My Summary:

The speakers participated in this partnering forum in fact are doing work that are
in great match to present ITRI research activities.
1

The first speaker , Jon Cooper from U. Glasgow specializes in rapid

diagnostics using a Surface Acoustic Wave (SAW) platform. This could
eliminate the need for channels while better control fluid movement and cell
separation in sample preparation and cost-effect diagnostic tests.
NOTE: He is very interested in international collaboration.

And I

believe that if time allows, we should include his technology (SAW) into
the , together with Dr. Veres.
2

Second speaker is from a UK manufacturing biomedical device Surgical

Innovation to work on minimally-invasive technologies. Their company
works on a number of novel designs to already-in-use products

Third speaker Dr. Pankaj from Uof Edinburgh specializes in mathematical

modeling based on microCT scan of bone behavior to predict possible
damage in stress/strain and to assess suitable replacement designs. This
modeling can reduce the amount of time and cost required to joint design.

Fourth speaker: Dr. Dahiya from U Glasgow works on ultrathin biosensors for
robotic use and also for further applications such as in mobile sensors.
has a specialty in graphene and inorganic sensors that can be used in 3D.

He

Event:
2016

(U of Glasgow , U of Edinburgh ,)
:
:

2016

British Office

: 2016 3 8 ()
09:30~12:00 ()
13:30~16:30 ()
: () 51 3A
:

09:3010:00
10:0010:10

10:10-

10:20

10:20-

10:40

: TBD
Novel formats for in vitro diagnostics

3/8
()

10:4011:00

: Professor Jonathan Cooper, University of Glasgow

Vice Principal Innovation & Knowledge Exchange
Wolfson Chair of Bioengineering
Founder of SAW Dx, Clyde Biosciences, and Mode Dx Ltd

11:0011:20

UK Manufacturing and drive to innovate

: Chris Rawnsley, Global Sales Manager of Surgical Innovations
Group Plc.
Modelling and optimising the behaviour of joint and

11:2011:40

fracture fixation implants in osteoporotic bone

: Dr. Pankaj Pankaj
Dean International (South Asia)
Deputy Head of the Institute for Bioengineering

11:45-

Robotics in Automation, Bendable electronics

12:00

Dr. Dahiya

(BEST Group at U. of Glasgow)

2

:
()
spin-out

: POC
:
:

: (NHS)

:E-skin; bendable
electornics

BEST group, University of

Glasgow

Notes from Speaker Presentation

Speaker 1. Dr. Min Wang
The Regulatory Pathway for Medical Devices in Asia
Three strategies for success
1. Determine if we are truly working with a medical device, if yes, then take the
regulatory pathway
2. Identify the appropriate risk level for your product
3. Implement proper design controls, learn the regulatory tools: be regulatory intelligent
Brief overview of the regulatory bodies in Southeast Asia
A) Taiwan, TFDA, division of medical devices and cosmetics
16 categories of medical devices; 3 risk classes: 1, 2,3
B) China CFDA/cMDE, undergo major changes such that registration and supervision
are now focused
C) Japan: Classes I-IV
D) South Korea: Ministry of Food and Drug Safety (MFDS) which also gone major
restructuring last year
E) ASEAN : AMDD
F) Asian Harmonization Working Party
Speaker 2: Dr. Paul Lai (Dephoron group) Development in digital health
Health , income, education, environment: Commonwealth countries rank among the top 10.
Overview of Taiwan Industry: 0.32% world population; 0.7% GDP, 0.48% health expenditure, 1.9%
total wealth; produces 3.2% medical products
8 million households consumes 60% GDP; healthcare consumption only 14.5% of total Taiwan;
when calculated, 200 billion is paid out-of-pocket
34,000 physicians in Taiwan, and each person visits the clinic 15 times/year
The US invested 2 billion for the HGP, but the return is more than 25x; one of the most successful
investments. So many initiatives and projects: HGP, HUPO, ENCORE, HCP, HBP, Brain initiative
So much data, who will spend the effort to work through these?
A recent example: adipokines conects obesity to dementia; Lancet Neurology 2014
Kevin Tracy connects nervous system to the immune system (TNF-a; Set Point)
Some initiatives in Taiwan: CRUX healthTech
The advantage of clinical consortiums throughout Taiwan

Speaker 3: Dr. Jon Cooper

University of Glasgow: Vice Principal for Knowledge Exchange
Acoustic Holograms to Shape Microfluidics Flows
Rapid diagnosis: PAST accomplishments
1. LED and origami paper isothermal PCR
2. MODE unit for detecting AFP in colorectal cancer
3.
Lab-on-chip microfluidics
Using surface acoustic waves (10 mm aperture)
1. Acoustic: voltage, frequency, affect internal friction in water , generation of heat with
collision caused by power-loss
2. Wafer- droplet interface: reflection, radiative pressure, capillary pressure
3. Rayleigh waves
4. Created disposable acoustic platform with lithium niobate wafer and disposable sampling
point
A. Applications: blood lysis 1000x enrichment
B. Warfarin titration: measure viscosity of blood
C. NHS: chlamydia and gonorrhorea Isothermal amplication to speed up the STI
workflow
D. Atomisation, nebulisation: drug delivery, gene therapy, 1-5uM to enter the lung
Cooperation with Abbott/Alere; Vectura; Illumina; advanced liquid logic (?), Gates
foundation
WEBSITE: http://www.gla.ac.uk/schools/engineering/staff/jonathancooper/
Publications (selected):
Reboud, J., Bourquin, Y., Wilson, R., Pall, G.S., Jiwaji, M., Pitt, A.R., Graham, A., Waters, A.P., and
Cooper, J.M. (2012) Shaping acoustic fields as a toolset for microfluidic manipulations in diagnostic
technologies. Proceedings of the National Academy of Sciences of the United States of America, 109(38),
pp. 15162-15167. (doi:10.1073/pnas.1206055109)
Wilson, R., Reboud, J., Bourquin, Y., Neale, S., Zhang, Y., and Cooper, J. (2011) Phononic crystal
structures for acoustically driven microfluidic manipulations. Lab on a Chip, 11(2), pp. 323-328.
(doi:10.1039/C0LC00234H)
Heron, S.R., Wilson, R., Shaffer, S.A., Goodlett, D.R., and Cooper, J.M. (2010) Surface acoustic wave
nebulization of peptides as a microfluidic interface for mass spectrometry. Analytical Chemistry, 82(10),
pp. 3985-3989. (doi:10.1021/ac100372c)
Faley, S. L., Copland, M., Wlodkowic, D., Kolch, W., Seale, K. T., Wikswo, J. P., and Cooper, J. M. (2009)
Microfluidic single cell arrays to interrogate signalling dynamics of individual, patient-derived
hematopoietic stem cells. Lab on a Chip, 9(18), pp. 2659-2664. (doi:10.1039/b902083g)

Speaker 4.

Surgical Innovations

UK Manufacturing and drive to innovate

: Chris Rawnsley, Global Sales Manager of Surgical Innovations
As the only British company that does manufacturing in the UK, there is much government
support!!
The long road from initial innovation in the house to the eventual building of manufacturing
plant, from little regard to regulatory details to stringent accordance to requirements, all
focused on a major product: the liver retractor (moving the liver out of the path of surgery)
Some innovative ideas behind success:
1. Reusable handle, disposable (always fresh) head
2. Decreasing size:

16mm 3mm

3. Segmented folding :

rod to pretzel design

Advanced medical innovation:

hernia fixation from staples to glue; minimal change and

visibility of procedure, minimal damage and speedy recovery.

http://www.surginno.com/

Speaker 5.

Dr. Pankaj Pankaj

University of Edinburgh
Modeling and optimizing behavior of joints
Medical simulation and modeling will save you much time and pain
1.

Bone properties: microCT scan

2. Material properties:

elasticity ; cortical bone data with microCT scan; periosteal and

endosteal
3. Time-dependent properties: prevent orthopedic implant loosening and response to
traumatic event prediction;

linear and nonlinear viscoelasticity

4. Material property: post-elastic : 29Million degree of freedom; the way bone eases however,
is very similar.

Strain and stress.

A. Application:

determine number of wires that are needed to hold joint in place

B. Locking plates:

length, plate d+l working strength, bone width, bone density,

bone plate fracture site

C. Joint replacement:

total knee replacement; modular stems, unilateral knee

replacement
5. Boundary conditions:

stresses in the pelvis, effect of muscles and ligaments

6. Other research areas

A. Implantable microsystems for anti-cancer treatment:

radiotherapy; oxygen/hypoxia;

O2, pH, temp

B. Industrial biotechnology:

LiFi

RF spectrum relief:

light for communication

Speaker 6: Dr. Ravinder Dahiya

University of Glasgow : Bendable electronics; skin in robotics;
applications (BEST Group)

prosthetics and medical

1. Ultraflexible, ultrathin, electronics

Focus on grapheme, flexible sensors; bendable chip modeling, nanostructure, 3D prosthetic
hands
2. Wearable systems: bioelectronics systems (James Watt Nanofabrication Centre)
Smallest electrobeam pattern of < 3nm
Alignment of 0.46nm
3.

Robotics in Automation: feedback is essential for machine control

POSFET piezoelectronics
a. 3D conformable, with touch, temperature, thermoelectric, memory
b. Organic and inorganic semiconductors: RoboSkin
c. 3D structure: 2D layout build semiconductor layout rebuild into 3D structure
(Triangular module)
d. Problem: inorganic semiconductors are only slightly flexible and therefore only large
curvatures can be made.
e. Organic semiconductors are tested based on graphene: cheap but does not work well
as electroconductors; form capacitance sensors.
f. Form printable tactile skin : top down or bottom up approaches have been developed.
g. Possible novel applications in biomedical instruments and self-health management
monitoring