THERAPY

WORKSHEET

CITATION :

Effectiveness of Pseudoepdherin Plus Acetaminophen for

Treatment of Symptoms Attributed to the Paranasal Sinuses
Associated with the Common Cold
Are the results of this single preventive or therapeutic trial valid ?
Was the assignment of patients
to treatments randomized?
Was the randomization list
concealed?
Was follow-up of patients
sufficiently long and complete?

We all patients analyzed in the

groups to which they were
randomized?
Were patients,clinicians, and
study personnel kept blind to
treatment?
Were the groups trated equally,
apart from the experimental
treatment?
Were the groups similar at the
start of the trial apart from the
experimental therapy?

Yes, (page 2, beside right, line 10) The study

was a randomized double blind placebo
Yes, (Page 2, beside right, line 10) The study
was a randomized double blind placebo
controlled clinical trial
No. (page 2, beside right, line 41-43)
Eighteen subject, 10 (4,6%) who received
pseudoephedrine and acetaminophen and
8(3,7%) who received placebo, did not
complete the study
Yes, (page 4, beside left, line 1).

Yes, (page 2, beside right, line 10) The study

was a randomized double blind
No.

Yes, (page 2, beside right, line 25) these

assessment were the same as those used

Are the valid results of this randomized trial important?

What is the magnitude of the
treatment effect?
How precise is the estimate of
the treatment effect?

This drug have effect of analgetik, and reducted

symptoms of sinus pain, headache,ect (page 6,
beside left, line 3-14).
pursuant to amount of a success patient with that
perception counted 206 ( 216-10) entirely - fail. (page 2,
beside left, line 40,)

Your calculations
RELATIVE RISK
REDUCTION (RRR)

CER

EER

CER-EER
CER

ABSOLUTE
RISK
REDUCTION
(ARR)
CER - EER

NUMBER
NEEDED TO
TREAT
(NNT)
1/ARR

96,26

95,37

96,26 95,37
0,009245
96,26
95% CI

96.26
95,37
= 0,89
-0,302 1,
478

1
1,123
0,89
-331,1-67,6

Can you apply this valid, important evidence about therapy in caring for your
patients?
Do these results apply to our
patients?
Is our patient so different from those
in the study that its results cannot
apply?
Is the treatment feasible in or
setting?
What are our patients potensial
benefits and harms from the
therapy?
Method I : f

Risk of the outcome in our patieny,

relative to patients in the trial
Expressed as a
decimal : ................................
NNT/ F : ...................../
..............= ..................

Method II : 1/(PEER X RRR)

(NNT for patients like ours)

Our patients expected event rate if they
received the control treatment (PEER)
= .....................
1/(PEER X RRR) = 1/...................
= ......................

Are our patients values and

preferences satisfied by regimen and
its consequences?
Do we and our patient have a clear
assesment of their values and
preferences?
Are they met by this regimen and its
consequences