groups.
There are 20 amino acids making up most of the proteins of living tissues..; Essential amino acids: Those amino
acids we cannot make, so we must get them from the foods we eat, are known as essential amino acids.
Nonessential amino acids: The body can make about half of the amino acids for itself, when it has the needed
partsnitrogen to form the amine group and backbone fragments, which are derived from carbohydrate or fat.
Are all proteins the same for us? : Complete proteins: Most animal products, such as fish, chicken, beef, pork,
eggs, milk, cheese, yogurt, and soy as well, contain all of the essential amino acids. (High quality proteins).;
Incomplete proteins: Plant foods, such as rice, wheat, oats, corn, may be low or lacking in one or more of the
amino acids.; How vegetarians get high quality proteins?: Complimentary action*: Incomplete proteins can be
mixed together to make a complete protein. Cereal grains+legumes, legumes+seeds (nuts) .; Functions:
Building blocks of human body: It is needed for cells to grow. It also repairs or replaces healthy cells and tissues.
Needed for normal function: Enzymes, some hormones, antibodies, albumin, hemoglobin, transport proteins, are
all made from protein. ; 4 kcal/gram (same as carbohydrates ), But protein is used for energy only when there isnt
any carbohydrate available as an energy source.; Recommended protein intake: Protein provides 10%~15% of
total caloric intake.; RDA for adults: 0.8 gram per kg body weight.
transport proteins, are all made from protein.; 4 kcal/gram ( same as carbohydrates ), But protein is used for
energy only when there isnt any carbohydrate available as an energy source.
Smoking during pregnancy is an important cause of ill health for both mother and fetus.It increases risk of placental
complications, pregnancy induced hypertensionPIH, reduced fetal growth and perinatal death.Smoking causes
various health problems in women in relation to their life cycle. About the effects of smoking on obstetric and
gynecological disorders, it is clarified that smoking has adverse effects on menopausal disorders, miscarriage,
premature birth, low birth weight infant, breast cancer, uterine cancer and ovarian cancer. Smoking affects not only
the women themselves, but also the fetus. It is necessary to promote smoking prevention education to prevent
women from developing a smoking habit and to provide smoking cessation education and support for smokers.
----> Retrieval.
Classification of memory : Instantaneous: several seconds.; Short-term: several minutes.; Long-term: several
minutes a few years.; From the Psychology:---Image memory.; ---Logical memory.; ---Emotional memory.;
---Motor memory.;
Describe some general difference between fat-soluble vitamins and water soluble vitamins.
General characteristics of water-soluble and fat-soluble vitamins :
Characteristics
Water soluble vitamins
(B vitamins and Vitamin C)
Dietary intake
Excess intake usually detected and
excreated bt the kidneys.
Body stores
Only a short-term storage supply
Available;daily intake recommended.
Deficiency
Defitiency symptoms appear
Relatively quickly.
Toxicity
Lower risk of toxicity
Absorption and
Easily absorbed into blood;travel
Transport
Freely in blood.
Solubility
Stability in food handling
And processing
Role(s) in
The body
Dissolves in water
Less stable
Dissolves in lipid
Stable
Carbohydrates-rich foods
Sugary foods: candy, cake, sugary drinks.; Plant foods like cereals, bread, rice, pasta, potatoes and corn are
good sources of starch. These starchy foods give us important vitamins and minerals, too. .; Dietary fibers-rich
foods: Whole grains, vegetables and fruits