Académique Documents
Professionnel Documents
Culture Documents
Agammagloblunemia
Def in Btk
Stays in Pre-B cell stage
Staph, strep pneumo, heamophilius, gram (-) rods, Giardria, polio
Hyper IgM syndrome
Defect in isotype switching (T cells affected)
Decrease in IgG, IgA, IgE
Increased levels of IgM
DiGeorge
Absent thymus
No T cells
Viruses, candida, intracellular bacteria susceptible
SCID
Multiple infections w/ viruses, candida, bacteria
ADA defect***
Rag1 and Rag 2 defect
Wiskott-Aldrich
Defect in cytoskeletal proteins (actin)
WASP protein defect
Presents as TIE (thrombocytopenia, infections, eczemamay say
excoriation of skin)
purpuric lesions, recuuring gasto infections, IgA and IgE are elevated
Selective IgA
Severe anaphylaxis
Low IgA
Neutropenia*** Chemotherapy
Toxoplasma
- HIV
- Cerebral manifestations ( multiple ring enhancing lesions)
- IgG levels elevated
- CD4 < 100
- Most of the time it is due to reactivation
- From cat poop oocysts
- Meat tissue bradyzoites tachyzoites
- Cat is DEFINITIVE host
- Pregnant woman damage maximum in 1st trimester IgM
elevated
- IgM in cord blood suggest infection of fetus
Nocardia
- From environment (inhaled)
- Lesions seen In lungs goes to brain
- Partially acid fast
- Filamentous
- Aerobic
- Responds to sulfa.
- May be seen in CGD***
Cryptococcus
HIV, transplant, immunosuppressive
- Cerebral meningitis
- Spherical budding cells w/ prominent polysaccharide capsule
- Acquired by inhalation
- Chronic meningitis in HIV pts
- Microscopy (India ink in CSF, and mucicaramine in tissue) and latex
agglutination test
- Produces melanin (virulence factor)
- TX: Amphotericin and Flucytosine (inhibits RNA and DNA)
Mycobacterium
MAC
-
Acid fast
Found in environment
CD4 < 50
Sensitive to cipro/azithro
Listeria
AIDs
Cell mediated immunity
Congenital
Tumbling motility
Grows in 4 degrees celsius
Actin tail moves from cell to cell
Gram (+)
Cat (-)
BR
CAMP (+)
Capsulated
Syphilis
H. ducreyi
Urethritis:
Gonococcal(short)
Dissemeniated>>> progressive arthritis, joints, skin lesions (SEPTIC arthritis
you will see BACTERIA)
Know MEDIA AND SELECTIVITY
Chlamydia(long)>> Reiters syndrome(immune mediated) joint fluid produce
NO BACTERIA!!! Obligate intracellular(cannot make ATP) no peptidoglycan
muramic acid