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TULANE UNIVERSITY HEALTH SCIENCES CENTER


DEPARTMENT OF PATHOLOGY & LABORATORY MEDICINE

PATHWAYS
NEWSLETTER VOLUME 6, ISSUE 1 WINTER 2016

Message from the Chairman

Dear Colleagues,
As we are entering year 2016 with pride in our academic excellence and aspiration
for new goals, it is worthwhile to reflect some of the memorable moments in the
past year. This issue of the departmental Newsletter highlights some of these
moments, from graduation of residents, fellows and students to the arrival of new
trainees and new faculty members. Looking back at the past year, the Department
achieved some of its intended goals. Our residents, fellows and students continue
high-standard learning with great success in their career goals. We continue to
provide excellent diagnostic services, albeit with increased volumes. Our research
missions continue to expand, as reflected by innovative projects, excellent
publications, and extramural grant supports. As we look back with satisfaction in
the accomplishments of our Department, we likewise look forward to achieving new
objectives.

Happy Mardi Gras!

Tong Wu, M.D., Ph.D.

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GRADUATION 2015
The Department of Pathology held its graduation ceremony last
June 13 in an evening filled with awards, recognition, and farewells to
graduating residents and fellows. Dr. Tong Wu, Department
Chairman, presented Lu Yao (see below, right) with the Outstanding
Graduate Student Award. Dr. Wu also presented the Award for
Outstanding Postdoctoral Fellow to Dr. Jun
Hong Park.
Dr. Barbara Herfel, Cytopathology
Fellow, received her certificate from Dr.
Krzysztof Moroz, while Dr. Janet Schmid
awarded Hematopathology Fellow, Dr.
Thad Primeaux his certificate for
successful program completion. Dr. Alun
Wang presented Dermatopathology Fellow,
Dr. Michael Lee (see below, left) a
graduation certificate.
Dr. Janet Schmid awarded graduation

certificates and a textbook of their choice


to the graduating class of residents: Dr.
Laura Bratton who will pursue a
Gastrointestinal Pathology Fellowship at
the University of Rochester in New York;
Dr. Buu Duong, Chief Resident, who will
remain in the Department of Pathology at
Tulane as a dermatopathology fellow;
Dr. Chancey Christenson, who will join
the New York Blood Center as a
Transfusion Medicine Fellow;
Dr. Greg Mayhall will undertake a
Surgical Pathology Fellowship at the
Medical College of Wisconsin in
Milwaukee; Dr. Lacey Sullivan, Chief Resident, who will assume the
duties of Cytopathology Fellow in the Department of Pathology at
Tulane.

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GRADUATION 2015 (Continued)


Dr. Andrew Sholl presented the Rokitansky Award for Excellence in

Autopsy to Dr. Darshan Trivedi (seen below, left).


Dr. Philip
Daroca awarded Dr. Greg Mayhall the Richard J. Reed Award for
Surgical Pathology (seen below, right).

Faculty members were likewise recognized for achievement in


pathology education for the year. Presented by Vice-Chairman Dr.
Byron Crawford, plaques recognizing their achievement were awarded
to Drs. Laura Kidd (below, left with Dr. Crawford); Tim Peterson
(second from left); John Schmieg (below, center) and Andrew Sholl
(below, right). Dr. Crawford was presented with the Philip J. Daroca
Award in Residency Education from Drs. Duong and Sullivan.

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NEW FELLOWS 2015-2016

Left to right: Dr. Lacey Sullivan,


Cytopathology Fellow; Dr. Michael
VanVrancken, Hematopathology Fellow.
Below: Dr. Buu Duong, Dermatopathology
Fellow. Drs. Duong and Sullivan were
Tulane Residents; Dr. VanVrancken
completed his residency at Baylor
University Medical Center in Dallas, TX.

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NEW RESIDENTS 2015-2016

Clockwise left to right: Drs. Victoria Collins;


Zahraa Ghandour, Cacey Peters, and Abida Kadi.

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Chief Resident Dr. Lacey Sullivan, (seen below),


presented a poster at the American Society of
Dermatopathology Conference last year, and two posters at
the American Society of Cytopathology.
Drs. Meggie Doucet and Eleanor Lewis, both PGY II,
presented a poster at the ASCP Conference last October in
Long Beach, CA. Dr. Doucet attended the CAP Conference
with Dr. Darshan Trivedi, PGY I in Nashville, TN as resident
delegates. Dr. Trivedi presented a poster at the CAP
Conference.

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GUEST SPEAKERS
The Dr. and Mrs. Michael A. Gerber
Memorial Lecture was delivered on
March 25, 2015 by Dr. Adrian
DiBisceglie (seen left), Chairman of
Internal Medicine, Chief of Hepatology at
the St. Louis School of Medicine. Dr.
DiBisceglies topic was, Prevention of
Hepatocellular Carcinoma.
The Fifth Annual SternbergReed Lecture Series was held
November 19-20, 2015. Guest
speaker Dr. Peter Burger (seen
right), a professor of Pathology,
Neurosurgery and Oncology, and
Director of Surgical Neuropathology
at Johns Hopkins in Baltimore, was
the featured guest. Dr. Burger
conducted resident slides reviews and
a lecture. His topic for the SternbergReed Lecture was, Glioblastoma
Evolution of our Understanding. Later he spoke to the
residents on, The WHO Classification of CNS Tumors.

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GUEST SPEAKERS (continued)



Dr. Gary Hoyle (seen left), Professor, Schools of
Medicine and Public Health Information Sciences at
the University of Kentucky at Louisville, was a guest
presenter for the Departments weekly Grand Rounds
on November 6, 2015. Dr. Hoyle spoke on,
Pathophysiology and Treatment of Chlorine-Induced
Lung Injury.

NEW FACULTY MEMBERS


Dr. Loren Gragert (below, right) joined the Pathology Faculty last
August as an Assistant Professor. Dr. Gragert received his B.A. degree
in Quantitative Methods/Computer Science and a B.S. degree in
Biochemistry at the University of St. Thomas, St.
Paul, MN. He received a Ph.D. in Biomedical
Informatics and Computational Biology at the
University of MinnesotaTwin Cities. He worked
as a Bioinformatics Analyst at the National
Marrow
Donor
Program/Be
the
Match/Bioinformatics Research in Minneapolis.
At the same institution, he was Senior
Bioinformatics Scientist. His area of expertise
includes bioinformatics and genetic association of
immune-mediated diseases and stem cell
transplantation.

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NEW FACULTY MEMBERS (continued)


Joining the Department last October as
an Assistant Professor of Pathology, Dr.
Nadja Falk graduated from Wellesley
College in Massachusetts with a B.A. in
German Language and Literature. She
received her M.D. from the University of
Texas Health Sciences Center at Houston
(UTHSC). She then worked as a General
Surgery Resident at St. Vincents
Hospital in New York, followed by
postdoctoral research training at MD Anderson Cancer Center
in Houston. After completing her residency training in
Anatomic and Clinical Pathology from UTHSC, she received a
Cytopathology Fellowship at MD Anderson, followed by a
fellowship in Surgical Pathology. She has co-authored 18
articles and abstract and is the first author of six articles.
CONGRATULATIONS
Graduate Student Lu Yao received his post-doctoral fellowship last
November. Yao, who works in the Department, focuses his research on
liver disease and hepatocellular carcinoma.

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NEW FACES
Sarah Garner (seen right) joined the Department last
June as a Pathologists Assistant
student. She received her B.S. and
M.S. degrees from Tulane University in
Cell and Molecular Biology. She is
working on obtaining a Masters degree
in Pathologists Assistant Studies at the
Rosalind Franklin University of
Medicine and Science.

Welcome to Brandi Johnson, Medical Transcriptionist.


(below).

PATHWAYS NEWSLETTER

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PUBLICATIONS
Kim N, Jeong S, Jing K, Shin S, Kim S, Heo JY, Kweon GR, Park SK,
Wu T, Park JI, Lim K. Docosahexaenoic Acid Induces Cell Death in
Human Non-Small Cell Lung Cancer Cells by Repressing mTOR via
AMPK Activation and PI3K/Akt Inhibition. Biomed Res Int.
2015;2015:239764. doi: 10.1155/2015/239764. Epub 2015 Aug 3.
PubMed [citation] PMID: 26339598, PMCID: PMC4538321
Panigrahi R, Dash S. ENT1 and treatment of viral diseases. Oncotarget.
2015 Oct 20;6(32):32281-2. doi: 0.18632/oncotarget.5859. PubMed
[citation] PMID: 26431496
Kimbrell HZ, Sholl AB, Ratnayaka S, Japa S, Lacey M, Carpio G,
Bhatia P, Kandil E. BRAF Testing in Multifocal Papillary Thyroid
Carcinoma. Biomed Res Int. 2015;2015:486391. doi:
10.1155/2015/486391. Epub 2015 Sep 13. PubMed [citation] PMID:
26448939, PMCID: PMC4584030
Liu L, Liu X, Mare M, Dumont AS, Zhang H, Yan D, Xiong Z.
Overexpression of Eg5 correlates with high grade astrocytic neoplasm.
J Neurooncol. 2016 Jan;126(1):77-80. doi: 10.1007/s11060-015-19543. Epub 2015 Oct 11. PubMed [citation] PMID: 26456023
Kwon H, Song K, Han C, Chen W, Wang Y, Dash S, Lim K, Wu T.
Inhibition of hedgehog signaling ameliorates hepatic inflammation in
mice with nonalcoholic fatty liver disease (NAFLD). Hepatology. 2015
Oct 16. doi: 10.1002/hep.28289. [Epub ahead of print] PubMed
[citation] PMID: 26473743

PATHWAYS NEWSLETTER PAGE 12


PUBLICATIONS
Song K, Kwon H, Han C, Zhang J, Dash S, Lim K, Wu T. Active
glycolytic metabolism in CD133(+) hepatocellular cancer stem cells:
regulation by MIR-122. Oncotarget. 2015 Dec 1;6(38):40822-35. doi:
10.18632/oncotarget.5812. PubMed [citation] PMID: 26506419
Yang Y, Jia D, Kim H, Abd Elmageed ZY, Datta A, Davis R, Srivastav S,
Moroz K, Crawford B, Moparty K, Thomas R, Hudson RS, Ambs S,
Abdel-Mageed AB. Dysregulation of microRNA-212 Promotes
Castration Resistance via hnRNPH1-Mediated Regulation of AR and
AR-V7: Implications for Racial Disparity of Prostate Cancer. Clin
Cancer Res. 2015 Nov 9. doi:pii: clincanres.1606.2015. [Epub ahead of
print] PubMed [citation] PMID: 26553749
Abdulnour-Nakhoul S, Brown KL, Rabon EC, Al-Tawil Y, Islam MT,
Schmieg JJ, Nakhoul NL. Cytoskeletal changes induced by allosteric
modulators of calcium-sensing receptor in esophageal epithelial cells.
Physiol Rep. 2015 Nov;3(11). doi:pii: e12616. 10.14814/phy2.12616.
Epub 2015 Nov 24. PubMed [citation] PMID: 26603452, PMCID:
PMC4673644
Qadir XV, Chen W, Han C, Song K, Zhang J, Wu T. miR-223 Deficiency
Protects against Fas-Induced Hepatocyte Apoptosis and Liver Injury
through Targeting Insulin-Like Growth Factor 1 Receptor. Am J Pathol.
2015 Dec;185(12):3141-51. doi: 10.1016/j.ajpath.2015.08.020.
PubMed [citation] PMID: 26598234
Falk N, Weissferdt A, Kalhor N, Moran CA. Primary Pulmonary Salivary
Gland-type Tumors: A Review and Update. Adv Anat Pathol. 2016
Jan;23(1):13-23. doi:10.1097/PAP.0000000000000099. PubMed
[citation] PMID: 26645458

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PUBLICATIONS
Park JH, Hur W, Lee SB. Intricate Transcriptional Networks of
Classical Brown and Beige Fat Cells. Front Endocrinol (Lausanne).
2015;6:124. doi: 10.3389/fendo.2015.00124. Review. PubMed
[citation] PMID: 26322018, PMCID:PMC4533000
Morris GF, Danchuk S, Wang Y, Xu B, Rando RJ, Brody AR, Shan B,
Sullivan DE. Cigarette smoke represses the innate immune response to
asbestos. Physiol Rep. 2015 Dec;3(12). doi:pii: e12652.
10.14814/phy2.12652. PubMed [citation] PMID: 26660560
Song R, Preston G, Kidd L, Bushnell D, Sims-Lucas S, Bates CM,
Yosypiv IV. Prorenin receptor is critical for nephron progenitors. Dev
Biol. 2016 Jan 15;409(2):382-91. doi: 10.1016/j.ydbio.2015.11.024.
Epub 2015 Dec 3. PubMed[citation] PMID: 26658320,
Penrose H, Heller S, Cable C, Makboul R, Chadalawada G, Chen Y,
Crawford SE, Savkovic SD. Epidermal growth factor receptor mediated
proliferation depends on increased lipid droplet density regulated via a
negative regulatory loop with FOXO3/Sirtuin6. Biochem Biophys Res
Commun. 2016 Jan 15;469(3):370-6. doi:
10.1016/j.bbrc.2015.11.119. Epub 2015 Nov 30. PubMed [citation]
PMID: 26657850
Aboulnasr F, Hazari S, Nayak S, Chandra PK, Panigrahi R, Ferraris P,
Chava S, Kurt R, Song K, Dash A, Balart LA, Garry RF, Wu T, Dash S.
IFN- Inhibits MiR-122 Transcription through a Stat3-HNF4
Inflammatory Feedback Loop in an IFN- Resistant HCV Cell Culture
System. PLoS One. 2015;10(12):e0141655. doi:
10.1371/journal.pone.0141655. PubMed [citation] PMID: 26657215,
PMCID: PMC4686105

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PUBLICATIONS
Liu YZ, Roy-Engel AM, Baddoo MC, Flemington EK, Wang G, Wang H.
The impact of oil spill to lung health-Insights from an RNA-seq study
of human airway epithelial cells. Gene. 2016 Mar 1;578(1):38-51. doi:
0.1016/j.gene.2015.12.016. Epub 2015 Dec 9. PubMed [citation]
PMID: 26692141
Nakanishi Y, LeVea C, Dibaj S, Habib F, Cheney R, Kanehira K.
Reappraisal of Serosal Invasion in Patients With T3 Colorectal Cancer
by Elastic Stain: Clinicopathologic Study of 139 Surgical Cases With
Special Reference to Peritoneal Elastic Lamina Invasion. Arch Pathol
Lab Med. 2016 Jan;140(1):81-5. doi: 10.5858/arpa.2014-0647-OA.
PubMed [citation] PMID: 26717059

Lin Z, Swan K, Zhang X, Cao S, Brett Z, Drury S, Strong MJ, Fewell C,


Puetter A, Wang X, Ferris M, Sullivan DE, Li L, Flemington EK.
Secreted oral epithelial cell membrane vesicles induce Epstein-Barr
virus (EBV) reactivation in latently infected B-cells. J Virol. 2016 Jan
13. doi:pii: JVI.02830-15. [Epub ahead of print] PubMed [citation]
PMID: 26764001

Strong AL, Shi Z, Strong MJ, Miller DF, Rusch DB, Buechlein AM,
Flemington EK, McLachlan JA, Nephew KP, Burow ME, Bunnell BA.
Effects of the endocrine-disrupting chemical DDT on self-renewal and
differentiation of human mesenchymal stem cells. Environ Health
Perspect. 2015 Jan;123(1):42-8. doi: 10.1289/ehp.1408188. Epub
2014 Jul 11. PMID: 25014179

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PUBLICATIONS
Kurt R, Chandra PK, Aboulnasr F, Panigrahi R, Ferraris P, Aydin Y,
Reiss K, Wu T, Balart LA, Dash S. Chaperone-Mediated Autophagy
Targets IFNAR1 for Lysosomal Degradation in Free Fatty Acid Treated
HCV Cell Culture. PLoS One. 2015 May 11;10(5):e0125962. doi:
10.1371/journal.pone.0125962. eCollection 2015. PMID: 25961570
Schubert S, Heller S, Lffler B, Schfer I, Seibel M, Villani G, Seibel P.
Generation of Rho Zero Cells: Visualization and Quantification of the
mtDNA Depletion Process Int J Mol Sci. 2015 Apr 30;16(5):9850-65.
doi: 10.3390/ijms16059850. PMID: 25941929
Cao S, Moss W, O'Grady T, Concha M, Strong MJ, Wang X, Yu Y,
Baddoo M, Zhang K, Fewell C, Lin Z, Dong Y, Flemington EK. New
Noncoding Lytic Transcripts Derived from the Epstein-Barr Virus
Latency Origin of Replication, oriP, Are Hyperedited, Bind the
Paraspeckle Protein, NONO/p54nrb, and Support Viral Lytic
Transcription. J Virol. 2015 Jul;89(14):7120-32. doi:
10.1128/JVI.00608-15. Epub 2015 Apr 29. PMID: 25926645

Gandhi CR, Chaillet JR, Nalesnik MA, Kumar S, Dangi A, Demetris AJ,
Ferrell R, Wu T, Divanovic S, Stankeiwicz T, Shaffer B, Stolz DB,
Harvey SA, Wang J, Starzl TE. Liver-specific deletion of augmenter of
liver regeneration accelerates development of steatohepatitis and
hepatocellular carcinoma in mice. Gastroenterology. 2015
Feb;148(2):379-391.e4. doi: 10.1053/j.gastro.2014.10.008. Epub 2014
Oct 13. PMID: 25448926

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PUBLICATIONS
Park JH, Kang HJ, Lee YK, Kang H, Kim J, Chung JH, Chang JS,
McPherron AC, Lee SB. Inactivation of EWS reduces PGC-1 protein
stability and mitochondrial homeostasis. Proc Natl Acad Sci U S A.
2015 May 12;112(19):6074-9. doi: 10.1073/pnas.1504391112. Epub
2015 Apr 27. PMID: 25918410
Pineda DA, Self R, Daroca PJ, Robinson WR. Pelvic pleomorphic
rhabdomyosarcoma presenting as oliguria in a 61-year-old woman.
J Community Support Oncol. 2015 Mar;13(3):120-1. doi:
10.12788/jcso.0119. PMID: 25880675
McCarty TP, Lee RA, Herfel BM, Pappas PG. Cytomegalovirus
appendicitis in solid organ transplant patients, two cases and a review.
J Clin Virol. 2015 May;66:48-50. doi: 10.1016/j.jcv.2015.03.004. Epub
2015 Mar 7. Review.
PMID: 25866336
Song K, Han C, Dash S, Balart LA, Wu T. MiR-122 in hepatitis B virus
and hepatitis C virus dual infection. World J Hepatol. 2015 Mar
27;7(3):498-506. doi: 10.4254/wjh.v7.i3.498. Review.
PMID: 25848473
Deniwar A, Hambleton C, Thethi T, Moroz K, Kandil E.
Examining the Bethesda criteria risk stratification of thyroid nodules.
Pathol Res Pract. 2015 May;211(5):345-8. doi:
10.1016/j.prp.2015.02.005. Epub 2015 Feb 27.
PMID: 25796296

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PUBLICATIONS
Chen W, Han C, Zhang J, Song K, Wang Y, Wu T.
Deletion of Mir155 prevents Fas-induced liver injury through upregulation of Mcl-1. Am J Pathol. 2015 Apr;185(4):1033-44. doi:
10.1016/j.ajpath.2014.12.020. PMID: 25794705
Peralta DV, Heidari Z, Dash S, Tarr MA. Hybrid paclitaxel and gold
nanorod-loaded human serum albumin nanoparticles for simultaneous
chemotherapeutic and photothermal therapy on 4T1 breast cancer
cells. ACS Appl Mater Interfaces. 2015 Apr 8;7(13):7101-11. doi:
10.1021/acsami.5b00858. Epub 2015 Mar 25. PMID: 25768122
Ibrahim Y, Mohamed SE, Deniwar A, Al-Qurayshi ZH, Khan AN, Moroz
K, Friedlander P, Kandil E. The impact of thyroid nodule size on the
risk of malignancy in follicular neoplasms. Anticancer Res. 2015
Mar;35(3):1635-9. PMID: 25750321
Yao L, Han C, Song K, Zhang J, Lim K, Wu T. Omega-3
Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in
Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression.
Cancer Res. 2015 Apr 1;75(7):1388-98. doi: 10.1158/0008-5472.CAN14-2561. Epub 2015 Feb 17. PMID: 25691459
Ibrahim Y, Crawford BE, Murci M, Masoodi H, Khan AN, Hu T, Kandil
E, Friedlander P. Thyroid cancer in black thyroid glands: the effect of
age and race. RL J Otorhinolaryngol Relat Spec. 2015;77(1):33-8. doi:
10.1159/000363188. Epub 2015 Feb 4. PMID: 25661419

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PUBLICATIONS
Cope JR, Ratard RC, Hill VR, Sokol T, Causey JJ, Yoder JS, Mirani G,
Mull B, Mukerjee KA, Narayanan J, Doucet M, Qvarnstrom Y, Poole
CN, Akingbola OA, Ritter JM, Xiong Z, da Silva AJ, Roellig D, Van Dyke
RB, Stern H, Xiao L, Beach MJ. The first association of a primary
amebic meningoencephalitis death with culturable Naegleria fowleri in
tap water from a US treated public drinking water system. Clin Infect
Dis. 2015 Apr 15;60(8):e36-42. doi: 10.1093/cid/civ017. Epub 2015
Jan 16. PMID: 25595746
Mader EC Jr, Richeh W, Ochoa JM, Sullivan LL, Gutierrez AN, Lovera
JF. Tumefactive multiple sclerosis and hepatitis C virus 2a/2C
infection: Dual benefit of long-term interferon beta-1a therapy? J
Neurol Sci. 2015 Feb 15;349(1-2):239-42. doi:
10.1016/j.jns.2014.12.034. Epub 2015 Jan 3.
PMID: 25575859
Comparison of sorafenib-loaded poly (lactic/glycolic) acid and DPPC
liposome nanoparticles in the in vitro treatment of renal cell
carcinoma. Liu J, Boonkaew B, Arora J, Mandava SH, Maddox MM,
Chava S, Callaghan C, He J, Dash S, John VT, Lee BR.
J Pharm Sci. 2015 Mar;104(3):1187-96. doi: 10.1002/jps.24318. Epub
2015 Jan 8. PMID: 25573425
Li Y, Liu J, Li W, Brown A, Baddoo M, Li M, Carroll T, Oxburgh L, Feng
Y, Saifudeen Z. p53 Enables metabolic fitness and self-renewal of
nephron progenitor cells. Development. 2015 Apr 1;142(7):1228-41.
doi: 10.1242/dev.111617. PMID: 25804735

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PUBLICATIONS
Park JH, Lee SB. An essential role for Ewing sarcoma gene (EWS) in
early white adipogenesis. Obesity (Silver Spring). 2015 Jan;23(1):13844. doi: 10.1002/oby.20934. Epub 2014 Nov 19.
PMID: 25407167
Cao S, Strong MJ, Wang X, Moss WN, Concha M, Lin Z, O'Grady T,
Baddoo M, Fewell C, Renne R, Flemington EK. High-throughput RNA
sequencing-based virome analysis of 50 lymphoma cell lines from the
Cancer Cell Line Encyclopedia project. J Virol. 2015 Jan;89(1):71329. doi: 10.1128/JVI.02570-14. Epub 2014 Oct 29. PMID: 25355872



Panigrahi R, Chandra PK, Ferraris P, Kurt R, Song K, Garry RF, Reiss
K, Coe IR, Furihata T, Balart LA, Wu T, Dash S. Persistent hepatitis C
virus infection impairs ribavirin antiviral activity through clathrinmediated trafficking of equilibrative nucleoside transporter 1. J Virol.
2015 Jan;89(1):626-42. doi: 10.1128/JVI.02492-14. Epub 2014 Oct
22. PMID: 25339775