Genetically modified organisms are organisms in which the genetic material

(DNA) has been altered in a way that does not occur naturally by mating or
natural recombination. This technology is known as modern biotechnology
or genetic engineering or recombinant DNA technology. It allows selected
individual genes to be transferred from one organism into another, also
between non-related species, to give new traits to the recipient.-by Kalpana
Palkiwala
26 July 2007
Transgenic Plants
-by Kalpana Palkiwala*
The term GMOs - Genetically Modified Organism is most commonly used to refer to
crop plants created for human or animal consumption using molecular biology
techniques. These plants are modified in the laboratory to enhance desired traits
such as increased resistance to plant diseases, germs or improved nutrition content.
The conventional plant breeding methods are very time consuming and often not
very accurate. Thus GM Foods offers a novel way to improve crop characteristics
such as yield, pest resistance, herbicide tolerance.

Genetically Modified Organisms

Genetically modified organisms are organisms in which the genetic material (DNA)
has been altered in a way that does not occur naturally by mating or natural
recombination. This technology is known as modern biotechnology or genetic
engineering or recombinant DNA technology. It allows selected individual genes to be
transferred from one organism into another, also between non-related species, to
give new traits to the recipient.

Transgenic Plants

A transgenic plant is a genetically modified organism, which contains artificially

inserted gene or genes from an unrelated organism. The inserted gene ( known as
trans-gene ) may come from another unrelated plant, or from completely different
species, for example Bt. Cotton, contains a gene from a bacterium.

The Ministry of Environment and Forests has formulated the ‘Rules for the
Manufacture, Use, Import and Export and Storage of Hazardous Micro
Organisms/Genetically Engineered Organisms or Cell, 1989’, commonly known as
‘Rule 1989’. These rules and regulations cover the areas of research as well as large
scale applications of GMOs and their products.These include recombinant pharma
products, transgenic crops, GM Food and product containing GM ingredients.

Biosafety Assessment’ Of Transgenic Crop

There are extensive rules and guidelines for evaluating environmental and health
safety aspects of genetically modified organism. Any Company involved in the use of
genetic engineering techniques has to obtain approval of the Review Committee on
Genetic Manipulation (RCGM) set up under the 1989 Rules in the Department of
Biotechnology for conducting tests under laboratory conditions and confined field
conditions. Based on these results, the RCGM makes its recommendation to the
GEAC. Thereafter approval of GEAC is required for conduct of large-scale field trails
for a number of parameters, which includes bio-safety, efficacy of the variety,
agronomic benefits and economic advantage of the GM crop. The results of the large-
scale field trials are evaluated by the Monitoring-Cum-Evaluation Committee (MEC).

The GM crops approved for large scale trials are also evaluated under the Indian
Council of Agriculture & Research (ICAR) testing system. The GEAC takes into
consideration the recommendations of the MEC and ICAR before approving the GM
groups for commercial cultivation.

The bio-safety assessment include environmental safety assessment as well as food

and feed safety.

Only those transgenic crops which are found to be safe for human consumption as
well as the environment are approved for commercial release.

Generating The Bio-Safety Data

Biotechnology product development and associated regulations for ensuring bio-
safety is capital-intensive requiring skilled personnel. Therefore, food safety studies
are being conducted in public institutions such as Indian Veterinary Research
Institute, Izatnagar;National Dairy Research Institute, Karnal; Indian Toxicological
Research Institute, Lucknow; Avian Research Institute, Rae Bareilly; Central Fish
Institute and Education, Mumbai; Rallies India Ltd. Bangalore. The data generated in
these institutions are further scrutinized by independent experts as well as expert
members of the regulatory bodies (RCGM and the GEAC).

The concept of testing toxicity and allergenicity is not new and is a common practice
in the Pharma sector where the DCGI under the Drugs and Cosmetic Act accept the
data generated by the applicants.

Further, to ensure that the data submitted by the company is correct, the provisions
under EPA provide for post- release monitoring and revoking of the clearance.

Policy For Approving Transgenic Crops

In the case of modern agricultural biotechnology, the benefits as well as risks vary
from crop to crop, region to region and technology. It is a scientifically established
fact that Gene functions differently in different crop and the impacts vary from
species to species and the environment in which it is hosted. Further the
performance of a transgenic crop species depends on the gene-environment
interaction. Therefore a policy of case by case approval in case of genetically
modified (GM) foods or food crop is being followed. As of date, the Genetic
Engineering Approval Committee has approved the commercial cultivation of only
one transgenic crop namely Bt. Cotton.

Various Stakeholder Ministries have initiated the process of evolving a GM policy

pertinent to their sector. Important initiatives are: The Food Safety and Standards
Act, 2006 by the Ministry of Food Processing and Industry; Import Policy for
GMO/LMO Products Under Foreign Trade Policy (2005-2009) by Ministry of
Commerce (DGFT); Draft notification on mandatory Labeling by Ministry of Health
and Family Welfare; Draft National Biotech Strategy, 2005 by Department of
Biotechnology and National Environment Policy, 2006 by Ministry of Environment and
Forests.

Bt Cotton
Bt cotton is the only transgenic crop approved for commercial cultivation in India. Bt.
Cotton containing Cry 1 AC gene (MON 531 event) of M/s Mahyco was the first
transgenic crop released in India in April 2002 with the approval of the GEAC.
Subsequently, 62 new Bt cotton varieties have been released.

Bt. Stands for Bacillus Thurigniensis, a soil bacterium which synthesizes a crystal
(Cry) protein . In the insect gut, the protein breaks down to release toxin, which kills
the insect. These Cry genes are known as Bt genes. Through genetic engineering,
the Bt. Gene is inserted into cotton, so that the plant produces its own Bt toxin.
Cotton plants with these genes provide resistance to ballworm, a major cotton pest.
Bt cotton is under commercial cultivation in USA, Australia, China, Mexico, South
Africa and Argentina.

Experience In Cultivation Of Bt Cotton

The Bt cotton technology has been beneficial to farmers. The total area under Bt
cotton has increased from 72,682 acres in 2002 to 8600000 acres in 2006. The total
estimated production during 2005-06 is about 25 million bales (170 kg. each). Bt
cotton has reduced pesticide usage by 2260 MT of pesticides. Among five cotton
growing States of Gujarat, Punjab, Maharashtra, Andhra Pradesh and Karnataka,
Gujarat tops the list with maximum yield.

World over, all GM crops are assessed for its toxicity and allergenicity prior to market
authorization.

GM crops containing Bt protein are being consumed in several countries (including

developed countries like Japan, EU, Australia and New Zealand) for many years and
there has been no scientific evidence generated on toxicity of Bt cotton to human
and animal health.

Bt Brinjal (Egg Plant)

M/s. Mahyco has produced transgenic brinjal plants with Cry I AC gene from Bacillus
thuringiensis tolerant to the fruit and shoot borer, one of the major pests which
attack the brinjal crop throughout its life cycle. This is the first GM food crop under
evaluation for release in India but it is also the first GM eggplant to be released
globally.

A number of public institutions and private sector companies are in various stages of
developing and attesting of GM with the approval of RCGM. Of the genetic
modifications attempt, the vast majority are intended to confer pest resistance.

Another focus of genetic transformations has been the production of higher value
hybrids in crops such as mustard.

The Genetically modified crops under field trials in the country are: brinjal, cabbage,
cauliflower, chickpea, cotton, groundnut, maize, mustard, okra, pigeon pea, potato,
rice, sorghum and tomato.

*Media & Communications Officer, PIB, New Delhi.

2007-07-26 04:41:33
Original Source : PIB