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317
MR Imaging
and Ewings
of Osteogenic
Sarcoma
Twenty
patients
with biopsy-proven
osteogenic
(1 1 cases)
or Ewings (nine cases)
sarcoma were evaluated
by MR imaging on a O.15-T resistive unit to determine
the value
of MR in the diagnosis
and treatment
of these two neoplasms
and to develop the best
protocol for MR imaging. In all 20 cases,
MR identified
tumor spread into bone marrow,
and it was superior to CT in five cases. Extension
of tumor into the soft tissues adjacent
to bone was shown better
by MR than CT in six cases. Improved
anatomic
information
from MR is the result of the ability
to image in the axial, coronal, and sagittal planes.
Compared
with CT, MR identifies
cortical disease but has inferior spatial resolution
and
defines calcium poorly.
MR can be used to monitor tumor
response
to chemotherapy,
and the relationship
of tumor to adjacent vasculature
can be determined
without the use
of contrast agents. Two pulse sequences
are necessary
for maximum display of disease,
since, in general,
tumor involvement
of the bone marrow
is best assessed
on Tiweighted
sequences,
and tumor involvement
of the soft tissue is best seen on T2-
Orest B. Boyko1
David A. Gory1
Mervyn
D. Cohen1
Arthur Provisor
David Mirkin3
G. Paul DeRosa4
weighted
sequences.
Additional
information
about bone-marrow
Clinical experience
with
1 1 1. MR is also becoming
MR imaging
increasingly
vessels
involvement,
makes
MR
soft-tissue
a valuable
of primary
important
after re-
Materials
Ray Society.
Department
Boston.
of Radiology.
School of Medicine,
anapolis,
IN 46223.
April
1985.
Indiana University
Indito 0.
B. Boyko, Department of Radiology, Indiana University School of Medicine, 926 W. Michigan St.,
Indianapolis,
2
diana
strief
and Regenstnef
Address
reprint
Institute,
requests
IN 46223.
Department
of Hematology
University
Institute,
School
and Oncology,
of Medicine,
Indianapolis,
and
In-
Regen-
IN 46223.
3Department
of Pathology,
Indiana
University
School of Medicine,
and Regenstrief
Institute,
Indianapolis,
IN 46223.
4Department
of Orthopaedic
University
School of Medicine,
stitute, Indianapolis,
IN 46223.
AJR 148:317-322,
0361 -803x/87/1
C American
February
Surgery,
Indiana
and Regenstrief
In1987
482-0317
Roentgen
Ray Society
and Methods
Twenty patients aged 9-21 years with either osteogenic sarcoma (1 1 cases) or Ewings
sarcoma (nine cases) had MR scans before chemotherapy
or radiation therapy. A 0. 15-T
resistive
scanner
(Technicare
Teslacon)
was used. All patients were examined with at least
one Ti
and one T2-weighted
spin-echo
(SE) pulse sequence,
and three patients were
examined with inversion-recovery
(IR) pulse
sequences.
The echo-delay
time (TE) was 30,
32, 60, or 120 msec; the repetition time (TA) was 250, 500, 550, 1000, or 2000 msec. (SE
250/32, 550/32, and 500/30 are Ti weighted; SE 1000/30, 1000/60, 2000/60, and 2000/
120 are more T2 weighted.) For the IR sequence, a 90#{176}-i
80#{176}
signal-reading
pulse pair
followed the initial 180#{176}
inverting pulse. The inversion time (TI) was 450 msec. The 90#{176}
and
180#{176}
refocusing
pulses were separated
by 1 5 msec. The TR was 1500 msec. IA images are
heavily Ti weighted. In one case, multiecho images were obtained with a TA of 2000 msec
and a TE ranging from 30 to 240 msec.
Contiguous
slices
of either
10 or 15 mm were obtained in the coronal,
axial,
or sagittal
plane. Images were reconstructed
into a 256 x 128 matrix and interpolated to 256 x 256 for
-
display.
No contrast
agents
were
used.
The distribution of the 1 1 cases of osteogenic sarcoma were femur (seven), pelvis (two),
humerus (one), and tibia (one). The nine cases of Ewings sarcoma were located in the femur
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318
BOYKO
Fig. 1.-Ewings
sarcoma
of the left fibula.
A, Soft-tissue-window
CT shows no soft-tissue
mass or marrow abnormality.
B, IR 1500/450
image shows marrow replacement
by tumor (arrow).
(two), pelvis (five), spine (one), and fibula (one). All patients
film examinations,
and i 9 patients
had CT scans
before
had plain-
MR imaging.
response
to therapy.
Diagnoses
in all 20 cases
were
observations
were
simultaneously,
and
correlated
a consensus
with
plain
impression
films
was
and
reached.
CT scans
Presence
was confirmed
at the
ET
AL.
AJR:148,
C, SE 1000/60
image shows soft-tissue
mass (arrows)
and periosteal
elevation
(arrowhead),
but fails to show difference
between
normal tibia
and abnormal
fibula marrow as was seen in B.
The soft-tissue
sarcoma
MR
identified
soft-tissue
masses
in all 20 cases.
In the
19
was
better
shown
by MR
in five cases.
CT
case.
Both Ti - and T2-weighted
images were required in the evaluation of tumor in soft tissue and bone marrow, since on Ti weighted images tumor that infiltrates muscle can have a
showed
signal
marrow
isointense
abnormalities
with
muscle
better
(Fig.
than
MR
in one
becomes
images
(Fig. 1 C). Conversely,
sequence
chosen can cause tumor that is
infiltrating
bone marrow to have a bright signal similar to
normal marrow
(Fig. 1 C).
In one case of a pelvic osteogenic sarcoma, the extensive
marrow involvement
shown by MR changed the surgical
approach
to a hemipelvectomy.
MR can also show metastatic
sites of osteogenic
sarcoma even when there is calcified
of both osteogenic
and Ewings
signal intensity,
and these
two tumors
could not be distinguished
based on Ti
signal intensity.
MR showed cortical thickening
and tumor infiltration
or T2
of the
dark
signal
of the
signal intensity
Both
component
had an inhomogeneous
creased
Resufts
February 1987
CT and
plain
cortex
with
the
of the invading
radiographs
and localization
of calcifications
of calcification
produced
comparatively
in-
tumor.
provided
better
definition
discrete
areas
of signal
void
(Fig.
sarcoma
extent
showed
of tumor
a lateral
correlation
the
reliability
in bone marrow
in two
of MR
mass
to display
cases of osteogenic
showed
the
true
In one case,
an osteoblastic
periosteal
reaction,
of a sagittal
and
MR image
the T2 pulse
tumor matrix
more
intense
on T2-weighted
(Fig. 2).
Histologically
no tumor
was
in the
epiphysis.
A large
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AJR:148,
February
MR
1987
OF
OSTEOGENIC
AND
EWINGS
319
SARCOMA
Fig. 2.-Osteogenic
sarcoma of the right humews.
A, coronal
SE 2000/60
image shows primary
tumor (arrows).
cakifiei
axillary node metastases (arrowheads)
appear
as areas
of decreased signal.
B, Chest radiograph confirms densely calcified axillary node metastases
(arrowheads).
Fig. 3.-Osteogenic
sarcoma
of the femur.
A, Bone-window
CT scan shows several small
areas of calcification
(arrows),
and tumor extension into marrow
and surrounding soft tissue.
B, Axial SE 1000/60
image shows inhomogeneous signal from tumor (arrows) that cannot be
correlated
with CT as being areas of calcification, which shows limitation
of MR in the evaluation of calcium.
Tumor replacement
of normal
marrow signal is seen.
better definition
than MR of calcium
deposition
in the tumor
matrix.
Response to therapy
(Fig. 8) and osteogenic
Examination
of osteogenic
genic sarcoma,
tumor enlargement
documented
by MR allowed for the early cessation of methotrexate
chemotherapy,
epiphysis
6). The
followed
(Fig.
extent
of tumor
involvement
blood
emitted
no signal
and appeared
directly
black
of the
on all
pulse sequences.
In 12 cases, MR showed the relationship
of tumor to blood vessels more easily than CT did. Scanning
in the sagittal plane was often useful for demonstration
superficial
femoral
and popliteal
arteries.
The coronal
by amputation.
corre-
of the
plane
the opportunity
to image in several
planes.
In Figure 8 a
coronal
MR image showed
extension
of a spinal Ewings
sarcoma
behind the diaphragmatic
crus. The CT scan was
initially interpreted
as an adrenal
mass that was invading
bone.
Discussion
We found infiltration
by osteogenic
and
Ewings
sarcoma
to be clearly shown by MR; in five cases it
was superior
to CT. Tumor has a long Ti relaxation
time and
Ti-weighted
Pathologic
images
[16].
correlation
fat on
of marrow
involvement
by two osteogenic
sarcomas
(Figs. 5 and 6)
showed the marrow involvement
demonstrated
by MR to be
within several millimeters of that documented
on the pathologic specimen.
This supports
the findings
gators of the reliability
of MR in showing
extent
of neoplasm
[10,
16].
320
BOYKO
ET
AL.
Fig. 4.-Ewings
sarcoma of the left ilium.
A, CT shows areas of calcification
(arrows)
within tumor with periosteal reaction and soft-
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tissue mass.
B, Axial SE 500/30
image shows
inhomogeneous signal in tumor, but areas of lowest signal
(arrowheads)
do not correspond
to calcifications
seen on CT. There is marrow
replacement
by
tumor (arrow).
Fig. 5.-Osteogenic
sarcoma
of the femur.
A, Preoperative
radiograph
shows osteoblastic
iosteal reaction
and a soft-tissue
mass (arrows).
B, Sagittal
SE 500/30 image shows proximal
(arrow)
marrow
lesion
with
per-
does
tumor
extent
tissue
component
can extend
of both
beyond
of these
the cortical
neoplasms.
not involve
mass
(arrowheads).
12 cm and
in marrow
The inhomogeneous
MR signal of osteogenic sarcoma did
not correlate
with the histologic
distribution
of chondroid
or
osteoid tumor matrix. We did find on MR that tumor spread
into the bone marrow
and soft-tissue
C, Gross specimen.
or soft-
Decreased
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AJR:148,
MR
February 1987
OF
OSTEOGENIC
AND
EWINGS
SARCOMA
32i
Fig. 7.-Ewings
sarcoma
arising from iliac
wings in two different
patients
shows displacement of right (A) and left (B) iliac arteries (arrows),
inferior vena cava (A, arrowhead),
and
bladder (B, arrowhead).
sequences.
Tumor invasion
of bone cortex can
because
of its prolonged
Ti and T2 relaxation
In both osteogenic
and Ewings
sarcoma,
MR can show
the relationship
of tumor to vasculature
without
the use of
was
T2-weighted
images enhanced
tumor and muscle better than
images.
found
to be inferior to CT in showing
soft-tissue
calcification
and tumor matrix mineralization
in all i 6 cases in
which calcium
was shown by either CT or plain films. This
in the interpretation
of osteogenic
sarcomas.
MR can show
cortex
by both
Bone cortex
on all pulse
be identified
thickening,
infiltration,
osteogenic
sarcoma
lacks mobile
protons
and destruction
and
Ewings
of the
sarcoma.
times. Although
was
more
obviously
322
BOYKO
ET AL.
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Fig. 8.-Ewings
sarcoma
arising from spine.
A, Coronal
SE 500/30
image shows soft-tissue mass (arrows) and decreased
marrow signal
of involved vertebral body (arrowhead).
B, Coronal
SE 2000/30 image after therapy
shows decrease
in size of soft-tissue mass (arrows).
contrast
agents.
of MR to image
and sagittal
planes.
Pettersson
to therapy
of osteogenic
sarcoma
[1 7],
we
found
MR to be a suitable alternative.
Interval growth of tumor
shown by MR allowed cessation of chemotherapy
and early
amputation
in three cases of osteogenic
sarcoma. MR was
useful as a follow-up to monitor therapy response of three
cases of Ewings sarcoma.
In summary, we have found MR to provide adjunct information in the preoperative
planning and posttherapy
followup in cases
of Ewings
and
osteogenic
sarcoma.
Images
display
provide
Sagittal
and
coronal
planes
provide
an
excellent
of the relationship
of tumor to major vessels and
images of the entire length of a bone for evaluation
of proximal
bone-marrow
or epiphyseal
extent
of tumor
and
reaction
in all cases.
healthy volunteers
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Musculoskeletal
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Radiology
1983;147:161-17i
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