Origin

Paraxial mesoderm

What it becomes
Somites

Dermomyotome
Intermediate mesoderm
Dorsomedial myotome
Ventrolateral mytomome
Ectoderm + dermatone
Lateral plate mesoderm

Dermis and muscle

Dermomyotome and sclertome
epaxial muscles around spine
hypaxial muscles overtop epaxial
Integument
Limbs

Somites

Notochord
Remaining schlerotome

Vertebrae
Proximal ribs
Distal rib
Nucleus pulposis
annulis fibrosis

Sclerotome

vertebrae

Signal involved
Wnt (from ectoderm) after SHH from
notochord
SHH and Wnt

Hox genes (more involved for caudal

vertebrae)
PdGR + FGF
BMP

hox genes signalling endochondral

ossifcation

Cavitation of lateral plate mesoderm

somatic layer beneath ectoderm
splanchnic layer over endoderm
Ectoderm + someatic mesoderm

somatopleura

Endoderm + splanchnic mesoderm

Splanchnopleure

Pleuropericardial

separate pericardial sac and pleural cavities

horizontal folding from lungs

pleuroperitoneal

separate pleural cavities form peritoneal cavities

single layer pericardial
single layer peritoneal
double layer pleural

vertical folding form lungs

Embryonic body cavity

initial body cavity (embryonic body cavity)

Body wall musc

Transverse septum
Mesentary esophagus
fusion of PP + transv septum + mesent.
Esophagus

Diaphragm
Central tendon
Right and Left crura

Precardiac mesoderm
Endocardial tubes

Tubular heart
Primite heart

Primary heart field

secondary heart field

Inflow, left ventricle, part of right ventricle

outflow, part of right ventricle

vertebrocostal triangle

Inflow

great vessels
smooth muscle in vaculature
parasympathetic neurons
sinus venous --> atria

outflow

bulbis cordis --> conus/truncus arteriosus

proepicardial organ

fibroblasts, coronary vessels, epicardium

dorsal heart wall towards cushions

Setptum primum with foramen primum

endocardial prominences and conotruncus

AV cushions

cardiac neural crest

Septum primum
foramen secundum
Apex of heart moving to cushions and bulbar
ridge
Muscular IV septum with IV formaen
IV foramen
membranous IV septum
crescent movement over septum primum and
forament secundum towards cushions
septum secundum with foramen ovale
septum primum
valve of foramen ovale
Bulbar truncal ridges
aortic and pulmonary outflow

bilateral folding

through pharg arches 3,4,6 to create

aorticopulmonary septum

ENT

ENT
apoptosis causing perforations

ENT

Subendocardial prominences

right vent: pulmonary trunk

left ventricle: aortic vestibule
semilunar valves

PAA 1
PAA 2

part of maxillary artery

part of hyoid and stapedial

PAA 3

ventral common carotid, dorsal internal carotid

PAA 4
PAA 5

rt = prox subclavian, lt = part of aortic arch

rudimentary vessel
rt = part of rt pulm artery; lt = part of lt pulmonary art
and ductus arteriosus
right side hooks around rt subclavian and left hooks
around ductus art

6th PAA dev

Vitelline veins
umbilical
Cardinal
Anastomose btw anterior l/r
right anterior cardinal

rt = hepatic portal
lt = ductus venous

hepatic sinusoids break up veins

path through liver --> IVC

posterior cardinal

subcardinal, supracardinal, sacrocardinal

subcardinal
supracardinal

kidney anastomose (renal IVC and assoc veins)

rt. Azygos; lt. hemizygos, sup intercost
anastome btw sub/supracardinal; lumbar IVC,
common iliac veins
join ant/post cardinals; rt = SVC; lt = oblique vein (part
of coronary sinus)
ligamentum venosum
ligamentum teres
Ligamentum arteriosus

Bulbis cordis

PAA 6
Recurrent laryngeal

sacrocardinal
common cardinal
Ductus venosus
uUmbilical artery
Ductus arteriosus

left brachiocephalic vein

right brachiocephalic vein

Problems?

Cervical rib

Block vertebrae (GDF6 mutation),

hemivertebrae , sagittal cleft

congential diaphragmatic hernia due to slow

growth

eventration of diaph due to lack of musculature

congential diaph hernia due to failure of fusion

Tbx, Mef-2, NKX2, Hand, Gata

Origin

What it becomes

Dorsal Mesentary

Ventral mesentery

Hepatic diverticulum

Splanc mesoderm of trans septum

Dorsal pancreas bud

Ventral pancreas bud

Cecal diverticulum

Meso esophagus
Greater omentum
Lineorenal lig
Gastrolineal lig
Gastrocolic lig
Gastrophrenic lig
small intestine mesentary
root of mesentary
mesoappendix
transverse mesocolon
sigmoid mesocolon
lesser omentum
gastrohepatic lig
hepatoduodenal lig
coronary lig
traiangular lig
falciform lig
liver
gall bladder
hepatic ducts, cytic duct, common
bile duct
hepatic sinusoids
kupffer cells
sup head of pancreas
body and tail
accessory panc duct
distal panc duct
proximal panc duct
inferior head
uncinate process
Cecum

Signal involved or association

liver to wall

Cecal diverticulum
Intermediate Mesoderm
Nephrogenic cord
Aorta
Metanephr mesenchyme

Appendix
Nephrogenic and genital ridges
Mesonephric tubules
gives branch --> glomerulus
Metanep kidney

Allantois

Urachus
Urogenital sinus
Vesicle part
bladder
male: prostatic urethra
Pelvic part
female: entire urethra
Phallic part
male: spongy urethra
Trigone
bladder
Males: ductus deferens
Mesonephric ducts (Wolffian)
Female: round ligament of ovary

Uretic bud contacts it

Obliteration of allantois

Passive regression
Mullerian inhibiting substance
from sertoli

Gonad
Gonad
Germ cells in dev testis

Male: actively regress

Female: uterus walls and tubes
Testis
Ovary
Seminiferous cords

Supporting epithelial cells

Sertoli cells

Steroidgen factor due to SRY

Leydig cells
External genitalia

Steroidgen factor due to SRY

Test and DHT from leydig

Mullerian duct

Mesenchyme of gonadal ridge

TDF by presence of SRY

Wnt 4

Problems?

Annular pancreas due to ventral bud

moving bilaterally around;
Heterotrophic pancreatic tissue shows
up in liver or duodenum due to error in
endoderm differentiation

Can be patent if allantois does not

completely obliterate

Incomplete fusion or atresia

Cortex regresses, medulla differ
Cortex differ, medulla regresses