CONVENTIONAL COATING PAN

Mixing and tumbling motions in coating pan

A: Rotation of vertical and horizontal axes as limits
of the motions;
B: Zone of tumbling action at the surface of the

surface bed

Conventional coating pans

A: Standard coating pan;
B: Immersion-tube system;
C: Immersion-sword system; D: perforated exhaust cones for
deep-bed air extraction

Perforated coating pans

A: Accela-Cota system; B: Hi-Coater system;
C: Driacoater system

THAI Coater
Film Coating System

TOP SPRAY FLUIDIZED BED COATER

Top spray fluidized bed coater

BOTTOM SPRAY FLUIDIZED BED COATER

Bottom spray fluidized bed coater

TANGENTIAL SPRAY FLUIDIZED BED

COATER

Tangential spray fluidized bed coater

Tangential spray fluidized bed coater

Hot-melt fluidized bed coater

Capsule filling process

Hand-operated capsule filling machine

Hand-operated capsule filling machine

Capsule filling machine Model Panviv A01

Capsule filling machine for pharmaceutical industry

(high capacity)

Capsule filling machine for pharmaceutical industry

(high capacity)

Capsule filling machine for pharmaceutical industry

(high capacity)

Filling capsules by the auger feed system

Lilly

Filling capsules by the vibration-assisted system

Liqfil

Filling capsules by tamping method

Hofliger & Karg

Bosch Capsule filling machine

Capsylon GKF705

Bosch Capsule filling machine

Capsylon GKF705

Filling capsules by soft slug method

Intermittent compression filling of capsule

Zanasi

Filling capsules by vacuum method

MG2

Filling capsules with pellets by double slide method

Filling capsules with pellets by piston & slide method

Filling capsules with tablets by slide dosage method 1

Filling capsules with tablets by slide dosage method 2

Soft gelatin capsule filling machine

Sedimentation centrifugation

Centrifugal filtration

Filtration centrifugation

Negative pressure

Positive pressure

Cartridge filter

Bubble point test

Diffusion test

Filtration system

Illustrating cake compressibility

Filter press

Filter press

Filter press

Filter press

Filter press

Rotary vacuum filter

Rotary vacuum filter

Metafilter

Microbial death kinetic

Sterilization

Microbial death kinetic

F value :

Sterilization

Dry heat sterilization

Sterilization

Dry heat sterilization

Validation :
Qualification and calibration
Air balance determination
Heat distribution of an empty chamber
Heat penetration studies
Microbial challenge studies

Sterilization

Dry heat sterilization

Tunnel oven :
Conveyor belt : Belt speed
Temperature sensor : Each zone

Sterilization

Moist heat sterilization

Sterilization

Moist heat sterilization

Autoclaving cycle :
Heating stage
Holding stage
Cooling stage

Sterilization

Moist heat sterilization

Process commonly used :
Gravity air displacement
Dynamic air removal (Prevac)
Air pressure system

Sterilization

Moist heat sterilization

Validation :
Qualification and calibration
Heat distribution studies
Heat penetration studies
Microbial challenge studies

Sterilization

Filtration sterilization

Negative pressure

Positive pressure
Sterilization

Filtration sterilization
Validation :
Destructive test
Bacterial challenge test

Sterilization

Filtration sterilization
Bubble point test :

Sterilization

Filtration sterilization
Duffusion test :

Sterilization

Filtration sterilization
Pressure hold test :

Sterilization

Gas sterilization
Gas sterilization equipment :

Sterilization

Radiation sterilization

Sterilization

Radiation sterilization

Sterilization

Radiation sterilization

Sterilization