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Oral Oncology
journal homepage: www.elsevier.com/locate/oraloncology
Perspectives
a r t i c l e
i n f o
Article history:
Received 8 November 2015
Accepted 17 November 2015
Available online 10 December 2015
Keywords:
Microbiota
Periodontitis
Inflammation
Cancer
Head and neck neoplasms
Tooth loss
Dental care
s u m m a r y
A wide range of studies has been successfully exploring the association between the human
microenvironment, sustained inflammation, and cancer. Growing evidence has then emerged in this field
over the past few years. Nevertheless, reliable data addressing the impact of the oral microbiome and
periodontitis on the pathogenesis and risk of head and neck malignancies remain scarce. Hence, this
communication focuses on briefly discuss the relationship between the oral microbiome, periodontitis
and head and neck cancer based on the current understanding of such a disease-associated scenario.
2015 Elsevier Ltd. All rights reserved.
Introduction
In the field of oncology, there is currently much attention given
to the possible causality between instabilities in the microbiome
dynamics, sustained inflammation and cancer [1,2]. In addition,
head and neck cancer (HNC) continues to be a major public health
issue, affecting over half a million new patients each year
worldwide [3]. Nonetheless, data regarding the significance of oral
bacteria and periodontitis in the development and rates of HNC
remain limited [4].
Most head and neck malignancies involve either the oral or
oropharyngeal sites, rates of which have not experienced significant decreases over the past few years [3]. Therefore, here we summarize important and recent findings that biological, clinical and
epidemiologic research have yielded, which started shedding light
on the impact of this pathogen-associated scenario on head and
neck carcinogenesis.
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L.V. Galvo-Moreira, Maria Carmen Fontoura Nogueira da Cruz / Oral Oncology 53 (2016) 1719
L.V. Galvo-Moreira, Maria Carmen Fontoura Nogueira da Cruz / Oral Oncology 53 (2016) 1719
Conflict of interest
None declared.
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