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SPINAL CORD
Slides for study # 1-13
# 1, 2 & 3
#4&5
#6&7
#8&9
# 10 & 11
# 11 & 13
Upper cervical
Lower cervical
Thoracic
Lumbar
Sacral
Coccygeal
General description
The spinal cord is the least modified portion of the embryonic neural tube and
the only part of the adult nervous system which clearly preserves a segmental
character (Fig. 5.1). Up to the third month of intra-uterine life, it occupies the entire
length of the vertebral canal, but in the adult it occupies only the upper two thirds of
the vertebral canal. Fig. 5.1
* Why? The lower limit of the spinal cord at birth is the third lumbar vertebra.
Using your slides and the drawings in this section (Figs. 5.2, 5.3, 5.4) try to
familiarize yourself with the following structures: Anterior median fissure,
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In the posterior horn identify the substantia gelatinosa. It forms a cap about
the head of the posterior horn. In Nissl stained sections, the cells of the substantia
gelatinosa appear as very small oval cells. Dorsolateral to the substantia gelatinosa is
the nucleus posteromarginalis which can be appreciated only in Nissl preparations.
Its cells are larger than those of the substantia gelatinosa but less numerous. In the
central part of the head of the posterior horn are medium size cells that constitute the
nucleus proprius (centrodorsalis).
At the base of the posterior horn (medially) is a well defined group of large
cells known as the nucleus dorsalis (of Clark). This cell group is found only between
C8 and L2 and is best seen in the lower thoracic and upper lumbar segments. Fibers
arising from this cell group are large and ascend to the cerebellum via the dorsal spino
cerebellar tract.
In the anterior horn identify the large motor neurons. These give rise to the
ventral root fibers which form the spinal nerves and supply skeletal muscles.
*** The ventral roots contain axons not related to motorneurons. Try to find the
location of their cell bodies and their functions.
Using Nissl stained sections try to compare the shape of the anterior horn at
different spinal levels.
Is it related to motorneurons?
Are there more than one motor neuronal group?
What would be the function of each group? Fig. 5.3 may help you to find the
correct answers?
In thoracic and upper lumbar segments identify the lateral horn and examine
cells of the intermediolateral cell columns.
What is the functional significance of this cell column?
What is the course of fibers originating in this cell group?
Where do they synapse?
Sacral autonomic nuclei are scattered along the dorso-lateral surface of the
anterior horn segments S-2, S-3, S-4.
Where do fibers from this cell group synapse?
What division of the autonomic nervous system do they belong to?
Fig. 5.5
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Try to label the Fig. 5.5 and to make a correlation between the nuclear
organization of the spinal cord (that you have seen) and the laminar organization
proposed by REXED. Remember that Rexed had excellent Nissl preparations, used
rather thick sections in which the grouping is more readily seen and based much of his
study on transverse sections.
Fig. 5.6
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Fig. 5.7
The medial division of the posterior root contributes fibers to two other ascending
tracts: (1) the posterior (Dorsal) spino cerebellar tract. What prominent cell group
is associated with this tract? Fibers of this tract are uncrossed and convey
proprioceptive impulses (2) some fibers from the dorsal root pass to the base of the
posterior horn where they synapse. Second order fibers originating from cells here
cross to the opposite side of the cord and ascend as the anterior spinocerebellar
tract.
Do proprioceptive impulses conveyed by the spinocerebellar tract reach
conscious levels?
Identify the approximate location of the posterior and anterior spinocerebellar
tracts.
Fibers in the lateral division of the spinal root are concerned with transmission
of impulses for pain, light touch, and thermal sense. These fibers enter the zone of
Lissauer (Fig. 5.7) and travel up and down for variable distances before synapsing
with cells of the substantia gelatinosa and nucleus centrodorsalis. Second order
neurons give rise to fibers of the spinothalamic tracts which decussate in the
anterior white commissure. These tracts are more difficult to identify in spinal
sections because they overlap or occupy areas containing descending fibers. Fibers of
the anterior and lateral spinothalamic tracts also are somatotopically arranged.
What is the arrangement?
What sensory modalities are transmitted by these tracts?
What is cordotomy?
For what purpose might an anterolateral cordotomy be done?
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Important remarks:
*
The student should remember that a number of other ascending and
descending fiber systems have been described in the spinal cord. In this lab module, a
brief description is given to tracts known to have a significant clinical relevance.
*
At the end of this lab session, try to draw the appropriate tracts in Fig. 5.9,
5.10 and 5.11 and to answer the given clinical cases.
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Case Discussions
Case History # 1
An individual sustained an injury to the spinal cord which resulted in the following
symptoms and signs:
1.
2.
3.
4.
Horner's syndrome
5.
6.
A.
B.
Make a simple outline drawing of the extent of the lesion at one level.
Approximately how many segments of the spinal cord were involved by the
lesion.
C. List any ascending and descending tracts which would be degenerated six
months later.
On the left side
Ascending Tracts
Descending Tracts
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Case History # 2
A housewife sustained a severe burn on her right hand without realizing it, until the
burned area was observed. No sensation of heat or pain was felt.
Neurological examination a short time later revealed impaired to absent pain and
thermal sense over most of the right and left upper extremities. Tactile sense was
somewhat impaired in the areas of most pronounced pain and thermal loss, but
position sense and vibratory sense were within normal limits. Weakness and atrophy
of the intrinsic muscles of the right hand were noted. Healing of the wound was slow
and the fingers remained swollen: the skin and fiber nails showed trophic changes.
Although the pupil and palpebral fissure on the right side were smaller than on the
left, both pupils reacted promptly to light and accomodation.
In the space below make a careful outline drawing of the transverse section through
the level of the lesion, drawing accurately the structures at that level and labeling
them. Outline the extent of the lesion.
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Fig. 5.9
Fig. 5.10
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Fig. 5.11
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