Anti-infectives course overview and intro to infectious diseases

S. James Matthews, RPh., Pharm.D.

Associate Professor of Clinical Pharmacy
Northeastern University
2016
Topics Covered Today
Overview of the syllabus
Why do infectious diseases matter?
o Importance of antibiotic overuse
o Lack of new antibiotics in the face of increased resistance
o What is your role in this issue?
Video on antibiotic resistance
Anti-infectives
The course is comprised of 3 components
1. Medical microbiology
2. Pharmacology of anti-infective agents
3. Medicinal Chemistry of anti-infective agents
This content is critically important to your success in CDM3 in the fall
Syllabus
CREDITS: 4 semester hours
CLASS SCHEDULE: Mondays and Wednesdays, 10:30 AM-12:10 PM
Coordinator: Pharmacology
S. James Matthews, RPh, PharmD
Associate Professor of Clinical Pharmacy
Office: 140 The Fenway, X215
Email: s.matthews@neu.edu
Phone: 617-373-4178
Office hours: by appointment
Faculty
Medical Microbiology
o Nikolaos S. Soukos, DDS, PhD
o n.soukos@neu.edu
Pharmacology
o Elizabeth Hirsch, PharmD, BCPS
o e.hirsch@neu.edu
o Medicinal Chemistry
o Ganesh Thakur, PhD
o g.thakur@neu.edu
Teaching assistants
o Murui Han
o Charles Perry
Course Objectives
Describe the structure and physiology of medically relevant bacteria
Explain the Gram stain, morphology (i.e. cocci, bacillus, etc.), and growth conditions (i.e.
aerobic, anaerobic) for the following genera of bacteria: . (look in the syllabus)
Describe the structure and physiology of medically relevant fungi
Summarize the difference between yeasts and molds.

Identify common yeasts and molds including but not limited to: Candida, Pneumocystis, Penicillium,
Histoplasma, Cryptococcus, Blastomyces, Coccidioides, Aspergillus, and Mucor
Explain the structure and life cycle (including targets of anti-virals) of the following viruses:
Influenza A and B, Hepatitis A, B, and C, Herpes Simplex Virus, Human Immunodeficiency Virus,
Cytomegalovirus, Rotavirus, and Varicella Zoster Virus.
Differentiate and describe the laboratory methods used in microbial diagnosis and antimicrobial
susceptibility testing, identifying the clinical application, advantages, and disadvantages of each
Explain the medicinal chemistry of selected anti-infective agents and discuss structure-activity
relationship within each class of drugs

Discuss drug-drug interactions with anti-infective agents

Explain the mechanism of action, general spectra of activity, common and severe adverse events,
and potential drug interactions for the following antibiotics or classes:
See syllabus for list
Differentiate the mechanism of action, general spectra of activity, common and severe adverse
events, and potential drug interactions for the following antifungal agents or classes:
See syllabus for list
Describe the mechanism of action, activity, common and severe adverse events, and potential for
drug interaction for the following antiviral agents or classes:
See syllabus for list
Explain major mechanisms of antimicrobial resistance of clinical importance
Describe the major routes of elimination/metabolism of all agents/classes presented in the course

Ability Based Educational Outcomes

Review the ABEOs in the syllabus
Course Materials: Required
Blackboard Marjorie Kelly Cowan. Microbiology: Systems Approach 4 rd edition
Katzung BG, Masters SB, Trevor AJ. Basic and Clinical Pharmacology current edition
Foyes Principles of Medicinal Chemistry current edition
A laptop computer for taking quizzes and exams
ExamSoft
Course materials: Suggested
Antibiotics Simplified, Third edition (2014), by Jason C. Gallagher and Conan MacDougall.
o Available in paperback or Kindle electronic edition
o The Sanford Guide to Antimicrobial Therapy, Current edition

A grade of C or better is required to pass the

course!

Quizzes
Quizzes will be administered via ExamSoft
o Administered in-class
o Quizzes will be 10 questions; 15 minutes in duration
The intent of quizzes is to keep you on track with studying, so you dont ignore this class for others

Policies and Expectations

Attend class
Please silence any device that makes noise
TRACE evaluations are very important. Changes are made each year based on your comments
Any issues with the administration of the course, including grading, should be directed to me first
Please use discussion board on BB for questions regarding content
Academic honesty; no cheating will be tolerated; see syllabus for full policy
Disabilities: please contact DRC and notify me
Turningpoint response ware
o Will be used in portions of course
o Please bring a device that will allow participation; Ill inform you
Tegrity
o Every effort will be made to capture lectures but it cannot be guaranteed
Schedule
Med Micro beginning 5/11 through 6/6
Pharmacology and Medicinal Chemistry for second half of course (6/8-8/10)
2 active learning sessions 6/29 and 8/1