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BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART

DRUG & STRENGTH


(Storage Prior to Use,
Manufacturer,
Preservative Status)
Aldesleukin
22 million units
(1.3 mg)
(Novartis)
(F)(PFL)
no preservative1

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

1.2 mL SWI1,2

18 million unit/mL
(1.1 mg/mL)1,2

48 h F1

50 mL D5W1

48 h F1

- do not use in-line


filter1,2
- avoid bacteriostatic
water for injection or
NS due to increased
aggregation1

30 70 mcg/mL1

direct diluent against


side of vial during
reconstitution1

Less than 30 mcg/mL:


dilute in D5W
containing human
albumin 0.1%2

do not shake1

SC syringe3,4

14 d F4
**(PFL)

Alemtuzumab
30 mg/mL
(Genzyme previously
Bayer)5
(F)(PFL)
do not shake
no preservative6

N/A

filter NOT required6


30 mg/mL6

discard unused
portion6

SC syringe7

discard at the end of


the day F or RT

100 mL NS or D5W6

8 h F or RT6
**(PFL)8

100 mL NS or D5W9

8 h F or RT8
**(PFL)8

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

1/46

- do not shake8

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Amifostine
500 mg
(MedImmune)
(RT)
no preservative10
Amsacrine
75 mg/1.5 mL
(Erfa Canada)
(RT)
no preservative12

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

9.7 mL NS only10

50 mg/mL10

24 h F, 5 h RT10

2550 mL* NS only10

540 mg/mL:
24 h F, 5 h RT10

glass syringes
preferred during
reconstitution;
max. time in plastic
syringe12: 15 min

5 mg/mL12

24 h RT12

500 mL D5W12

7 d F, 48 h RT12-14

PFL12

(plastic or glass
container)12

discard unused
portion15

100-250 mL NS,
D5W15

13.5 mL supplied
diluent (L-lactic
acid)1
transfer 1.5mL from
ampoule into the
diluent vial12
Arsenic
10 mg/10 mL
(Lundbeck)
(RT)
no preservative15

N/A

1 mg/mL15

24 h RT, 48 h F15

(use filter needle to


withdraw from
ampoule)

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

2/46

Special
Precautions/Notes

- discard cloudy
solution11

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Asparaginase
(asparaginase E. coli)
10,000 units
(CGF/EUSA)
(F)
no
preservative{[12004}}

Erwinia asparaginase
(asparaginase Erwinia
chrysanthemi)
10,000 units
(CGF/EUSA)
(F)
no preservative19

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

4 mL SWI16

2500 units/mL

3 h RT or 72 h F16

syringe

complete
administration within
3 h RT or 72 h F16

50-250 mL NS or
D5W17

complete
administration within
3 h RT16,18

glass or
polypropylene
syringe19

4 h RT19

do not shake; rotate


gently16

1-2 mL NS19

10 000-5000
units/mL

15 min RT19

do not shake; mix


gently to minimize
bubbles and contact
with stopper19

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

3/46

Special
Precautions/Notes

- contact with the


rubber stopper may
denature the
reconstituted drug,
creating filaments of
insoluble material; if
present, use 5
micron filter during
administration19
- do not use sterile
water for
reconstitution as the
resulting product is
not isotonic19

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
PEG-asparaginase see pegaspargase in
L-Z chart
(pegylated
asparaginase E. coli)
azaCITIDine
100 mg
(Celgene)
(RT)
no preservative20

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

4 mL SWI20

25 mg/mL20

8 h F, 45 min
RT20

SC syringe20

8 h F, 45 min RT20

25 mg/mL20

22 h F21,22

- discard if contains
large particles20
- re-suspend syringe
contents before
injection by
vigorously rolling
syringe between
palms20
-if cold diluent
reconstitution is used
to extend stability,
minimize exposure to
RT; ensure proper
refrigeration of
diluent, reconstituted
vial, and final
product

shake vigorously20

cold diluent
reconstitution:
4 mL SWI at 28C21,22

22 h F21,22

Refrigerated
syringes20:
allow up to 30 min
prior to
administration to
reach a
temperature of ~2025C
discard syringe if
time elapsed at RT
is greater than 30
min

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

4/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
BCG
81 mg
(Sanofi Pasteur)
(F)(PFL)
preservative23

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

do not shake; roll to


reconstitute23

10.5 8.7108
CFU/vial
(Connaught
strain)23

2 h F, RT23

50 mL NS23

2 h F or RT after
reconstitution23

- auxiliary label:
biohazard18

1 to 8108
CFU/vial24

2 h F (PFL)24

3 mL supplied
diluent23

**(PFL)23

record time of
reconstitution
BCG
(Tice substrain)
50 mg = 1 to 8 x 108
CFU
(Hospira/Organon)
(F)(PFL)
no preservative24

1 mL preservative
free NS for
injection24
use reconstitution
device provided

transfer from vial to


60 mL syringe, rinse
vial with another 1 mL
NS. Add rinse to
same 60 mL syringe.
qs to 50 mL with NS24

2 h F24

allow to stand for a


few minutes, then
gently swirl to
suspend24

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

5/46

- auxiliary label:
biohazard18
- overfill unknown
- protect from light24
- do not filter24

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Bendamustine
25 mg
100 mg
(Lundbeck)
(RT)(PFL)
no preservative25

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

25 mg vial:
add 5 mL SWI25

5 mg/mL25

30 minutes25

500 mL NS25
0.2-0.6 mg/mL25

complete
administration within
24 h F, 3 h RT25

1.4-16.5 mg/mL27

48 h F, RT26-28

Special
Precautions/Notes

100 mg vial:
add 20 mL SWI25
shake well;
dissolves completely
in 5 minutes25

Bevacizumab
100 mg/4 mL
400 mg/16 mL
(Roche)
(F)(PFL)
do not shake
no preservative26
Bleomycin
15 units
(NB: dose in units only)
(Bristol)
(F)
no preservative29

N/A

25 mg/mL26

discard unused
portion26

- do not shake26

100-250 mL NS
only26,27

6 mL* NS29

2.5 units/mL

48 h F29

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

50 mL* NS29

24 h RT29

6/46

- no overfill30

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Bleomycin
15 units
(NB: dose in units only)
(Hospira)
(F)(PFL)
no preservative31
Bleomycin
15 units
(NB: dose in units only)
(Fresenius Kabi)
(F)(PFL)
no preservative34
Bortezomib
3.5 mg
(Actavis)
(RT)(PFL)
no preservative35

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

6 mL* NS or SWI31

2.5 units/mL31

48 h F, 24 h RT31

50 mL* NS, SWI31

24 h RT32

6 mL NS34

2.5 units/mL34

48 h F34

50 mL NS34

24 h RT34

3.5 mL NS35

1 mg/mL35

8 h RT35

syringe35

8 h RT35

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

7/46

Special
Precautions/Notes

- no overfill33

- auxiliary label:
WARNING:
SUBCUTANEOUS
or INTRAVENOUS
use only. Fatal if
given by other
routes.18

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Bortezomib
3.5 mg
(Janssen)
(RT)(PFL)
no preservative36

Bortezomib
3.5 mg
(Teva)
(RT)(PFL)
no preservative38

Brentuximab vedotin
50 mg
(GMD Distribution for
Seattle Genetics)
(F)(PFL)
no preservative39

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

3.5 mL NS36

1 mg/mL36

2 d RT13,37

syringe36

8 h RT36

- auxiliary label:
WARNING:
SUBCUTANEOUS
or INTRAVENOUS
use only. Fatal if
given by other
routes.18

3.5 mL NS38

1 mg/mL38

8 h RT38

syringe38

8 h RT38

- auxiliary label:
WARNING:
SUBCUTANEOUS
or INTRAVENOUS
use only. Fatal if
given by other
routes.18

10.5 mL SWI39

5 mg/mL39

24 h F39

0.4-1.8 mg/mL in NS,


D5W, Lactated
Ringers (i.e. 100-250
mL)39

24 h F39

- solution should be
clear to slightly
opalescent,
colorless, and free of
visible particulates39

Direct diluent
against side of
vial during
reconstitution39

Do NOT freeze39

Do NOT shake39

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

8/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Busulfan
60 mg/10 mL
(Orphan Medical)
(F)
no preservative40

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

N/A

use 5-micron nylon


filter provided with
ampoule to
withdraw drug40

discard unused
portion40

NS or D5W (dilute in
volume 10 times the
busulfan volume to
~0.5 mg/mL)40

complete
administration within
12 h F: NS40
8 h RT: NS, D5W

1 h RT41

0.10 0.26 mg/mL


NS, D5W41
(e.g., 250 mL*)

complete
administration within
8 h RT, 48 h F41

Special
Precautions/Notes

6 mg/mL40
Cabazitaxel
60 mg/1.5 mL
(sanofi-aventis)
(RT)
no preservative41

supplied diluent:
withdraw entire
contents of diluent
vial and inject into
the concentrate
vial41

10 mg/mL41

slowly direct diluent


against inside of vial
to limit foaming41
mix by repeated
inversions for 45
sec41
do NOT shake41
let sit for 5 min41

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

9/46

- concentrate and
diluent vials contain
overfill41
- use non-DEHP bag
and tubing41
- use 0.22 micron inline filter41
- diluent contains
13% (w/w) ethanol in
water41
- discard if
crystallization
occurs41

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
CARBOplatin
50 mg/5 mL
150 mg/15 mL
450 mg/45 mL
(Accord)
(RT)(PFL)
no preservative42
CARBOplatin
50 mg/5 mL
150 mg/15 mL
450 mg/45 mL
600 mg/60 mL
(Hospira)
(RT)(PFL)
no preservative43
CARBOplatin
50 mg/5 mL
150 mg/15 mL
450 mg/45 mL
(Teva/Novopharm)
(RT)(PFL)
no preservative46

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

10 mg/mL42

discard unused
portion42

0.5-10 mg/mL42

8 h RT, 24 h F42

- do NOT use
aluminum-containing
needle, syringe, or
tubing42

discard unused
portion43

0.3-10 mg/mL44

24 h RT,45 48 h F43

- do NOT use
aluminum-containing
needle, syringe, or
tubing44

discard unused
portion RT46

0.5-10 mg/mL47

8 h RT46

- do NOT use
aluminum-containing
needle, syringe, or
tubing46

N/A

N/A

10 mg/mL43

10 mg/mL46

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

NS, D5W42

NS, D5W11,43

NS, D5W11,46,48

10/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Carfilzomib
60 mg
(Amgen)
(F)(PFL)
no preservative49

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

29 mL SWI49

2 mg/mL49

24 h F, 4 h RT49

50 100 mL D5W
only49
do NOT dilute in NS49

complete
administration within
24 h F, 4 h RT after
reconstitution49

- infusion lines may


be flushed with
either NS or D5W49

glass50 or polyolefin
container11

24 h F: in glass50 or
polyolefin container11

500 mL NS or D5W50

- do not use if
product has oily
droplets50

use within 4 h of
reconstitution RT50

swirl gently; do not


shake to avoid foam
formation49
if foaming occurs,
allow to settle until
clear (~5 minutes)49
record time of
reconstitution

Carmustine
100 mg
(Bristol Labs)
(F)
no preservative50

3 mL diluent
(supplied)50

3.3 mg/mL in 10%


ethanol50

24 h F, 8 h RT50

diluent to reach RT,


then dissolve drug
with 3 mL diluent;
add 27 mL SWI50
record time of
reconstitution

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

11/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Cetuximab
100 mg/50 mL
200 mg/100 mL
(ImClone/BMS)
(F)
do not dilute
do not shake
no preservative51

CISplatin
10 mg/10 mL
50 mg/50 mL
100 mg/100mL
(Hospira)
(RT)(PFL)
no preservative52

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

2 mg/mL51

discard unused
portion after 12 h
F, 8 h RT51

syringe51

12 h F, 8 h RT51

sterile evacuated
container or bag e.g.
polyolefin,
polyethylene,
ethylene vinyl
acetate, DEHP
plasticized PVC, PVC
bag, or glass51

12 h F, 8 h RT51

- administer with a
0.2 or 0.22 micron
low protein binding
in-line filter51
- normal saline may
be used to flush the
line51
- solution may
contain white
particulates which do
not affect product
quality51

Less than or equal to


60 mg: 100 mL* NS

48 h RT53

N/A

1 mg/mL52

48 h RT53

Greater than 60 mg:


250 mL* NS
500 or 1000 mL* NS,
D5-NS, D5-1/2S, D5NS with mannitol, D51/2S with
mannitol52,54; D5W1/3S with mannitol52

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

12/46

- do NOT use
aluminum-containing
needle, syringe or
tubing52

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
CISplatin
10 mg/10 mL
50 mg/50 mL
100 mg/100mL
(Sandoz)
(RT)(PFL)
no preservative55

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

1 mg/mL55

48 h RT55,56

Less than or equal to


60 mg: 100 mL NS*

24 h RT55

- do NOT use
aluminum-containing
needle, syringe or
tubing55

24 h RT58

- do NOT use
aluminum-containing
needle, syringe or
tubing58

Greater than 60 mg:


250 mL NS*
NS; 0.45 % Sodium
Chloride with or
without mannitol57
2 L of D5 in one-half
or one-third NS
containing 37.5 g of
mannitol55

CISplatin
10 mg/10 mL
50 mg/50 mL
100 mg/100mL
(Teva)
(RT)(PFL)
no preservative58

N/A

1 mg/mL58

discard unused
portion18

Less than or equal to


60 mg: 100 mL* NS
Greater than 60 mg:
250 mL* NS
2 L of D5 in one-half
or one-third NS
containing 37.5 g of
mannitol58

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

13/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Cladribine
10 mg/10 mL
(Janssen-Ortho)
(F)(PFL)
no preservative59

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

1 mg/mL59

discard unused
portion59

SC syringe60

48h F, end of day


RT13,59,61,62

500 mL NS only59

- shake vigorously to
dissolve any
precipitates from
refrigeration59

24 h RT59

Do NOT use D5W59


Cassette:
qs to 100 mL with
bacteriostatic NS
only via SIMS
DELTEC INC.
MEDICATION
CASSETTES59 filter
drug and diluent
through 0.22 micron
filter as each solution
is being introduced
into the cassette

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

at least 7 days59

14/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Cladribine
10 mg/10 mL
(Fresenius Kabi)
(F)(PFL)
no preservative63

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

N/A

1 mg/mL63

discard unused
potion63

SC syringe60

discard end of
day13,62,63

500 mL NS only

24 h RT

Do NOT use D5W

Clodronate
300 mg/10 mL
(Oryx)
(RT)
no preservative64

N/A

30 mg/mL64

discard unused
portion64

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

Cassette:
qs to 100 mL with
bacteriostatic NS
only via SIMS
DELTEC INC.
MEDICATION
CASSETTES63 filter
drug and diluent
through 0.22 micron
filter as each solution
is being introduced
into the cassette

at least 7 days63

500 mL NS or D5W64

12 h RT64

15/46

Special
Precautions/Notes

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Cyclophosphamide
200 mg
500 mg
1000 mg
2000 mg
(Baxter)
(RT)(PFL)
no preservative65

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

NS66

20 mg/mL65

48 h F,56,65,67
24 h RT65

Less than or equal to


1 g: 100 mL NS*

72 h F,65,67
24 h RT65

200 mg: 10 mL
500 mg: 25 mL
1000 mg: 50 mL
2000 mg: 100 mL65

Special
Precautions/Notes

Greater than 1 g: 250


mL NS*
high dose in BMT:
may need 500 NS*
NS, D5W, D5NS65

Cytarabine
100 mg/1 mL
1000 mg/10mL
2000 mg/20mL
(Hospira)
(RT)(PFL)
no preservative68

N/A

100 mg/mL68

24 h RT68

record time of
puncture

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

100 mL* NS, Water


for Injection, D5W,
Lactated Ringers68

72 h F, 24 h RT from
initial vial puncture68

16/46

- do not use for IT


injection

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Cytarabine
IT injection
100 mg/1 mL
1000 mg/10mL
2000 mg/20mL
(Hospira)
(RT)(PFL)
no preservative68

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

100 mg/mL68

24 h RT68

diluents containing
preservatives should
NOT be used for
intrathecal
administration68

use within 4 h of
initial vial puncture18

- auxiliary label: IT
injection18
- label to include
route in full (i.e.,
INTRATHECAL
injection) attached to
both syringe and
outer ziplock bag18

record time of
puncture

qs to 6 mL with
preservative free NS69

Cytarabine
SC injection
100 mg/1 mL
1000 mg/10mL
2000 mg/20mL
(Hospira)
(RT)(PFL)
no preservative68

record time of
puncture

Dacarbazine
100 mg
200 mg
(Abraxis)
(F)(PFL)
no preservative71

100 mg: 9.9 mL


SWI71
200 mg: 19.7 mL
SWI71

N/A

100 mg/mL68

24 h RT68

syringe

14 d F, 48 h RT18,70

- do not use for IT


injection

10 mg/mL71

72 h F, 8 h RT71

250-1000 mL* NS or
D5W

24 h F, 8 h RT71

- protect container
from light during
storage and
administration72
- overfill unknown

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

**(PFL)11,71
see Special
Precautions/Notes
Column

17/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Dacarbazine
200 mg
600 mg
(Hospira)
(F)(PFL)
no preservative73

DACTINomycin
0.5 mg
(GMD Pharma for
Recordati)
(RT)(PFL)
no preservative75

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

200 mg: 19.7 mL


SWI73
600 mg: 59.1 mL
SWI73

10 mg/mL73

48 h F, 8 h RT73

0.193.0 mg/mL13,73

24 h F73

(PFL)74

250-1000 mL* NS or
D5W

**(PFL)72
see Special
Precautions/Notes
Column

1.1 mL SWI
(preservative-free)75

0.5 mg/mL
(500 mcg/mL)75

discard at end of
day56

syringe75

use within 4 h of
initial vial puncture56

Do NOT use SWI


with preservative
(may form
precipitate)75

10 mcg/mL or
greater75
NS, D5W75,76

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

18/46

Special
Precautions/Notes

- protect container
from light during
storage and
administration72
- no overfill33,74

- drug loss reported


with some cellulose
ester membrane inline filters75

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Daratumumab
100mg/5mL
400mg/20mL
(Jannsen)
(F)(PFL)
do not shake
no preservative77

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

20 mg/mL77

discard unused
portion77

500-1000 mL NS
dilute to final volume
by withdrawing
volume from bag
equal to volume of
drug to be added77

24 h F, followed by
15 h infusion (total 39
h)77

- administer with a
0.22 or 0.2 micron
low protein binding
in-line filter77
- discard if visible
particles are
observed77
- complete infusion
within 15 hours77

mix by gentle
inversion77
DAUNOrubicin
20 mg
(Erfa Canada Inc.)78
(RT)(PFL)79
no preservative80

DAUNOrubicin
20 mg
(Teva/Novopharm)
(RT)(PFL)
no preservative82

4 mL SWI78

5 mg/mL78,81

48 h F, 24 h RT80

100-250 mL in
isotonic solution e.g.,
NS78

allow bag to come to


room temperature,
then use
immediately77

24 h RT, 48 h F78

no data for D5W80


4 mL SWI82

5 mg/mL82

24 h RT, 48 h F82
(PFL)82

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

100-250 mL
NS or D5W11

48 h F, 24 h RT82
**(PFL)82

19/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Degarelix
80 mg
120 mg
(Ferring)
(RT)
do not shake83
no preservative84

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

80 mg: 4.2 mL SWI


(supplied diluent)83

20 mg/mL83

2 h RT83

SC syringe83

2 h RT83

120 mg: 3 mL SWI


(supplied diluent)83

40 mg/mL83

swirl gently; avoid


shaking to prevent
foam formation83
reconstitution may
take up to 15 min83

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

20/46

Special
Precautions/Notes

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Denosumab
(XGEVA)
120 mg/1.7 mL
(Amgen)
(F)(PFL)
do not shake
no preservative85

Dexrazoxane
250 mg
500 mg
(Pfizer)
(RT)
no preservative86

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

N/A

71 mg/mL85

discard unused
portion56,85

SC syringe85

use within 4 h of
initial puncture56

SWI86

10 mg/mL86

30 min RT, 4 h
F86

MUST BE FURTHER
DILUTED With
Lactated Ringers
Injection to 1.3 3.0
mg/mL86

1 h RT, 4 h F86

250 mg: 25 mL
500 mg: 50 mL

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

21/46

Special
Precautions/Notes

- not interchangeable
with PROLIA85
- do not use if
solution is cloudy;
trace amounts of
translucent to white
proteinaceous
particles are
acceptable85
- avoid vigorous
shaking85
- bring to room
temperature 15-30
minutes prior to
administration85

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
DOCEtaxel
20 mg/2 mL
80 mg/8 mL
160 mg/16 mL
(Hospira)
(F, RT)(PFL)
preservative87

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

N/A

10 mg/mL87

20mg/2 mL vial:
discard unused
portion18,87

0.3-0.74 mg/mL87

complete
administration within
4 h F,87 48 h RT18,88

(250 mL NS or
D5W)87

80 mg/8 mL or
160 mg/16 mL
vial (maximum
number of
punctures: up to 3
doses can be
removed when a
venting needle is
also inserted, i.e.,
6 punctures
total)90
14 d F18,87
**(PFL)18,87

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

22/46

Special
Precautions/Notes

- use non-DEHP bag


and IV administration
set87
- do not use chemo
dispensing pins89

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
DOCEtaxel
20 mg/0.5 mL
80 mg/2 mL
(sanofi-aventis)
(F, RT)(PFL)
no preservative91

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

supplied diluent :
- if vials were
refrigerated, allow to
warm for 5 min at
RT. Withdraw entire
contents of the
diluent and inject the
entire contents of
the syringe into the
corresponding
concentrate vial. Mix
by repeated
inversions for 45
sec91

10 mg/mL91

48 h F, RT18,91,92

0.3-0.74 mg/mL91

complete
administration within
4 h F,91
48 h RT18,92

- use non-DEHP
bag and IV
administration set91

24 h F, RT from initial
vial puncture93

- for ULYEPOCHR
protocol, see entry
for EPOCHR
(3-in-1solution
containing
etoposide,
DOXOrubicin,
vinCRIStine)

(250 mL NS or
D5W)91

DO NOT SHAKE91
Let sit for 5
minutes91
DOXOrubicin
10 mg/5 mL
20 mg/10 mL
50 mg/25 mL
200 mg/100 mL
(Accord)
(F)(PFL)
no preservative93

N/A

2 mg/mL93

8 h93

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

syringe93

23/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
DOXOrubicin
10 mg
50 mg
150 mg
(Hospira)
(RT)(PFL)
no preservative94

DOXOrubicin
10 mg/5 mL
20 mg/10 mL
50 mg/25 mL
200 mg/100 mL
(Teva/Novopharm)
(F)(PFL)
no preservative96
DOXOrubicin
10 mg/5 mL
50 mg/25 mL
200 mg/100 mL
(Pfizer)
(F)
no preservative97

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

NS, SWI, D5W94


(NS reconstitution
takes longer)
10 mg: 5 mL
50 mg: 25 mL
150 mg: 75 mL

2 mg/mL94

48 h F, 24 h
RT13,94

syringe94

48 h F, 24 h RT13,95

- for ULYEPOCHR
protocol, see entry
for EPOCHR
(3-in-1solution
containing
etoposide,
DOXOrubicin,
vinCRIStine)

N/A

2 mg/mL96

8 h96

syringe96

48 h F, 24 h RT96
from initial vial
puncture

- for ULYEPOCHR
protocol, see entry
for EPOCHR
(3-in-1solution
containing
etoposide,
DOXOrubicin,
vinCRIStine)

2 mg/mL97

discard unused
portion56,97

syringe97

48 h F, 24 h RT97

- for ULYEPOCHR
protocol, see entry
for EPOCHR
(3-in-1solution
containing
etoposide,
DOXOrubicin,
vinCRIStine)

record time of
puncture

N/A

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

24/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
DOXOrubicin
Pegylated Liposomal
20 mg/10 mL
(Janssen)
(F)
no preservative98

Epirubicin
10 mg/5 mL
20 mg/10 mL
50 mg/25 mL
150 mg/75 mL
200 mg/100 mL
(Novopharm)
(F)(PFL)
no preservative99
Epirubicin
10 mg/5 mL
50 mg/25 mL
200 mg/100 mL
(Fresenius Kabi)
(F)(PFL)
no preservative100

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

N/A

2 mg/mL98

discard unused
portion98

Less than 90 mg: 250


mL D5W only98

24 h F98

Greater than or equal


to 90 mg: 500mL
D5W only98
N/A

2 mg/mL99

8 h F, RT99

syringe99

48 h F, 24 h RT
from initial vial
puncture99

N/A

2 mg/mL100

8 h100

syringe100

48 h F, 24 h RT
from initial vial
puncture100

100 mL* NS or D5W

2 d F, RT:
NS or D5W18,100

record time of
puncture

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

25/46

Special
Precautions/Notes

- do not filter98

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Epirubicin
10 mg/5 mL
50 mg/25 mL
200 mg/100 mL
(Pfizer)
(F)(PFL)
no preservative101
EPOCHR
(ULYEPOCHR protocol)
(RT)(PFL)
no preservative18,102-105

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

N/A

2 mg/mL101

8 h101

syringe101

48 h F, 24 h RT from
initial vial puncture101

100 mL* NS or D5W11

2 d F, RT: NS or
D5W53

etoposide dose
125 mg/24 h:
in 500 mL NS

etoposide
concentration
0.25 mg/mL:
complete
administration within
72 h RT

record time of
puncture

see brand specific


entries for:
DOXOrubicin as
applicable

see brand specific


entries for:
DOXOrubicin,
etoposide,
vinCRIStine

see brand
specific entries
for: DOXOrubicin,
etoposide,
vinCRIStine

etoposide dose
>125 mg/24 h:
in 1000 mL NS

precipitation occurs
at etoposide
concentrations
>0.25 mg/mL
**(PFL)
see Special
Precautions/Notes
column

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

26/46

Special
Precautions/Notes

- final product is a
3-in-1 solution
containing
etoposide,
DOXOrubicin,
vinCRIStine (refer to
ULYEPOCHR
protocol)
- use non-DEHP bag
and tubing only
- use inline filter
- protect container
from light during
administration and
storage

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
eriBULin
1 mg/2 mL
(Eisai Limited)
(RT)(PFL)106
no preservative18

Etoposide
100 mg/5 mL
500 mg/25 mL
1000 mg/50 mL
(BMS)
(RT)
preservative107

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

0.5 mg/mL106

discard at end of
day18,106

IV syringe106

24 h F, 6 h RT106

- do not administer
through dextrose
containing lines106
- vials contain
dehydrated alcohol
USP (5% v/v)106

N/A

20 mg/mL107

14 d RT11,13,108-110

0.2-0.4 mg/mL107

0.2 mg/mL:
48 h RT13,107

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

500 mL* NS or
D5W107

0.4 mg/mL:
24 h RT107

27/46

- use non-DEHP bag


and tubing only
- use 0.22 micron inline filter111
- for ULYEPOCHR
protocol, see entry
for EPOCHR
(3-in-1solution
containing
etoposide,
DOXOrubicin,
vinCRIStine)

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Etoposide
100 mg/5 mL
200 mg/10 mL
500 mg/25 mL
1000 mg/50 mL
(Sandoz)
(RT)(PFL)
preservative112

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

20 mg/mL112

14 d RT112

0.2-0.4 mg/mL NS,


D5W112

0.2 mg/mL:
7 d F, RT112

500 mL* NS or D5W

0.4 mg/mL:
12 h F, RT112

- use non-DEHP bag


and tubing only
- use 0.22 micron inline filter111
- for ULYEPOCHR
protocol, see entry
for EPOCHR
(3-in-1solution
containing
etoposide,
DOXOrubicin,
vinCRIStine)

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

28/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Etoposide
100 mg/5 mL
200 mg/10 mL
500 mg/25 mL
1000 mg/50 mL
(Teva/Novopharm)
(RT)(PFL)
no preservative113

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

20 mg/mL113

discard unused
portion113

NS

0.2-0.3 mg/mL:
7 d F,114 2 d RT114,115

- use non-DEHP bag


and tubing only
- use 0.22 micron inline filter111
- for ULYEPOCHR
protocol, see entry
for EPOCHR
(3-in-1solution
containing
etoposide,
DOXOrubicin,
vinCRIStine)

Stability is
concentration
dependent

0.4-0.5 mg/mL:
1 d F,114 1d RT114
0.6-9.0mg/mL:
generally unstable
9.5 mg/mL:
2 d F,114 1d RT114
10-12 mg/mL:
7 d F,114 2 d RT114,115

Etoposide phosphate
(ETOPOPHOS)
100 mg
(BMS)
(F)(PFL)
no preservative117

5 mL NS, D5W,
SWI, BWI117,118

20 mg/mL117,118

10 mL NS, D5W,
SWI, BWI117,118

10 mg/mL117,118

24 h RT117,118, 48
h F18,117,118

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

D5W113

4 h RT113,116

500 mL* NS,


D5W117,118

24 h F, RT117,118

(do not dilute to less


than 0.1 mg/mL)117,118

29/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Filgrastim
(NEUPOGEN)
300 mcg/1 mL
480 mcg/1.6 mL
(Amgen)
(F)(PFL)
do not shake
no preservative119

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

300 mcg/mL119

discard unused
portion18

SC syringe119

14 d F18,120

50-100 mL D5W
only121

48 h RT, 7 d F18,120

- albumin is added to
D5W to prevent
filgrastim adsorption
to plastic119
- incompatible with
saline119,121
- do NOT dilute to
less than 5
mcg/mL119

in PVC, polyolefin, or
glass119
(for filgrastim
concentrations of 515 mcg/mL in D5W,
add albumin 2
mg/mL)119

Fludarabine
50 mg
(Berlex)
(F)
no preservative122

Fludarabine
50 mg
(Teva/Novopharm)
(F)
no preservative124

2 mL SWI122

25 mg/mL122

48 h F or RT13,53

dilute to maximum of
1 mg/mL122,123

48 h F, RT13,53

50-100 mL* NS or
D5W122
N/A

25 mg/mL124

discard unused
portion124

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

dilute to maximum of
1 mg/mL124

48 h F, 24 h RT124

50-100 mL* NS or
D5W

30/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Fluorouracil
5000 mg/100 mL
(Accord)
(RT)(PFL)
no preservative125

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

N/A

50 mg/mL125

8 h RT125

syringe125

8 h RT125

2 mg/mL in D5W125

24 h RT125

50-1000 mL* D5W

Fluorouracil
5000 mg/100 mL
(Hospira)
(RT)(PFL)
no preservative129

N/A

50 mg/mL129

8 h RT126,129

CIVI: ambulatory
pump126

complete within
8 d127,128

syringe13

48 h RT13,28,126

2-10 mg/mL in
D5W126,129

24 h RT126,129

50-1000 mL* D5W


CIVI: ambulatory
pump126

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

complete within
8 d11,13,127,128

31/46

Special
Precautions/Notes

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Fluorouracil
500 mg/10 mL
5000 mg/100 mL
(Sandoz)
(RT)(PFL)
no preservative130

Gemcitabine
200 mg
1000 mg
2000 mg
(Accord)
(RT)
no preservative131

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

N/A

50 mg/mL130

4 h RT18

syringe

4 h RT18

D5W130

24 h RT130

CIVI: ambulatory
pump126

complete within
8 d11,13,127,128

0.1-10 mg/mL NS131

48 h RT18,132,133

200 mg: 5 mL NS
1000 mg: 25 mL NS
2000 mg: 50 mL
NS131

38 mg/mL131

24 h RT131

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

32/46

Special
Precautions/Notes

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Gemcitabine
200 mg
1000 mg
(Eli-Lilly)
(RT)
no preservative134

Gemcitabine
200 mg
1000 mg
2000 mg
(Hospira)
(F)
no preservative136
Gemcitabine
200 mg
1000 mg
2000 mg
(Hospira)
(RT)137
no preservative138

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

200 mg: 5 mL NS
1000 mg: 25 mL
NS134

38 mg/mL134

48 h RT134,135

syringe134

48 h RT13,134,135

0.110 mg/mL
NS134,135

48 h F, RT13,134,135

N/A

38 mg/mL136

discard unused
portion at the end
of the day136

0.1 38 mg/mL NS,


D5W136

24 h RT136

200 mg: 5 mL NS
1000 mg: 25 mL NS
2000 mg: 50 mL
NS137

38 mg/mL137

48 RT56,137,139

syringe137

24 h RT137,139

0.1 - 26 mg/mL
NS137,139

48 h RT56,139

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

33/46

Special
Precautions/Notes

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Gemcitabine
200 mg
1000 mg
(Teva/Novopharm)
(RT)
no preservative140
Gemcitabine
200 mg
1000 mg
(Sandoz Standard)
(RT)
no preservative141

IDArubicin
5 mg
10mg
(Pfizer)
(RT)(PFL)
no preservative146

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

200 mg: 5mL NS


1000 mg: 25 mL
NS140

38 mg/mL140

24 h RT140

0.1 - 38 mg/mL NS140

24 RT140

200 mg: 5 mL NS
1000 mg: 25 mL
NS141

38 mg/mL141

48 h RT141,142

syringe141

48 h RT141-143

0.1 - 38 mg/mL NS or
D5W141,144

48 h RT13,145

syringe146

48 h F, 24 h RT146

5 mg: 5 mL SWI146
10 mg: 10 mL
SWI146

1 mg/mL146

48 h F,
24 h RT146
**(PFL)146

vial contents under


negative pressure146
do NOT use BWI to
reconstitute146

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

34/46

Special
Precautions/Notes

- avoid alkaline
solutions146

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
IDArubicin PFS
5 mg/5 mL
10 mg/10 mL
20 mg/20 mL
(Pfizer)
(F)(PFL)
no preservative146
IDArubicin
5 mg/5 mL
10 mg/10 mL
20 mg/20 mL
(Fresenius Kabi)
(F)(PFL)
no preservative147
Ifosfamide
1000 mg
3000 mg
(Baxter)
(RT)
no preservative148

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

1 mg/mL146

24 h RT,
48 h F

syringe146

4 h from initial
puncture18

- avoid alkaline
solutions146

- avoid alkaline
solutions147

**(PFL)146

N/A

1 mg/mL147

discard unused
solution147

syringe147

4 h from initial
puncture18

1000 mg: 20 mL
SWI148

50 mg/mL148

24 h RT, 48 h
F18,148

0.620 mg/mL148

24 h RT, 72 h F148

5001000 mL* NS,


D5W, Lactated
Ringers148

24 h F, RT when
mixed with mesna11

3000 mg: 60 mL
SWI148
shake well

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

35/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Ifosfamide
1000 mg
3000 mg
(Fresenius Kabi)
(RT)
no preservative149

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

1000 mg: 20 mL
SWI
3000 mg: 60 mL
SWI149

50 mg/mL149

24 h RT, 48 h
F18,149

0.6-20 mg/mL149

24 h RT, 72 h F149

500-1000 mL* NS
D5W, Lactated
Ringers149

shake well
Iniparib
100 mg/10 mL
(sanofi-aventis)
(F)
no preservative150

Interferon Alfa -2b


10 million units/1 mL
(Merck)
(F)
preservative151,152

N/A

10 mg/mL150

discard unused
portion150

24 h F, RT when
mixed with mesna11

24 h RT150

- *may also use


empty IV bag and qs
to final volume of
250 mL with NS,
D5W150

syringe151

7 d F18

final concentration
0.3 million IU/mL151

24 h F, RT151

- vials can be kept at


RT for up to 7 days
before use; discard if
not used within this
time151

250 mL NS, D5W


dilute to 250 mL final
volume by
withdrawing volume
from bag equal to
volume of drug to be
added*150

N/A

10 million
units/mL151

7 d F151

50 mL NS151

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

Special
Precautions/Notes

36/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Interferon Alfa -2b
18 million units/3 mL
(Merck)
(F)
preservative151,152

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

6 million
units/mL151

14 d F18,151

syringe151

14 d F18,152

final concentration
0.3 million IU/mL151

24 h F, RT151

- vials can be kept at


RT for up to 7 days
before use; discard if
not used within this
time151

50 mL NS151
Interferon Alfa -2b
25 million units/2.5 mL
(Merck)
(F)
preservative151,152

N/A

10 million
units/mL151

14 d F18,151

syringe151

14 d F18,152

final concentration
0.3 million IU/mL151

24 h F, RT151

50 mL NS151

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

37/46

- vials can be kept at


RT for up to 7 days
before use; discard if
not used within this
time151

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Interferon Alfa -2b
10 million units
(Merck)
(F)
no preservative (unless
reconstituted with
BWI)151

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

1 mL supplied
diluent (SWI)151

10 million
units/mL151

24 h F151

syringe151

24 h F18,152

final concentration
0.1 million IU/mL151

24 h F, RT152

- after reconstitution,
provides an isotonic
solution which may
be used for
intralesional
injection151
- non-reconstituted
vials can be kept at
RT for up to 4 weeks
before use; discard if
not reconstituted for
use within this
time151

do not shake; roll to


reconstitute151

100 mL NS151
1 mL BWI151

14 d F18,151

syringe151

14 d F18,151

final concentration
0.1 million IU/mL151

24 h F, RT152

do not shake; roll to


reconstitute151

100 mL NS151

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

38/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Interferon Alfa -2b
18 million units
(Merck)
(F)
no preservative (unless
reconstituted with
BWI)151

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

1 mL supplied
diluent151

18 million
units/mL151

24 h F151

syringe151

24 h F18,152

final concentration
> 0.1 million IU/mL151

24 h F, RT152

- non-reconstituted
vials can be kept at
RT for up to 4 weeks
before use; discard if
not reconstituted for
use within this
time151

do not shake; roll to


reconstitute151

100 mL NS151
1 mL BWI151

14 d F18,151

do not shake; roll to


reconstitute151

syringe151

14 d F18,151

final concentration
> 0.1 million IU/mL151

24 h F, RT152

100 mL NS151

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

39/46

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Ipilimumab
50 mg/10 mL
200 mg/40 mL
(BMS Canada)
(F)(PFL)
no preservative153

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

N/A

5 mg/mL153

24 h F,RT153

1 4 mg/mL in
NS, D5W 100 mL153

24 h F,RT153

OR
undiluted in empty
viaflex bag or glass
bottle
(allow vials to stand at
RT for ~5 min prior to
withdrawal of
contents)153

Irinotecan
40 mg/2 mL
100 mg/5 mL
500 mg/25 mL
(Accord)
(RT)(PFL)
no preservative154

N/A

20 mg/mL154

discard unused
portion154

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

0.12 2.8 mg/mL154

48 h F, 24 h RT

500 mL*
D5W (preferred),
NS154

**(PFL)154

40/46

Special
Precautions/Notes

- do NOT shake153
- administer with 0.2
or 0.22 low protein
binding in-line filter153
- vials may contain
translucent-to-white
amorphous
particles153
- discard if cloudy or
has pronounced
colour change
(should be clear to
pale yellow)153
- flush line with NS or
D5W after infusion153

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Irinotecan
40 mg/2 mL
100 mg/5 mL
500 mg/25 mL
(Hospira)
(RT)(PFL)
no preservative155
Irinotecan
40 mg/2 mL
100 mg/5 mL
(Pfizer)
(RT)(PFL)
no preservative158
Irinotecan
40 mg/2 mL
100 mg/5 mL
500 mg/25 mL
(Sandoz)
(RT)(PFL)
no preservative159

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

N/A

20 mg/mL155

2 days RT13,156,157

0.12 2.8 mg/mL155

24 h RT: D5W, NS155

500 mL11 D5W


(preferred), NS155

- do NOT refrigerate
if in NS158

48 h F: D5W

0.12 2.8 mg/mL158

24 h RT: D5W, NS158

500 mL11 D5W


(preferred), NS158

48 h F: D5W

0.12-2.8 mg/mL159

24 h RT: D5W, NS159

D5W (recommended),
NS159

48 h F: D5W159

N/A

N/A

20 mg/mL158

20 mg/mL159

discard unused
portion158

discard unused
portion56,159

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

**(PFL)155

**(PFL)158

**(PFL)159

41/46

- do NOT refrigerate
if in NS158

BC CANCER AGENCY CHEMOTHERAPY PREPARATION AND STABILITY CHART


DRUG & STRENGTH
(Storage Prior to Use,
Manufacturer,
Preservative Status)
Ixabepilone
15 mg
(contains 16 mg)
45 mg
(contains 47 mg)
(BMS)
(F)(PFL)
no preservative160

Reconstitute
With:

To Give:

Vial
Stability

Product

Product Stability

Special
Precautions/Notes

15 mg: 8 mL
supplied diluent160

2 mg/mL160

1 h RT160

0.2 0.6 mg/mL in


Lactated Ringers
Injection USP (use
non-DEHP infusion
container)160

6 h RT160

- use 0.2-1.2 micron


in-line filter160
- use non-DEHP bag
and administration
set160

45 mg: 23.5 mL
supplied diluent160

* Suggested volume based on usual dose range and any concentration range of stability data
** Protect from light means minimizing exposure to direct sunlight over a storage period. More specific information on protection from light (eg, protecting container and tubing during
administration) will be indicated in the Special Precautions/Notes column.

Centres are not to change the content locally but should forward suggestions to the Cancer Drug Manual staff.
Explanatory Notes
Stability data assumes products prepared using standard aseptic technique in biological safety cabinet at low risk for contamination according to the classification outlined in USP
28,161
797.
Vial stability: Stability of solution after first puncture or reconstituted solution.
Storage temperature: If information states same stability with refrigerator and room temperature storage, then fridge stability is bolded as preferred (ie, to minimize growth of microorganisms).
Discard unused portion: Unused portion from single use vials should be discarded at the end of the day.
overfill known is stated if the manufacturer states overfill that is present is within acceptable limits.
Complete administration within __ is stated if the manufacturer specifies that the infusion must be completed in a specific time frame following preparation, usually including entire
time required for preparation (from first puncture), storage, and administration of infusion.

Abbreviations
BWI = bacteriostatic water for injection
CIVI: ambulatory pump = Continuous Intravenous Infusion (e.g., elastomeric infusor)
D5W = dextrose 5% in water
F = refrigerate
Non-DEHP = not containing Di(2-ethylhexyl) phthalate (DEHP)
NS = normal saline
PFL = protect from light
RT = room temperature
SWI = sterile water for injection

BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

42/46

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BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


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Revised Date: 1 June 2016

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Revised Date: 1 June 2016

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BC Cancer Agency Chemotherapy Preparation and Stability Chart version 2.00


Activation Date: 2 March 2006
Revised Date: 1 June 2016

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