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Brucellosis
Leptospirosis
Campylobacteriosis
Trichomoniasis
Local names
Bangs Dz
Weils Dz
Vibriosis
Trichomonas
Trich
Causative Agent
L. Pomona / icterohaemorrhagiae /
canicola / hardjo (mastitis)
C. fetus venerealis
T. foetus
Epidemiology
(behaviour of dz
in env / epi triad)
-Late gestation
-Natural mating B. ovis (ram is
affected) (not of concern)
-Unpasteurized milk
-Ingestion of dsch from infected cows
that hv just aborted placenta
-purchased of carrier cows
-inhalation,cuts,abrasions or droplet
-infected material at time of calving or
abortion
-most calves infected at birth clear the
infection
-lack at precaution at movemen
-infected breeding bulls transmit during
service to cow from infected semen.
occurence
-rare
-cattle
Pathogenesis
-ingestion
-replicate in LN
-bacteremia followed by colonisation of
supramammary LN,mammary gland,and
gravid uterus
-uterine infctn at 2nd trimester
- bacteria appears in placenta and
replicates in chorioallantoic trophoblast
due to presence of erythritol
-organisms also occur in foetal
placenta,endothelial cells,and capillary
lumina causing vasculitis and destructon
of chorionic villi.
-placental inflammation and disruption
causes foetal death and expulsion of
fetus
-shedding of bacte usually stops at 3
Pathogenesis
-abrasions, mucosa multiplies
-septicemia in 4-7 d
-meninges-meningitis
-kidney n tubules-shedding
-uterus n placenta-abortion
-liver-hemolysin-hemolytic anemiajaundice
Pathogenesis
-passes thru cervix
-organism establish in uterus, one week
after vaginal infection.
-causes mucopurulent endometritis
(persist for 3-4 months)
-also salpingitis
-prevent conception,or causes
embryonic death and heifers return to
estrus by 40d
-abortion less common
Pathogenesis
-endometritis
-salpingitis=death of conceptus,b4 or
after conceptus
Typical Signs
Abortion
Third trimester
-calves born immature and weak
-inflammation of uterus n excessive
vaginal dsch
No pyometra
Abortion
Towards the end pregnancy
(stillbirth)
No pyometra
Calves
-meningitis
-severe depression n reduced appetite
-pyrexia
-opisthotonus
-muscle tremor
-paddling when in lateral recumbency
-occasionally, extensor rigidity
-ophthalmitis w hypopyon
-PLR is slow-maybe blind dt optic disc
oedema n renal vessel congestion
-infertility
-early embryonic death
-Hx of high return to estrus prolonged
interestrous interval
-sporadic abortion=4-8 months gestation
Adults
-milking cows in early stage-milk drop
syndrome
-pyrexia
-eating normally w no obvious
abnormality in demeanour
-yellow orange coloured milk,thick sticky
like colostrum
-all 4 Q affx-no evidence of
inflammation,hardness
-milk yield slowly return to normal
-high leukocyte count in milk
-following localization in kidney-abortion
can occur at gestation 4-9 months
especially in younger cows
-calves born alive in late gestation
maybe weak, lethargic and non viable.
-high conc of organisms excreted
following abortion.
Samples
Urine
Blood
Diagnosis
-PM on fetus
=placentitis,necrotic
cotyledons,intercotyledonary placenta is
thickened n opaque
-histo
=suppurative placentitis (endometritis in
dam)
=suppurative bronchopneumonia in
fetus
-serology
Milk Ring test (ag+ab+??) TEST 1
RBPT(ag) reagent (test presence of ab)
ELISA ag)
-culture
=foetal lung,abomasum,placenta,
maternal urine,mammary secretion
Trx long acting Oxytet, streptomycin
No Trx- Test n slaughter
Mgmt
Control rat (reservoir)
Feed storage
Env feed trough (possible
contamination)
Vaccination
Treat incoming animals
Hygiene
Do not keep stagnant h2o
AI
Justification trx
Treatment
Control
-disch-direct microscopy=flagellated
-culture= vaginal disch,preputial
scraping
-mucus agglutination-IgA
-ELISA-IgA
-necrotizing placentitis
-hepatitis
-bronchopneumonia
-isolation of organisms
(placenta,abomasum)
-