First measurement of energy released from a virus during infection 2/13/10 11:51 AM

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First Measurement of Energy Released from a Virus During Infection Synthetic Gene-Like Crystals to Capture CO 2
ScienceDaily (Feb. 7, 2010) — Within a virus's tiny Science Video News
exterior is a store of energy waiting to be
unleashed. When the virus encounters a host cell, Detecting Disease In Less Than
this pent-up energy is released, propelling the viral 60 Seconds
DNA into the cell and turning it into a virus factory. Chemists and immunologists devised
a new rapid system for detecting and
For the first time, Carnegie Mellon University identifying viruses. It uses surface
physicist Alex Evilevitch has directly measured the enhanced Raman spectroscopy to
energy associated with the expulsion of viral DNA, measure. ... > full story
a pivotal discovery toward fully understanding the Pediatricians Reduce Ear Infections By
physical mechanisms that control viral infection and Vaccinating Children
designing drugs to interfere with the process. Infectious Disease Specialists Design New Rapid
3D reconstruction of bacteriophage lambda with Flu Test
"We are studying the physics of (left) and without (right) DNA. (Credit: Image
courtesy of Carnegie Mellon University) Pathologists Invent Easy Way To Diagnose
See Also: viruses, not the biology of viruses,"
MRSA
said Evilevitch, associate professor
Health & Medicine of physics in the Mellon College of Ads by Google more science videos
Viruses Science at Carnegie Mellon. "By
Genes treating viruses as physical objects, Latest Science News
Infectious Diseases we can identify physical properties Find Breaking News About
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Virology are common to a variety of viruses, www​.google​.com​/news
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Biochemistry
development of broad spectrum Rapid VLP results for Flu RSV HSV
Research
antiviral drugs." Baculovirus Rubella Adenovirus CSV
Reference www​.​In​Dev​R​.com
Human Current antiviral medications are
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burgeoning field of physical virology stands to provide tools Breaking News ... from NewsDaily.com
for the rational design of less-specialized antiviral drugs that
will have the ability to treat a broad range of viruses by Related Stories First Russian launch
interrupting the release of viral genomes into cells. from French Guiana
Researchers Uncover Direct Evidence On How delayed-agency
Evilevitch's current findings also have the potential to improve
HIV Invades Healthy Cells (Dec. 22, 2005) — Astronauts install
the development of gene therapy, which uses viruses to
New insight into how HIV infects healthy cells space station's last
deliver functional genes directly to human cells to replace
could lead to new drug therapies, according to hub
defective genes that are causing disease. Gene therapy takes
new research at Saint Louis University's Institute
advantage of viruses' modus operandi -- injecting genetic New study links
for Molecular ... > read more
material into cells. But instead of forcing in harmful, viral DNA, drilling to Indonesia
gene therapy delivers helpful, functional genes. Controlled Transcriptional Coactivators Not Useful As mud volcano
packaging of the functional genes into the viral delivery Herpes Antiviral Drug Targets (Mar. 25, 2009)
system is one of the key factors involved in developing a Scientists find clue
— Researchers have determined that the herpes to anxiety drug
successful gene therapy. simplex virus type 1 (HSV-1) does not require addiction
transcriptional coactivators for viral gene
Many viruses, whether they infect bacteria, plants or animals, NASA launches
expression early in the infection process. The
are adept at packing long stretches of nucleic acid (DNA or satellite to watch for
finding is ... > read more
RNA) within their nanometer-sized protein shells. In many of solar storms
the viruses that contain double-stranded DNA, the DNA gets NYU Study Reveals How Brain's Immune
packaged so tightly that it bends upon itself, resulting in more science news
System Fights Viral Encephalitis (Mar. 30, 2005)
repulsive forces that exert a tremendous amount of pressure — New York University biologists have uncovered
on the virus's outer shell, indicating a great amount of stored In Other News ...
how the innate immune system in mice's brains
energy. At the moment of infection, when the DNA is being fights viral infection of neurons. The findings, Marines spearhead
shot out of the virus, the energy stored in the tightly packed published as the cover study in the latest issue of major Afghanistan
DNA is released and converted into thermal energy. ... > read more offensive
Eight die in India's

http://www.sciencedaily.com/releases/2010/02/100205102620.htm Page 1 of 2
First measurement of energy released from a virus during infection 2/13/10 11:51 AM

Evilevitch and his colleagues from Lund University in Sweden, Eight die in India's
Herpes Virus Hijacks DNA Repair Process
where Evilevitch was previously employed, and the Universite first big attack since
(June 15, 2007) — Scientists probing the details of
de Lyon in France used an experimental technique known as Mumbai
viral infection have discovered an intriguing
isothermal titration calorimetry (ITC) to directly measure the surprise: in mice, herpes viruses hijack their host Obama names U.S.
heat, and thus the thermal energy, released during viral cells' tools for fixing DNA damage and use those envoy to Muslim
genome ejection. Until now, only indirect measurements of tools to enhance ... > read more world body
this energy have been available. They describe this new Men's start switched
method in the Feb. 5 issue of the Journal of Molecular Lifespan Of HIV-Infected Cells Might Be
after fatal crash
Biology. Shorter Than Previously Believed (July 3, 2009)
— Researchers have used mathematical models to Unsafe conditions
"We are the first group to use titration calorimetry to study demonstrate that cells infected with HIV could die prompt 4.9 million
genome release from viruses," Evilevitch said. "In this study, sooner than was thought until now. If infected cells pound meat recall
we looked at viruses that infect bacteria, called have a shorter lifespan then this increases the ... Wen warns of
bacteriophages, as an experimental model system, but ITC > read more challenges as China
can also be applied to other types of viruses. We're currently welcomes new year
investigating the rotavirus, which causes stomach flu, using Ads by Google
our new technique." U.S. reviewing
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AMITIZA® (lubiprostone)
In the Journal of Molecular Biology report, Evilevitch used ITC procedures: report
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results from genome packaging. His results, which agree with management:
analytical models and computer simulations, show that the Virus and Trojan Remover Draghi
heat released increases as DNA length increases. He also Download Free Trojan & Virus Scan
discovered that the ordering of water molecules around DNA more top news
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strands inside the virus (called hydration entropy) has a www​.pctools​.com
tremendous influence on the build up of energy. This Copyright Reuters 2008. See Restrictions.
unpredicted effect was not accounted for in the previous Pfizer for Professionals
models. Get Specialized Resources at The
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"Understanding the energy profile for viral genome release www​.​Pfizer​Pro​.com
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provides information on how to interfere with the process. For
example, developing ways to decrease the internal energy in Electricity on the Cheap? Get the latest science news with our free email
viruses could prevent viruses from ejecting their genome and $49.97 kit has energy co's execs newsletters, updated daily and weekly. Or view
prevent infection," Evilevitch said. seeing red! Calling for ban on sale hourly updated newsfeeds in your RSS reader:
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