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  • Fungal Diseases (Mycoses)

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    This document discusses several fungal diseases (mycoses) including: - Isolation and growth of fungi which typically grow on media with simple nitrogen and carbohydrate sources at pH 7. Inhibitory Mold Agar is often used to recover fungi from clinical specimens. - Pathogenic fungi can exhibit a morphological transition between mycelial and parasitic yeast forms. Thermal dimorphism is common. - Superficial mycoses include those caused by Microsporum, Trichophyton and Epidermophyton such as ringworm. - Subcutaneous mycoses discussed are blastomycosis, paracoccidioidomycosis and histoplasmosis. Drugs of choice for treatment

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    This document discusses several fungal diseases (mycoses) including: - Isolation and growth of fungi which typically grow on media with simple nitrogen and carbohydrate sources at pH 7. Inhibitory Mold Agar is often used to recover fungi from clinical specimens. - Pathogenic fungi can exhibit a morphological transition between mycelial and parasitic yeast forms. Thermal dimorphism is common. - Superficial mycoses include those caused by Microsporum, Trichophyton and Epidermophyton such as ringworm. - Subcutaneous mycoses discussed are blastomycosis, paracoccidioidomycosis and histoplasmosis. Drugs of choice for treatment

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    18 vues10 pages

    Fungal Diseases (Mycoses)

    Transféré par

    Ranty
    This document discusses several fungal diseases (mycoses) including: - Isolation and growth of fungi which typically grow on media with simple nitrogen and carbohydrate sources at pH 7. Inhibitory Mold Agar is often used to recover fungi from clinical specimens. - Pathogenic fungi can exhibit a morphological transition between mycelial and parasitic yeast forms. Thermal dimorphism is common. - Superficial mycoses include those caused by Microsporum, Trichophyton and Epidermophyton such as ringworm. - Subcutaneous mycoses discussed are blastomycosis, paracoccidioidomycosis and histoplasmosis. Drugs of choice for treatment

    Droits d'auteur :

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    Signaler comme contenu inapproprié
    sur 10

    FungalDiseases(Mycoses)

    MarliaSinggih
    SchoolofPharmacyITB

    ISOLASIDANPERTUMBUHANFUNGI
    Kebanyakan fungidapat tumbuh pada media
    dengan sumber nitrogendan karbohidrat
    sederhana,misalnya SDAyg mengandung
    glukosa dan pepton pH7
    Selain itu,InhibitoryMoldAgar,sering
    digunakan utk recoveryfungiyangberasal dari
    clinicalspecimens
    Untuk spesimen ini,mediaperlu ditambahkan
    antibakteri spt gentamisin atau kloramfenikol

    Sifatdimorfic
    pathogenicfungiexhibitamorphological
    transitionfromathemycelialorsaprobicform
    totheparasiticformfoundininfected
    tissue. Thermaldimorphismiscommon!

    SUPERFICIALMYCOSES
    Microsporum,TrichophytonandEpidermophyton

    Ringworm Trichophyton
    mentagrophytes

    SUBCUTANEOUSMYCOSES

    BLASTOMYCOSIS

    PARACOCCIDIOIDOMYCOSIS

    chronicgranulomatousandsuppurative(bleeding
    pus)diseasehavingaprimarypulmonarystagethat
    isfrequentlyfollowedbydisseminationtoother
    bodysites(e.g.,skinandbone).
    occursinhumansanddogs(alsoseeninhorses,wild
    animals,northernsealion).
    anamorph,asexual,orimperfectformoffungus,
    Blastomycesdermatitidis istheetiologicalagent
    (perfectformofthisfungusisAjellomyces
    dermatitidis,anascomycete).
    dimorphicordiphasicfungus(convertsfrom
    filamentousformtoyeastformandviceversa)

    Drugofchoice
    sulfas sulfamethoxypyridazineand
    sulfadimehtoxine0.5gfollowingan
    initialdoseof1gperdayforoneweek
    relapseiscommon.

    HISTOPLASMOSIS DARLING'SDISEASE

    Amphotericin B is the drug of choice

    HISTOPLASMOSIS DARLING'SDISEASE

    worldwide;prevalentineasternU.S.
    dimorphicfungusHistoplasmacapsulatum
    infectionthroughinhalationofconidia
    95%ofcasesareinapparent,subclinical,orcompletelybenign
    diagnosedbyxraysthroughresidualareasofpulmonarycalcificationand
    apositivehistoplasminskintest.
    chronicprogressivelungdisease,chroniccutaneousorsystemicdisease,
    oranacutefulminating,rapidlyfatal,systemicinfection.
    growthoffungusassociatewithguanoanddebrisofbatandbirds,
    particularlyduetotheroostinghabitsofstarlings.
    InterestingTrivia: AlltheEuropeanStarlingsinNorthAmericadescendedfrom
    100birdsreleasedinNewYork'sCentralParkintheearly1890s.Agroup
    dedicatedtointroducingAmericatoallthebirdsmentionedinShakespeare's
    workssetthebirdsfree.Today,EuropeanStarlingsrangefromAlaskatoFlorida
    andnorthernMexico,andtheirpopulationisestimatedatover200millionbirds
    (Source: http://www.birds.cornell.edu/AllAboutBirds/BirdGuide/European_Starli
    ng.html).

    Drugofchoice
    AmphotericinBisthedrugofchoice.Atotal
    of13gramsadministeredovera12month
    period.Sideeffectsarecommonandneedto
    bemonitored. Indisseminatedcases,0.6mg
    perKgofbodyweightperdayforsixweeks.
    Ketoconazolehasbeencurativeincentral
    nervoussystemdiseaseatadoseof200mg
    perday.

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