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US 20140256687A1

(19) United States


(12) Patent Application Publication (10) Pub. No.: US 2014/0256687 A1
(43) Pub. Date:

Tamura et al.

(54)

AGRICULTURAL AND HORTICULTURAL


INSECTICIDE COMPOSITION AND
METHOD FOR USING THE SAME

Publication Classi?cation

(51)

(75) Inventors: Shingo Tamura, Tokyo (JP); Takao


Aoki, Osaka (JP); Ken Kuriyama,

Tokyo (JP)

Sep. 11, 2014

(52)

Int. Cl.

A01N57/14
A01N57/12

(2006.01)
(2006.01)

A01N 41/10

(2006.01)

U.S. Cl.
CPC .............. .. A01N57/14 (2013.01); A01N41/10

(2013.01); A01N57/12 (2013.01)

(73) Assignee: NIHON NOHYAKU CO., LTD., Tokyo

USPC

(JP)
(21) Appl. No.:

14/125,508

........................................................ ..

(57)

514/136

ABSTRACT

Provided are an agricultural and horticultural insecticide

(22)

PCT Filed:

Jun. 28, 2012

composition comprising ?ubendiamide and dichlorvos and/

(86)

PCT No.:

PCT/JP2012/066474

agricultural and horticultural insecticide composition, com

371 (0X1)
(2), (4) Date:

Feb. 14, 2014

or profenofos as active ingredients; and a method for using an

(30)

prising treating insect pests directly, treating crops potentially

Foreign Application Priority Data

Jun. 29, 2011

infested With the insect pests, or treating surrounding soil or


cultivation medium of the crops With an effective amount of

(JP) ............................... .. 2011444379

an agricultural and horticultural insecticide composition


comprising ?ubendiamide and dichlorvos and/ or profenofos
as active ingredients.

Sep. 11,2014

US 2014/0256687 A1

AGRICULTURAL AND HORTICULTURAL


INSECTICIDE COMPOSITION AND
METHOD FOR USING THE SAME

stances, the development of novel technologies for ef?ciently


controlling insect pests that have been dif?cult or impossible
to control is desired.

TECHNICAL FIELD

[0001]

The present invention relates to an agricultural and

Solution to Problem

[0013]

The present inventors conducted extensive research

horticultural insecticide composition comprising ?ubendia

to solve the above-described problems. As a result, the

mide and dichlorvos and/ or profenofos as active ingredients;


and a method for using the same.

present inventors found that a combined use of ?ubendiamide

BACKGROUND ART

[0002] Flubendiamide is a commercially available com


pound as an agricultural and horticultural insecticide. It is
known that various combinations of ?ubendiamide or its rela
tive compound and an agricultural and horticultural insecti
cide have a complementary effect on the insecticidal spec
trum and that speci?c combinations of them produce a
synergistic effect (for example, see Patent Literature 1 to 5
and Non Patent Literature 1). Dichlorvos and profenofos are

also commercially available compounds as agricultural and


horticultural insecticides (for example, see Patent Literature 6

and 7 and Non Patent Literature 1). However, compositions


comprising a combination of ?ubendiamide and dichlorvos
and/ or profenofos are not known, and it is not known at all that
the insecticidal effect of such a composition is synergistically

greater than that of each compound used separately.


CITATION LIST
Patent Literature

[0003]
[0004]
[0005]
[0006]
[0007]
[0008]
[0009]

Patent Literature 1:
Patent Literature 2:
Patent Literature 3:
Patent Literature 4:
Patent Literature 5:
Patent Literature 6:
Patent Literature 7:

JP-A 2001 -131 141


WO 2002/087334
WO 2004/034786
WO 2005/004603
WO 2005/004604
US. Pat. No. 2,956,073
GB Patent No. 1417116

(general name) (chemical name: 3-iodo-W-(2-mesyl-1,1


dimethylethyl) -N- {4 -[1 ,2, 2, 2-tetra?uoro -1 -(tri?uorom
ethyl)ethyl]-o-tolyl}phthalamide), known as an agricultural

and horticultural insecticide, and dichlorvos (general name)


(chemical name: 2,2-dichlorovinyl dimethyl phosphate) and/
or profenofos (general name) (chemical name: O-4-bromo

2-chlorophenyl O-ethyl S-propyl phosphorothioate), simi


larly each known as an agricultural and horticultural
insecticide, has advantages over a separate use of each com

pound, such as remarkable synergistic effect, expansion of


the range of target insect pests, dose reduction, reduction of
treatment frequency, etc. Thus, the present invention was

completed.
[0014]

That is, the present invention relates to the follow

ing.
[1] An agricultural and horticultural insecticide composition
comprising ?ubendiamide and dichlorvos and/ or profenofos
as active ingredients.

[2] The agricultural and horticultural insecticide composition


according to the above [1], comprising 0.1 to 10 parts by mass
of dichlorvos and/or profenofos per part by mass of ?uben
diamide.
[3] A method for using an agricultural and horticultural insec

ticide composition, comprising treating insect pests directly,


treating crops potentially infested with the insect pests, or
treating surrounding soil or cultivation medium of the crops
with an effective amount of an agricultural and horticultural

insecticide composition comprising ?ubendiamide and


dichlorvos and/or profenofos as active ingredients.

[4] A method for controlling agricultural and horticultural

insect pests, comprising treating insect pests directly, treating


Non Patent Literature

[0010]

Non Patent Literature 1:

[0011] The Pesticide Manual 14th Edition (British Crop


Production Council)
SUMMARY OF INVENTION

crops potentially infested with the insect pests, or treating


surrounding soil or cultivation medium of the crops with an
effective amount of an optionally diluted formulation con
taining ?ubendiamide as an active ingredient and an effective

amount of an optionally diluted formulation containing


dichlorvos and/or profenofos as an active ingredient(s), the
two formulations being used separately but in the same

period.
Technical Problem

[0012]

In the production of agricultural produce, the dam

age caused by various insect pests is still large and treatment


with various insecticides is required for control of the insect
pests. Such insecticide treatment imposes a particularly great
burden on farmers, and reducing the treatment operation has
been strongly desired in terms of occupational health, in
particular the reduction of farmers workload, as well as in

terms of economics, in particular the reduction of production


costs of agricultural produce. To this end, various kinds of
agricultural and horticultural insecticide compositions have
been developed. However, in conventional art, effective pest
control cannot be achieved in some cases because of the kind

of insect pest to be controlled, habitat characteristics, devel


opment of insecticide resistance, etc. Under such circum

[5] A method for controlling agricultural and horticultural

insect pests, comprising treating insect pests directly, treating


crops potentially infested with the insect pests, or treating
surrounding soil or cultivation medium of the crops with an
effective amount of an optionally diluted formulation con
taining ?ubendiamide as an active ingredient and an effective

amount of an optionally diluted formulation containing


dichlorvos and/or profenofos as an active ingredient(s), the
two formulations being used separately at a given interval.

[6] A method for controlling agricultural and horticultural


insect pests, comprising mixing an effective amount of a
formulation containing ?ubendiamide as an active ingredient
and an effective amount of a formulation containing dichlo
rvos and/or profenofos as an active ingredient(s); optionally

diluting the mixture; and treating insect pests directly, treat

Sep. 11,2014

US 2014/0256687 A1

ing crops potentially infested with the insect pests, or treating

suspension concentrate (?owable), an emulsi?able suspen

surrounding soil or cultivation medium of the crops with the

sion concentrate, an emulsi?able concentrate, a soluble con

optionally diluted mixture.

centrate, a wettable powder, a water-dispersible granule, a


granule, a dust, a microcapsule, a capsule, a tablet, a jumbo
and a pack.
[0019] The inactive carrier may be a solid or liquid carrier.
Examples of the solid carrier include natural minerals, such as

Advantageous Effects of Invention


[0015]

The present invention relates to an agricultural and

horticultural insecticide composition comprising ?ubendia


mide and dichlorvos and/ or profenofos as active ingredients;
and a method for using the same. The agricultural and horti
cultural insecticide composition and the method have advan
tages over a separate use of each compound, such as remark

able synergistic effect, expansion of the range of target insect


pests, dose reduction, reduction of treatment frequency, etc.
Therefore, the present invention provides a novel technology

for ef?ciently controlling insect pests that have been impos


sible or dif?cult to control by conventional technologies.
DESCRIPTION OF EMBODIMENTS

[0016] Flubendiamide, which is one of the active ingredi


ents of the agricultural and horticultural insecticide compo
sition of the present invention, can be produced according to
the production method disclosed in Patent Literature 1 etc.,

quartz, clay, kaolinite (kaolin), pyrophyllite, sericite, talc,


bentonite, acid clay, attapulgite, zeolite and diatomite; inor
ganic salts, such as calcium carbonate, ammonium sulfate,
sodium sulfate and potassium chloride; organic solid carriers,
such as synthetic silicic acid, synthetic silicates, starch, cel
lulose and plant powders (for example, sawdust, coconut
shell, corn cob, tobacco stalk, etc.); plastics carriers, such as

polyethylene, polypropylene and polyvinylidene chloride;


urea; hollow inorganic materials; hollow plastic materials;
and fumed silica (white carbon). These solid carriers may be
used alone or in a combination of two or more kinds.

[0020] Examples of the liquid carrier include alcohols


including monohydric alcohols, such as methanol, ethanol,

propanol, isopropanol and butanol, and polyhydric alcohols,


such as ethylene glycol, diethylene glycol, propylene glycol,

hexylene glycol, polyethylene glycol, polypropylene glycol

purchase. These compounds, an appropriate inactive carrier

and glycerin; polyol compounds, such as propylene glycol


ether; ketones, such as acetone, methyl ethyl ketone, methyl
isobutyl ketone, diisobutyl ketone and cyclohexanone; ethers,
such as ethyl ether, dioxane, ethylene glycol monoethyl ether,
dipropyl ether and tetrahydrofuran; aliphatic hydrocarbons,
such as normal paraf?n, naphthene, isoparaf?n, kerosene and

and a surfactant, and if needed an adjuvant are blended in an

mineral oil; aromatic hydrocarbons, such as benzene, tolu

but commercial formulations thereof are also available for

purchase. The other active ingredient(s), dichlorvos (also


called DDVP) and profenofos, can be produced according to
the production method disclosed in Patent Literature 6 and 7,
but commercial formulations thereof are also available for

appropriate ratio, and through the step of dissolution, sepa

ene, xylene, solvent naphtha and alkyl naphthalene; haloge

ration, suspension, mixing, impregnation, adsorption and/or


adhesion, are formulated into an appropriate form for appli

nated hydrocarbons, such as dichloromethane, chloroform


and carbon tetrachloride; esters, such as ethyl acetate, diiso

cation, such as a suspension concentrate (?owable), an emul

propyl phthalate, dibutyl phthalate, dioctyl phthalate and

si?able suspension concentrate, an emulsi?able concentrate,

dimethyl adipate; lactones, such as gamma-butyrolactone;


amides, such as dimethylformamide, diethylformamide, dim

a soluble concentrate, a wettable powder, a water-dispersible


granule, a granule, a dust, a microcapsule, a capsule, a tablet,

ajumbo and a pack.


[0017] The total content of the active ingredients in the
agricultural and horticultural insecticide composition of the
present invention can be adjusted as needed without particu
lar limitation, but is usually about 0.01 to 90 parts by mass.
For example, in the case where the agricultural and horticul
tural insecticide composition is a dust or a granule, the total
content of the active ingredients is preferably about 0.1 to 30
parts by mass, and in the case where the agricultural and
horticultural insecticide composition is an emulsi?able con
centrate, a wettable powder, a ?owable, a water-dispersible

granule or the like, the total content of the active ingredients


is preferably about 0.1 to 60 parts by mass. The blending ratio
of the active ingredients ?ubendiamide and dichlorvos and/or

profenofos in the agricultural and horticultural insecticide


composition of the present invention is appropriately selected
from the range of 0.1 to 10 parts by mass of dichlorvos and/or

profenofos per part by mass of ?ubendiamide.


[0018] As for these active ingredients, their commercial
formulations may be used as they are. Alternatively, the active
ingredients can be prepared into separate formulations or a
combined formulation. For the preparation of a formulation,

ethylacetamide and N-alkyl pyrrolidone (N-methylpyrroli


done etc.); nitriles, such as acetonitrile; sulfur compounds,
such as dimethyl sulfoxide; vegetable oils, such as soybean
oil, rapeseed oil, cotton seed oil and castor oil; and water.
These liquid carriers may be used alone or in a combination of
two or more kinds.

[0021]

Examples of the adjuvant include surfactants used

as a dispersant, a wetting agent, a spreader, a sticking/spread

ing agent, etc., binders, tacki?ers, thickeners, colorants, anti


freeZing agents, anti-caking agents, disintegrants and stabi
liZing agents. If needed, preservatives, plant fragments, etc.
may be additionally used. These adjuvants may be used alone
or in a combination of two or more kinds.

[0022]

Examples of the surfactants used as a dispersant, a

wetting agent, a spreader, a sticking/spreading agent, etc.


include nonionic surfactants, such as sorbitan fatty acid ester,
polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid

ester, polyoxyethylene fatty acid ester, polyoxyethylene resin


acid ester, polyoxyethylene fatty acid diester, polyoxyethyl
ene alkyl ether, polyoxyethylene alkyl aryl ether, polyoxyeth

ylene alkyl phenyl ether, polyoxyethylene dialkyl phenyl

and through the step of dissolution, separation, suspension,


mixing, impregnation, adsorption and/or adhesion, are for

ether, polyoxyethylene alkyl phenyl ether-formaldehyde con


densates, polyoxyethylene-polyoxypropylene block copoly
mers, polystyrene-polyoxyethylene block polymers, alkyl
polyoxyethylene-polypropylene block copolymer ether,
polyoxyethylene alkylamine, polyoxyethylene fatty acid
amide, polyoxyethylene fatty acid bis(phenyl ether), poly

mulated into an appropriate form for application, such as a

alkylene benzyl phenyl ether, polyoxyalkylene styryl phenyl

the active ingredient(s) and an appropriate inactive carrier,


and if needed an adjuvant are blended in an appropriate ratio,

Sep. 11,2014

US 2014/0256687 A1

ether, acetylene diol, polyoxyalkylene-added acetylene diol,


polyoxyethylene ether-type silicone, ester-type silicone,
?uorosurfactants, polyoxyethylene castor oil and polyoxy

oxidants, such as phenolic compounds, amine compounds,


sulfur compounds and phosphoric acid compounds; and
ultraviolet absorbers, such as salicylic acid compounds and

ethylene hydrogenated castor oil;

benzophenone compounds. Examples of the preservatives

anionic surfactants, such as alkyl sulfates, polyoxyethylene

include potassium sorbate and 1,2-benzothiazolin-3-one.

alkyl ether sulfates, polyoxyethylene alkyl phenyl ether sul


fates, polyoxyethylene styryl phenyl ether sulfates, alkylben
zene sulfonates, alkylaryl sulfonates, lignosulfonates, alkyl

spreading agents, activity enhancers such as metabolic inhibi

tors (piperonyl butoxide etc.), antioxidants (BHT etc.) and

sulfosuccinates, naphthalene sulfonates, alkylnaphthalene

ultraviolet absorbers can also be used if needed.

sulfonates, salts of naphthalenesulfonic acid-formaldehyde


condensates, salts of alkylnaphthalenesulfonic acid-formal

[0029] Further, other adjuvants including functional

[0030]

The crops for which the agricultural and horticul

tural insecticide composition of the present invention can be

dehyde condensates, fatty acid salts, polycarboxylic acid


salts, polyacrylates, N-methyl-fatty acid sarcosinates,
resinates, polyoxyethylene alkyl ether phosphates and poly
oxyethylene alkyl phenyl ether phosphates;

used is not particularly limited, and the examples include

cationic surfactants including alkyl amine salts, such as lauryl

mandarin oranges, oranges, lemons, limes, grapefruits, Chi


nese quinces, quinces, pears, European pears, Japanese pears,

amine hydrochloride, stearyl amine hydrochloride, oleyl


amine hydrochloride, stearyl amine acetate, stearyl amino
propyl amine acetate, alkyl trimethyl ammonium chloride
and alkyl dimethyl benzalkonium chloride; and amphoteric
surfactants, such as amino acid-type or betaine-type ampho

cereals such as rice, barley, wheat, rye, oats, corn and sor

ghum; legumes such as soybeans, azuki beans, broad beans,


green peas and peanuts; fruit trees and fruits such as apples,

grapes, blueberries, cranberries, blackberries, raspberries,

strawberries, peaches, Japanese plums, nectarines, Japanese


apricots, cherries, apricots, prunes, walnuts, hazelnuts,
almonds, pistachio nuts, cashew nuts, macadamia nuts,

teric surfactants. These surfactants may be used alone or in a

bananas, persimmons, olives, loquats, date palms, coconut

combination of two or more kinds.

palms and oil palms; vegetables such as cabbages, tomatoes,


spinach, broccoli, lettuce, onions, welsh onions, green pep
pers, eggplants, kohlrabi, Chinese cabbages, leaf mustard,

[0023]

Examples of the binders or the tacki?ers include

carboxymethyl cellulose and salts thereof, dextrin, soluble


starch, xanthan gum, guar gum, sucrose, polyvinyl pyrroli

done, gum arabic, polyvinyl alcohol, polyvinyl acetate,


sodium polyacrylate, polyethylene glycols with an average
molecular weight of 6,000 to 20,000, polyethylene oxides
with an average molecular weight of 100,000 to 5,000,000,

phospholipids (for example, cephalin, lecithin, etc.), cellu


lose powder, dextrin, modi?ed starch, polyaminocarboxylic
acid chelating compounds, cross-linked polyvinyl pyrroli
done, maleic acid-styrene copolymers, (meth)acrylic acid
copolymers, half esters of polyhydric alcohol polymer and
dicarboxylic anhydride, water soluble polystyrene sul

fonates, para?in, terpene, polyamide resins, polyacrylates,


polyoxyethylene, waxes, polyvinyl alkyl ether, alkylphenol
formaldehyde condensates and synthetic resin emulsions.
[0024] Examples of the thickeners include water soluble
polymers, such as xanthan gum, guar gum, diutan gum, car

boxymethyl cellulose, polyvinyl pyrrolidone, carboxyvinyl

cauli?ower, garland chrysanthemum, artichoke, asparagus,


carrots, parsley, celery, parsnips and chard; root vegetables
such as carrots, burdock roots, potatoes, sweet potatoes, J apa

nese yam, taro, Japanese radishes, lotus roots and tumips;


crops for processing such as cotton, hemp, paper mulberry,

oriental paperbush, rapeseeds, oil palms, Barbados nuts,


buckwheat, beet, hops, sugarcane, sugar beet, olives, rubber,
coffee, tobacco, mulberry and tea; gourd such as Japanese
pumpkins, cucumbers, zucchini, waterrnelons and melons;
pasture grass such as orchard grass, sorghum, timothy, clover

and alfalfa;
lawn grass such as Japanese lawn grass, Korean lawn grass,

Bermuda grass, redtop, creeping bentgrass, colonial bent

grass, Kentucky bluegrass, rough bluegrass, tall fescue,


chewings fescue, creeping red fescue, annual ryegrass, peren
nial ryegrass, orchard grass and timothy grass; spice and
aromatic crops such as lavender, rosemary, thyme, parsley,

polymers, acrylic polymers, starch derivatives and polysac


charides; and inorganic ?ne powders, such as high grade

pepper, red pepper, Japanese horseradish, ginger, garlic,

bentonite and fumed silica (white carbon).


[0025] Examples of the colorants include inorganic pig
ments, such as iron oxide, titanium oxide and prussian blue;
and organic dyes, such as alizarin dyes, azo dyes and metal

chrysanthemum, lisianthus, babys breath, sun?ower, ger


bera, marigold, salvia, petunia, verbena, tulip, aster, gentian,
lily, pansy, cyclamen, orchid, lily of the valley, lavender,
stock, omamental kale, primula, poinsettia, gladiolus, catt

phthalocyanine dyes.

shiso, mint and basil; ?oweringplants such as rose, carnation,

propylene glycol and glycerin.

leya, daisy, verbena, cymbidium and begonia; and trees such


as Japanese ash, birch, ?owering dogwood, eucalyptus,
ginkgo, lilac, maple, live oak, poplar, Chinese redbud, Chi
nese sweet gum, plane, Japanese zelkova, Japanese Thuja,

[0027] Examples of the adjuvants serving to prevent caking

Momi ?r, southern Japanese hemlock, temple juniper, pine,

[0026] Examples of the antifreeZing agents include poly


hydric alcohols, such as ethylene glycol, diethylene glycol,
or facilitate disintegration include polysaccharides (starch,

spruce, Japanese yew, elm, buckeye, sweet Viburnum, Bud

alginic acid, mannose, galactose, etc.), polyvinyl pyrroli

dhist pine, Japanese cedar, Japanese cypress, croton, Japa

done, fumed silica (white carbon), ester gum, petroleum


resin, sodium tripolyphosphate, sodium hexametaphosphate,
metal stearates, cellulose powder, dextrin, methacrylate

nese spindle and Japanese phalinia.

copolymers, polyvinyl pyrrolidone, polyaminocarboxylic


acid chelating compounds, sulfonated styrene-isobutylene
maleic anhydride copolymers and starch-polyacrylonitrile

[0031] The crops include crops provided with a useful


trait by a classical breeding technique and a recently
advanced gene recombination technique, for example,
genetically modi?ed crops (e.g., herbicide-tolerant crops,

graft copolymers.

insect pest-resistant transgenic crops producing insecticidal


proteins, disease-resistant transgenic crops producing induc

[0028] Examples of the stabiliZing agents include desic


cants, such as zeolite, quicklime and magnesium oxide; anti

ers of disease resistance, palatability-enhanced crops, long


term preservable crops, high-yield crops, etc.).

Sep. 11,2014

US 2014/0256687 A1

[0032]

Exemplary crops provided with herbicide tolerance

by a classical breeding technique include varieties of rape


seed, wheat, sun?ower, rice and corn tolerant to the imida
zolinone family of ALS-inhibiting herbicides such as
imazethapyr, and such crops are sold under the trade name of

Examples of the foregoing toxins and genetically modi?ed


crops capable of synthesizing these toxins are described in

EP-A-0374753, WO 93/07278, WO 95/34656, EP-A


0427529, EP-A-451878, WO 03/052073, etc. The toxins con
tained in such genetically modi?ed crops are suitable for

control of pests, in particular, Coleopteran insect pests,


Dipteran insect pests and Lepidopteran insect pests, and due

Clear?eld (registered trademark). Also included is a variety


of soybean provided with tolerance to the sulfonyl urea fam
ily of ALS-inhibiting herbicides such as thifensulfuron-me
thyl by a classical breeding technique, and this is sold under

to the toxins, the crops exhibit resistance to such pests.


[0036] Genetically modi?ed crops which express one or

the trade name of STS soybean. Also included are crops

more of the insecticidal toxins are already known, and some

provided with tolerance to acetyl-CoA carboxylase inhibitors


such as trione oxime herbicides and aryloxy phenoxy propi
onic acid herbicides by a classical breeding technique, for

of them are commercially available. Examples of such geneti


cally modi?ed crops include YieldGard (registered trade
mark), which is a variety of corn expressing a CrylAb toxin;
YieldGard Rootworm (registered trademark), which is a vari
ety of corn expressing a Cry3Bb1 toxin; YieldGard Plus (reg
istered trademark), which is a variety of corn expressing

example, SR corn and the like.

[0033] Exemplary crops provided with herbicide tolerance


by a gene recombination technique include glyphosate-toler
ant varieties of corn, soybean, cotton, rapeseed and sugarbeet,

CrylAb and Cry3Bb1 toxins; Herculex I (registered trade

and such crops are sold under the trade names such as

mark), which is a variety of corn expressing a CrylFa2 toxin

Roundup Ready (registered trademark) and Agrisure GT.

and phosphinothricin N-acetyltransferase (PAT) for tolerance


to glufosinate; NuCOTN33B (registered trademark) and

Also included are varieties of corn, soybean, cotton and rape

seed genetically engineered to be tolerant to glufosinate, and


such crops are sold under the trade name of LibertyLink

(registered trademark) etc.Also included is a variety of cotton


genetically engineered to be tolerant to bromoxynil, and this
is sold under the trade name of BXN.

[0034]

Crops provided with tolerance to acetyl-CoA car

Bollgardl (registered trademark), which are varieties of cot


ton expressing a Cry1Ac toxin; Bollgard 11 (registered trade
mark), which is a variety of cotton expressing Cry1Ac and
Cry2Ab toxins; VIPCOT (registered trademark), which is a
variety of cotton expressing aVlP toxin; NewLeaf (registered
trademark), which is a variety of potato expressing a Cry3A

boxylase inhibitors are described in Proc. Natl. Acad. Sci.

toxin; NatureGard (registered trademark) Agrisure (regis

USA, 87, 7175-7179 (1990), and the like. Further, acetyl


CoA carboxylase mutants resistant to acetyl-CoA carboxy

trait), Agrisure (registered trademark) CB Advantage (a Bt11

lase inhibitors are reported in Weed Science, 53, 728-746


(2005), and the like, and by introducing the gene of such an
acetyl-CoA carboxylase mutant into crops by a gene recom
bination technique, or introducing a resistance-conferring
mutation into acetyl-CoA carboxylase of crops, crops toler
ant to acetyl-CoA carboxylase inhibitors can be engineered.

tered trademark) GT Advantage (a GA21 glyphosate-tolerant


corn borer (CB) trait); and Protecta (registered trademark).
[0037] Further, the crops also include crops genetically

engineered to produce selectively acting anti-pathogenic sub


stances. Examples of the anti-pathogenic substances include
PR proteins (PRPs; described in EP-A-03 92225); ion channel
inhibitors, such as sodium channel inhibitors and calcium

channel inhibitors (for example, KPl, KP4 and KP6 toxins,

Alternatively, by introducing a nucleic acid causing base


substitution mutation into crop plant cells (a typical example
of this technique is chimeraplasty technique (Gura T. 1999.
Repairing the Genomes Spelling Mistakes. Science 285:
316-318.)) to allow site-speci?c substitution mutation in the
amino acids encoded by an acetyl-CoA carboxylase gene of

bibenzyl synthase; chitinase; glucanase; and substances pro


duced by microbes, such as peptide antibiotics, heterocyclic

crops, crops tolerant to acetyl-CoA carboxylase inhibitors

WO 03/000906). Examples of the foregoing anti-pathogenic

which are produced in viruses, are known); stilbene synthase;

antibiotics and plant disease resistance-related protein factors


(referred to as plant disease resistance genes and described in

can be engineered.

substances and genetically modi?ed crops capable of produc

[0035] The crops also include crops genetically engi

ing these substances are described in EP-A-0392225, WO

neered to synthesize insecticidal toxins etc. Exemplary insec


ticidal toxins expressed in such genetically modi?ed crops

95/33818, EP-A-0353191, etc.


[0038] Further, the crops also include crops provided

include insecticidal proteins derived from Bacillus cereus or

with a useful trait such as an improved proportion of oil


components and a higher amino acid content by a gene

Bacillus papilliae; Bacillus Zhuringiensis-derived delta-en


dotoxins, such as CrylAb, CrylAc, CrylF, CrylFa2,
Cry2Ab, Cry3A, Cry3Bb1 and Cry9C, and other insecticidal

recombination technique. Examples of such crops include


VlSTlVE (registered trademark), which is a variety of soy

proteins, such as VlPl, VlP2, VlP3 and VlP3A; nematode

bean engineered to have a reduced linolenic acid content, and

derived insecticidal proteins; toxins produced by animals,

high-lysine (or high-oil) corn, which is a variety of corn

such as scorpion toxins, spider toxins, bee toxins and insect

engineered to have an increased content of lysine or oil.

speci?c neurotoxins; toxins of ?lamentous fungi; plant lec


tins; agglutinin; protease inhibitors, such as trypsin inhibi
tors, serine protease inhibitors, patatin, cystatin and papain
inhibitors; ribosome inactivating proteins (RIP), such as ricin,
maize RIP, abrin, saporin and bryodin; steroid metabolizing
enzymes, such as 3-hydroxy steroid oxidase, ecdysteroid

UDP-glucosyltransferase and cholesterol oxidase; ecdysone

[0039]

Furthermore, the crops also include stacked vari

eties with a combination of two or more selected from the

above-described classical herbicide-tolerant traits, herbicide


tolerant genes, insecticidal pest-resistance genes, anti-patho
genic substance-producing genes and useful traits including
an improved proportion of oil components and a higher amino

inhibitors; HMG-CoA reductase; ion channel inhibitors, such

acid content. When the agricultural and horticultural insecti


cide composition of the present invention is used for crops

as sodium channel inhibitors and calcium channel inhibitors;

modi?ed to be tolerant to a herbicide, systematic and/or

juvenile hormone esterase; diuretic hormone receptors; stil

mixed treatment with the herbicide (for example, glyphosate

bene synthase; bibenzyl synthase; chitinase; and glucanase.

or its salts, glufosinate or its salts, dicamba or its salts,

Sep. 11,2014

US 2014/0256687 A1

imazethapyr or its salts, isoxa?utole, etc.) and the agricultural


and horticultural insecticide composition of the present

rated into bed soil, covering soil or the whole soil. Simply, soil
and such a formulation may be alternately layered. In the

invention can control weeds and insect pests in an integrated

application at the seeding time, the timing of the application

manner.

may be before, at the same time as, or after seeding, or after

[0040]

In the use of the agricultural and horticultural insec

ticide composition of the present invention, the above-de


scribed formulation(s) containing an active ingredient(s)
is/are optionally diluted or suspended in water etc., and insect
pests are directly treated with, or target crops potentially
infested with the insect pests, seeds of the target crops, soil or
cultivation medium for planting the seeds, or the like are
treated with the optionally diluted or suspended formulation

(s) in an amount (s) effective for insect pest control according


to a usual method. Examples of the treatment method include
spray treatment of foliage etc., treatment of nursery boxes for

paddy rice, seed treatment such as dust coating, dipping and


disinfection of seeds, planting hole treatment, plant foot treat
ment, planting row treatment, drench treatment and soil
incorporation treatment. Also included is treatment of water

culture media in hydroponics.


[0041] The seed treatment may be performed in a usual
manner. The exemplary methods include dipping of seeds in
a diluted or undiluted ?uid of a liquid or solid formulation for

the permeation of agrochemicals into the seeds; mixing, dust


coating or other treatment of seeds with a liquid or solid
formulation for the adherence of agrochemicals onto the sur

faces of the seeds; monolayer or multilayer coating of seeds

covering with soil. In the case of paddy rice, submerged


application of a granule etc. to a paddy ?eld is often per
formed.
[0045] For ?eld crops, such as potato, sweet potato and

soybean, preferred is treatment of their seeds, cultivation


media in the vicinity of plants, or the like in the period of
seeding to seedling culture. For plants of which the seeds are
directly sown in the ?eld, in addition to direct seed treatment,
treatment of cultivation media in the vicinity of plants or the
like during cultivation is preferable. Speci?cally, the treat
ment can be performed by, for example, applying a granule
onto soil, or drenching soil with a formulation in a water

diluted or undiluted liquid form.


[0046] In the case of culture plants to be transplanted,

examples of the treatment in the period of seeding to seedling


culture include, in addition to direct seed treatment, drench
treatment of nursery beds for seedlings with a formulation in

a liquid form; and granule application to nursery beds for


seedlings. Also included are treatment of planting holes with
a granule; and incorporation of a granule into cultivation
media in the vicinity of planting points at the time of ?x

planting.

adhesive carrier such as resins and polymers; and application

[0047] For the above-described treatment, a ?ubendiamide


single formulation and a dichlorvos or profenofos single for
mulation can be used after mixed with each other on site, and

of a liquid or solid formulation to the vicinity of seeds at the


same time as seeding. The term seed used in the seed
treatment is, in a broad sense, synonymous with a plant body

Alternatively, for the above-described treatment, the two


single formulations canbe separately used in the same period,

with a mixture of a liquid or solid formulation and a highly

used for propagation. The examples include, in addition to a

such a use can also produce the desired insecticidal effect.

so-called seed, a plant body for vegetative propagation, such

and such a use can also produce the desired insecticidal effect.
The term the same period does not mean that treatments

as a bulb, a tuber, a seed potato, a discoid stem and a stem used

with the two single formulations are performed at the exact

for cuttage.
[0042] In the method of the present invention, the term

same time, and in the case where treatments with the two

soil or cultivation medium refers to support medium for

plant cultivation and the materials are not particularly limited


as long as plants can grow. Examples of the support medium
include so-called soils of various kinds, seedling mats and

water, and also include sand, vermiculite, cotton, paper,

diatomite, agar, gelatinous substances, high-molecular


weight substances, rock wool, glass wool, wood chip, bark
and pumice.
[0043] Exemplary methods of soil application include

single formulations are performed within a time frame of


about one week, the treatments can be regarded as being
performed in the same period. Further, each treatment can

be performed by a different method. Alternatively, for the


above-described treatment, the two single formulations can
be separately used at a given interval, and such a use can also

produce the desired insecticidal effect. The interval between


the treatments is not particularly limited as long as the effect

of the present invention can be exerted, but in general, the


interval is preferably 3 months or less, and particularly pref

application of a water-diluted or undiluted liquid or solid

erably 2 months or less. In this case, the ?rst treatment may be

formulation to the vicinity of planting points, nursery beds for


seedlings, or the like; application of a granule to the vicinity
of planting points or nursery beds; application of a dust, a
wettable powder, a water-dispersible granule, a granule or the
like onto soil and subsequent incorporation of the formulation
into the whole soil before seeding or transplanting; and appli

performed with any of the active ingredients and each treat


ment may be performed by a different method.
[0048] In recent years, IPM (integrated pest management)

cation of a dust, a wettable powder, a water-dispersible gran


ule, a granule or the like to planting holes, planting rows or the

technology using insect sex pheromones (e.g., communica


tion disrupting agents against Tortricidae and Hadeninae,
etc.), natural enemy insects, etc. has made progress, and this
technology and the composition of the present invention can
be used in combination or used systematically.

like before seeding or planting.


[0044] To nursery boxes for paddy rice, for example, a dust,

[0049] The amount of the agricultural and horticultural


insecticide composition used for treatment may vary with

a water-dispersible granule, a granule or the like can be

various factors, for example, the purpose, the target insect


pest, the crop growing conditions, the weather, the environ
mental conditions, the formulation, the application method,
the application site, the application time, etc., but for
example, the amounts of the active ingredient compounds are

applied, although the suitable formulation may vary depend


ing on the application time, in other words, depending on the
cultivation stage such as seeding time, greening period and
planting time. In the soil application, a formulation such as a

dust, a water-dispersible granule, a granule or the like may be


mixed with soil. For example, such a formulation is incorpo

as follows: in the case of spray treatment, 1 to 200 g/ha of

?ubendiamide and 100 to 2000 g/ha of dichlorvos and/or

Sep. 11,2014

US 2014/0256687 A1

profenofos are applied to target crops; and in the case of soil


treatment or drench treatment, 1 to 100 g/ha of ?ubendiamide
and 50 to 1000 g/ha of dichlorvos and/ or profenofos are
applied onto or in?ltrated into the surrounding soil of target
crops.
[0050] The agricultural and horticultural insecticide com

position of the present invention is suitable for controlling a

variety of insect pests Which may damage paddy rice, veg


etables, fruits, other ?owering plants, etc. The insect pests to
be controlled are, for example, agricultural and forest pests,
horticultural pests, stored grain pests, sanitary pests, nema
todes, etc. The speci?c examples include the following:
species of the Order Lepidoptera such as Parasa consocia,
Anomis mesogona, Papilio xuthus, Matsumuraeses

Papilio helenus, Colias erate poliographus, Phalera ?ave


scens, species of the family Pieridae such as Pieris rapae,

Euproctis similis, Acrolepiopsis suzukiella, Ostrinia nubila


lis, Mamestra brassicae, Ascotis selenaria, Phtheochroides

clandestina, Hoshinoa adumbratana, Odonestisprunijapon


ensis, Triaena intermedia, Adoxophyes oranafasciata, Gra

pholita inopinata, Spilonota ocellana, Spilonota lechriaspis,


Illiberispruni, Argyresthia conjugella, Caloptilia zachrysa,
Archips breviplicanus, Anomis ?ava, Pectinophora gossyp
iella, Notarcha derogata, Diaphania indica, Heliothis vire
scens and Earias cupreoviridis;

species of the Order Hemiptera such as Nezara antennata,

Stenotus rubrovittatus, Graphosoma rubrolineatum, Trigo


notylus coelestialium, Aeschynteles maculatus, Creontiades

Ostrinia scapulalis, Spodoptera exempta,

pallidifer, Dysdercus cingulatus, Chrysomphalus ?cus,

Hyphantria cunea, Ostrinia furnacalis, Pseudaletia sepa


rata, TillELl translucens, Bactra furfurana, Parnara guttata,
Marasmia exigua, Parnara guttata, Sesamia inferens, Broch

leucopterus, Iceryapurchasi, Piezodorus hybneri, Lagynoto

azukivora,

mia triannulella, Monema?avescens, Trichoplusia ni, Pleu

roptya ruralis, Cystidia couaggaria, Lampides boeticus,


Cephonodes hylas, Helicoverpa armigera, Phalerodonta
manleyi, Eumeta japonica, Pieris brassicae, Malacosoma
neustria testacea,

Stathmopoda masinissa, Cuphodes diospyrosella, Archips


xylosteanus, Agrotis segetum, Tetramoera schistaceana,
Papilio machaon hippocrates, Endoclyta sinensis, Lyonetia

prunifoliella, Phyllonorycter ringoneella, Cydia kurokoi,


Eucoenogenes aestuosa, Lobesia botrana, Latoia sinica,

Euzophera batangensis, Phalonidia mesotypa, Spilosoma


imparilis, Glyphodespyloalis, Olethreutes mori, Hneola bis
selliella, Endoclyta excrescens,

Nemapogon granellus, Synanthedon hector, Cydia


pomonella, Plutella xylostella, Cnaphalocrocis medinalis,

Aonidiella aurantii, Graptopsaltria nigrofuscata, Blissus


mus elongatus, Thaia subrufa, Scotinophara lurida, Sitobion

ibarae, Stariodes iwasakii, Aspidiotus destructor, Taylorily


gus pallidulus, Myzus mumecola, Pseudaulacaspis pruni
cola, Acyrthosiphon pisum, Anacanthocoris striicornis,
Ectometopterus micantulus, Eysarcoris lewisi,
Molipteryx fulginosa, Cicadella viridis, Rhopalosophum
ru?abdominalis, Saissetia oleae, Trialeurodes vaporari
orum, A guriahana quercus, Lygus sp., Euceraphispunctipen

nis, Andaspis kashicola, Coccus pseudomagnoliarum, Cav


elerius
saccharivorus,
Galeatus
spinifrons,
Macrosiphoniella sanborni, Aonidiella citrina, Halyomor

pha mista, Stephanitisfasciicarina, Trioza camphorae, Lep


tocorisa chinensis, Trioza quercicola, Uhlerites latius, Eryth
roneura comes, Paromius exguus, Duplaspidiotus claviger,

Nephotettix nigropictus, Halticiellus insularis, Perkinsiella

saccharicida, Psylla malivorella,

Sesamia calamistis, Scirpophaga incertulas, Pediasia teter

Anomomeura mori, Pseudococcus longispinis, Pseudaula

rellus, Phthorimaea operculella, Stauropus fagi persimilis,


Etiella Zinckenella, Spodoptera exigua, Palpifer sexnotata,
Spodoptera manuritia, Scirpophaga innotata, Xestia c-ni
grum, Spodoptera depravata, Ephestia kuehniella, Angerona
prunaria, Clostera anastomosis, Pseudoplusia includens,
Matsumuraeses falcana, Helicoverpa assulta, Autographa

Togo hemipterus, Toxoptera aurantii, Saccharicoccus sac


chari, Geoica lucifuga, Numata muiri, Comstockaspisperni
ciosa, Unaspis citri, Aulacorthum solani, Eysarcoris ventra
lis, Bemisia argentifolii, Cicadella spectra, Aspidiotus

nigrisigna, Agrotis ipsilon, Euproctis pseudoconspersa,


Adoxophyes orana, Caloptilia theivora, Homona magn
anima,

Ephestia elutella, Eumeta minuscula, Clostera anachoreta,


Heliothis maritima, Sparganothispilleriana, Busseolafusca,
Euproctis sub?ava, Biston robustum, Heliothis zea, Aedia
leucomelas, Narosoideus?avidorsalis, Vlminia rumicis, Buc

culatrix pyrivorella, Grapholita molesta, Spulerina astau


rota, Ectomyelois pyrivorella, Chilo suppressalis, Acrolepi
opsis sapporensis, Plodia interpunctella, Hellula undalis,
Sitotroga ceralella, Spodoptera litura, a species of the family
Tortricidae (Eucosma aporema), Acleris comariana,

Scopelodes contracus, Orgyia thyellina, Spodoptera fru


giperda, Ostrinia zaguliaevi, Naranga aenescens, Andraca

bipunctata, Paranthrene regal is, Acosmeryx castanea,

Phyllocnistis toparcha, Endopiza viteana, Eupoecillia


ambiguella, Anticarsia gemmatalis, Cnephasia cinereipal
pana, Lymantria dispar, Dendrolimus spectabilis, Legumini
vora glycinivorella, Maruca testulalis, Matsumuraeses

caspis pentagona, Pulvinaria kuwacola, Apolygus lucorum,

hederae, Liorhyssus hyalinus, Calophya nigridorsalis, Soga


tellafurcifera, Megoura crassicauda, Brevicoryne brassicae,
Aphis glycines, Leptocorisa oratorius, Nephotettix virescens,
Uroeuconformosanum, Cyrtopeltis tennuis, Bemisia tabaci,
Lecanium persicae, Parlatoria theae, Pseudaonidia paeo

niae, Empoasca onukii, Plautia stali, Dysaphis tulipae, Mac

rosiphum euphorbiae, Stephanitis pyrioides, Ceroplastes


ceriferus, Parlatoria camelliae, Apolygus spinolai, Nephotet
tix cincticeps, Glaucias subpunctatus, Orthotylus?avospar
sus, Rhopalosiphum maidis, Peregrinus maidis, Eysarcoris
parvus, Cimex lectularius, Psylla abieti, Nilaparvata lugens,

Psylla tobirae, Eurydema rugosum, Schizophis piricola,


Psylla pyricola, Parlatoreopsis pyri, Stephanitis sashi, Dys
micoccus wistariae, Lepholeucaspis japonica, Sappaphis
piri, Lipaphis erysimi, Neotoxopteraformosana, Rhopaloso
phum nymphaeae, Edwardsiana rosae, Pinnaspis aspidis
trae, Psylla alni, Speusotettix subfusculus, Alnetoidia alneti,
Sogatella panicicola, Adelphocoris lineolatus, Dysdercus
poecilus, Parlatoria Ziziphi, Uhlerites debile, Laodelphax
striatellus, Eurydemapulchrum, Cletus trigonus, Clovia
punctata, Empoasca sp., Coccus hesperidum, Pachybrachius

phaseoli, Caloptilia soyella, Phyllocnistis citrella, Hadylepta


indicata, Archips fuscocupreanus, Acanthoplusia agnata,

luridus, Planococcus kraunhiae, Stenotus binotatus, Arbo

Bambalina sp., Carposina niponensis, Conogethes punc

Adelphocoris triannulatus, Vlteus vitifolii, Acanthocoris sor

tiferalis, Synanthedon sp., Lyonetia clerkella,

didus, Leptocorisa acuta,

ridia apicaris, Macrostelesfasci?ons, Dolycoris baccarum,

Sep. 11,2014

US 2014/0256687 A1

Macropes obnubilus, Cletus puncliger, Riplorlus clavalus,


Paralrioza cockerelli, Aphrophora coslalis, Lygus disponsi,
Lygus saundersi, Crisicoccus pini, Empoasca abielis, Crisi
coccus malsumoloi, Aphis craccivora, Megacopla punclalis

simum, Eysarcoris gulliger, Lepidosaphes beckii, Diaphorina


cilri, Toxoplera cilricidus, Planococcus cilri, Dialeurodes
cilri, Aleurocanlhus spiniferus, Pseudococcus cilriculus,
Zyginella cilri, Pulvinaria cilricola, Coccus discrepans,
Pseudaonidia duplex, Pulvinaria auranlii, Lecanium corni,
Nezara viridula, Slenodema calcaralum, Rhopalosiphum
padi, Silobion akebiae,
Schizaphis graminum, Sorhoanus Zrilici, Brachycaudus heli

chrysi, Carpocoris purpureipennis, Myzus persicae, Hya


lopleruspruni, Aphis farinoseyanagicola, Melasalispopuli,
Unaspis yanonensis, Mesohomoloma camphorae, Aphis spi
raecola, Aphis pomi, Lepidosaphes ulmi, Psylla mali, Hel
erocordylus?avipes, Myzus malisuclus, Aphidonuguis mali,
Orienlus ishidai, Ovalus malicolens, Eriosoma lanigerum,

Ceroplasles rubens and Aphis gossypii;


species of the Order Coleoptera such as Xyslrocera globosa,
Paederusfuscipes, Eucelonia roelofsi, Callosobruchus chin

ensis, Cylas formicarius, Hypera poslica, Echinocnemus


squameus, Oulema oryzae, Donacia provosli, Lissorhoplrus

oryzophilus, Colasposoma dauricum, Euscepes poslfascia


Zus, Epilachna variveslis, Acanlhoscelides obleclus,
Diabrolica virgifera virgifera, Involvulus cupreus, Aula

cophorafemoralis, Bruchuspisorum, Epilachna viginlioclo


maculala, Carpophilus dimidialus, Cassida nebulosa,
Luperomorpha Zunebrosa, Phyllolrela slriolala, Psacolhea
hilaris, Aeoleslhes chrysolhrix,
Curculio sikkimensis, Carpophilus hemiplerus, Oxycelonia
jucunda, Diabrolica sp., Mimela splendens, Silophilus zea
mais, Tribolium caslaneum, Silophilus oryzae, Palorus sub

depressus, Melolonlha japonica, Anoplophora malasiaca,


Nealus picipes, Leplinolarsa decemlineala, Diabrolica
undecimpunclala howardi, Sphenophorus venalus, Crioceris
qualuordecimpunclala, Conolrachelus nenuphar, Ceulho
rhynchidius albosuluralis, Phaedon brassicae, Lasioderma
serricorne, Silonajaponicus, Adorelus Zenuimaculalus, Tene
brio m0li20r, Basilepla balyi, Hypera nigriroslris, Chaeloc
nema concinna, Anomala cuprea, Heplophylla picea, Epil

achna viginlioclopunclala, Diabrolica


Eucelonia pilifera, Agrioles spp.,

longicornis,

Allagenus unicolorjaponicus, Pagria signala, Anomala rufo

Zicola, Liriomyza chinensis, Culex quinquefascialus, Aedes


aegypli, Aedes albopiclus, Liriomyza Zrifolii, Dacus dorsal is,
Dacus Zsuneonis, Silodiplosis m0sellana, Meromuza
nigrivenlris, Anaslrepha ludens and Phagolelis pomonella;
species of the Order Hymenoptera such as Prislomyrmex
pungens, species of the family Bethylidae, Monomorium
pharaosis, Pheidole noda, Alhalia rosae, Dryocosmus

kuriphilus, Formica fusca japonica, species of the subfamily


Vespinae, Alhalia infumala infumala, Arge pagana, Alhalia
japonica, Acromyrmex spp., Solenopsis spp., Arge mali and
Ochelellus glaber;
species of the Order Orthoptera such as Homorocoryphus

lineosus, Gryllolalpa sp., Oxya hyla inlricala, Oxya yezoen


sis, Locusla migratoria, Oxya japonica, Homorocoryphus
jezoensis and Teleogryllus emma;
species of the Order Thysanoptera such as Selenolhrips

rubrocinclus, Slenchaelolhrips biformis, Haplolhrips


aculealus, Ponliculolhrips diospyrosi, Thrips?avus, Anapho
Zhrips obscurus, Liolhrips?oridensis, Thrips simplex, Thrips
nigropilosus, Heliolhrips haemorrhoidalis, Pseudodendro
Zhrips m0ri, Microcephalolhrips abdominalis, Leeuwenia
pasanii, Lilolelolhrips pasaniae, Scirlolhrips cilri, Haplo
Zhrips chinensis, Myclerolhrips glycines, Thrips selosus, Scir
Zolhrips dorsalis, Dendrolhrips minowai, Haplolhrips niger,
Thrips Zabaci, Thrips alliorum, Thrips hawaiiensis, Haplo
Zhrips kurdjumovi, Chirolhrips manicalus, Frankliniella
inlonsa, Thrips coloralus, Franklinella occidentalis, Thrips
palmi, Frankliniella lilivora and Liolhrips vaneeckei;
species of the Order Acari such as Leplolrombidium aka

mushi, Telranychus ludeni, Dermacenlor variabilis, Telrany


chus Zruncalus, Ornithonyssus bacoli, Demodex canis, Tel

ranychus viennensis, Telranychus kanzawai, species of the


family lxodidae such as Rhipicephalus sanguineus, Cheyl
eZus malaccensis, Drophagus pulrescenliae, Dermalopha
goidesfarinae, Lalrodeclus hassellii, Dermacenlor Zaiwani

cus, Acaphylla Zheavagrans, Polyphagolarsonemus lalus,

Aculops lycopersici, Ornithonyssus sylvairum, Telranychus


urticae, Eriophyes chibaensis, Sacroples scabiei, Haema

physalis longicornis, Ixodes scapularis, Drophagus similis,


Cheylelus erudilus, Panonychus cilri, Cheylelus m00rei,
Brevipalpus phoenicis, Oclodecles cynolis, Dermalopha
goides plrenyssnus, Haemaphysalis ?ava, Ixodes ovalus,
Phyllocoplrula cilri, Aculus schlechlendali, Panonychus
ulmi, Amblyomma americanum and Dermanyssus gallinae;

cuprea, Palorus ralzeburgii, Alphilobius laevigalus, Anthre

species of the Order lsoptera such as Reliculilermes

nus verbasci, Lyclus brunneus, Tribolium confusum,

miyalakei, Incisilermes minor, Coplolermes formosanus,

Medylhia nigrobilineala, Xylolrechus pyrrhoderus, Epilrix

Hodolermopsis japonica, Reliculilermes sp., Reliculilermes

cucumeris, Tomicus piniperda, Monochamus allernalus,

?aviceps amamianus, Glyplolermes kushimensis, Coploler

Popillia japonica, Epicaula gorhami, Silophilus zeamais,

mes guangzhoensis, Neolermes koshunensis, Glyplolermes

Rhynchiles heros, Lislroderes cosliroslris, Callosobruchus


maculalus, Phyllobius armalus, Anthonomus pomorum,

kodamai, Glyplolermes salsumensis, Cryptolermes domesti


cus, Odonlolermes formosanus, Glyplolermes nakajimai,

Linaeidea aenea and Anthonomus grandis;

Pericaprilermes nilobei and Reliculilermes speralus;


species of the Order Blattodea such as Periplanelafuliginosa,

species of the Order Diptera such as Culex pipiens pallens,

Pegomya hyoscyami, Liriomyza huidobrensis, Musca domes


Zica, Chlorops oryzae, Hydrellia sasakii, Agromyza oryzae,

Hydrellia griseola, Ophiomyia phaseoli, Dacus cucurbilae,


Drosophila suzukii, Rhacochlaenajaponica, Muscina slabu
lans, species of the family Phoridae such as Megaselia spi
racularis, Clogmia albipunclala, lipula aino, Phormia
regina, Culex Zrilaeniorhynchus, Anopheles sinensis, Hyl
emya brassicae, Asphondylia sp., Delia plalura, Delia anti
qua, Rhagolelis cerasi, Culexpipiens m0leslus Forskal, Cer

alilis capilala, Bradysia agreslis, Pegomya cunicularia,


Liriomyza salivae, Liriomyza bryoniae, Chromalomyia hor

Blallella germanica, Blalla orientalis, Periplanela brunnea,


Blallella liluricollis, Periplanela japonica and Periplanela
americana;
species of the Order Siphonaptera such as Pulex irritans,

Clenocephalidesfelis and Ceralophyllus gallinae;


species of the Phylum Nematoda such as Nolholylenchus

acris, Aphelenchoides besseyi, Pralylenchus penetrans,


Meloidogyne hapla, Meloidogyne incognila, Globodera ros

Zochiensis, Meloidogyne javanica, Helerodera glycines,


Pralylenchus cofeae, Pralylenchus negleclus and Hlenchus
semipenelrans; and

Sep. 11,2014

US 2014/0256687 A1

species of the Phylum Mollusca such as Pomacea canalicu

lala, Achalinafulica, Meghimalium bilinealum, Lehmannina


valenliana, Limacus?avus andAcusZa despecla sieboldiana.
Other agricultural and horticultural insect pests to be con
trolled are, for example, Tula absolula and the like.
[0051] The agricultural and horticultural insecticide com

position of the present invention can be used simultaneously

With agricultural and horticultural microbicides, agricultural


and horticultural insecticides, agricultural and horticultural
herbicides, synergists, phytotoxicity reducers, etc. for control
of diseases/insect pests, weeds, etc. Which may spread in the

application period of the composition of the present inven


tion, enhanced effects and reduced phytotoxicity to crops.

Non-limiting examples of typical compounds used as the


agricultural and horticultural microbicides, the agricultural
and horticultural insecticides, the agricultural and horticul
tural herbicides, the synergists or the phytotoxicity reducers
are listed beloW.

afen, picoxystrobin, picobenzamide, bithionol, bitertanol,


hydroxyisoxazole, hydroxyisoxazole-potassium, binapacryl,
biphenyl, piperalin, hymexazol, pyraoxystrobin, pyracar
bolid, pyraclostrobin, pyrazophos, pyrametostrobin, pyri
ofenone, pyridinitril, pyrifenox,
pyribencarb, pyrimethanil, pyroxychlor, pyroxyfur, pyro
quilon, Vinclozolin, ferbam, famoxadone, fenapanil, fenami
done, fenaminosulf, fenarimol, fenitropan, fenoxanil, ferim
zone, fentin, fenpiclonil, fenpyrazamine, fenbuconazole,
fenfuram, fenpropidin, fenpropimorph, fenhexamid, phtha
lide, buthiobate, butylamine, bupirimate, fuberidazole, blas
ticidin-S, furametpyr, furalaxyl, ?uacrypyrim, ?uaZinam, ?u
oxastrobin, ?uotrimazole, ?uopicolide, ?uopyram,
?uoroimide, furcarbanil, ?uxapyroxad, ?uquinconazole, fur
conazole, furconazole-cis, ?udioxonil, ?usilazole, ?usulfa
mide, ?utianil, ?utolanil, ?utriafol, furfural, furrnecyclox,
?umetover, ?umorph, proquinaZid, prochloraZ, procymi
done, prothiocarb,

[0052] Examples of the agricultural and horticultural


microbicides include aureofungin, azaconazole, aZithiram,

prothioconazole, propamocarb, propiconazole, propineb,

acypetacs, acibenzolar, acibenzolar-S-methyl, azoxystrobin,


anilaZine, amisulbrom, ampropylfos, ametoctradin, allyl
alcohol, aldimorph, amobam, isotianil, isovaledione, isopy
razam, isofetamid, isoprothiolane, ipconazole, iprodione,
iprovalicarb, iprobenfos, imazalil, iminoctadine, iminocta
dine-albesilate, iminoctadine-triacetate, imibenconazole,

penconazole, benzamorf, pencycuron, benzohydroxamic


acid, bentaluron, benthiazole, benthiavalicarb, benthiavali

uniconazole, uniconazole-P, echlomezole, edifenphos, eta


conazole, ethaboxam, ethirimol, etem, ethoxyquin, etridiaZ

ole, enestroburin, epoxiconazole, oxadixyl, oxycarboxin,


copper-8-quinolinolate, oxytetracycline, copper-oxinate,
oxpoconazole, oxpoconazole-fumarate, oxolinic acid,
octhilinone, ofurace, orysastrobin, metam-sodium,
kasugamycin, carbamorph, carpropamid, carbendaZim, car
boxin, carvone, quinazamid, quinacetol, quinoxyfen, chi

nomethionat, quinomethionate, captafol, captan, kiralaxyl,


quinconazole, quintozene, guazatine, cufraneb, cuprobam,
glyodin, griseofulvin, climbazole, cresol, kresoxim-methyl,
chlozolinate, clotrimazole,

chlobenthiazone, chlorani

formethan, chloranil, chlorquinox, chloropicrin, chloroneb,


salicylanilide, zarilamid, cyazofamid, diethyl pyrocarbonate,
diethofencarb, cyclafuramid, diclocymet, dichlozoline,
diclobutrazol, dichlo?uanid, cycloheximide, diclomeZine,
dicloran, dichlorophen, dichlone, disulfuram, ditalimfos,
dithianon, diniconazole,
diniconazole-M, Zineb, dinocap, dinocton, dinosulfon, dinot
erbon, dinobuton, dinopenton, dipyrithione, diphenylamine,
difenoconazole, cy?ufenamid, di?umetorim, cyproconazole,
cyprodinil, cyprofuram, cypendazole, simeconazole, dime
thirimol, dimethomorph, cymoxanil, dimoxystrobin, methyl
bromide, Ziram, silthiofam, streptomycin, spiroxamine, sul
tropen, sedaxane, zoxamide, dazomet, thiadiaZin, tiadinil,
thiadi?uor, thiabendazole, tioxymid, thioquinox, thiochlor
fenphim, thiophanate, thiophanate-methyl, thicyofen, thi

furophanate, probenazole, bromuconazole, hexachlorobuta


diene, hexaconazole, hexylthiofos, bethovain, benalaxyl,

benalaxyl-M, benodanil, benomyl, pefurazoate, benquinox,


carb-isopropyl, penthiopyrad, pen?ufen, boscalid, phos
diphen, fosetyl, fosetyl-Al, polyoxins, polyoxorim, polycar
bamate, folpet, formaldehyde, machine oil, maneb,
mancozeb, mandipropamid, myclozolin, myclobutanil, mil
diomycin, milneb, mecarbinZid, methasulfocarb, metazoxo
lon, metam, metam-sodium, metalaxyl, metalaxyl-M, meti
ram, methyl isothiocyanate, meptyldinocap, metconazole,
metsulfovax, methfuroxam, metominostrobin, metrafenone,
mepanipyrim, mefenoxam, meptyldinocap, mepronil, mebe
nil, iodomethane, rabenzazole, benzalkonium chloride, inor
ganic microbicides such as basic copper chloride, basic cop

per sulfate and silver, sodium hypochlorite, cupric hydroxide,


wettable sulfur, calcium polysul?de, potassium hydrogen
carbonate, sodium hydrogen carbonate, sulfur, copper sulfate
anhydride, nickel dimethyldithiocarbamate, oxine copper,
Zinc sulfate and copper sulfate pentahydrate.

[0053]

Examples of the agricultural and horticultural insec

ticides include 3,5-xylyl methylcarbamate (XMC), crystal


line protein toxins produced by Bacillus Zhuringiensis such as
Bacillus Zhuringiensis aizawai, Bacillus Zhuringiensis israe

lensis, Bacillus Zhuringiensis japonensis, Bacillus Zhuring


iensis kurslaki and Bacillus Zhuringiensis Zenebrionis,
BPMC, Bt toxin-derived insecticidal compounds, CPCBS

methyl, tolprocarb, natamycin, nabam, nitrostyrene,

(chlorfenson), DCIP (dichlorodiisopropyl ether), D-D (1,3


dichloropropene), DDT, NAC, O-4-dimethylsulfamoylphe
nyl 0,0-diethyl phosphorothioate (DSP), O-ethyl O-4-nitro
phenyl
phenylphosphonothioate
(EPN),
tripropylisocyanurate (TPIC), acrinathrin, azadirachtin, aZin
phos-methyl, acequinocyl, acetamiprid, acetoprole, aceph
ate, abamectin, a?dopyropen, avermectin-B, amido?umet,
amitraZ, alanycarb, aldicarb, aldoxycarb, aldrin, alpha-en
dosulfan, alpha-cypermethrin, albendazole, allethrin, isazo
fos, isoamidofos, isoxathion, isofenphos, isoprocarb (MIPC),
ivermectin, imicyafos, imidacloprid, imiprothrin, indoxac
arb, esfenvalerate, ethiofencarb, ethion, ethiprole, etoxazole,
ethofenprox, ethoprophos, etrimfos, emamectin, emamectin
benzoate, endosulfan, empenthrin, oxamyl, oxydemeton-me
thyl, oxydeprofos (ESP), oxibendazole, oxfendazole, potas

nitrothal-isopropyl, nuarimol, copper nonylphenol sulfonate,


halacrinate, validamycin, valifenalate, harpin protein, bix

carbosulfan, carbofuran, gamma-cyhalothrin, xylylcarb,

?uzamide, thiram, decafentin, tecnazene, tecloftalam, teco


ram, tetraconazole, debacarb, dehydroacetic acid,

tebuconazole, tebu?oquin, dodicin, dodine,


dodecyl benzensulfonate bis-ethylene diamine copper(ll)
(DBEDC), dodemorph, drazoxolon, triadimenol, triadime
fon, triaZbutil, triazoxide, triamiphos, triarimol, trichlamide,
tricyclazole, triticonazole, tridemorph, tributyltin oxide, tri
?umizole, tri?oxystrobin, triforine, tolyl?uanid, tolclofos

sium oleate, sodium oleate, cadusafos, cartap, carbaryl,

US 2014/0256687 A1

quinalphos, kinoprene, chinomethionat, cloethocarb,


clothianidin, clofenteZine, chromafenozide, chlorantranilip
role, chlorethoxyfos, chlordimeform, chlordane, chlorpyri
fos, chlorpyrifos-methyl, chlorphenapyr, chlorfenson, chlor
fenvinphos, chlor?uazuron, chlorobenZilate, chlorobenzoate,
kelthane (dicofol), salithion, cyanophos (CYAP), diafenthi
uron, diamidafos, cyantraniliprole, theta-cypermethrin,

dienochlor, cyenopyrafen, dioxabenzofos, diofenolan,


sigma-cypermethrin, dichlofenthion (ECP), cycloprothrin,
disulfoton, dinotefuran, cyhalothrin, cyphenothrin,
cy?uthrin, di?ubenzuron, cy?umetofen, di?ovidaZin,
cyhexatin, cypermethrin, dimethylvinphos, dimethoate,
dime?uthrin, sila?uofen, cyromaZine, spinetoram, spinosad,
spirodiclofen, spirotetramat, spiromesifen, sul?uramid, sul
profos, sulfoxa?or, zeta-cypermethrin, diaZinon,
tau-?uvalinate, dazomet, thiacloprid, thiamethoxam, thiodi
carb, thiocyclam, thiosultap, thiosultap-sodium, thionaZin,
thiometon, deet, dieldrin, tetrachlorvinphos, tetradifon, tet

ramethyl?uthrin, tetramethrin, tebupirimfos, tebufenozide,


tebufenpyrad, te?uthrin, te?ubenzuron, demeton-S-methyl,
temephos, deltamethrin, terbufos, tralopyril, tralomethrin,
trans?uthrin, triazamate, triazuron, trichlamide, trichlorphon
(DEP), tri?umuron, tolfenpyrad, naled (BRP), nithiaZine,
nitenpyram, novaluron, novi?umuron, hydroprene, vanilip
role, vamidothion, parathion, parathion-methyl, halfenprox,
halofenoZide,
bistri?uoron, bisultap, hydramethylnon, hydroxy propyl
starch, binapacryl, bifenazate, bifenthrin, py?ubumide,

pymetroZine, pyraclofos, pyra?uprole, pyridafenthion,


pyridaben, pyridalyl, pyri?uquinazon, pyriprole, pyriproxy
fen, pirimicarb, pyrimidifen, pirimiphos-methyl, pyrethrins,
?pronil, fenazaquin, fenamiphos, phenisobromolate, feni
trothion (MEP), fenoxycarb, fenothiocarb, phenothrin,
fenobucarb, fensulfothion, fenthion (MPP), phenthoate
(PAP), fenvalerate, fenpyroximate, fenpropathrin, fenbenda
zole, butathiofos, buproerin, furathiocarb, prallethrin, ?u
acrypyrim, ?uaZinam, ?uazuron,
?uensulfone, ?ucycloxuron, ?ucythrinate, ?uvalinate,
?upyradifurone, ?upyrazofos, ?u?prole, ?ufenerim,
?ufenoxuron, ?ufenZine, ?ufenprox, ?uproxyfen, ?ubro
cythrinate, ?umethrin, ?urimfen, prothiofos, protrifenbute,
?onicamid, propaphos, propargite (BPPS), pro?uthrin, pro
poxur (PHC), ?ometoquin, bromopropylate, beta-cy?uthrin,
hexa?umuron, hexythiazox, heptenophos, permethrin, ben
clothiaZ, bendiocarb, bensultap, benzoximate, benfuracarb,
phoxim, phosalone, fosthiazate, fosthietan, phosphamidon,
phosphocarb, phosmet (PMP), polynactins, formetanate, for
mothion, phorate, machine oil,
malathion, milbemycin, milbemycin-A, milbemectin, mecar

ham, mesulfenfos, methomyl, metaldehyde, meta?umizone,


methamidophos, metam-ammonium, metam-sodium,
methiocarb, methidathion (DMTP), methylisothiocyanate,
methylneodecanamide, methylparathion, metoxadiazone,
methoxychlor, methoxyfenozide, meto?uthrin, methoprene,
metolcarb, meper?uthrin, mevinphos, monocrotophos,
monosultap, lambda-cyhalothrin, ryanodine, lufenuron, res
methrin, lepimectin, rotenone, levamisole hydrochloride,
fenbutatin oxide, morantel tartarate, methyl bromide, tricy
clohexyltin hydroxide (cyhexatin), calcium cyanamide, cal
cium polysul?de, sulfur and nicotine-sulfate.
[0054] Examples of the agricultural and horticultural her

bicides include 1-naphthylacetamide, 2,4-PA, 2,3,6-TBA,


2,4,5-T, 2,4,5-TB, 2,4-D, 2,4-DB, 2,4-DEB, 2,4-DEP, 3,4
DA, 3,4-DB, 3,4-DP, 4-CPA (4-chlorophenoxyacetic acid),

Sep. 11,2014

4-CPB, 4-CPP, MCP, MCPA, MCPA-thioethyl, MCPB, ioxy


nil, aclonifen, azafenidin, aci?uorfen, aZiprotryne, aZimsul
furon, asulam, acetochlor, atraZine, atraton, anisuron, anilo
fos, aviglycine, abscisic acid, amicarbazone, amidosulfuron,

amitrole, aminocyclopyrachlor, aminopyralid, amibuZin,


amiprophos-methyl, ametridione, ametryn, alachlor, alli
dochlor, alloxydim, alorac, iofensulfuron, isouron, isocarba
mid, isoxachlortole, isoxapyrifop, isoxa?utole, isoxaben, iso

cil, isonoruron, isoproturon, isopropalin, isopolinate,


isomethiozin, inaben?de, ipaZine, ipfencarbazone, iprymi
dam, imazaquin, imazapic, imazapyr, imazamethapyr,
imazamethabenZ, imazamethabenZ-methyl, imazamox,
imazethapyr, imazosulfuron, indaZi?am, indanofan, indole
butyric acid, uniconazole-P, eglinaZine, esprocarb, ethamet
sulfuron, ethametsulfuron-methyl, ethal?uralin, ethiolate,
ethychlozate-ethyl, ethidimuron, etinofen, ethephon, ethox
ysulfuron, ethoxyfen, etnipromid, ethofumesate, etobenza
nid, epronaZ, erbon, endothal, oxadiazon, oxadiargyl, ovai
clomefone, oxasulfuron, oxapyrazon, oxy?uorfen, oryzalin,
orthosulfamuron, orbencarb, cafenstrole, cambendichlor,
carbasulam, carfentrazone, carfentrazone-ethyl, karbutilate,
carbetamide, carboxazole, quizalofop, quizalofop-P, quizalo

fop-ethyl, xylachlor, quinoclamine, quinonamid, quinclorac,


quinmerac, cumyluron, clacyfos, cliodinate, glyphosate, glu
fosinate, glufosinate-P, credaZine, clethodim, cloxyfonac,
clodinafop, clodinafop-propargyl, clopyralid, cloproxydim,
cloprop, clofop, clomazone, chlomethoxynil, chlomethoxy
fen, clomeprop, chloraZifop, chloraZine, chloranocryl,
chloramben, cloransulam,
cloransulam-methyl, chloridazon, chlorimuron, chlorimu
ron-ethyl, chlorsulfuron, chlorthal, chlorthiamid, chlortolu
ron, chlomitrofen, chlorfenac, chlorfenprop, chlorbufam,

chlor?urazole, chlor?urenol, chlorprocarb, chlorpropham,


chlorbromuron, chlormequat, chloreturon, chloroxynil,
chloroxuron, chlorotoluron, chloropon, sa?ufenacil, cyana
Zine, cyanatryn, di-allate, diuron, diethamquat, dicamba,

cycluron, cycloate, cycloxydim, diclosulam, cyclosulfamu


ron, dichlorprop, dichlorprop-P, dichlobenil, diclofop, diclo

fop-methyl, dichlormate, dichloralurea, diquat, cisanilide,


disul, siduron, dithiopyr, dinitramine, cinidon-ethyl,
dinosam, cinosulfuron, dinoseb, dinoterb, dinofenate, dino
prop, cyhalofop-butyl, diphenamid, difenoxuron, difeno

penten, difenzoquat, cybutryne, cypraZine, cyprazole,


di?ufenican, di?ufenzopyr, dipropetryn, cypromid, cyper
quat, gibberellin, simaZine, dimidazon, dimexano, dimeth

achlor, dimethametryn, dimethenamid, simetryn, simeton,


dimepiperate, dimefuron, cinmethylin, swep, sulglycapin,
sulcotrione, sulfallate, sulfentrazone, sulfosulfuron, sulfo
meturon, sulfometuron-methyl, secbumeton, sethoxydim,
sebuthylaZine, terbacil, daimuron, dazomet, dalapon, thiaZ
a?uoron, thiazopyr, thiencarbazone, thiencarbazone-methyl,
tiocarbaZil, tioclorim, thiobencarb, thidiaZimin, thidiazuron,
thifensulfuron, thifensulfuron-methyl, desmedipham, desm
etryn, tetra?uoron, thenylchlor, tebutam, tebuthiuron, terbu
meton, tepraloxydim, tefuryltrione, tembotrione, delachlor,
terbacil, terbucarb, terbuchlor, terbuthylaZine, terbutryn,
topramezone, tralkoxydim, triaZi?am, triasulfuron, triafa
mone, tri-allate, trietaZine, tricamba, triclopyr, tridiphane,
tritac, tritosulfuron, tri?usulfuron, tri?usulfuron-methyl, tri
?uralin, tri?oxysulfuron, tripropindan,
tribenuron, tribenuron-methyl, trifop, trifopsime, trimeturon,
naptalam, naproanilide, napropamide, nicosulfuron, nitralin,
nitrofen, nitro?uorfen, nipyraclofen, neburon, nor?urazon,
noruron, barban, paclobutrazol, paraquat, para?uoron,

Sep. 11,2014

US 2014/0256687 A1

haloxydine, haloxyfop, haloxyfop-P, haloxyfop-methyl,


halosafen, halosulfuron, halosulfuron-methyl, bilanafos,
picloram, picolinafen, bicyclopyrone, bispyribac, bispyribac
sodium, pydanon, pinoxaden, bifenox, piperophos, hymex
azol, pyraclonil, pyrasulfotole, pyrazoxyfen, pyrazosulfuron,
pyrazosulfuron-ethyl, pyrazolate, bilanafos, pyra?ufen
ethyl, pyriclor, pyridafol,
pyrithiobac, pyrithiobac-sodium, pyridate, pyri?alid, pyribu
ticarb, pyribenzoxim, pyrimisulfan, primisulfuron, pyrimino
bac-methyl, pyroxasulfone, pyroxsulam, fenasulam, phen
isopham, fenuron, fenoxasulfone, fenoxaprop, fenoxaprop-P,
fenoxaprop-ethyl, phenothiol, fenoprop, phenobenzuron,
fenthiaprop, fenteracol, fentrazamide, phenmedipham, phen
medipham-ethyl, butachlor, butafenacil, butamifos, buthi
uron, buthidazole, butylate, buturon, butenachlor, butroxy
dim, butralin, butroxydim, ?azasulfuron, ?amprop,
furyloxyfen, prynachlor, primisulfuron-methyl, ?uaZifop,
?uaZifop-P, ?uaZifop-butyl,
?uazolate, ?uoroxypyr, ?uothiuron, ?uometuron, ?uorogly
cofen, ?uorochloridone, ?uorodifen, ?uoronitrofen, ?uoro
midine, ?ucarbazone, ?ucarbazone-sodium, ?uchloralin, ?u

cetosulfuron, ?uthiacet, ?uthiacet-methyl, ?upyrsulfuron,


?ufenacet, ?ufenican, ?ufenpyr, ?upropacil, ?upropanate,
?upoxam, ?umiovain, ?umiclorac, ?umiclorac-pentyl, ?u
mipropyn, ?umeZin, ?umetsulam, ?uridone, ?urtamone, ?u
oroxypyr, pretilachlor, proxan, proglinaZine, procyaZine,

?urazole, ?uxofenim, furilazole, mefenpyr-diethyl, MG191,


oxabetrinil, allidochlor, isoxadifen-ethyl, cyprosulfamide,
?uxofenim and 1,8-naphthalic anhydride.
EXAMPLES

[0057] Hereinafter, representative Examples and Test


Examples in connection with the present invention are shown,
but the present invention is not limited thereto. In Examples,
the part(s) means a part(s) by mass.

Formulation Example 1
Emulsi?able Concentrate

[0058]
Flubendialnide
Dichlorvos

5 parts
10 parts

Xylene
Nmethyl pyrrolidone
Mixture of polyoxyethylene nonylphenyl ether

65 parts
10 parts
10 parts

and calcium alkylbenzene sulfonate

[0059] The above ingredients are mixed and dissolved uni


formly to give an emulsi?able concentrate.

Formulation Example 2

prodiamine, prosulfalin, prosulfuron,


prosulfocarb, propaquizafop, propachlor, propaZine, propa

nil, propyzamide, propisochlor, prohydrojasmon, propyrisul


furon, propham, pro?uazol, pro?uralin, prohexadione-cal
cium, propoxycarbazone, propoxycarbazone-sodium,
profoxydim, bromacil, brompyrazon, prometryn, prometon,
bromoxynil, bromofenoxim, bromobutide, bromobonil, ?o
rasulam, hexachloroacetone, hevainone, pethoxamid, bena
zolin, penoxsulam, pebulate, be?ubutamid, vemolate, per
?uidone,
bencarbazone,
benzadox,
benZipram,
benzylaminopurine, benZthiazuron, beanendizone, ben

sulide, bensulfuron-methyl, benzoylprop,


benzobicyclon, benzofenap, benzo?uor, bentazone, pen
tanochlor, benthiocarb, pendimethalin, pentoxazone, ben?u
ralin, benfuresate, fosamine, fomesafen, foramsulfuron,
forchlorfenuron, maleic hydraZide, mecoprop, mecoprop-P,
medinoterb, mesosulfuron, mesosulfuron-methyl, mesotri
one, mesopraZine, methoprotryne, metazachlor, methazole,
metazosulfuron, methabenZthiazuron, metamitron, metami
fop, metam, methalpropalin, methiuron, methiozolin,
methiobencarb, methyldymron, metoxuron, meto sulam, met

sulfuron, metsulfuron-methyl, met?urazon, metobromuron,


metobenzuron, methometon, metolachlor, metribuZin, mepi
quat-chloride, mefenacet, me?uidide, monalide, monisou

Dust

[0060]
Flubendialnide
Profenofos

3 parts
10 parts

Clay powder

72 parts

Diatomite powder

15 parts

[0061] The above ingredients are uniformly mixed and then


pulverized to give a dust.

Formulation Example 3
Granule

[0062]
Flubendialnide
Dichlorvos
Profenofos

1 part
2 parts
2 parts

Mixture of bentonite powder and clay powder


Calcium lignosulfonate

90 parts
5 parts

ron, monuron, monochloroacetic acid, monolinuron, moli

nate, morfamquat, iodosulfuron, iodosulfuron-methyl


sodium, iodobonil, iodomethane, lactofen, linuron,
rimsulfuron, lenacil, rhodethanil, calcium peroxide and
methyl bromide.
[0055] Examples of the synergists include piperonyl butox
ide, sesamex, sulfoxide, N-(2-ethylhexyl)-8,9,10-trinorbom

[0063]

The above ingredients are uniformly mixed. After

addition of an appropriate volume of water, the mixture is

kneaded, granulated and dried to give a granule.

Formulation Example 4

5-ene-2,3-dicarboximide (MGK 264), N-declyimidazole,


WARF-antiresistant, TBPT, TPP, IBP, PSCP, methyl iodide,
t-phenylbutenone, diethyl maleate, DMC, FDMC, ETP and

Wettable Powder

[0064]

ETN.

[0056]

Examples of the phytotoxicity reducers include

benoxacor, cloquintocet-mexyl, cyometrinil, daimuron,


dichlormid, cyprosulfamide, fenchlorazole-ethyl, fenclorim,

Flubendialnide
Dichlorvos

2 parts
18 parts

Sep. 11,2014

US 2014/0256687 A1
11

regarded as having not a mere additive effect but a synergistic


effect. The results are shown in Table 1.

-c0ntinued
Kaolin and synthetic highdispersion silicic

75 parts

<Formula 1>

acid

Mixture of polyoxyethylene nonylphenyl ether


and calcium alkylbenzene sulfonate

5 parts

[0069]

Ta?he number of surviving larvae after the agro

chemical treatment in a treatment plot

[0070]
[0065] The above ingredients are uniformly mixed and then
pulverized to give a wettable powder.

Tb?he number of surviving larvae before the agro

chemical treatment in a treatment plot

[0071]

Ca?he number of surviving larvae after the agro

Formulation Example 5

chemical treatment in a non-treatment plot

Flowable

chemical treatment in a non-treatment plot

[0072]

[0066]

Cb?he number of surviving larvae before the agro

Colbys equation
E (expected value):(X+Y)(X>< Y/100)

Flub?ndiamide
Profenofos

5 pans

[0073]

X?he control effect of ?ubendiamide alone

25 parts

[007 4]
alone

Y?he control effect of d1ch10rvos or profenofos


TABLE 1

Number of surviving larvae

Control effect (%)

Expected value (%)

2 days

6 days

2 days

6 days

2 days

6 days

Dose
(g a.i./ha)

Before
treatment

after
treatment

after
treatment

after
treatment

after
treatment

after
treatment

after
treatment

Flubendiamide
Dichlorvos
Flubendiamide
Profenofos

60
400
60
320

575

207

30

62

94

49

88

373

51

13

86

96

68

98

Flubendiamide
Dichlorvos
Profenofos

60

307
188
121

212

320

533
236
246

56

400

44

39
16
48

88
O
80

i
i
i

*
i
i

Nontreatment

348

329

314

Test agrochemical

The a.i. in the table stands for active ingredient.

-00ntinued
So

01 3105 manufactured b

Inigstry CO_ (ML Japan)

Test Example 2

Toho Chemical

Propylene glycol

arts

Control Effect on Chzlo suppressalzs

5 parts

15135310101 23 (manufacmr?d by Rhon?'POUlenc

2 PMS

Wat-6r

58 pans

[0075]

Rice plants (variety: Kinmaze) were planted in 2-L

pots and grown to a height of about 80 cm (about 82 days after

transplantation, 18 to 25 sheaths). The depth of paddy water


.

[0067] The above 1ngred1ents are uniformly mixed and then


dispersed in water to give a ?owable.

in each

0t was ad'usted t0 4 cm and then s ra

treatment to

p
J
p y
the rice plants was conducted with an agrochemical solution
diluted to a predetermined concentration in an amount

Test Example 1

equivalent to 400 L/ha. After the spray-treated plants were


air-dried, each pot was covered with a vinyl chloride cylin

Control Effect on Plulella xyloslella

drical cover 30 cm in height. At 1 day before the treatment and


at 5 and 12 days after the treatment, 20 larvae of the test insect
pest Chilo suppressalis were released into each of the covered

[0068] Transplants ofBrassica oleracea var. capilala (vari


ety: YR Seitoku) were planted in a glass greenhouse, and in
the 12- t0 15-leaf stage, inoculated with 3rd-instar larvae of

Plulella xyloslella. The number of surviving larvae in three


plants per plot before agrochemical treatment was counted
and then spray treatment to the test plants was conducted with
an agrochemical solution diluted to a predetermined concen
tration in an amount equivalent to 800 L/ha. The number of

surviving larvae was counted at 2 and 6 days after the spray


treatment and the control effect was calculated according to

formula 1. In addition, the expected value for the control


effect of the mixed use was calculated according to Colbys

equation shown below. When the control effect of the mixed


use is superior to the expected value, the mixed use is

pots (60 larvae in total per pot). At 29 days after the treatment,
in each pot, the number of damaged stems of the rice plants
was counted, the percentage of damaged stems was calcu
lated, and from this percentage, the control effect was calcu

lated according to formula 2. In addition, the expected value


was calculated according to Colbys equation in the same
manner as in Test Example 1. The results are shown in Table
2.
Control effect (%):100(the percentage of damaged
stems in a treatment plot/the percentage of dam
aged stems in a nontreatment plot)><100

<Formula 2>

Sep. 11,2014

US 2014/0256687 A1

TABLE 2

Test agrochemical

Number of stems at 29 days

Percentage of

Dose

after treatment

damaged stems

Percentage of

Expected

(g a.i./ha)

Normal stems Damaged stems

(%)

control (%)

value (%)

Flubendiamide
Dichlorvos
Flubendiamide
Profenofos

30
393
30
500

Flubendiamide
Dichlorvos
Profenofos

30
393
500

Nontreatment

58

100

57.5

49

3.9

95.7

66.7

29
7
18

21
38
35

42.0
84.4
66.0

54.0
7.5
27.7

i
i
i

42

91.3

The a.i. in the table stands for active ingredient.

[0076] In each test, the control effects observed in (i) the


?ubendiamide and dichlorvos mixed treatment plot and in (ii)
the ?ubendiamide and profenofos mixed treatment plot were

greater than the expected effect (expected value) calculated


from the effect observed in the ?ubendiamide treatment plot
and the effect observed in the dichlorvos or profenofos treat

ment plot.
1. An agricultural and horticultural insecticide composi
tion comprising ?ubendiamide and dichlorvos and/or pro
fenofos as active ingredients.

2. The agricultural and horticultural insecticide composi


tion according to claim 1, comprising 0.1 to 10 parts by mass
of dichlorvos and/or profenofos per part by mass of ?uben
diamide.
3. A method for using an agricultural and horticultural

insecticide composition, comprising treating insect pests


directly, treating crops potentially infested with the insect
pests, or treating surrounding soil or cultivation medium of

effective amount of an optionally diluted formulation con


taining ?ubendiamide as an active ingredient and an effective

amount of an optionally diluted formulation containing


dichlorvos and/or profenofos as an active ingredient(s), the
two formulations being used separately but in the same

period.
5. A method for controlling agricultural and horticultural

insect pests, comprising treating insect pests directly, treating


crops potentially infested with the insect pests, or treating
surrounding soil or cultivation medium of the crops with an
effective amount of an optionally diluted formulation con
taining ?ubendiamide as an active ingredient and an effective

amount of an optionally diluted formulation containing


dichlorvos and/or profenofos as an active ingredient(s), the
two formulations being used separately at a given interval.
6. A method for controlling agricultural and horticultural
insect pests, comprising mixing an effective amount of a
formulation containing ?ubendiamide as an active ingredient

horticultural insecticide composition comprising ?ubendia

and an effective amount of a formulation containing dichlo


rvos and/or profenofos as an active ingredient(s), optionally

mide and dichlorvos and/or profenofos as active ingredients.


4. A method for controlling agricultural and horticultural

ing crops potentially infested with the insect pests, or treating

the crops with an effective amount of an agricultural and

insect pests, comprising treating insect pests directly, treating


crops potentially infested with the insect pests, or treating
surrounding soil or cultivation medium of the crops with an

diluting the mixture; and treating insect pests directly, treat


surrounding soil or cultivation medium of the crops with the

optionally diluted mixture.


*