1 Pharma Questions

2014 2015
2014
2015
Pearsonvue
Exam of
Pharmacy

-
- Cases -

:
https://www.facebook.com/groups/pearsonvue.questions
1- antibiotic needed in community acquired pneumonia which need

hospitalization
a-macrolid
b-ceftriaxone +macrolid
c-Doxycyclin
d-Moxifloxacin+vancomycin

ceftriaxone +macrolid or doxy

Ceftriaxone plus either a respiratory fuoroquinolone or azithromycin
**
2-drug need dose adjustment in renal failure
a-Impeniem/cilastatin
b-Clindamycin
c-Ceftrisxon
d-Amoxicillin
**
3- lab tests can be done now:

a-TSh
analysis
b-Lipid profile and urine
c-Blood test just take blood sample
d-Iron
**
4-what lab tests have to done today:
a-Urin analysis
b-Coagulation test
c-Thyroid test
d-Cbc
**
5- patient with ulcerative colitis ttt on cortison and mesalazin must use
what
a-Iron
b-Vit b12
c-Calcium
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Ca ... due to corticosteroid drugs induce osteoprosis ..

so we give ca as prophylaxis therapy if there is (( ca+vit b12 )) is better
if colitis without cortisone the answer will be vit (( B12 ))
**
6-In ovulation phase hormone which predominant
A-FSH
B-LH
C-PROGESTERONE
D-progesterone and Lh
**
7-which of the following drug increase the incidince of BPH

a-Paracetamol
b- diclofenac
c- chlorpheniramine
BPH (Benign Prostatic Hyperplasia)

**
8- The dose of folic acid in non pregnant woman is
a- 400 mcg/day
mcg/day
b-700 mcg/day
c-1200 mcg/day
d- 900
Note:
non pregnant
pregnant
Lactating
400 mcg/day
600 mcg/day
500 mcg/day
**
9-which drug will be more absorped in prescence of rantidine
a-warfarin
b-aspirin
c-triazolam
d-naproxen
concomitant administration of H2 blockers may increase the dissolution

rate of enteric-coated naproxen, causing the drug to be released in the
stomach instead of the small intestine.
**
10-antibiotic used in community acquired pneumonia in hospitalization:
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a-azithromycin
c doxycyclin
b- ceftriaxone and azithromycin

d moxifloxacin and vancomycin
**
11- p.r.n = when required (when needed)

**
12- when we need to use omeprazole as a single therapy:
a-ulcer due to H.pylori
b gastritis
N.B:
H.pylori treated by triple therapy (( PPI + 2 antibiotics )) usually ((
omeprazole + metronidazole + clarithromycin )) omeprazole alone used for
Gastritis
**
13-drug used in moderate to severe asthma : omalizumab
**
14-which of the following vaccines should be administerd for every
pregnancy ?
a-Tdap ( tetaunes .. diaphtheriapertussis)
b-dap
c-Dtap
d-mmr
Pregnant women should receive a dose of Tdap during each pregnancy,
ideally between 27 and 36 weeks gestation.
Tdap & Dtap are the same vaccines but Tdap is used for adult and
pregnant , Dtap is used for (0-6) years old children
**
15-what is the antidote for methotrexate toxicity:
a-Leucovorin
b-naproxen
c-Vit k
d-naloxon
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**
16-recommended calcium dose for geriatric
a-800mg
b-600mg
c-500mg
d-1200mg
**
17-recommended vit d3 dose for geriatric
a-200 iu
b-400iu
c-600 iu
d-300iu
for Vit d dose

Younger than 70 years old
Older than 70 years old
600 iu
800 iu
**
18- human chorionic gonadotropin is used to :

a-Induce ovulation and treatment of infertility
b-Induce ovulation
c-Infertility
d-hormon
**
19-mechanism of action of bisacodyl (stimulant laxative)
a-stimulation of nerves to cause contractions in abdomen
b-stimulation of enteric nerves to cause colonic contractions
c-add bulk and water to the stool
**
20-bulk laxatives mechanism of action
-add water and bulky to stool and soften stool like a jelly
**
21- gray baby syndrome caused by :
a-chloramphenicol
b-doxycyclin
c-amoxcillin
d-cefclor
Page 5
**
22 - gray man syndrome caused by :
a-amiodarone(antiarrhytmic drug)
b-amlodipin
c-amiloride
d-propranalol
**
23 red man syndrome caused by :

a-vancomycin
b-doxucyclin
c-cefpodixme
d-amoxcillin
**
Q- Drug induces lupus like syndrome: Hydralazine & Procainamide
**
24-diphenoxylate and loperamide are narcotics or opioid agonists which
are used as :
a-anti-inflammatory
b-anti diarrheal
c-antipyretic
d-anitcholergic
**
25-both of cimetidine(h2blochker) and spironolactone have anti
androgenic effect
**
26- which of the following is the drug of choice for giardiasis
a-propranolol
b-metronidazole(flagyl)
c-thiabendazole
d-mebendazole
**
27-total body clearance= CLhepatic+ CLpulmonary +CLrenal

**
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28- tyramine when taken with MAOIs(monoamine oxidase inhibitor) cause

severe crysis of
a-hypertension
b-asthma
c-influenza
**
29-tertiary amine of TCA (tricyclic antidepressant) is
a-Amitriptylline and imipramine
b-desipramine and nortriptyline(secondry antidep.)
**
30-GRAIN= .065gram or 65mg
**
31-cyclosporin used as immunosuppressant after organ transplantation to
reduce possibility of rejection of new organ by immune system
**
32-Respiratory acidosis is caused by
a-CO2 retention
b-O2 retntion
c-N retention
**
33- the main side effect of alpha antagonist (blocker) as prazosin is
Postural hypotension (orthostatic hypotension)
**
34-morphine cause constipation
**
35-anti cholinergic cause constipation
**
36-narcotic addiction is treated by:
a-methadone
b-naloxone (antidote not treatment)

**
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37-erythropoiten (eprex) is used for anemia caused by chronic kidney

disease
**
38- the action of epiotin enhanced with
a-iron
b-vit.b12
**
39-with anti-inflammatory and analgesic : ibuprofen

**
40-patient with hepatic and renal failure which of the following skeletal
muscle relaxant can be used
a-atracurium
b-vecuronium
c-doxacurium
**
41-tyrosine kinase class II receptors are insulin receptors
**
42-drug of choice for pneumonia is pencillins
**
43-mechanism of action of choloroquine(anti malaria ) : choloroquine
bind to heme and prevent it's polymerization to hemozin
**
44-P.C: after meal
A.c: before meal
P.R.N: as needed
QID=QDS=4times daily
**
45-quinidine(anti arrythma) side effect : cinchonism

**
46-treatment of h.pylori infection by triple therapy
(proton pump inhibitor+2 antibiotics)
(omeprazole+clarithromycin+(amoxicillin or metronidazole) )
Page 8
**
47-desmopressin used in treatment of : nocturnal enuresis and diabetes
insipidus
**
48-mechanism of action of clomiphene :
Inhibit negative feed back of estrogen
**
49-rifampicin is used in : leprosy &tuberculosis
**
50-morphine act on mu receptors
**
51-after drug metabolism the drug become
a-polar
b-nonpolar
c-active
d-nonactive
**
52-antidote of iron toxicity: desferroxamine
**
53-digoxin shouldn't be taken with renal failure
**
54-amphotericin-b is
a- parentral anti fungal
b-oral
c-subc
**
55-drug of choice for pseudomonal aeruginosa is:
a-meropenem
b-penicilln
c-imepeinm
Carbepenems (Imipenem, Meropenem, Doripenem) have the propensity to

induce resistance during treatment & Fluoroquinolones (Ciprofloxacin,
Levofloxacin) are the only class of antibiotics which has an oral
formulation that is reliably active against P. aeruginosa
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**
56-digoxin toxicity increased with
hypokalemia or hypomagnesmia or renal failure all of them
**
57- lorazepam is hypnotic at dose of 4mg
**
58-antibiotic which cause yellow teeth tetracycline
**
59-long acting) insulin is :
a-NPH
b-glargine(
c-regular
NPH ==> intermediate acting and no excess protamine (basic)

**
60-antidote for patient with drowsiness , drymouth ,and pupil constriction
:
a-naloxone
b-methadone
**
61-routine medication for influenza is

a-antibiotic
b-antiviral
c-influenza vaccine
**
62-atenolol is selective beta 1 blocker

**
63-acyclovir is used for herpes simplex
**
64-albumin and dextran and starch are colloid solutions
**
65-which of the following used in treatment of anaphylactic shock
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**
a-epinephrine ( used as broncho dilator)
b-cimetidine
c-reserpine
**
66- loop diuretics (furosemide) cause ototoxicity ( deafness)
**
67-drug need serum creatinine to be monitored
a-gentamycin (aminoglycoside)
b-cefourixme
c-doxycycline
**
68-drug need serum level monitoring with quinidine :digoxin
**
69-magnesium sulphate( antiacid) has cathartic side effect so used as
laxative
**
70-beta2 blocker and aspirin are contraindicated with
a-asthma
b-hypertention
c-diabetes
**
71- ascorbic acid is : vitamin c

**
72- B-carotene is precursor of vitamin A(retinol)
**
73- beta blocker with intrinsic sympathomimetic activity :
pindolol and acebutalol
**
74- fluoxetine is SSRI(selective serotonin reuptake
inhibitors)antidepressant
**
75-insulin given iv is : regular

**
76-zyrtec family is h1blocker
(zyrtec (cetirizine)
**
77-oral contraceptive work on Gnrh hormone in phase of ovulation

**
78-nevirapine is used for treatment of HIV (AIDS)
**
79-for otitis media in children use high dose of amoxicillin
note :that if there is no (high dose of amoxicillin) choose
(azithromycin)
**
80-loperamide stimulate MU receptors
**
81-etidronate used for osteoporosis or paget disease
**
82-hydralazine is category C pregnancy
**
83-reflex tachycardia of hydralazine treated with
a-propranalol
b-amiolride
c-naloxone
**
84-medication cause long Qr and bradycardia:
Qr.....propranolol
**
85-clonidine and methyldopa are alpha 2 agonists
**
86-amantadine(antiviral) used for treatment of parkinsonism

**
87-paracetamol is category B for pregnancy
Paracetamol (oral & rectal form) is category B and for (IV formulation) is
category C in pregnancy
**
88-diuretic of choice in renal failure:
a-loop diuretic
B-thiazide
**
89-rofecoxib is selective cox2 inhibitor

**
90-local anesthesia agent is lidocaine
**
91-which of the following anesthetics cause cardiotoxicity
a-lidocaine
b-Bupivcaine
c-mepvicaine
**
92-if aspirin taken with warfarin or heparin lead to bleeding
**
93-drug of choice for tape worms : praziquantel or neclosamide
**
94-deltiazem used in hypertension to inhibit calcium influx
**
95-mechanism of aminglycoside: protein synthesis inhibitor
**
96-antacid is used in heart burn to neutralize acidity
**
97-procss of using the drug is :ADMINSTRATION

**
98-corticosteroids with lowest potency : hydrocortisone
**
99-erythropoiten(eprex) will not be useful in case of iron deficiency
Erythropoietin should not be started until iron status has been evaluated,
and iron supplements should be given first in patients with evidence of
iron deficiency. An adequate response to erythropoietin requires the
maintenance of sufficient iron stores.
**
100-bromocriptine reduce prolactin level
**
101-emergency members should take the following vaccine to avoid
noscomial infection
a-influenza vaccine
b-meningitis
c-measles
**
102-antipsychotic cause agranulocytosis: clozapine atypical
**
103- metformin and metronidazol cause : metallic taste
Captopril cause loss of taste
**
104-treatment of myasthenia gravis( ) by pyridostigmine or
neostigmine
**
105-influenza vaccine contraindicated in (0-6) months baby
**
106-drug should be used with precaution in asthma :b2 antagonist
**
107-neuromusclar blocker block : acetylcholine

**
108-prazosin is post synaptic alpha1 blocker
**
109-influenza vaccine is safe for pregnant
(IIV) Inactivated influenza vaccine is safe for pregnant
**
110-clindamycin cause clostridium difficile
**
111-metronidazole used in treatment of clostridium difficile
**
112-for female with DVT , combination contraceptive shouldn't be used
(birth pills) . use only progesterone pills(levonorgestrel)
**
113-flutamide is used for treatment of prostate cancer
**
114-zanamivir is used for treatment and prophylaxis of influenza
115-daily dose in case of iron deficiency anemia
a-100mg three times daily
b-1200
c-200
d-300
**
Dose in iron defecieny anaemia is:A- 100mg tid
B- 212,5 mg tid
C- 275 mg tid
4- 325 mg bid
If in the question elemental iron: the recommended oral daily dose for
the treatment of iron deficiency in adults is in the range of 150 to
200mg/day of elemental iron"50-65 mg 3 times per day.
If in the question (ferrous sulfate): it is in the range of (1000

1200mg/day) of ferrous sulfate in 3 or 4 divided doses, 1000mg divided in
3 doses and 1200mg divided in 4 doses
**
116- omeprazole used before 30 minutes breakfast
**
117-probiotics are bacteria and yeast eaten to provide patient with health
**
118-ganciclovir(antiviral) used in treatment of cytomegalovirus
**
119-propylthiouracil cause agranulocytosis
**
120-digitalis arrhythmia can be treated with
a-phenytoin
b-quinidin
c-procainamide
d-propranolol
Ventricular arrhythmia >> Procainamide

Ventricular arrhythmia with heart block >> Phenytoin
Digitalis arrhythmia >> lidocaine .. in not exist so Phenytoin will be the
answer
**
121- cushing - like syndrome is due to
a) adrenal hyperplasia
b) adrenal hyporplasia
c) Hypothyroidism
d) hyperthyroidism
**
122-To know the severity of immunodeffiecency in HIV
a-ESR
b-LEUCOCYTE COUNT
c-WBC COUNt
d- CD4 count
**
123-Which of the following vaccine should be taken although you dont
need it
a-influenza vaccine
b-mmr vaccine
c- dap vaccine
**
124- which of the following drug taken by inhalation
a-Amyl nitrite or halothane
**
125-what is cytochrome subtype responsible for drug interaction between
omeprazol and clopidegrol :CYP2C19
**
126- digoxin mechanism : +ve inotropic effect
**
127- grinding of solid or powder in liquid or ointment is
a-LEVIGATION
c-disintegration
b-grinding
d-reduction
**
128-disintegration change the drug from tablet to final powder

**
129-warfarin oral anticoagulant determined or calculated by
INR: international normalized ratio
**
130-heparin injection anti coagulant determined by
APTT activated partial thromboplastin time
**
131-Which of the following used to counteract toxicity of a drug after 1
hour of ingesion
a-enema water
b- cathartics
c- activated charcoal
**
132-drug of choice for tape worms

a-Mebendazole
b-thiabendazole
c-neclosamide
Drug of choice in tape worms is (praziquantel)..if it is not available in

choices choose (niclosamide) is an acceptable alternative to be used.
**
133- which of the following decrease heart rate ?
a-phenylephrine
b- reserpine
c-metoprolol (beta1 blocker)
d-vasopressin
**
134- Which of the following is colloid solution ?

a-albumin
b-ringer`s solution
c- krebs solution
**
135-Which of the following is released by bacterial cell wall during
phagocytosis?
a-endotoxin
b-exotoxin
d-cytotoxin
e-non of the
above
N.B:
During infection or growth exotoxin
During phagocytosisendotoxin
**
136- Early symptoms of aspirin poisoning are :
a-lethargy & fatigue
b-throbbing headache & dizziness
d-ringing in the ears & blurred
c-fluid retention hypotension
vision
**
137-WHICH METAL USED IN TREATMENT OF RHEUMATOID
ARTHIRITIS?
A-GOLD
B-SILVER
C- COPPER
**
138-What first line agent may be considered for an obese type 2 ?

a-glyburinid
b-insulin
c-metformin
erepaglinid
TYPE 1 : insulin + healthy diet + exercise ..

TYPE 2 :
we have steps to follow with pt :
1- healthy diet + exercise = if not work go to next step
2- healthy diet + exercise + ORAL anti diabetic "metformin" = if not go to
the next step
3- healthy diet + exercise + ORAL anti diabetic + insulin
**
139- The antimalarial to be avoided in glucose-6-phosphate dehydrogenase
deficiency:
a-primaquine
b-quinine
c-chloroguanide
**
140- To increase duration of lidocaine in anasethia
a-propranolol
b-succinyl chline
c-epinephrine
**
141- Which organism is the cause of travelers diarrhea :E.coli
**
142- Anticancer from plant alkaloids origin:
A-Cisplatin
B- Cyclophosphamide
C-Etoposide
Plant origin ... Etoposide

Vinca Plant ... Vincristine, Vinplastin
**
143-Combination contraceptive act on :
A-Ovulation
B-Implantation
C-Follicle develpment
**
144- PPM mean:- part per million OR million part

**
145- Doxorubicin(anti cancer) side effect :-
a- cardiac toxicity
c- postural hypotension
b- nephrotoxicity
d- arrhythmia
**
146- Daily recommended dose for vit. C in male :-:

a-30mg/day
b-50 mg/day
c-90mg/day
d-200 mg/day
if asked in female the answer is 75mg \ day

**
147-
Drug after metabolized in liver it will become:-
A-polar
insoluble
b- non polar
c- Lipophilic
d-
**
148- which drug may used as anti-spasmodic
a-reserpine
propranolo
c-baclofen
b-amphetamine
d-
**
149- desmopressine used in :- nocturnal enuresis & diabetes insipidus
**
150- Coal tar uses in (psoriasis)
**
151- Cephalosporin act as:a-Inhibitors of cell membrane function
synthesis
c-Inhibitors of protein synthesis
synthesis
b-inhibitors nucleic acid

d-Inhibitors of cell wall
**
152- ISONIAZIDE used in Tuberculosis
**
153- The latin abbreviation for(state):- Immediately
**
154- Dopamine is used in cardiac shock as:a- decrease C.O.P.
b- Don't induce preiphral vasoconistriction
c- Increase .force of contraction
d- constrict selective dilate renal & mesenteric
**
155- Which of following is the drug of choice for treatment of all forms of
Schistosomiasis?
a-Praziquantel
Thiabendazole
b-Mebendazole
c-Niclosamide
d-
**
156-- which of these have interinsc sympathomemtices effect:
a-labetlol
b-timlol
c-nadolol
d-pindolol
**
157- amphetamine pharmacological action:
a- direct acting adrenergic agonist.
b-direct acting adrenergic
antagonist.
c- indirect acting adrenergic agonist.
d-muscarinic acting agonist
**
158-live attenuated vaccine:
a-measless,mumbs & rubella (MMR)
diphtheria
b-influenza
c-
**
159-sevelamer used in patients with chronic kidney disease for
a-Hypermagnesmia
Hyperphosphatemia
b-Hyperkalemia
c-
**
160- mechanism of action of clomiphene
a-inhibit negative feedback of estrogen

b-increase release of gonadotropin hormones
c-decrease estrogen
**
161- amikacin cause which of the following adverse effect
a-liver toxicity
failure)
b-cardiac toxicity
c-nephrotoxicity(kidney
**
162-which of the following diabetic drugs approved by fda for pediatric
use
a-pioglitazone
rastinone
b-metformin
c-glimeperide
d-
**
163- Pharmacy and therapeutic committee
a-storage of drug
c-expiration of drug
b-adverse effect
d-maintain of formulary of drug
**
164 - When the pharmacopeia put the drug as phase 4

a-safety
b- potency
c- indication
**
165- drug used to treat prostate cancer

a-flutamide
b-tamsulin
c-bethanecol
d-defranecin
**
166-which of the following used to deal with adverse drug effects
a-pharmacokinetics
c-pharmacoeconomics(cost)
b-pharmacovigilance(safty)
d-pharmacognosy(plants)
**
167- an elderly women with osteoporosis after giving her Calcium +

vitamin D she become better , so we give her in the next step :
a- teriparatide
c-alendronate
b- calcium gloconate
d-non of the above
**
168- a study in which we use different studies to make a conclusion :

a) double blind study
c) Continuous study
b) consensus statement
d) meta analysis
A "meta-analysis" is a statistical approach to combine the data derived

from a systematic-review.
so the answer is meta analysis or systematic review
meta analysis is not exist so will be the answer Systematic review
**
169- mechanism of using salbutamol inhaler
a-exhale , shake the inhaler , put it between your lips then breath slowly
**
170- drug of choice for gestational diabetes
a-insulin
b-pioglitazone
c-metformin
**
171-which vaccine should be taken every year
a-influenza vaccine
b-vzv
c-tetanus vaccine
**
172-estrogen antagonist and used first line in treatment of breast cancer
A-anastrazole
B -tamoxifen
**
173-drug of choice for giardiasis and amoeba
a-niclosamide
c-primaquin
b-metronidazole
d-mebendazole
**
174-Antidote for warfarin:
vit k or the other name of it phytomenadion
Alternative names of Vit. K

(Phylloquinone; K1;)
(Menaquinone; K2;)
(Menadione; K3)
**
175-toxidrome is
a-over poison induced syndrome
b-steps involved in treat of toxicity
c-symptoms and signs due to toxicity
**
176-a geriatric patient with osteoarthritis mild pain in hip . he has
hypertension and coronary artery disease what is the best drug for pain
a-glucosamine
c-ibubrofen
b-paracetamol(acetaminophen)
d-aspirin
**
177-how many phases applied to drug to be approved by FDA

a-1phase
b-2phases
c-3phases
d-4phases
**
178-prescription label should contain
a-patient telephone
c-patient name
b-physician telephone
d-physician name
**
179- FDA Fast Track what this mean:

a-For drug that shows promising results for life-threatening disease with
other drugs available can treat it
b- drug that shows promising results for life-threatening disease with NO
others available can do that
c-drug that shows cost effectiveness
d-drug with side effects
**
180- Cervical cancer caused by or treatment of infertility or to prevent

cervical cancer
a-hpv (human papilloma virus vaccine)
b-tdap
c-dtp
**
181-Thimerosal (mercury)containing vaccine may cause: autism
**
182- Unit dose cassettes in hospital has doses of:
a-day
b-week
c- next change
d-single dose
**
183-septic shock patient with normal sodium value with high potassium
and creatine the treatment is : dopamine
- Cardiac shock = Dopamine
- Anaphylactic shock= Epinephrine
- Septic shock= 1.intravenous fluid (normal saline) first
2.Dopamine
Septic shock in this question with normal sodium level and renal failure
(kidney injury)= Dopamine
**
184- Nitro glycrin side effect is:a-headache
b-bradycardia
c-hypotension
**
185- loperamide act as:
a- Opioid antagonist anti-diarrheal
b- analgesic
c- in parkinsonism
d- opioid agonist anti-diarrheal
**
186- florouracil is Pyrimidine derivative
**
187-which of the following is more prone to influenza symptoms and

problems
a-geriatric patient
years old
b-pregnant
c-children older than 12
**
188- when taking oral contraceptive with erythromycin :

a) the erythromycin increase contraceptive effect
b) the contraceptive increase erythromycin effect
c) the erythromycin decrease contraceptive effect
d) the contraceptive decrease erythromycin effect
**
189- the best drug to be used as an anti-platelet drug ?
a) clopidogrel
c) warfarin
b) urokinase
d) Abciximab
**
190- Opioids can be used as :

a) analgesics
c) anti- epeleptic
b) anti_hypertensive
d) in chemotherapy
**
191- a drug used to treat prostate cancer : a-Androcure

Flutamide and androcure are anti androgenic drug to treat prostate cancer
**
192- vit c for female: 75mg
**
193- which of the following is indicator for a toxicity of a drug
a) necrosis of liver by acetaminophen
b) carcinogenesis in chemotherapy
**
194.
The answer of table :

**Drug A is anti renin (rennin blocker)
**Drug B is ace inhibitor
**Drug C is ARB(angiotensin receptor blocker)
**Drug D is diuretic
**
195-cyclizine is used in nausea and vomiting
**
196-Captopril is contraindicated with ::
a-Pregnancy
CHF
b-hypertension
c-diabetes
d-
**
197--Drug with high Distribution Volume , What Means :
a-drug has Diffuse distribution
b- localized distribution
c-conc. of drug in plasma is higher than that in tissues
d- conc. of drug in tissues is higher than that in plasma
Note : Vd= total amount of drug in the body / drug plasma conc
**
198-A fixed dose of drug that follows 1st order elimination depends on ::
a- dose of drug
b- dosing intervals
c- elimination Half-life
to reach STEADT STATE for drug follows 1st order it depends on rate of
elimination
**
199-Kidneyfailure patient with hyperkalemia which of the following
should be used
a-insulin
b-thiazide diuretic
c- calcium carbonate (may use calcium gluconate or calcium carbonate)
d-spironolactone
**
200-the oesophageal ulcer occurred due to: increase gastric secretion
**
201- if a medication error happened , the first person to refer to :
a) patient
b) prescriber
c) medication safety office
**
202-- another definition for a soluble solution : homogenous
**
203- Opioids can be used as:
a- analgesics
c- antiepileptic
b- anti hypertensive
d- in chemotherapy
**
204- 2 years old child come to clinic for taking hepatitis vaccine , we
know that he took pneumonia vaccine from month ago , so we should :
a- give him the vaccine immediatly
c- wait for 6 months
b- wait for 3 months

d- wait for 1 year
**
205-acetyl salicylic acid used in :

a-antibiotic
b-analgesic
c-anticancer
**
206-which of the following is less potent than tubocurarine

a-Doxacurium
b-succinylcholine
c-rocuronim
**
207-which of the following conditions have non preventable adverse
effect ?
a-allergy from amoxicillin with some one is known that hasn't adverse
effect with any drug
b-tachy cardia with some forgot his dose of anti hypertensive drug and
took 3pills
c-half dose of acetaminophen will cause fever

**
208-which of the foolowing is contraindicated with angina
a-aspirin
b-isosorbide
c-metoprolol
d-vassopresin
note : with angina/ vasopressin: vasopressin worsens cardiac output in

angina , with asthma : aspirin
**
209-phentolamine mechanism of action
a-adrenergic antagonist
b-alpha antagonist
c- adrenergic agonist
**
210-usual daily dose of phenytoin
a-100-300mg
b-15 mg
c-6mg
d-3mg
**
211-mechanism of action of dantrolene :
(direct acting)
a-cause skeletal muscle relexant bybinding to the ryanodine receptor
decreasing intracellular calcium concentration
**
212-ergot alkaloid used in
a-Uterine stimulant
b-hyperlipidemia
c-hyperuricemia
**
213-perphenazin used in (anti psychotic)
a- nausea and vomiting
b-gout
**
214-used for alzehimer : a-donepzil

**
215-phenylephrine used in
a- decongestion
b-hypertension
c- arrhythmia
**
216-Which of the following used as anti estrogen when used cause
abortion
a-anastrozole
b-tamoxifen
**
217-which of the following can be used in treatment of hyperthyrodism ?

A-potassium iodide
chloride
b-sodium chloride
d-potassium
**
218--storage of narcotic prescriptions according to Saudi national

regulations
a-6 months
b-12 months
c-24 months
d-36 months
**
219-You should keep the prescription of narcotics in the pharmacy for
a- two year
years
b- three years
c- four years
d- five
**
220-Release from bacteria during The growth :
a- Endotoxin
b- Cytotoxin
c-Exotoxin
**
221-drug dependence means: addiction
**
222-The following is related to dependence :
a- increasing dose of drug to obtain the same effect
b- increasing the dose of drug but no withdrawal symptoms
c- increasing the dose of drug associated with withdrawal symptoms if
sudden decrease
d- decreasing dose to obtain the same effect gradually
**
223-The following is related to tolerance :
a- increasing dose of drug to obtain the same effect
b- increasing the dose of drug but no withdrawal symptoms
c- increasing the dose of drug associated with withdrawal symptoms if
sudden decrease
d- decreasing dose to obtain the same effect gradually
**
So
dependence : increasing the dose of drug associated with withdrawal

symptoms if sudden decrease
tolerance : increasing dose of drug to obtain the same effect
**
224--drug interaction between
a-furosemide and osteoporosis (cause hypocalcemia)
b-pirocxicam and heart failure
**
225- Effect of aspirin decrease prostaglandin
**
226- drug decreases synthesis of cholesterol in liver
Simvastatin
**
227- Dont give vaccines to:
A-hypertension patient
b-patients with kidney disease
c- Patients with CD4 < 200
live vaccine c/i with which of the following
choose pt who have CDcount less than 200
**
228- anti diabetic drug used in pregnancy
A-rosiglitazone
b- Metformin
c-glargine Glargine is long acting insulin
NOTE:
Metformin is category B in pregnancy & can be used.
Insulin is the drug of choice in gestational diabetes (diabetic
pregnant) but glargine (long acting insulin) is category C in
pregnancy.
If there is no insulin in choices choose metformin NOT glargine.
**
229- drug for esophageal reflux Pantoprazole
**
230-Drug exaggrated blood glucose hydrochlorothiazide (cause hyper

glycemia)
**
231-Drug exaggrated insulin metoprolol(masking hypoglycemic
symptoms)
**
232- Analogue for HIV zidovudine
**
233- Omeprazole can be used as a single drug in:
A-gastric ulcer
B-pylori-gastritis
c- gastritis as a side effect of Nsaids
**
234-antibiotic with diarrhea as a side effect
a-doxycycline
b-ciprofloxacin
c- Amoxicillin combination with clavunic
**
235- Antidote : antagonism of the toxicity of over dose of a drug
**
236- The most dangerous adverse effects of Amikacin is: (kidney
disease)
Kidney damage and hearing loss( nephrotoxicity and ototoxicity)
(as all aminoglycoside)
kidney damage = nephrotoxicity \\\ hearing loss = ototoxicity
**
237-45 year old man his volume of distribution is 35 L what the
interpretation
A-drug is bound to DNA
B-Drug is lipid soluble
C-drug is highly distributed in.plasma
D-low bioavailability of drug
**
Vd = total amount of drug in the body / drug in plasma conc so vd =

increase conc in tissue + decrease conc in plasma
**
238-Man came to ER vomiting and dizzy...after he ingested toxic dose of
certain drug Which is the most important step?
A-decrease amount of drug absorbed
B-Increase elimination of drug
C-Watch the vital signs and Make them normal
D-Compensate the neurological symptoms of the toxicity
**
239- which of the following cause metallic taste
a-metoformin
b-cimetidine
c-captopril
Mtformin & metronidazole .. metallic taste
Captopril .. loss of taste
**
240-Women came to the ER with pointed pupil. With vomiting and
dizziness... Which drug is responsible?
A-Heroin (Heroin because it is opoid agonist and cause miosis)
B-Cocaine (Cocaine ia indirectly sympathomimetic and cause mydriasis)
Note :
cocaine make mydriasis & Heroin miosis as morphine =pin point pupil
**
241- The most error that may occur when a patient is transferred from
one unit of facility to another
A-wrong dose
B-wrong drug prescribed
C-Missing drug he was taking
**
242- The prescribion of drug should contain:
A-prescriber name
C-patient telephone
B-prescriber telephone
D- Pharmacist name
if the priscribtion contain opoids the answer will be Patient name

**
243-- Pregnant woman taking valporic acid go to physician with tonicclonic seizures.. Which of the following is true?
a-stop valporic and use another drug

b- Use valporic with iron supplementation
c- use valporic with folic acid
d- Use valporic with multivitamins
e- go to the doctor
the answer is C if go to doctor in option so the answer is E
**
244- Phenytoin decreases the effect of digoxin because:
a-liver microsomal enzyme inducer
b-Liver microsomal enzyme inhibitor
**
245- Unit dose system in hospital :
a-to decrease medication error
b- to decrease medication cost
c- to decrease size of the area of the drug
**
246- Nitroprusside in congestive heart failure patient is administered by:
a-Sublingual
b-Transdermal
c-Subcutaneous
d-slow i.v.
infusion
**
247-which of the following is an antimetabolite and anti-cancer :
a-Etoposide
b-Cisplatin
c-Fluorouracil Antimetabolite (Pyrimidine Analog)
**
248 -Pregnant woman with G6PD deficiency has G-ve. M.o. and UTI,
which is the drug of choice to treat her UTI:
A-vancomycine
C-cefuroxime
B-nitrofurantoin
D-sulphamethoxazole
N.B:
Nitrofurantoin & Sulpha drugs cannot be used in GDPD deficiency
patients because it has high risk to them.
**
249- Pregnant woman has UTI (Urinary Tract Infection) which is the drug
of
choice to treat her UTI :
a-ciprofloxacin
nitrofurantoin
b-tetracyclin
c-sulphamethoxizole
d-
If there is no cefuroxime as an option choose nitrofurantoin in this

case
Nitrofurantoin is pregnancy category B. It is one of the few drugs
commonly used in pregnancy to treat UTI & contraindicated only at
term (during labor & delivery).
vancomycin is the last choice
Sulphamethoxazole & tetracycline cannot be used in pregnancy
**
250- acetylcystiene is
A- Laxative
B- mucolytic
C- Skeletal muscle relaxant
**
251-drug that makes urine red
A- Rifampicin
b- nitrofurantoin (brown)
**
A-Drugs that make urine red are:
phenazopyridine
senna laxative
rifampicin
Doxorubicin
B-Drugs that make urine brown are
metronidazole dark urine
nitrofuration brown colour
**
252- which antibiotic more likely to cause diarrhea
a-ciprofloxacin
b-doxycycline
c-penicillin
Augmentin
d-
NOTE : Augmentin = Amoxicillin + clavulanate potassium

**
253-Drug stored in the body in
a- fat
b- protein
c- connective tissue
A&B
d- muscle
If youdon't have "a&b" the answer will be "fat"

e-
**
254- If a drug has the same active ingredient like other drug but not
contain the same inactive ingredient this mean-:
a- Bioequivalent
c- pharmaceutical alternative
b-pharmaceutical equivalent
d- A and B
**
255- Enkephalins are peptides that:

a- have narcotic antagonist activity
b-similar in action to morphine.
c- are found only in the central nervous system.
d- cause blood vessel wall relaxation
e- transmit pain impulses
**
256- To know the severity of immunodeffiecency in HIV
a-ESR
c-WBC COUNt
b-LEUCOCYTE COUNT
d- CD4 count
**
257-The ethical principle of veracity requires that:

a. we respect the rights of others to make choices.
b. we act with honesty, without deception.
c. we avoid, remove or prevent harm.
d. we do good to patients.
e. we act with fairness.
**
258- The style of management in which the owner of a pharmacy
emphasizes the development of detailed policies and written procedures
for employees to observe at all times is referred to as:
a. autocratic
c. participative
.b. bureaucratic.
.d. benevolent.
**
259- A patient purchasing sublingual nitroglycerin tablets should be told

to store the medication:
a. in the refrigerator.
b. in a plastic vial with a childproof cap.
c. with the original cotton.
d. in an amber glass bottle with a metal cap.
e. in a warm, dry place
**
260- Following the ethical principle of nonmaleficence requires that
pharmacists:
a. respect the rights of patients to make choices.
b. do good to patients, placing the benefit of the patient above all else.
c. avoid, remove or prevent harm from people.
d. act with fairness, allowing people access to pharmacy care.
e. act with honesty, without deception.
**
261- Hydroxyurea is antineoplastic drug
**
262- Which one of the following is taken orally
a-Estrogen
c- Estrogen malate
b- Estrogen gluconate
d- all of the above
**
263- The responsibility of pharmacist in hospital is

a- administration of drug
c- deal with drug interaction
b- deal with patient

d- notice effect of drug
**
264- Plasma conc. Of drug in all body is
a- rate of absorption
c- rate of binding
b- rate of distribution
d- therapeutic volume
**
Q.You should keep the prescription of narcotics in the pharmacy for
a- two year
b- three years
c- four years
d- five years
36
**
265-The following statements are wrong about domperidone except
a- anti-emetic without CNS effect
b- anticoagulant
c- anti-emetic with sever CNS effect
d- non of the above
**
266- Pka for normal water in room temperature :
A- 7
B- 14
C- 7^10
D- 10^14
**
267- drug make urine red other than rifampicin?
phenazopyridine (Pyridium), and laxatives containing senna
**
268-syncop may occure with the 1st dose of the folowing
c-prazosin
d-reserpin
a-digoxin
b-salbutamol
**
269 -which one is more effective agaienst in traveller diarrhea:
a-amoxiciilin
c-sulphamethoxasol
b-ciprofloxacin
d-erythromycin
N.B: quinolones have been the drug of choice

**
270- antihypertensive produce tackycardia :
a)Hydralazine
b)Reserpine
c)Methyldopa
d)Atenolol
**
271- the action of digoxin can reduced with
a- antacid
d-hypothirodism
b-verapamil
e-hyperthyrodism
c-hypokalemia
a & e both are right

**
272- the main cause of digitalis toxicity is
a-diabetes milli
b-hypertension
c-hepatitis
d-renal faliure hypokalimai is main cause of digitalis toxicity
**
273- digitalis arrhythmia can be treated with
a-lidocain
b-quinidin
c-procainamide
d-propranolol
Digitalis arrhythmia treatment drugs RESPECTIVILY :
1.lidocaine
2. phenytoin
3. procainamide
4. propranolol
**
274- which one used in ventricular arrhthmia with heart block Phynetoin
**
275-which one is antiarrythmic class 1A
a-phynetoin
b-disopyramide
c-propranolol
d-verapamil
**
276-- Anticancer derived from plant origin NOT venca_
Etoposide
- anti cancer derived from venca is_ Vincristine
Plant origin ... Etoposide
Vinca Plant ... Vincristine
**
277-which one used to trigeminal neuralgia
tegretol(Carbamazepine)
**
278- process require CYP450 :
a)Oxidation
c)Glucoronidation
b)Hydrolysis
d)Deamination
**
279- Adsorption , which is not true :

a) Chemical property
c) Reversible
b) Physical property
d) Irreversible
e) A + d
**
280- about steady state concentration during IV administration
a-directly proportional to volume of distribution

b-inversly proportional to volume of distribution
c-directly proportional to infusion rate
d- inversly proportional to total body clearance
e- c&d
**
281-which of the following decrease gastric emptying rate
a- metoclopramid
c- hypothyroidism
b- atropine
d-b&c
**
282-one of following is not alpha 2 agonist :
a) Clonidine((alpha 2 agonist ))
b) Alpha methyl noradrenaline
c) Guanfacine
d) Guanabenz
e) Guanethidine
- about side effect of quinidine :
Cinchonism
Q- volatile substance given by inhalation:
a) Halothane**
**
283-about digitoxin , which is false :
a) Oral bioavaiability 100%
b) Protein binding 95%
c) Half life is 7 days
d) Mainly hepatic metabolism by microsomal
N.B: oral bioavailability of digitoxin 90% (practically we call its
completely absorbed) and 70% for digoxin
**
284-to compare between 2 drugs use:
a) Physical appearance
b) Weightif comparing bioequivalency))
c) Pharmacokinetic parametersif effect
d) Pharmacodynamic parameter
e) Taste
N.B: c and d are true .. in the exam must give one of them not both
**
285- about sid effect of oral contraceptive except :
a) Depressoin
b) Hypertension
c)constipation
**
286- drug used in ventricular arrhythmia :
a) Phynetoin
Verapamil
b) Quinidine
c) Procainamide
d)
N.B: If asked arrhythmia with heart block the answer is phynetoin

**
287- in tolerence
patient need more dose to obtain the same effect
**
288- causes of hypo thyrodism :
iodine deficiency , low hypothulmus&pituitary hormons
**
289-phenytoin uses other than anti convelcent agent are :
ttt irregular heart beat&ttt painful nerve coduction (neuralgia)
**
290- arrhythmia due to :
dysfunction in generate heart pulse or conduction of it abnormal
impulse conduction and abnormal impulse propagation
**
291- Hydralazine, vessel relaxation. It dilates arterioles more than veins.
**
292- guanthedin SE are all
a-prevent ejaculation
b-orthostatic hypotension
c- diarrhea
**
293- not from WBC
a- reticleucyte
**
294- about minoxidil

a - it decrease myocardium contractility
b - dilate arteries only
c- cause bradycardia
295- mizolastine used as
**
a- antibiotic
c - anti platlet
antihistaminic
b- anticoagulant
d- ) non sedating
**
296- all these drugs are anti metabolite execept
Cisplatin
**
297- about digioxin what is not true ?
taken only orally
**
298- Captopril and Enalapril do all the following except:

a- Increaserennin concentration in blood
b- Inhibit an enzyme
c- Competively blocks Angiotensin II at its receptors
d- Raises the blood Potassium concentration
**
299- Various opiates may be used as all of the following except:
a- Analgesics
b- Anti-inflammatories
c- Antidiarreals
d- Aids to anesthesia
e- Antitussive
**
300- Which of the following action is not seen with sympathomimetics ?
a- Pupil constriction
b- Increased heart rate
c- Bronchiole dilation
d- Systemic blood vessel constriction
**
301- Which of the following beta-adrenergic agents is not short acting?
a- Pirbuterol
b- Salmetrol
c- Terbutaline
d- Albuterol
**
302-Which of the following drugs is not a Tricyclic Antidepressant?
a- Trimipramine
b- Maprotiline (tetracyclic)
c- Nortryptiline
**
303- The most common disintergrator in compressed tablets is
a- Dextrose
bitartrate
b- Lactose
c- Starch
d- Potassium
**
304-Which of the following is found in vitamin b12?
a- Magnesium
b- Nickel
c- Iron
d- Cobalt
**
305-Gums are used in tabletting primarily as
a- Disintegrators
c- Lubricants
b- Glidants
d- Binding agents
**
306-Cyclosporine is used for

a- allergies
c- prevention of transplant rejection
b- angina
d-steroids deficiency
**
307-Ultra-short acting barbiturates are used primarily as
a- Sedatives
c- Anti-parkinsonian agent
b- Hypnotics
d- Preanesthetic agents
**
308-for a 4 year old child, the maximum daily dose of paracetamol is
a- 240mg
b- 480 mg
c- 1 g
d- 2 g
N.B. Dose for children of paracetamol:

Four years old child should take 240 mg paracetamol per dose,
repeated every four hours, Maximum: 5 doses daily>>>>> so, 5 x
240mg= 1200 mg =1.2g choice: 1g (as age based dose)
For (age based dose): 10 to 15 mg/kg/dose every 4 to 6 hours as
needed; do not exceed 5 doses in 24 hours; maximum daily dose: 75
mg/kg/day
Adult maximum dose of paracetamol: 4000mg = 4g

**
309- To supply the myocardium with O2 shortly after myocardial
infarction we give
a-anticoagulant
b-fibrinolytic
c-aspirin
d-ACEI
**
310-Which one of the following cannot be dispensed without prescription:
a- Ibuprofen
c- Aspirin
b- Doxycycline
d- Bisacodyl
**
311-The aim in the management of uncomplicated hypertension:
a- > 90\65
180\110
b- > 130\80
c- > 150\95
d- >
**
312- A hospital on formulating drugs, Efficacy, Work overload, and Costs
are taken in concern. A, B, C, D, and E are antifungal drugs available in
the market. All have the same efficacy. The hospital was using drug E for
a period of time. According to the following data which drug is best to be
used by the hospital:
DRUG COST FREQUENCY DURATION
A-3.25 BID 14 DAYS
C-5.5 BID 7 DAYS
B-2.25 ONCE DAILY 14 DAYS

D-2.25 BID 7 DAYS
**
313- Solid dosage forms are better than Solution dosage form because:
a- Accurate dose
stable
d- Faster action
b- Easy to handle
c- More
e- a&b and c
**
314- Tolerance is a problem when using Nitroglycerin, which of the
following is true:
a- Tolerance doesn't occur in young patient
b- Over 50 years patient doesn't develop tolerance
c- Dosing schedule may affect tolerance
d- Isosorbide dinitrate doesn't develop tolerance
**
315- arranging the electro magnetic waves alpha,,, beta,,,gamma in an

increase ranking in air will be
a-alpha,beta,gamma
b-beta,gamma, alpha
c-gamma,,alpha,,beta
d-alpha,,beta negative,,,gamma,,,beta positive
**
316-indapemide used in
Pulmonary eodema
Essential hypertension
if we have choice both of them this choice is correct or if not have both we
must choice essential hypertension
**
317- one of the followimg not related to heparin
a-prevent blood clotting
b-decrease antithrombine time
c-prevent formation of factor VII
d-used in pulmonary empolie
Warfarin affects the vitamin K-dependent clotting factors (II, VII, IX,X) ,
whereas heparin and related compounds increase the action of
antithrombin on thrombin and factor Xa
**
318-Which not effect of caffiene-:
a)preiphral vasoconistriction
c)dieresis
d)skeletal muscle relaxant
b)cardiac stimulation
e)stimulation of C.N.S
A & D are false because caffiene cuz cerebral VC not preiphral
**
319-Hypertonic solutions can be adjusted by:
a-Add Nacl salt to solution
b-add any other salt
c-Make dilution by add more solvent

d-This solution can not be adjusted
**
320-enteroHepatic recycling depend on all of the following except:
a-Dosage form of the drug
b- Extent of drug passed in feaces
c- extent of drug absorption from stomach
d-gall blader state
**
321-which of the foll. drugs show most multidrug resistance
a)antibiotics
c)a&b
b)anticancer
**
322-The following liquids are least likely to be miscible:

A- polar + polar
C- non-polar + non-polar
B- non-polar + polar
D- all of the above will be miscible
**
323- At 25 C, benzoic acid is much more soluble in benzene (C6H6) than it

is in water. In this situation benzoic acid could be considered to be:
A- Hydrophilic
C- Non-polar
B- Colloidal
D- Polar
**
324- The following properties are similar for both solutions and
suspensions:
A-The components of both solutions and suspensions can be separated
from each
other by physical processes. .
B-Solutions and suspensions are composed of two or more components.
C-Solute in the solutions and suspensions settle out over a period of time.
D-Both A and B
**
325- Concerning COX-2 inhibitor, which is not true ?
A- they have lower risk gastric adverse reactions than non-selective agents
B- good evidence about their effectiveness in osteoarthritis
C- cardiac toxicity is a recent concern of this class of drugs
D- they are. usually administered once or twice daily
E- combination with non-selective agents provide additional benefit
**
326- In the treatment of the osteoporosis, which of the following is not
correct:
A- alendronate should be taken in the morning 60 min before breakfast
B- calcium and vitamin D are essential
C- hormone replacement therapy (HRT) should be considered in all
postmenopausalpatients with osteoporosis
D- outcome should be assessed with periodic bone density studies
E- raloxifene is selective estrogen modulator that is contraindicated in
DVTpatients
We use HRT when other ttt have failed
**
327- Side effects of albuterol include which of the following?
A- Bradycardia
D- Hypotension
B- Tachycardia
E- Alopecia,
C- Convulsion
**
328-Which of the following side effects is associated with the use of
norepinephrine:
A-Nausea and vomiting.
B- Ischemic damage due to vasoconstriction and tissue hypoxia.
C- Hypoglycemia due to increase insulin reiease.
D- Skin rashes.
E- Headache and constipation.
**because the drug vasoconstriction
**
329- the pharmacological property of amphetamine is:
A- Causes release of estrogen.

B- Causes release of stored norepinephrine.
C- Does not cross the blood brain barrier.
D- Causes the release of stored acetylcholine.
**
330- Which of the following statements describing first dose phenomenon
that associatedwith prazosin is true? .
A- A marked increase in the level of glucose following the initial dose of
prazocin.
B- A marked decrease in the level of glucose following the initial dose of
prazocin.
C- A marked increase in the level of cholesterol foilowing the initial dose of
prazocin.
D- A marked postural hypotension 30 to 90 minutes following the initial
dose of prazocin.
**
331- all the following diazoxide side effects except
a-tachycardia
c-hyperglycemia
b-diuresis
d-hyperuricemia
**
332- which one causes hypotension due to blockage of efferent limb

baroreceptor reflex
a- bretylium
amphetamine
b-phenytoin
c- ranitidine
d-
**
333-thiopental is ?
a ) short acting barbiturates
c ) spinal anaesthesia
b ) long acting barbiturates

d ) antihistaminic
**
334- which of the following is NOT macrolide antibiotic?

a ) erythromycin
c ) chloramphenicol
b ) spiramycin
d ) clarithromycin
**
335- Digoxin action except :a-+ve inotropic
b-shorten refractory period in atrial and ventricular myocardial
c-increase conduction velocity in AV node
d-contraction of myocardial muscle
**
Q-All of the following to decrease the exposure to the radiation except
a-increase the distance from radiation source
b-out from the place of radiation
c-put shelves
e-decrease the activity of radiation person
**
336- Milironin has following except :
a-+ve inotropic
b-vasodilator
c-increase ca intercellular
intercellular
C....as it increase ca intracellular not
d-phosphodiasterase inhibitor
e-potantiate the effect of CAMP
**
337- Very small molecule(1 part ) soluble in more than 10,000 part of water
a- fairly soluble
b- slightly soluble
C-immiscible
d- miscible
e- insoluble
**
338- Which one of the following cause hypertensive crisis if withdrawn
suddenly
a- Clonodine
b- hydrochlorthiazide
c- b-blocker
d- prazocin
**
339-which one is not effect of Nitroglycerin vasodilation
b- slow heart rate
a- relax of biliay muscle
c- taken sublingually
d- decrease blood pressure
**
340-protect from light" in usp means :
a- air tight container
b- plastic container
c- Light resistant container
d- Amber glass
e- Amber plastic
N.B: if the ques. asked about "InUSP " the answer is Amber glass
if not the answer is " Light resistant container"
**
340-drugs have different crystal structures so different in

a-polymorphism
b-solubility
c-crystalitis
d-drug form
**
341-DAILY intake of vitamin A for adult female is :
a-500 mcg
b-700 mcg
c-1500 mcg
accurate doses (if mentioned in other question)

adult male
adult female
pregnant
breastfeed
1000 mcg
800 mcg
900 mcg
1200-1300
**
342-most potent anti-inflammatory corticosteroid systemically is :
a-cortisone
b-hydrocortisone
c-triamcinolone
d-prednisone
e- dexmethasone
**
343-suspension eye drop differ than ophthalmic solution in:
a-less commonly used
b- decrease contact time of drug with
eye
c- used for insoluble drugs
d- a&c
**
344-cushing - like syndrome is due to
a) adrenal hyperplasia
b) adrenal hyporplasia
c) Hypothyroidism
d) hyperthyroidism
**
345- Morphine causes respiratory depression by
a) depression of respiratory center in brain
b) activation of respiratory center in brain
c) depression of CTZ receptors center in brain
d) activation of CTZ receptors center in brain
**
346-Calcium-channel blockers mode of action
a) increase the inward calcium to cells
b) decrease the inward calcium to cells
**
347-which is (are) electromagnetic waves??
a)X-ray
b) Beta- ray
c) Gama- ray
d)a+c
**
348-Phenylepherine
a- used in nasal decongestant
b-in high doses stimulate b adrenergic receptor
c- not substrate for chatecholamin omethyltransferase ( comt)

e- both a and b
**
349- One of the statement considering Tetracaine One of neuromuscular
blockera-In the ttt of T.Bb- Opioid analgesicc- Vit d metabolited- The most one of choice in spinal anaesthesia
**
Q- Neuromuscular blocker is used of choice in renal and hepatic failure:
A -tubocurarine.
B - Vecuronium.
C -pancuronium.
D -gallamine.
E atracurim
**
350- enzyme kinetics law:
A - MichaelisMenten law.
C -franks law
B -henry s law.
.D - Henderson hasselbach law.
**
351-amphetamine pharmacological action:

A - direct acting adrenergic agonist.
B -direct acting adrenergic antagonist.
C - indirect acting adrenergic agonist.
D - indirect acting adrenergic antagonist.
**
352-most described dosage solid form:
a-powder
b- tablet
c- soft capsule
d- hard capsule
e- both types of capsule

**
353- has 5-HT antagonist and H1 antihistamine effects Cyproheptadine

**
354- Dobutamine is used as:
a- Parasympathomimetic
c- Hypotensive agent
b- In cardiac surgery
d- All of the above
**
355- Controled released drug delivery depends on:

a- Body fluid interaction
b- Enzymatic reactions
c- Ready programmed&no influece of the body fluid
d- Stomach PH .
**
356- All of these are antichlonergic except:
a- Atropine sulphate
b- Hydroatropine
c- Mebeverine
d- Iprotropium bromide
**
357- all these drugs used in ameobic dysentery exept
a-metronidazole
b-diloxanid
c-gentamycin
d-tetracyclin
**
358-Example of pathological toxicity:
A-carcinogenesis from chemotherapeutics
B-Hepatic necrosis from acetaminophine
C-dry mouth of antidepressant
**
359- Allopurinol
a- uricosuric
b- Anti-inflammatory
N.b:
1- uricosuric drugs are substances that increase the excretion of uric acid
in the urine, thus reducing the concentration of uric acid in blood plasma
2- Allopurinol decrease uric acid synthesis (xanthine oxidase inh.)

3- Probencid Increase uric acid excretion (prevent uric acid reabsorption)
(probenecid is a uricosuric.)
**
360- Antidepressant helps in stop smoking
a- citalopram
(Zyban)
b-nofodozine
c-trimipramin
d-bupropion
note:
Bupropion is a ( Dopamine/Norepinephrine-Reuptake Inhibitor) used in
smoking cessation.
Nortriptyline (TCA) is used as (off-label) use in smoking cessation.
Champix (Varenicline) is partial nicotine agonist used in smoking
cessation aid also.
**
361- Amount of water in adult male 60%
N.B: male 60 % female about 55%
**
362- Neuromuscular blocker has the lowest t half
Succinylcholine
**
363- Clonidine MOA in treatment of Hypertension:
Alpha2 Agoinst decrease sympath outflow
it inhibits the release of norepinephrine (noradrenaline) in a form of
negative feedback
**
364- May used as anti-spasmodic

a-reserpine
Propranolol
b-amphetamine
c-baclofen
d-
**
365- Hormone released from posterior gland
a-FSH
b-TSH
c-ADH
d-vasopressin and oxytocin
N.B
1-An I.V infusion of oxytocin is used to induce labor
2-Vasopressin is antidiuretic hormone (ADH)
**
366- Food increase effect of
a-aspirin
b-lisinopril
c-doxycyline
d-Prpranolol
Food may decrease the rate but not the extent of oral absorption of aspirin.
**
367- Hb1genotybe hepatic patient (hepatitis C genotype 1) fot ttt take ?
a-interferon and ribavirin
b-first ribavirin then interferon
c-only interferon
d-only ribavirin
**
368- metabolism in intestine . Hydrolysis

**
369- Role of B-blocker for angina: Prevent reflex tachycardia(decrease O2
demand )
**
370-Drug cause renal disease aminoglycosides
N.B. Aminoglycoside cause ototoxicity& nephrotoxicity
**
371-The most rapid relief of acidity
a- omeprazole
b- antacid (Al/Mg hydroxide)
c- Sucralfate
d- H2 receptor antagonist
Note : PG for prophylaxis Antacid>>>Mg/AL hydroxide
neutralize acidity>>antacids
**
372- drug used for prevention of influenza
a-antiviral
b- vaccination
C-antibiotic
**
373- Which of the following dilate the lateral esophageal sphincter

A-calcium carbonate
B-verapamil
c-amlodipine
D-antacid
Amlodipine relaxes smooth muscles, including those of lower esophageal

sphincter and esophageal body
N.B:
1- verapamil CCB on the heart
2- Amlodipine CCB on BV
**
374-which of the following can neutralize acidity and treats gastritis
resulted from NSAIDs
c-proton pump inhibitors
a -prostaglandin E
b-h1 blocker
h2 blocker
d-
N.B:
Sucralfate (aluminum sucrose sulfate) , H2 blocker and PPI are effective in ttt
NSAIDs induced ulcer
The most effective is PPI
prostaglandin analogue (misoprostol ) (cytotec), gastric mucous barrier is
prophylaxis , cant treat the ulcer
**
375- Sodium bicarbonate antacid makes an out elimination of )
A-pka=1.2, weak acid
B-pka=5.1, weak acid
C-pka=7.8, weak base
D-pka= 9 , weak bas
**
376- a pregnant woman at 43 week pregnancy She began labor actions for
12 hrs. The contractions were strong at first but after some while became
very weak
Which of the following could be useful in her case :
A- ergotamine
B- saline infusion
C-oxytocin
**
377- Drug contraindicated with ischemic heart disease patient with

dyslipidemia:
a-celecoxib
B-simvastatin
N.B:
Dyslipidemia: A disorder of lipoprotein metabolism, including lipoprotein
overproduction or deficiency.
**
378-Side effect of albuterol
a-Tachycardia.
b- bradycardia
c-hypotension
**
379-Drug of choice in absence seizures .. ethosuximide
**
380- DOC tape worms
a-thiabendazole
b-mebendazol
c- Niclosamide
If praziquental is not an option .. choose Niclosamide

**
381- A diabetic old patient with hyperlipidemia complains of erectile
dysfunction so DOC
A) sildenafil
B) testosterone patch
**
382- a drug increases the effect of highly bound to plasma protein
a- digoxin
b-phenobarbiton
c-valporic acid
**
383-Rapid relief of acidity:
a- omeprazole
b- Al hydroxide
c- alginic acid
**
384-Anemic patient refuses to take injection so DOC:
a- Iron sucrose
b-Ferrous gluconate
c-Vit. b12
Note : ferrous gluconate taken orally
iron sucrose .. injection
**
385-the drug that most likely causes peptic ulcer
a- ibuprofen
b-indomethacin
c-diclofenac
d-naproxen
If there is piroxicam or ketorolac in choices choose them better
**
386- Drug that increases paracetamol toxicity
a-Alcohol ( ethanol )
b-phenobarbitone
**
386- Dopamine is used in cardiac shock as ..
a-don't induce peripheral vaso construction
b-decrease c.o.p
c-dec. force of contraction
d-selective dilate renal and mesenteric(vasodilation) **
387- Dopamine is used in cardiac shock as:a) decrease C.O.P.
b) Don't induce preiphral vasoconistriction
c) Increase .force of contraction

mesenteric
e) constrict selective dilate renal &
(dopamine will increase the force of contraction its b1 agonist so work on

heart in term of contraction)
Dopamine mechanism of action:
Stimulates (both adrenergic and dopaminergic) receptors, lower doses are
mainly dopaminergic stimulating and produce renal and mesenteric
vasodilation,
higher doses also are both dopaminergic and beta1-adrenergic stimulating
and produce cardiac stimulation (Inotropic) and renal vasodilation;
large doses stimulate alpha-adrenergic receptors

**
388- a patient come to you taking alendronate , you advise him :
a) take alendronate 1/2 hour before breakfast and stand upright for 1/2
hour
b) take alendronate 1/2 hour before breakfast and rest
c) take alendronate 1/2 hour before breakfast with water and stand upright
for 1/2 hour
**
389-when FDA needs more experiments, analysis and researches about a
drug in phase 4 it means :
a) need more researchs about saftey
b) need more researches about response
c) need more researches about potency
d) need more researches about side effects
**
390- Which one has narrow therapeutic index:
b) digoxin
c) sildenafil
a) nifedipine
Narrow therapeutic index (NTI) means the ratio between LD50 and ED50 is
small
NTI = more dangerous
**
391-which drug will be more absorbed in presence of ranitidine
a-warfarin
b-aspirin
c-triazolam
d-naproxen
**
392-Drug prevent Microalbuminuria ACEI
N.B: Microalbuminuria describes a moderate increase in the level of
urine albumin.
It occurs when the kidney leaks small amounts of albumin into the urine
**
393-Overdose of the following lead to prolongation of Qr and bradycardia
a-propranol
b-verapamil
c-captopril
**
394-Pregnant woman have hepatitis B when deliver we must give for baby?
A. Hepatitis B vaccine only
B. Hepatitis B vaccine with interferon
C. Hepatitis B vaccine with immunoglobulin hepatitis.
D-Hepatitis B immunoglobulin with lamivudine
**
395- According to FDA the most dangerous abbreviation that shouldnt be
written on prescription is???
a-Ac
b- pc
c- prn
d- pe
**
396- 85 years man have pain in joint .. what the most dangours abbreviation
put in prescription ?
a-Qid
b-P.R.N
c-pe
d-OD
OD meaning Once daily Mistaken as right eye (OD-oculus dexter), leading
to oral liquid medications administered in the eye SO it can be fatal
QD (Every day), QOD (Every other day), Q1d (Daily) If any of them in
choices choose them . Because these abbreviations can be mistaken
with QID (Four times daily).
**
397-drug decreases warfarin action
A-Multivitamins
B-Paracetamol
multivitamins contain Vit K
vit k in warafarin antidote

**
398-Patient has Low creatinine clearance= high serum creatinine=kidney

injurycontraindicated in this case is?
A-spironolactone
B- Furosemide
C-propranolol
Dinsulin
N.B:
aminoglycoside may exist instead of spironolactone
i.e aminoglycosides and any potassium sparing diuretics(spironolactone
,triamterene and amiloride) is C.I with any kidney diseases
**
399-12 years old boy has diabetes type1 which drug can take?
A.metformin
B. glipizide
C. Pioglitazone
D. glibenclamide
Note :
if " insulin" is an option .. choose it .
**
400- Megaloplastic anemia folic acid /cyanocoblamin..i.e (vitb9+vitb12)
N.B: Pernicious anemia. Deficiency of vit b12 ..Only
**
401-Indapamide used in
a-Essential hypertenstion
failure
b-Angina pectoris
c-Heart
Indapamide used in hypertension or for swelling " salt and water retention
due to congestive heart failure
(Indepamid is thiazide diuretic)
**
402- ethosuximide is antiepileptic used in absence (petit mal) seizure
**
403-A Child with otitis media ,,, high dose amoxicillin
**
404- hormone is released from adrenal cortex Adrenocorticotropic
a-oxytocin
b-progesteron
Hormone released from posterior gland Vasopressin and oxytocin.
**
405-Pregnant has DVT (Deep Vein Thrombosis) take

a- warfarin
b- aspirin
c- heparin
( warfrin is contraindicated in pregnancy)
Heparin (unfractionated and low molecular weight) is the preferred drug for
managing VTE " venous thromboembolism " in pregnancy.
**
406-A pregnant women in her 35 week has a headache she should take
a- ergotamine
b- acetaminophen(= Paracetamol)
Acetaminophen is the drug of choice
Ergotamine is contraindicated in pregnancy category X
**
407- Paracetamol category b in pregnancy means
a-absolutely safe
b-Used with caution
Used with caution = generally safe in short term use with least possible
effective dose
**
408-A drug for hyperthyroidism associated with a agranulocytosis is
propyl thiouracil
**
409- Bioavailability refers to the extent and rate at which the active moiety
(drug or metabolite) enters:
a- systemic circulation ( the site of action)
b- intestine
**
410- Hb1Vgenotybe hepatic patient for ttt take ?
a.interferon and ribavirin
b- First ribavirin then interferon
c-only interferon
d-only ribavirin
**
411-A pregnant women with syphilis should take
a- ampicillin
B-amoxicillin
c- clavulanate
b- ciprofloxacin
Note : Pinicillin is the drug of choice for syphalis during pregnancy So if

there is
((Pinicillin eg: Benethamine penicillin (Benzylpenicillin))) in choices will be
better
**
412- liquid dosage form differ from solid in
a- ease to administation
b- low bioavailability compare to solid form
c- take more time to reach blood circulation
d- more stable
**
413-Drugs act on non-receptor mechanism?
a- Deferoxamine
b- Desloratadine.
N.B:
Deferoxamine acts by binding free iron in the bloodstream and enhancing
its elimination in the urine
**
414-Anti-inflammatory MOC
b.decrease prostaglandin
ca-increase prostaglandin
leukotriene inhibition
**
415- The concomitant administration of H2 blockers may increase the
dissolution rate of enteric-coated naproxen
**
416-which one has narrow therapeutic index:
a) nifedipine
b) digoxin
c) sildenafil
**
417-symptoms of digitalis toxicity include whitch one of the following :
a- Ototoxicity
b- arrhythmia
**
418-Which drug is contraindicated with asthma :
A. alpha 2 agonist
c. cortecosteroid
B. Beta 2 antagonist
D. Leukotriene modulator
Note : - B1 receptor exist in heart - B2 receptor exist in lung - alpha 1

receptor exist in Blood vessels
Note: Aspirin also is contraindicated in asthma
**
419-which of the following use with caution (( or with precation )) an
asthma pt.
A. alpha 2 agonist
B. Beta 2 antagonist
c. cortecosteroid
D. leukotrine modulator
Beta 1 antagonist should be used in caution with asthmatic patients>>> if

there is no Beta 1 antagonist in choices the answer will be Beta 2
antagonist
**
420-deltiazem used in hypertension to inhibit calcium influx
**
421-FDA Fast Track means:
a-A drug that shows promising results for life-threatening disease with
other drugs available can treat it
b- drug that shows promising results for life-threatening disease with NO
others available can do that
c- Drug that shows cost effectiveness
d- Drug with side effects
**
422-A Drug Increases of benign prostate hypertrophy (BPH)
Chlorpheniramine
**
423-Essential element thought which Thiazide produces its
pharmacological action (diuretics effect):
A-sodium
b- Potassium
C-Bicarbonate
D-phosphate
N.B: They control hypertension in part by inhibiting reabsorption of sodium

(Na+) and chloride (Cl) ions from the distal convoluted tubules in the
kidneys
**
424-long long term treatment with thiazide requires
a- K
b- Na
c- Ca
d- CO3
**
425-The drug is most commonly used in the selective COX2 inhibitors:
A. Rifocoxib
B. Etidolac
C. Celecoxib
**
426-The method most commonly used in the sterilization in our society
A. Radiological
B. Ethyl propyl
C. Autoclave
**
427- A Drug that may cause arrhythmia Digoxin
**
428-drug need to monitor its plasma level Gentamycin
**
429-drug make complex with dairy product Ciprofloxacin
**
430- Drugs that make complex with antacids?
(tetracyclines and fluoroquinolones)
N.B: Aluminum, magnesium in anti-acid s and calcium in dairy products, all
of these cations make a complex with fluoroquinolone and tetracycline
antibiotics
**
431-Drug makes complex with antacid
A-Warfarin
b-propranolol
c-Doxycycline
**
432- Antiarrhythmic drug class 1A Disopyramide
N.B class A 1 : quinidine, Procainamide & dispyramide
**
433- Which the following hormone suppress due to take oral contraception:
A) FSH( Follicle-stimulating hormone)
B) LH(Luteinizing hormone) (in phase of ovulation)
C) GnRH (Gonadotropin-releasing hormone)
**
434-in ovulation phase, Which hormone predominate?
a-FSH
b-LH
C) GnRH
1.Lh hormone is predominate in ovulation phase.
2.Contraceptives make feedback inhibition to (GNRH )hormone
**
435- A small group of medications in any health organization that medical
staff deal with them in caution and their loss from the place cause a very
serious problem so there is special way to store and dispense them
A- Low alert drugs
B- High alert drugs
C- Narrow therapeutic index
**
436- Sign of shock:
A. Hyper infusion
D. Bradycardia
B. Hypoperfusion
C. Tachycardia
**
437- Antidote of DIGITALIS ? Fab fragment
**
438-Drug interaction of heparin:
A-antacid
B- Aspirin
C- Proton pumps inhibitors
N.B: Aspirin replace heparin in plasma protein bind Increase the effects of
heparin. And risk of bleeding
**
439- Mechanism of action of Dopamine : Dopamine b1agonist
**
440-MOA of Chorionic gonadotrophic during of treatment of infertility?
A. Follicle
ovulation
B. Inhibition of educe ovulation
C. Follice and induce
**
441-sevelamer is to treat Hyperphosphatemia(Renagel)
**
442- Antiviral for HIV which nucleoside reverse transcriptase inhibitor
zidovudine
**
443-Route of administration of morphin and enoxaparin ??
Morphine IV ,,,,,,,,, Enoxparin SC
Note: Morphine can be taken also as: Oral, IM, Rectal
**
444-the LABEL of drug should has:
A. Patient name
B. Physician name
C. Physician number
The label must contain the pt. name due to no other pt. take this
drug
Prescription must contain physician name
**
445- All of the following to decrease exposure to radiation except:
a-increase the distance from radiation source
radiation
c-put shelves
person
b-out from the place of
d-decrease the activity of radiation
446- One of the following is contraindication to all vaccines

A-cd <200
B-renal artery stenosis
C- CHF
D-a patient taking prednisone
**
447-Probencid alters which of the following to prevent penicillin excretion?
a-renal tubular reabsorption
b-renal tubular secretion
c-glomerular filtration
**
448- Side effect of diphenhydramine
a- drowsiness
b- diarrhea
**
449-Antidote to reducetoxicity effect

**
450- One of the following is a component of drug processes:
a-transportation
Advertising
b-storage
c-Administration
d-
**
451- A pregnant woman has deep vein thrombosis (DVT) hospitalized
treated by:
unfractionated heparin
**
Doses qusetions
Vitamin D
Calcium
Folic acid
Geriatrics
Adult.....1000mg
Male......400mcg
<70years....600Iu
Pregnant
....1200mg
Female....400800mcg
> 70years...800iu
Geriatric ....1200mg Pregnant.....600mcg
Pregnant....600iu
Adult...600iu
**
452- A Drug causes sodium and water retention
A.indomethacin
B.verapamil
C.atenolol
D.ACEI drugs
Indomethacin if there is no Minoxidil in choices
**
453-Which of the following induce diarrhea Indomethacin
**
454-Phenytoin effect decrease by
a- kidney impairment
b-using isoniazid
**
455- streptokinase is used in
a-T.B
b-myocardial infarction
c-increase fat absorption
**
456-Vitamin k is antidote of
A-warfarin
B-Digoxin
C-heparin
**
457-Antidote of heparin is
a- vitamin k
c-propranolol
b-Protamine sulfate
d-desferoxamine
**
Drug
1-warfarin
2-Heparin
3-urokinase
Streptokinase ,alteplase
Reteplase,
Tenecteplase
4-paracetamol
5-morphine
6-Iron
antidote
I.V vitamin K (phytonadion)
Protamine sulfate
aminocaproic acid
tranexamic acid
N- Acetyl cysteine
Naloxone
Deferoxamine
**
458-Atropine is
a- Muscarinic agonist
b- Muscarinic antagonist
c- Nicotinic agonist
D-nicotinic antagonist
**
459-Benefits of using the unit- dose system:
To decrease medication errors (dose errors)
**
460- MOA of cromolyn ( cromolyn sodium)
a- anti-leukotriene
b- mast cell stabilizers
c- pg modifier
**
461- Treatment of patient with chronic wheezing and cough:
A-corticosteroid
B-beta 2 agonist
**
462-which of the following prevents Neural tube defects ( birth defects)
Folic acid (vit. B9)
**
463- Category X
Category X
Studies in animals or humans have demonstrated fetal abnormalities
and/or there is positive evidence of human fetal risk based on adverse
reaction data from investigational or marketing experience, and the
risks involved in use of the drug in pregnant women clearly outweigh
potential benefits.
Example drugs: atorvastatin, simvastatin, warfarin, methotrexate,
finasteride
**
464- The task of pharmacists and medicine centers& hospitals
Control formulary of drugs
**
465- Verapamil inhibit metabolism of
a- Digoxin
b- Sulindac ( NSAIDs)
c-Naproxen
d-Piroxicam
**
466- MOA of antiarrhythmic Class 1A (quinidine)
a- Increase rate of phase 0 depolarization,
b- decrease rate of phase 0 depolarization
**
467-Acetaminophen for a patient with osteoarthritis suffering from pain
**
468- Drug that is susceptible to cause drug dependence:
Benzodiazepines
**
469-A drug is contraindicated with patients have G6PD deficiency
suffering from malaria:
A-Chloroquine
B- primaquine
**
470-- Magnesium is contraindicated in renal impairment because of
a-accumulation
b- Decreased absorption
c-increased
reabsorption
**
471- A Child born to a hepatitis B positive mother must take
a-first dose of the hepatitis B vaccine
b-one dose of the Hepatitis B Immune Globulin (HBIG).
c- C. Both of them
**
472- Child on oxcarbazepine for epilepsy and suffers from rash
Change to ethosuximide
**
473- A Drug to manage nausea and vomiting for cisplatin (or

chemotherapy):
Granisetron
(Kytril)
N.B it is Serotonin (5HT3) antagonist

Also Ondansetron, Dolasetron
**
474- Why Beta blockers are used to treat angina?
A - Increase parasympathetic cardiac stimulation
B -increase sympathetic cardiac stimulation
C - decrease sympathetic cardiac stimulation
**
475-Why creatinine is used as an indicator for renal function:
it's bound to protein that is only excreted by kidney
**
476-Major side effects of anti-coagulant like heparin and warfarin:
Hemorrhage
**
477-vitamin d for patients with renal failure:
A-1,25-dihydroxycholecalciferol( Calcitriol)
B-D3
C-D2
**
478- Digitalis toxicity due to
A-hypo kalimia
B-hyper kalmia
C-hypocalcaemia
D- hypercalcemia
**
479- Linear pharmacokinetics = First order

Non-linear = Zero order
**
480- The following is related to dependence :
A- increasing dose of drug to obtain the same effect
B- increasing the dose of drug but no withdrawal symptoms
C- increasing the dose of drug associated with withdrawal symptoms if
sudden decrease
D- decreasing dose to obtain the same effect gradually
**
481- Tolerance- increasing dose of drug to obtain the same effect
**
482-B-blockers are contraindicated for hypertensive patient in case of
A Angina
C - Renal failure
B - Asthma
D - Liver failure
Selective B1 blockers can be used in asthma & nonselective beta

blockers are contraindicated in asthma
N.B: should be corrected to non-selective b blockers
**
483- Cockcroft-Gault Equation is used for glomerular filtration and is
indicted for
A.dialysis
B.chronic renal failure OR Bilateral renal failure & Bilateral= chronic
C.acute renal faliure
D.functional renal failure
**
484- MOA of beta-carotene Precursor for vit A (retinol) Antioxidant
**
485-DRUG Clearance means: The elimination of drug from the body
Clearance is defined as the rate of drug elimination divided by the plasma

concentration of the drug.
**
486- Antidote of warfarin
What other names is Vitamin K known by?
4-Amino-2-Methyl-1-Naphthol, Fat-Soluble Vitamin, Menadiol
Acetate, Menadiol Sodium Phosphate, Menadione
vit k: naphthol , menadione
**
487- Emergency staffs vaccine
a-meningitis
b -influenza
c-pneumonias
**
488- Drugs induced cough Except
.Losartan (angiotensin II receptor antagonists)
**
489-MOA of. spironolactone (Adverse effect of Spironolactone (
a-hypokalemia
b-hyperkalemia
c-hypnetermia
**
490.ACEI contraindication ?
a- HTN .
b- angina.
c- arrhythmia.
d- renal failure
**
491. Diltiazem actin? CCB cacuim channel blocker
**
492. LDL indicate ? Arteriosclerosis
**
493- cholestyramin use in ? .ttt hypercholesterolemia
**
494. Used in hyperlipidemic? simvastatin
**
495. Benzodiazepine is used in treatment of ? note:( Anxiolytic and
anticonvulsant)
a-anxiolytic
(a & c are correct)
b-anti parkinsonism
c-anti-epileptic
**
496.benzyl benzoic acid use ? for ACNE
**
497. Pt. with Low creatinine clearance= high serum creatinine=kidney
injury contraindicated? Gentamycin
**
498- benzodiazepine action? Inhances GABA inhibitory effect
(gamma-Aminobutyric acid( GABA agonist)
**
499Treatment of Diabetic patient with Glycated hb 9 as initial ttt:
a- Metformin
b-glipzide
c-insulin
d-another choice
**
500-Use of combination OCs(Oral contraceptives) contraindicated in
case of
DVT(Deep vien thrombosis)
**
501-A woman had DVT and was treated a year ago ,now she wants to
use oral contraceptive pills
the most suitable ocs for her
a-Levonorgestrel (or l-norgestrel or D-norgestrel)
b-ethinyle estradiol
Note: estrogen increase the risk of DVT
Progestin-only OCs are commonly prescribed when women wish to take
OCs but estrogen
is contraindicated.
Levo=progesterone=synthetic progesterone=second generation
progestin
**
502-pregnant hypertensive woman take
a-prazosine
b-methyldopa
c-propanolo
**
503-Iron deficiency anemia treated with.......iron
Megaloblastic anemia treated with.....folic acid and vit b12

Pernicous anemiea treated with......vit b12
Anemia of chronic renal failure treated with......epoetin ..but if there is
iron deficiency it will be treated with.....derbepoetin
**
504/ phase 2 in cardiac mean that :
a)depolarization due to Na influx
influx
b)repolarization due to Na
c)depolarization due to k influx
d) non of them
**
505/phase 3 in cardiac mean that :

a)depolarization due to Na influx
influx
b)repolarization due to Na
c)depolarization due to k influx

outflux
d)repolarization due to k
**
506- which of the following may cause acute renal failure ?

a .hypertension
b .diabetes
c .IV radiological substance

**
507-Early symptoms of aspirin poisoning are

a-lethargy & fatigue
b-throbbing headache & dizziness
c-fluid retention hypotension
d-ringing in the ears & blurred
vision
**
508-Dose of folic acid to
non pregnant: 400 mcg/day
pregnant: 600 mcg/day
and Lactating: 500 mcg/day
**
509- Dose of calcium for woman 65year
A/600 mg
B/800 mg
C/1200mg
**
510- Obese patient what the effect of obesity on absorption of lipid

soluble drug
A-Decrase
B- increase
C- no effect
D- increase then decrase
N.B no effect on absorption but increase volum of distribution
**
511-woman taking oxycarbamazipine, after 2 weeks of administration,
redness and flushing appear.
A/ shift to phenytoin
B/ shift to carbamazepine
C/ take clozapine
D/ keep using oxycarbamazipine
It is normal side effect but in other question (young girl)
answer is shift to ethosuximide
**
512- a postmenopause old woman suffering from facial flushing and

vaginal drying She has done hysterectomy procedure .. which drug of
the following should she use:
A/ estrogen
B/ progesterone
**
513-Which of the following drugs lead to addiction:

a- fluxotin
b- benzodiazepine
**
514- What is the vaccine that reduces the incidence of infertility or
prevent infertility:
human papilloma virus
**
515-Definition of half-life(t1/2)
Time it takes for the plasma concentration or the amount of drug in the
body to be reduced by 50%
**
516- a nurse was giving tratment to a hepatitisB patient when she
infected with his blood , when she made analysis the result was HBSAG
negative and HBSAB negative , so she should be treated with :
a) Give her hepatistis B vaccine immediatly
b) she need no treatment
c) give her immunoglublin only
d) give her immunoglublin + hepatitis B vaccine
**
517- patient take 4 drugs .. he did kidney function test and the result
was high serum cr and high BUN ( blood urea nitrogen)and high
potassium serum level so which drug should be stopped
A/ metformin
B/ tigcyciln
C/ insulin
**
518- note:drugs act as antiestrogen
Clomiphene, tamoxifen,, raloxifen, anastrazol, letrozol
**
519--A 22 years woman wants to become a pregnant , she is taking
metformin and pioglitazone . she has a history of hypoglycemia and she
prefers oral therapy .. What will be the best approach in her case?:
a - stop pioglitazone and titrate metformin
b - stop both if them and start insulin therapy
c- stop metformin and titrate pioglitazone
d.do nothing
**
520-which drug increase the action of warfarin
A/ carbimazole
B/ oral contractive
C/phenobaritone
D/ none of the above

**
521- Primidone prodrug of phenobarbitone and

Used as anti epileptic
**
522-Influenza vaccine in pregnancy is?
Safe
(IIV) Inactivated influenza vaccine is safe for pregnant
**
523- Drug used in treatment for Hypertension and migraine :
clonidin or probranolol
**
524 - An elderly man around 60 years old , complain from polyuria , dry
mouth .. there is no family history of diabetes .. he has done a lab tests
and the results were positive for disbetes .. initial treatment should be !
metformin
**
525- A patient with renal faiulre on erythropoietin therapy . which of the

following may decrease the effect of therapy:
a-folic acid deficiency
b- iron deficiency
c- B12 deficiency
Note :
Erythropoietin treat anemia induced by CRF by increasing the number of
new red blood cells your body .
Things that may make this therapy less effective include :
1. iron deficiency.. This is the most common reason that erythropoietin
may not be effective
2. High levels of aluminum .. which may interfere with your ability to use
iron
3. Vitamin deficiencies such as vitamin B12 or folate
so .. IRON is the most important mineral during erythropiotin treatment
**
526- Patients with ulcerative colitis ttt on cortisone and mesalazin must
use what?
if Colitis & Cortison .>> the answer is Ca
if Colitis only..>> the answer is vit b12
**
527- What is the vitamine needed with treatment by corticosteroids for 2
years for chronic disease?? Vitamin d with ca.
**
528- month-old baby with a history of premature birth and chronic lung
disease is admitted to the pediatric intensive care unit with respiratory
distress requiring intubation; fever; and a 3-day history of cold-like
symptoms. A nasal swab is positive for RSV. Which one of the following
is the best intervention?
A. Palivizumab.
B. Corticosteroids.
C. Cefuroxime.
D. Intravenous fluids and supportive care
**
529 - Pregnant woman with G6PD deficiency has G-ve. M.o. and UTI,
which is the drug of choice to treat her UTI:
A-vancomycine
B-nitrofurantoin
C-cefuroxime
D-sulphamethoxazole
Nitrofurantoin & Sulpha drugs cannot be used in GDPD deficiency

patients because it has high risk to them.
**
530- DRUG cause more peptic ulcer:
a- Ibuprofen
b-indomethacin
c-diclofenac
d-naproxen
indomethacin is potent anti inflamm. so more serious on GIT and kidneys
If there is piroxicam or ketorolac in choices choose them better
**
531-Penciliins are similar in MOA AS:
a-Erythromycin
b- Clindamycin
c- cephalexine
d-doxycycline
**
532- Decreased efficacy of epoietin due to deficiency of:
a-b12
b- b9
c - b6
d - b1
**
533- CASE WOMAN Hyprttention diabetic and sensitive of sulph. which

is contraindicated with sulpha
A-Glyburide
B- metformine
C-amidrone
D-enalopril
glipride as it is sulphonylurea derivative and she is allergic to any sulpha

containing drugs
**
534- main side effect of nitrates ? Headache
**
535- the importance of ceriatinine in monitoring kidney disease :

a) it's synthesis in bone and excreted by kidney
b) synthesis in liver and excreted by kidney
c) no relevant with disease
d) bound to protein and excreted by kidney
**
536- Patient has septic shock and his
BP 70/40 mmHg , a slight increase in K level and Na within normal range
.. which drug should be treated with ..
A - dopamine
B- lasix
C- saline
D albumin
**
537- A pregnant women senstive to amoxicillin which is the Drug Of
Choice for her disease ... what will be the suitable altrenative anti-biotic
for her
A- Erythromycin
B- Sulfacetamide
C- Cefixime
**
538-Class of drugs can transform macroalbuminurea to
microalbuminurea :
c- Digoxin
d- Calcium channel blockers
a-diuretic
b- ACEI
**
539-Side effect of atropine
a-urine retention
b- diarrhea
c- increase salivation
**
540-Pharmacy and therapeutic committee

a-expiration of drug
c- management of the drug
b- adverse effects
d- drug store
**
541-Mechanism of action of aminoglycosides

inhibitor
protein synthesis
**
542-Which of the following is given to neutralize stomach acidity and

prevent peptic ulcer
a-H2 blockers
b-Proton pumb inhibitor
c- prostaglandine agonist
d- antacid
**
543-misoprostol is ............................. category X

**
544- mechanism of action of bethancol .......................... selective
muscarinic agoinst
**
545- Flutamide indication and mechanism of action
Used in treatment of prostate cancer which act as Nonsteroidal
antiandrogen that inhibits androgen uptake and/or inhibits binding of
androgen in target tissues.
**
546- Pioglitazon side effect ......................... hypoglycemia
**
547- on treatment of insulin , which should be monitored ?
Potassium as it cause hypokalemia
**
548- drug-drug interaction with plavex.. omperazol.
**
549- old man have rheumatoid arthritis taking ( methotrexate - ibuprofen Losec ) and these drugs were not effective , so the next step we use :
a-hydroxy chloroquine
Alendronate Na
b- Lefulonamide
c-
**
549- teatment of digitalis induced arrthymea ......................... phenytoin or
lidocain
**
550- cyanide toxicity ................. cardiac toxicity
**
551- treatment for severe allergic asthma ? omalizumab used in
Treatment of moderate to severe persistent asthma
Ways to Treat asthma RESPECTIVLY :
1-Short acting beta agonist as salbutamol
2-inhaled corticosteroid
3- long acting beta agonist
4- antiinterleukin
5- oral cs(oral corticosteroid)
6- omalizumab
**
552- daily dose of iron in iron defficency anemia is .......... 100 mg 3 times
daily
**
553- mechanism of action of domperidone & doxazocin
Domperidone has peripheral dopamine receptor blocking properties
(dopamine antagonist) and does not readily cross the blood-brain
barrier.
Doxazosin Competitively inhibits postsynaptic alpha1-adrenergic
receptors.
**
554- BPH is worsen by ...................... anticholinergic drugs
**
555- mechanism of action of benzodiazepine..............GABA agonist
**
556- drugs that physician should care when using it .........
a-low safty drugs
b- low therapeutic index

**
557- First-Pass Effect

a. Blood that perfuses virtually all the gastrointestinal tissues passes
through the liver by means of the
hepatic portal vein.
b. Fifty percent of the rectal blood supply bypasses the liver (middle and
inferior hemorrhoidal veins).

c. Drugs absorbed in the buccal cavity bypass the liver.
d. Drugs affected most by the first-pass effect are those with a high
hepatic extraction ratio.
**
558- PQ is a 75 year old patient who has just been diagnosed with
hypothyroidism. Her past medical history is significant for congestive
heart failure, type 2 diabetes mellitus, osteoporosis and chronic stable
angina, all of which are well-controlled. Her medications include:
Metoprolol 25 mg bid
Calcium carbonate 1250 mg bid
Vitamin D 1000 IU daily
Glyburide 2.5 mg bid
Enalapril 10 mg bid
Furosemide 40 mg daily
Nitroglycerin SL spray prn
*PQ should be started on a low dose of levothyroxine because of her:
a. age.
b. gender.
c. diabetes.
d. metoprolol use.
e. nitroglycerin use
**
Q- Appropriate counselling and follow-up for PQ with initiation of
levothyroxine includes all of the following, EXCEPT:
a. separate the levothyroxine dose from calcium tablets by several hours.
b. take levothyroxine on a full stomach for greater absorption.
c. improved control of thyroid levels may also improve her glycemic
control.
d. physician follow-up is needed in 6-8 weeks to have her thyroid
function tests
repeated.
e. closer monitoring of her angina should be done during dosage
titration of levothyroxine.
**
Q- Which of the following parameters is the most appropriate for PQ's
self-evaluation of the effectiveness of levothyroxine therapy?
a. Increased energy
b. Weight loss
c. Improved vision
d. Less frequent angina
e. Less frequent urination
**
559- anti acid make complex with:
A-aspirin
B-doxycycline
**
560- most low potency corticosteroid hydrocortisone
**
561-.toxiderm meaning:
A.the toxin that cause syndrome
B.the signs and symptoms of toxcity syndrome
C.the causes of the syndrome made by toxin
D.the syndromes caused by toxin
**
562-anti coagulant taken oral
A . clopidogril
B.streptokinas
C.altepase
D.enoxaprin
**
563-selective beta blocker for treatment glucoma:
A.Betaxolo
B.timolol
C- acebutalol
D-propranolol
Betaxolol selective Beta-1 blocker

Timolol is non selective Beta blocker
**
564- T 1/2 .. in frist line is ....
A .1/k
B . 0.693 k
**
565- statin mechanism
Decrease cholesterol by HMG coA reductase enzyme inhibitor
**
566-Dopamine is used in cardiac shock as ..-1.don't induce peripheral vaso construction
2.decrease c.o.p
3.dec. force of contraction
4.selective dilate renal and mesenteric(vasodilation)
**
567-Dopamine is used in cardiac shock as:a) decrease C.O.P.
b) Don't induce preiphral vasoconistriction
c) Increase .force of contraction
e) constrict selective dilate renal & mesenteric
(dopamine will increase the force of contraction <<<its b1 agonist so
work on heart in term of contraction)
Dopamine mechanism of action:
Stimulates (both adrenergic and dopaminergic) receptors, lower

doses are mainly dopaminergic stimulating and produce renal and
mesenteric vasodilation,
higher doses also are both dopaminergic and beta1-adrenergic

stimulating and produce cardiac stimulation (Inotropic) and renal

vasodilation;
large doses stimulate alpha-adrenergic receptors

**
568-a patient come to you taking alendronate , you advise him :

a) take alendronate 1/2 hour before breakfast and stand upright for 1/2
hour
b) take alendronate 1/2 hour before breakfast and rest
c) take alendronate 1/2 hour before breakfast with water and stand
upright for 1/2 hour
**
569-A 39 years old what is oral birth control pills appropriate for her
A-Levonorgestrel
B-Ethinyl estradiol/lnestrenol
C- lynestrenol/norethisterone
D-medroxyprogesterone (depot contraceptive)
This ques. may be incomplete if there is any of the following
contraindications of COCP the answer will be Levonorgestrel
Take the minipills of progestin if
Older than age 35 + smoke
Older than age 35 + migraine headache
Older than age 35 + obese
Older than age 50
Breast feeding
Diabetes mellitus with vascular disease
Risk of DVT or history of thromboembolism "blood clots"
History of uncontrolled HTN or heart problems
Breast or endometrial cancer
Need to get pregnant

**
570-14years-obese girl comes to the clinic with severe rash. She was
initiated on oxcarbazepine about 3 weeks ago for management of partial
seizures.
Her medical history is significant only for seizures. She has recently
become sexually active and admits to inconsistent contraceptive use.
Which one of the following interventions is best for her?
A. Change to carbamazepine.
B. Change to topiramate.
C. Change to valproic acid.
D. No change in therapy is necessary
**
571-A 12 years old girl suffer from rashes after treating with
oxycarbamazepine
A-shift to ethosuxamide
B-shift to topiramate
**
572-PH measures:
A-acidity
B-soluibilty
**
573- If a drug is eliminated by first order elimination, what determines
when will it reach steady state?
c) Drug dose D) t(1/2)
a) Dose interval
b) Elimination rate
half life
Note:f or a drug with one-compartment characteristics, the time to reach
steady state is independent of the dose, the number of doses administered,
and the dosing interval, but it is directly proportional to the half-life.
**
574-A drug induces Water retention
a.indomethacin
b-Verapamil
c-Atenolol
**
575-Bioavailbility Area under the curve
**
576-MOA of Fluoxetine selective serotonin reuptake inhibitor (SSRI)
**
577- Relief pain due to MI (Myocardial Infarction)
A.Morphine
B. Ibuprofen
C- Benzodiazepine
**
578- Which of the following show penicillinase resistance
a-Penicillin v
b-Flucloxacillin (floxacillin)
c-amoxicillin
d- Augmentin
**
579-the recommended maximum adult daily dose of paracetamol
A-2500 mg
B- 3500 mg
C-4000mg
N.B. Dose for children of paracetamol:
Four years old child should take 240 mg paracetamol per dose,
repeated every four hours, Maximum: 5 doses daily>>>>> so, 5 x 240mg=
1200 mg =1.2g choice: 1g (as age based dose)
For (age based dose): 10 to 15 mg/kg/dose every 4 to 6 hours as

needed; do not exceed 5 doses in 24 hours; maximum daily dose: 75
mg/kg/day
Adult maximum dose of paracetamol: 4000mg = 4g
**
580- Pregnant woman has vaginal discharge and has Candida albicans
what's the drug of choice?
b-Clotrimazole
c-Tetracycline
dA-Acyclovir
Fluconazole
**
581-Low denisty lipoprotein(LDL)act as:
A- carrier cholesterol in plasma
B-transport fatty acid
C- good lipoprotein
HDL : high density lipoprotein (Good cholisterol )
LDL low density lipoprotein Bad cholesterol
**
The larger the therapeutic index (TI), the safer the drug is. If the TI is
small (the difference between the two concentrations is very small), the
drug must be dosed carefully and the person receiving the drug should
be monitored closely for any signs of drug toxicity.
**
582-A drug with narrow therapeutic index
A -Quinidine
B-Procainamide
C-Phenytoin
**
583- Which of the following drugs are considered drugs dependence in
normal dose???
a- Valproate
b-phenytoin
c-fluxetine
(Prozac)
d-quindine
N.B: Fluoxetine is a selective serotonin reuptake inhibitors (SSRI)
antidepressant
**
584- A drug has Dose-dependent according to pharmacokinetic
parameter
A-phenytoin
B-quinidine
**
585- A patient with iron deficiency anemia refused to take any parenteral
drugs
give him
a-ferrous gluconate
b- Iron sucrose
cOther
choices
**
586-which drug has the rapid effective action in esophageal burn and
acidity
A-omeprazole
B- magnesium/aluminum hydroxide
c - Other choices
**
587- Studies in which data collected from different studies
A-double blind
B-systematic review C-other choices
Note : meta analysis is better answer if not exist the answer will be
systematic review
**
588- Naloxone exert its action through...antagonism
**
589- African American women take lisinopril and another hypertensive
drug suffer from nose swelling and other symptoms what make her more
suspected to this reaction
a-age
b - Gender
c-drug combination
d- ethnicity
Note :
- Black patients have low renin than normal
-ACEI (lisinopril) causes angioedema more in african americans
if no ethnicity in choices .. choose Drug combination
**
590- MOA of Benzodiazepine?
a- Anxiolytic
c- Ant Parkinsonism
b-Antiepileptic
d-anti-psychotic
**
591- Which of the following cardiac glycoside doesnt occur

naturally?????
a. Digoxin
b.Oubain
c.Digitoxin
d.Amrinone
**
592-A patient who is taking sevelamer drug means that he/she suffers
from
a-hyper phosphatemia
b--hyper calcemia
c-hyper magnesiumea
**
593-Mg antacid for patient with renal failure the antacid will cause
a- .increase the absorption of Mg

b- decrease the abs of Mg
c-Increase the Elimination of Mg
d- decrease the Elimination Of Mg
**
594-Omeprazole alone is used for ttt of
a-Hemorrhage
b- Helicobacter pylori(H. pylori)
c-gastric ulcer
d-gastritis
**
595-which the drug used in the lysis of clot
a-warfarin
b-Heparin
c-onaxprine
d-streptokinase
**
596-which of this groups indicate pharmacological toxicity
a-indepamide and hypo tension
b-dry mouth and drowsiness and tricyclic anti-depressant
c-carcinogenesis and anti-carcinogen drugs
d-liver cirrhosis and paracetamol
**
597-drug induced BpH
a- chlorpheniramine
c-reserpine
b-metformin
d-clonidine
**
598- Treatment of Pregnant with vaginal candida
clotrimazole
**
599-Dopamine causes:
A- increase gastric acid secretion

B-elevate blood pressure
C-relaxation of skeletal muscle
D- CNS stimulation
N.B: Dopamine is a precursor to norepinephrine in noradrenergic nerves
and is also a neurotransmitter in certain areas of the central nervous
system
**
600-.when you say on two drugs have the same bioequivalence
A-taste
B-weight
C-physical appearance
D-Pharmacokinetic parameters
N.B: pharmacokinetics: It is the way that body deal with the drug
1-absorption
2-Distribution
3-Metabolism
4-Excretion
**
601-.which antacid give cathartic effect as a side effect
A-Mg hydroxide
B-Ca sulfate
C-Ca hydroxide
**
602-.Cimetidine is
enzyme inhibitor
**
603-side effect of atropine is
urine retention
**
604-Diazepam action is....

A-Inhibit glutamate secretion
B.increase glutamate secretion
**
605-.what is the b-lactam antibiotic, its mode of action is cell wall

synthesis inhibitor
A.cephalosporin
b-Tetracycline
c-.neomycin
d-.erythromycin
N.B: penicillin MAC: cell wall synthesis inhibitor too
**
606--for female with DVT, which is contraindicated...combined
contraceptives
(Estrogen containing contraceptive)
**
607-probiotics are....live yeast or bacteria
N.B: Probiotics are live bacteria and yeasts that are good for health
**
608-cytochrome responsible for interaction between omeprazole and
clopidogrel...cyp2c19
i.e Interactions between omeprazole clopidogrel GENERALLY AVOID
609-Streptokinase used in...Myocardial infarction
**
610-.drug and disease interaction:
a-piroxicam and heart failure
b-Furosemide and osteoporosis
Furosemide is loop duiretic cause hypocalcemia and induce
osteoporosis NOT osteoarthritis**
**
611-.Increase of BPH is... chlorpheniramine
**
612- A 12 years old girl suffer from rashes after treating with
oxycarbamazepine
A-shift to ethoxsumide
**
613- rapid relief of acidity...Al hydroxide
**
614-MOA of Labetalol
Labetalol is a selective alpha-1 and non-selective beta adrenergic blocker
used to treat high blood pressure. It works by blocking these adrenergic
receptors cardiac output.
**
615-MOA of :(Isoprenaline)
Non selective stimulant
1- 1 works on heart as Agonist------strengthens the action of heart
2- 2: Agonist works on lung---------------- Dilate lung for asthmatic
patient
Sympathomimetic
Bronchodilator Agents
Cardio tonic Agents
Adrenergic beta-Agonists
**
616- A drug Treats Bph by relaxation of bladder neck?
A-Terazocin
B-metolol
N.B: Bph (benign prostatic hyperplasia (enlarged prostate)
Terazosin is alpha-adrenergic blockers so it relaxes arteries so that
blood can more easily pass through them. It also relaxes the muscles in
the prostate and bladder neck, making it easier to urinate.
**
617- Decreases effect of phenytoin?
A-Isoniazid
b- Alcohol
C-kidney disease stage 2

D-alkalization of kidney by diuretic
ans: alcohol / ethanol .. decrese the level of phenytoin by increase
metabolism
**
618-Normal water is used for which of these preparations?
A-Ophthalmic
b- Oral solutions
c- Parenteral solutions
d- External preparations
**
619-Hydralazine acts on heart by:
a-relax cardiac muscle
b- Relax smooth muscle
N.B: hydralazine is a vasodilator (direct-acting) smooth muscle relaxant
works by relaxing blood vessels (arterioles more than venues) and
increasing the supply of blood and oxygen to the heart while reducing its
workload
**
620-Anti metabolite anti-cancer
A-vindesin(Vindesine is an anti-mitotic vinca alkaloid used in
chemotherapy )
B-Cyclophosphamide(an alkylating agent)
c-flurouracil
**
621- When taking MAOIs avoid food containing -- tyramine
**
622- A patient has megaloblastic anemia should receive?
B12 cobalt and b9 folic acid
**
623-A women takes estrogen and she made hysterectomy should take ?
A-testosterone
b-hydroxyprogestrone
When you take estrogen, you should always take progesterone to
counteract the negative effect of estrogen
**
624-A patient takes clopidogrel and omeprazole so should shift to?--Pantoprazole

**
625-the aminoglycoside? Antibiotic
**
626-which of the following true?
ACEi cause dry cough
**
627-Aspartame is added to some preparation as
a-Nutrients
B-sweeting agent
C-flavor
D-preservative
**
628- Drug of choice for hemolytic anemia?
a-EnoxaprinB-Cortisone
c-antibiotic
**
629- Toxidrome meaning:
A-poison induced toxicity syndromes
B- physical signs and symptoms due to specific toxicity syndrome
C-the causes of the syndrome made by toxin
**
630-.rapid relief of acidity...Al hydroxide
**
631-.case has pain and solid tumor... Oral contraceptives
N.B:
- hormone therapy " e.g . oral contraceptive pills" are used to treat
endometriosis-associated pain and they are effective.
- Danazol can be used but it isn't the first choice because it can cause
serious side effects and can be harmful to the baby if the patient become
pregnant while taking this medication.
- Progestins have a more favorable side effect profile than danazol.
- surgery is the last resort and is recommended if the patient planning for
pregnancy
**
632-A case of 22 years old woman that wants to get pregnant, she takes
Pioglitazone with metformin as her treatment. She has a history of
hypoglycemia and she prefers to take oral therapy. What will be the best
approach in her case?
a-stop both drugs and take insulin
b-stop metformin and titrat the pioglitazon
c-stop pioglitazone and titrate the metformin
d- do nothing
**
633-case in which glucose is high and its weight 103 kg and ha1c is 9, he
will take..
A-metformin
B-insulin
C-glyclizide
Metformin as weight is an indication for type 2diabetes
**
634-case 12_years old girl suffer from rashes after treating with
oxycarbamazepine
A-shift to ethoxsumide
**
635- a pregnant woman in her third week she take levothyroxine 100 mcg
, you advise her :
a) stop the medication immediately
b) increase the dose of levothyroxine
c) ask the prescriber to change the medication
d) continue using the medication as prescribed
Levothyroxine is considered the treatment of choice for the control of
hypothyroidism during pregnancy.
Due to alterations of endogenous maternal thyroid hormones, the
levothyroxine dose may need to be increased during pregnancy and the
dose usually needs to be decreased after delivery.
**
636) The lowest in potency
a)Dexamethasone
b)Triamcinolon
d)Betamethasone
c)Hydrocortisone
**
637-The ability of liquid to dissolve in another liquid is called
A- Solubility equilibrium
B- solvation power
C- Miscibility
D- Hydrophilicity
**
638-ACEI role in CHF
A.alpha 1 blocker
B.block ca influx to cells
C.prevent ventricular remodeling
D.cannot remember but wasnot related to angiotensin
**
639-.dispyramide as anti arrhythmia:
A.dec. phase 0
B.inc. phase 0
C.dec. phase 3
D.inc phase 3
**
640-.drug interact with statin:
A . aspirin
B Ketoconazole
C-Carvedilol
**
641-. vitamins prevent fetus abnormalities. .
A.iron
B.ca
C.vit a
D.vit b9
N.B. vitb9 ( folic acid )
**
642-antiestrogen cause abortion..>> anastrozole
- antiesterogen used in breast cancer>> .. tamoxifen
**
643-.Antiprogesterone cause abortion.. Mifepristone
**
644-.Drug known to cause kidney injury
A.Thiazide
B. Aminoglycoside
**
645-.carpidopa act anti-parkinsonism by..
A. block dopamine receptor
B.inc. dopamine
NOTE: Carbidopa mechanism: is a peripheral decarboxylase inhibitor. It
inhibits the peripheral decarboxylation of levodopa to dopamine; and as it does
not cross the blood-brain barrier, unlike levodopa, effective brain
concentrations of dopamine are produced with lower doses of levodopa.
That is why carbidopa is used in combination with levodopa to treat
Parkinsonism.
**
646--MOA of Amlodipine:
Calcium channel blocker (CCBs) Block calcium and block contractility of
heart and induce vasodilatation of blood vessel
Note: Verapamil , diltiazem block Ca on heart
Amlodipine , nifedipine block Ca on Blood vessel and heart
**
647-anti arrhythmic cause lupus :
A-procainamide
B.quinidine
N.B:
1-The most common medicines known to cause drug-induced lupus are:
Isoniazid.
Hydralazine.
Procainamide.
2- lupus is any of various diseases or conditions marked by inflammation
of the skin, especially lupus vulgaris or lupus erythematosus
**
648-pharmacological uses of cholestyramine is anti hyperlipidemic
**
649-pharmacological benefit of cholestyramine
a-increase LDL
b-decrease HDL
c- Increase efficiency of lipoprotein removal
d-decrease LDL
Note: cholestyramine decrease LDL )decrease low density lipoprotein( in

body or increasing the removal of bile acids from the body or increase
high density lipoprotein (HDL) in body.
N.B: cholystramine increases the fecal loss of bile salt-bound low
density lipoprotein cholesterol
650-Drug for hyperlipidemia not decreaseLDL

a- nicotinamide
b_ fibrate ( Fenofibrates (gemfebrozil) acts on Triglycerides
**
651-which of the following drugs cause dependence
A.benzodiazepenes
B.fluxetin
**
652-ceftriaxone "3rd generationcephalosporin
**
653-.anti coagulant taken oral
A . clopidogril
B.streptokinas
C.altepase
D.enoxaprin
N.B .. Oral anti coagulant is warfarin but clopidogril is anti platelets.
clopidogril is anti platelets and so can aid in inhibiting clot formation
**
654- Phenylephrine act on ..
a. alpha agonist
b. beta
c. alpha & beta
Phenylephrine mechanism: Potent, direct-acting alpha-adrenergic

agonist with virtually no beta-adrenergic activity; produces systemic
arterial vasoconstriction.
**
655- beta blocker used in angina because ...

a.increase para sympathomimtic cardiac stimulation
b.decrease sympathomimtic cardiac stimulation
**
656.liquid prep. differs from solid in
a.take long time to reach stomach & sirculation
b.lower bioavailability
c.easy in administration
**
657-Antiprogestin causes abortion is: Mifepristone
**
658- gray man syndrome due to
amiodarone
Gray baby syndrome ----> Chloramphenicol induced
Gray man syndrome ----> Amiodarone induced
Red man syndrome ----> Vancomycin induced
Lupus like syndrome----> Hydralazine & Procainamide induced
**
659- A Drug decrease Na&k and increases uric acid reabsorption:
A-bumetanide
B-hydrochlorothiazide
**
670-linear pharmacokinetic parameter mean
a.straight line relationship
b. to reach steady state
c.clearance don"t changed
1-linear pharmacokinetic parameter mean
Linear pharmacokinetics is so-called because the graph of the
relationship between the various factors involved (dose, blood plasma
concentrations, elimination, etc.) gives straight or an approximation to
one. For drugs to be effective they need to be able to move rapidly from
blood plasma to other body fluids and tissues.
**
671- method used in sterilization (autoclave was not in the choices:
a-radiation
b- dry heat
c-moist heat
**
672-to avoid acute renal failure

a-maintain hydration
b-vit cc-take protein
d-avoid antibiotic
**
673-ceftazidime is third generation cephalosporin
674-vitamine is contraindicated in pregnancy in highly doses

a- vit. A
b- vit. D
c- vit. C
d- vit. B12
**
675another use of lidocaine beside local anesthetic (class 1 B
antiarrythmic
**
676-amantadine M.O.A: antiviral and antiparkinsonian
**
677-antihypertensive drug act by increase of urination
a- hydrochlorothiazide
b- ramipril
c- nifidipine
**
678- drug alpha 2 agonist cause
a-facial flushing
b-decrease hypertenstion
(alpha 2 agonist as: Methyl dopa &clonidine)

**
679-Verapamil antiarrhythmic class is: Class IV (4)
**
680-Propranolol antiarrhythmic class is: Class II (2)
**
681- Obese patient what the effect of obesity on distribution of lipid
soluble drug
A-Decrase
B- increase
C- no effect
**
682-Obese patient what the effect of obesity on absorption of lipid
soluble drug
A-Decrase
B- increase
C- no effect
**
683-Side effect of thiazide diuretic:
a)Hypokalemia
b)Hyperkalemia
c)Hypocalcemia
**
684-Cardiotoxicity is caused by: Celecoxib
**
685-Cyclizine is used for: nausea and vomiting
**
686-Ranitidine mechanism of action: H2 antagonist

**
687-Cyproheptadine acts as: Antihistamine
**
688-Change the drug from tablet to final powder: Disintegration
**
689-Mechanism of action of TCAs is:
a-increase gaba
b-increase reuptake of amine at synaptic
c-decrease reuptake of amine at synaptic
**
690-uses of promethazine:
Nausea & Vomiting
N.B: strong sedative and weak antipsychotic effects reduces motion
sickness and has antiemetic and anticholinergic properties.
**
691-drug increase excretion of na,k&increase reabsorption of uric acid
a- hydrochlorothiazide
b-bumetamide
c-triamterene
**
692-Erythromycin is macrolide class act mainly gm +ve and is safe in
pregnancy
**
693-ssri fluoxetine used as---mood stabilizer
**
694-MOA of nitroglycerin --coronary vasodilation
**
695-ACEi is contraindicated in --bilateral renal artery stenosis

**
696-life threatening arrhythmia is side effect of --- digoxin
**
697-which is most likely to cause heartburn
A-kcl
B-one of h1 blocker,
C-dont remember
N.B.Medications that cause heartburn pain include:
Antibiotics , Bisphosphonates taken orally , Iron supplements , Quinidine
,Pain relievers, Potassium supplements .
**
698-Hypothyrodism is caused by:
1-low temperature
2-weight gain
3-cushing syndrome
**
700- LPL is responsible for transportation of:
1-lipids from cell to cytoplasm
2-cholesterol
3-fats to tissue
Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many
tissues.
LPL is the rate-limiting enzyme for the hydrolysis of the triglyceride (TG)
core of circulating TG-rich lipoproteins, chylomicrons, and very lowdensity lipoproteins (VLDL).
LPL-catalyzed reaction products, fatty acids, and monoacylglycerol are
in part taken up by the tissues locally and processed differentially; e.g.,
they are stored as neutral lipids in adipose tissue, oxidized, or stored in
skeletal and cardiac muscle or as cholesteryl ester and TG in
macrophages.
**
701- LDL is responsible for transportation of:
1-lipids from cell to cytoplasm
2-cholesterol
3-fats to tissue
Low density lipoproteins (LDLs) carry cholesterol from the liver to body
cells.
**
702- PPI (Proton Pump Inhibitor) is used in GIT bleeding is:
1-omeprazole
2-pantoprazole
3-esomprazole
**
703_ Ophthalmic preparation should have these properties except:
A-sterile
B-purified
C-should contain preservative sitotosc
d- isotonic
**
704_ Altepase used is
a.Acute coronary syndrome
b.Neoplastic disorder
c.Fat metabolism
d.Acute bacterial infection
**
705. Which is category X ?
a.Ciprofloxacin
b.Rituximab
N.B:
FDA pregnancy category : C use rituximab only if clearly needed and
benefit outweighs risk
FDA pregnancy category : C Cirofloxacin should not be used during
pregnancy unless the potential benefits justifies the potential risk to both
fetus and mother
**
706.Quinidine is similar in its action to ?
a.phenytoin
b.lidocaine
c.procainamide
**
sulphasalazine used in ttt of

Sulfasalazine is used in the treatment of inflammatory bowel disease,
including (ulcerative colitis and Crohn's diseas). It is also indicated for
use in rheumatoid arthritis and used in Juvenile rheumatoid arthritis.
The right answer is inflammatory bowel disease, including (ulcerative

colitis and Crohn's disease). The irritable bowel syndrome is different
than inflammatory bowel disease.
Examples of drug inducing hepatotoxicity:

a- Paracetamol.
b- Ketoconazole.
c- Rifampicin.
d- Quinolones.
Mechanism of action of ACE (Angiotensin Converting Enzyme): converts

angiotensin I to potent vasoconstrictor angiotensin II
**
Important Notes :
- intrinsic sympathomimetic activity DRUGS :
pin= pindolol
ox= oxprenolol
ac=acebutelol
- electromagnetic ray incude ( radio, micro, ultraviolet, x_ray,
gama )
- Terbutaline is used as >> Antiasthmatic
- Freeze drying is done by >> Sublimation.
- Converting big fragments into small fragments is >>
Reduction
- q.d.s = q.i.d = four times per day
- p.r = for the rectum
- qqh means every 4 hours
- Bretylium class3 anti antiarrythmic is an adrenergic neuronal
blocking agent
- ceftazidime is 3rd generation cephalosporin
- Amantadine is dopamine agonist
- Diphtheria is an upper respiratory tract illness (makes tough
pharyngeal membrane) caused by Corynebacterium
diphtheria
- Indamide use ------ sulphonyle urea "Diabetic treatment"
indapamide ( natrilix) ---- thiazide diuretic
- Drug used in abscence seizure (petit mal seizures).....
ethosuximide
- ANGIOTEC is the trade name of Enalapril
- The parameter describing dissociation in solution: pka
- Reserpine mechanism: deplete catecholamines from
sympathetic nerve endings
- MAOI work through: increase avialability of monoamine
neurotransmitter
- All the following side effects of atropine:
urine retention, constipation, blurred vision, dyspnea
- Mechanism of action hydrochlorothiazide: inhibition NA
reabsorption in the distal tubules causing increased excretion
of sodium and water as well as potassium and hydrogen ions.
- Phase 1 of Arrhythmia: Transient early repolarization, due to
potassium efflux
- Phase 2 of Arrhythmia: plateau Phase Calcium influx
continues and is balanced to some degree by potassium
efflux
- Main side effect of nitrites is..headache
- Volatile liquid drug given as inhaler.Amyl nitrite

- About tonic clonic seziure:
unconciousness , unvoluntry movement
The seizures usually involve (tonic phase) muscle rigidity,
followed by violent muscle contractions (clonic phase), and
loss of alertness (consciousness) --- its also called grand-mal
epilepsy
- Phentolamine (Rogitine) is a nonselective alpha-adrenergic
antagonist
Considerable variation occurs in the use of capitalization,

italicization and punctuation in abbreviations.
The following list shows the abbreviations that are not often
encountered by pharmacists:
A, aa., or aa = of each
dil = dilute
ad = to, up to
D.C.,dc, or disc. = discontinue
a.d. = right ear
a.s. = left ear
a.u. = each ear, both ears
o.d. = right eye
o.I. or o.s. = left eye
o.u. = each eye, both eye
disp. = dispense
ad lib = At pleasure freely
div. = divide, to be divided
d.t.d. = give of such doses
aq. = water
DW= distilled water
D5W= dextrose% in water
asa = aspirin
e.m.p. = as directed
et = and
ex aq. = in water
BP = British pharmacopeia
BSA = body surface area
c.or c = with
ft = make
amp. = ampoule
cap or caps = capsule
Inj. = injection
IM =intramuscular
IV = intervenes
Pulv. = powder
Gtt or gtt = drop, drops
elix = elixir
comp. = compound, compounded
g or GM =gram
gr or gr = grain
gal = gallon
Cc or cc. cubic centimeter
oz. = ounce
M2 or m2 = square meter
l or L = microlitre
Mcg, mcg or g = microgram
I or L = liter
Lb = pound
mEq = milliequivalent
mg = milligram
ml or Ml = milliliter
fl or fld = fluid
fl oz = fluid ounce
dl or dL = deciliter
cp = chest pain
D.A.W. described as written
GI = gastrointestinal
Non rep. = do not repeat
H = hypodermic
NPO = nothing by mouth
N.S., NS = normal saline
NS = half-strength normal saline
O = pint
IVP = intervenous push
IVPB = intervenous piggyback
OTC = over the counter
K =POTASSIUM
PDR = Physicians, Desk Reference
= Greek mu
M = mix
Ppt = precipitated
p.o. = by mouth
Pr = for rectum
Pv = vagenal use
Prn or p.r.n. = as needed
Pt. = pint
N & V = nausea & vomiting
N.F. = National formulary
ante = before
a.c. = before meals
p.c. = after meals
h or hr. = hour
q. = every
q.d. =every day
q.h. = every hour
q.4 hr. = every 4 hours
b.i.d. = twice daily
a.m. = morning
Noct. = night, in the night
h.s. = at bed time
**
Dont Forget to Study the other Files (Cases &Calculations)
GOOD LUCK

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1 Pharma Questions

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2014 2015

1- antibiotic needed in community acquired pneumonia which need

3- lab tests can be done now:

b-Lipid profile and urine

c-Blood test just take blood sample

Ca ... due to corticosteroid drugs induce osteoprosis ..

7-which of the following drug increase the incidince of BPH

BPH (Benign Prostatic Hyperplasia)

concomitant administration of H2 blockers may increase the dissolution

b- ceftriaxone and azithromycin

11- p.r.n = when required (when needed)

for Vit d dose

18- human chorionic gonadotropin is used to :

23 red man syndrome caused by :

27-total body clearance= CLhepatic+ CLpulmonary +CLrenal

28- tyramine when taken with MAOIs(monoamine oxidase inhibitor) cause

b-naloxone (antidote not treatment)

37-erythropoiten (eprex) is used for anemia caused by chronic kidney

39-with anti-inflammatory and analgesic : ibuprofen

A.c: before meal

45-quinidine(anti arrythma) side effect : cinchonism

Carbepenems (Imipenem, Meropenem, Doripenem) have the propensity to

NPH ==> intermediate acting and no excess protamine (basic)

61-routine medication for influenza is

62-atenolol is selective beta 1 blocker

71- ascorbic acid is : vitamin c

75-insulin given iv is : regular

77-oral contraceptive work on Gnrh hormone in phase of ovulation

86-amantadine(antiviral) used for treatment of parkinsonism

89-rofecoxib is selective cox2 inhibitor

97-procss of using the drug is :ADMINSTRATION

107-neuromusclar blocker block : acetylcholine

If in the question (ferrous sulfate): it is in the range of (1000

Ventricular arrhythmia >> Procainamide

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128-disintegration change the drug from tablet to final powder

132-drug of choice for tape worms

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Drug of choice in tape worms is (praziquantel)..if it is not available in

c-metoprolol (beta1 blocker)

134- Which of the following is colloid solution ?

138-What first line agent may be considered for an obese type 2 ?

TYPE 1 : insulin + healthy diet + exercise ..

Plant origin ... Etoposide

144- PPM mean:- part per million OR million part

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146- Daily recommended dose for vit. C in male :-:

if asked in female the answer is 75mg \ day

Drug after metabolized in liver it will become:-

b-inhibitors nucleic acid

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a-inhibit negative feedback of estrogen

164 - When the pharmacopeia put the drug as phase 4

165- drug used to treat prostate cancer

167- an elderly women with osteoporosis after giving her Calcium +

168- a study in which we use different studies to make a conclusion :

A "meta-analysis" is a statistical approach to combine the data derived

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174-Antidote for warfarin:

vit k or the other name of it phytomenadion

Alternative names of Vit. K

177-how many phases applied to drug to be approved by FDA

179- FDA Fast Track what this mean:

180- Cervical cancer caused by or treatment of infertility or to prevent