15 January 2009\

1.

Structure belongs to
a)
b)
c)
d)
e)

Purine
Pteridine
Prydine
Dihydropyridine
Imidazoline
2.

a)
b)
c)
d)
e)

Macrolide
Cephalosporin
Quinolone
Vitamin K
Trimethoprim
4.
5.

3.

6.

this inhibit following

enzyme
a) HMG co reductase
b) Beta lactase
c) Cholinesterase
d) Alcohol dehydrogenase
e) Acetyltranferase
7. Define o.u
a) To both ear
b) In both eyes
c) Topical
d) In right eye
e) In left eye
8. A person is preparing to travel in forest
area. He comes to pharmacy to purchase
epipen and laratidine. You have to
counsel him, Which of the following is
not appropriate counseling
a) How to use epipen by himself
b) Tell family members method of
using epipen

c) Take loratidine after epipen

d) If there is any allergy or insect
bite take loratidine and then take
epipen injection
e) Always carry epipen when
outside
9. A person is suffering from Menieres
disease. Following is used to treat it.
a) Losartan
b) Dimenhydramine
c) Citrizine
d) Morphine
e) ACEI
10. A person is on treatment with allopurinol
and he is suffering from hypertension.
You can use all except
a) Spirnolactone
b) Atenolol
c) Bisoprolol
d) Chlorothiazide
e) Propanolol
11. A woman is in perimenopausal stage and
is at risk for osteoporosis has previous
history of DVT. Which of the following
is not appropriate to treat osteoporosis..
a) Vitamin D
b) Calcium supplement
c) Estrogen supplement
d) Elendronate
e) Resendronate
12. Which of the following is first health
expenditure second one is drug therapy
in Canada.
a) Doctor
b) Hospital
c) Pharmacist
d) Dentist
e) Pharmaceutical industry
13.
14. Canadian health expenditures are
dependent on
a) Federal tax
b) Provincial tax
c) Both provincial and federal tax
d) Both provincial and federal tax
along with health insurance ,
copayment, coinsurance of
patient

e) Patient
15. What is the advantage of corporate
business
a) Government control
b) Large number of Stock share
holder
c) No direct relationship of
stockholders in debts and
liabilities in case of deficit
d) Maximum capital
e) Direct distribution of profits
16. Canadian health act include all except
a) Health facilities to all Canadians
b) Accessibility
c) International
d) Emergency
e) Public administration
17. Flu Shot high risk involves
I.
Male
II.
Old people
III.
Pregnant lady
18. What is the pH of 0.1M sodium
hydroxide
a) 1
b) 13.6
c) 13.5
d) 13
e) 7
19. Tonicity include all except
a) Colligative property
b) If solution is hypertonic then to
make it isotonic add NaCl
c) Ophthalmic solutions require
isotonicity
d) It determines solute absorption
20. A transdermal patch follows zero order.
Its stability is established at room
temperature
a) Arhenious equation
21.
22.
23. Prepare 35 % salicylic acid with white
petrolatum
I.
Add water to salicylic acid
II.
Deep freeze the preparation
III.
The preparation is a paste

24. Hemoglobin do not bound to oxygen

when
25. Aberva (Docosanol) is used for
a) Cold sores
b) Herpes genitals
c) Impetigo
d) Mouth ulcers
e) Chicken pox
26. Glutathione consist of
a) Cysteine, glycine, glutamate
b) Cysteine, aspartate, glutamate
c) aspartate, glycine, glutamate
27. which of the following link directly with
cell integrity
a) mercapturic acid
b) vitamin A
c) vitamin E
d) EDTA
e) Sodium state
28. Which of the following is not
polypeptide
a) Bentonite
b) Sodium alginate
c) Methyl cellulose
d) Acacia
e) Begum (Clay of Aluminium)
29. Site of action of Warfarin
a) Bone marrow
b) Spleen
c) Liver
d) Platelet
e) Stomach
30. Clarithromycin belongs to same class as
a) Penicillin G
b) Cefotriaxone
c) Tetracycline
d) Azithyromycin
e) Cotrimoxole
31. Which of the following is not typical
antipsychotic
a) Haloperidol
b) chloropromazine
c) thioridazine
d) Clozapine
32. First drug used in status epileptics
a) Valproic acid
b) Carbamazapine
c) IV lorazepam
d) Ethosuximide
e) Lamotriginine
33. Inventory relates to efficiency by

a) Net profit
b) Increase
c) Turnover
d) Gross margin
e) Net margin
34. Which of the following compare clinical
parameters and cost effectiveness of two
drugs
a) CUA
b) ABC
c) Cost effectiveness
d) Cost minimization
35. Dose of one drug is 50 mg, Css is 18.5
36. A drug dose of 100mg is shows AUC for
IV dose is 120, AUC for oral dose is 80.
Calculate percentage bioavailability of
oral dose
a) 25
b) 66
c) 78
d) 54
e) 39
37. What is true regarding insulin
a) Eat with in 15 minutes of rapid
acting insulin
38. A person comes to pharmacy regarding
concern about use of spacer. Which of
the following is true
a) Clean spacer with dry cloth and
do not wash with water
b) Mask for the spacer is same for
all ages with adjustment
according to mouth size
c) It increase bioavailibity
d) It minimize the mouth hand
coordination
39. A person is concern about aeroplan
travel. counsel him regarding motion
sickness
a) Dimenhydramine for motion
sickness
b) Take lot of fluid
c) Eat less
40. Counseling regarding hemorrhoids
I.
Decrease fiber diet
II.
Decrease sitting time on toilet
sheet
III.
Avoid straining during bowel
movement

41. Why second treatment for head lice is

required after 7-10 days of first
treatment
a) To kill egg laid by lice
42. What is first treatment for
uncomplicated Diaper rash
a) ZnO
b) Nystatin
c) 5% hydrocortisone
43. What is true regarding DNA
I.
It stores genetic information of
person
II.
hereditary
III.
a
44. expression of gene in fast proliferating
cells more efficient with
a) gene gun
b) direct free DNA in nucleus
c) retrovirus
d) adenovirus
45. which of the following not used in
plasmid
a) bacteria
b) phage
c) DNA
d) Eukaryotic cell
46. Antineoplastic cells mostly effect which
of following cells
a) Neutrophyls
b) Erythrocytes
c) Platelets
d) Lymphocytes
e) Bone marrow
47. Which of the antibody is used in
metastasis breast cancer?
a) Teramunzumab
b) Aldemunzumab
48. A patient has weight of 70 kg and doctor
prescribed 2.5mEq/kg weight of NaCl.
Molecular weight of NaCl is 58.5. Find
how much volume of NaCl you
dispense.
49. A lady is pregnant and experiencing rise
in blood pressure. Which of the
following drug is contraindicated
a) Atenolol
b) Thaizide
c) Hydralazine
d) ramipril
e) Methyldopa

50. The following balance sheet is given.

The manager of the pharmacy purposed
that he will decrease the cost of goods
will decrease by 30000$ without
changing the expenses. Calculate the %
increase in the gross margin.
51. Cost of goods sold- 150000
52. Sale
53. Gross margin
54. Expenses
55. Net profit 120, 0000
56. All are Steven Johnson syndrome
symptoms except
a) Peripheral edema
b) Erithyma
c) Fever
d) Skin rash
e) Blisters
57. Which of the following represents
psoriasis
a) Erthyma, dry scale
b) Tingling , group of small blisters
c) Papules
d) Small blisters
e) Erthyme roseace
58. Pharmacist will advice to take plenty of
water with
I.
Cotrimoxazole
II.
Allopurinol
III.
Losartan
59. Which of the following decrease uric
acid production
a) Sulphaparazine
b) Probenacid
c) Pencillamine
d) Allopurinol
e) Sulphasalazine
60. In stable angina treatment all are used
except
a) Diuretics
b) Beta blockers
c) ACEI
d) Nitroglycerine
61. Use of sildenafil is contraindicated with
a) Nitroglycerine
b) Beta blocker
c) Dihydropridines
d) Losartan
62. Prazosin act by
a) Alpha1 receptor antagonist

b) BZD receptors
c) GABA receptors
d) Beta receptors
63. Cholestramine mechanism of action
a) Decrease VLDL and TG
b) Decrease HDL and TG
c) Decrease cholesterol and HDL
d) Decrease HDL
64.
65. Most common enzyme involved in
metabolism of drugs
a) CYP1
b) CYP2
c) CYP3
d) CYP4
e) CYP5
66. Rx 10 g pencilline G (E=0.18). how
much water is needed to make it isotonic
67. Treponema palladium involved with
a) Chancre
b) Single bar body
c) Emphysema
68. Which of the following act on
angiotensin receptor II as antagonist
a) Losartan
b) Ramipril
c) Thaizide
d) Atenolol
e) Prazosin
69. Which is present in normal flowing
blood
a) Prothrombin
b) Thrombin
c) Fibrin
d) Fibrinogen
70. Drugs in body bind mostly to
a) Alpha1 glycoprotein, albumin
b) Albumin
c) Alpha1 glycoprotein
71. Sensitivity of balance is 4 mg and it can
weigh 80 mg. find the error in weighing.
72. RX
73. Predinisolone 40mg.
74. Decrease 5mg every day. How many
days it will take to finish the medicine.
75. A stock solution of 5mg/5ml is present.
Doctor prescribed a dose of 30mg for 3
days
a) Daily dose is 100 mg

b) Total volume you will dispense is

90 ml
76.
77. The stock solution is 125mg/5ml. dose
is 12mg BID for 7 days
a) Give 2 bottles of 55ml
b) Give 1 bottles of 55ml and 1
bottle of 110 ml
c) Give1bottles of 55ml
d) Give 1 bottles of 110ml
e) Give 2 bottles of 110ml
78. A pharmacist wants to check any
discrepancy in prescription. Which the
most important part of Rx to find out any
problem.
a) DIN
b) Physician initials
c) Dose
d) No of drugs
79. Pharmacist job except
a) Council the patient about drug
b) DRP
c) Knowledge programs for society
d) Criticize the health system when
there is deficiency
e) Counsel the patient who is
contrary to system
80. Phenols undergoes conjugation with
a) Glycine
b) Methylation
c) Glucuronidation
d) Reduction
81. Which of the following is not part of
Phase II reactions
a) Sulfoxidation
b) Acetylation
c) Glucuronidation
d) Glycine conjugation
e) Glutathione conjugation
82. Phase one reactions of the body are also
defined as
a) Functionalization of the
compounds
83. If there is overdosing of acetaminophen
then there is overloading of enzyme
a) Glutathione S-transferase
b) N-acetyltransferase
c) Acetyltransferase
d) UDP

84. Cardiac remodeling occur in all except

to compensate CHF
a) Interstitial fibrosis
b) Hypertrophy
c) Left ventricular dilation
d) Myocyte loss
e) Increase coronary artery
thickness
85. Angiogenesis is defined as
a) Formation of new blood vessels
b) Remodeling of blood vessels
86. Hypertrophy is known as
a) Increase in cell size without cell
division
b) Increase in cell no
87. Anemia related to decrease in iron
include all except
a) Most potent test is ferritin
b) No change in stored iron
c) Decrease in MCV
d) Due to hemorrhage
88. Megaloblastic anemia include deficiency
I.
Folic acid
II.
Vitamin B12
III.
Iron
89. Subclinical hypothyroidism is monitored
by
a) Serum TSH
b) T4
c) Antibodies against Iodine
peroxidase
d) T3
90. Antihyperthyroid drugs are used in
treatment of
a) Addison disease
b) Cushing syndrome
c) Graves disease
d) Cretinism
e) Hoshimoto
91. TSH is secreted from
a) Anterior pituitary
b) Posterior pituitary
c) Thyroid
d) Adrenal gland
e) Parathyroid
92. All of the following open in duodenal
duct except
a) Adrenal gland
b) Pancreatic duct
c) Bile

d) Gastric secretions
e) Saliva
93. All are produced from epithelial tissue
except
a) Bile
b) Parotid
c) Saliva
d) HCl
e) Sweat
94. Acute therapy of asthma for
bronchospasm
a) Solubutamol
b) Steroids
95. Cystitis belongs to
a) Bladder
b) Pancreases
c) Uterine tract
d) Ovary
e) Liver
96. Counseling regarding recurrent UTI in
woman
I.
Use diaphragm
II.
Drink lot of fluids
III.
Void after intercourse
97. Complicated UTI differ from
Uncomplicated
a) Fever and chill
b) Cloudy discharge
98. Risk factor for gout all except
a) DM
b) HT
c) Pulmonary problem
d) Obesity
99. Risk factors for osteoporosis
I.
Long term use of corticosteroids
II.
Decrease in androgens
III.
Decrease in estrogens
100. 60 ml of solution having 1:15000
diluted to 1:750. Find out final volume.
101.
102. Clozapine side effect
a) Agranulocytosis
b) Weight loss
c) EPS
d) TD
103. Pilocarpine in eye causes
a) Miosis
b) Mydriasis
c) Cycloplagia
d) Myopia

104. If A drug undergoes zero order

reaction to find out concentration we
will
a) Slope of [A] Vs time
b) Slope of rate Vs time
c) LnA Vs time
d) dA Vs dt
105. BMI is
a) Height / weight
b) Surface area/ height
c) Surface area/ weight
106. Iron antidote defuroxamine act by
a) PH neutralization
b) Chelation
c) Reduction
d) Oxidation
107. Factors effecting dissolution
a) pH changes
108. Blood supply from intestine to liver
a) Portal vein
109. Blood supply to brain regulated by
a) pCO2
b) pO2
110. reabsorption of drugs in kidney doest
not depend on
a) flow rate
b) metabolism
c) pH
d) tubular secretion
e) tonicity
111. Which of the following does not
included in ist line therapy of
tuberculosis
a) Sulfaslagiline
b) All other antitubercular drugs
112.
113. Sulpha drug structure for burn
treatment
114. Rate limiting step in topical
absorption in which layer of skin occurs.
a) Stratum cornium
115. Lyophilization
a) Not effective for polypeptides
b) Effective for peptides
c) Dehydrogenation of
manufactured drug products
116. GLC requires
a) Non volatile
b) Volatile
117. Contact angle determine

a) Wetting capacity
118. Aerosol substitute for CFC
a) HFA
b) HCFA
c) CFA
119. Acne treatment is unaffected with
topical agents and antibiotics. Which of
the following you use
a) Isotretenoin
b) Tritenoin
120. Advantage of hard gas permeable
lens on soft fragile lens
I.
Decrease in fragility
II.
Increase in durability
III.
Increase in water content
121. Which is not polypeptide
a) Acacia
b) Bentonite
c) CMC
d) Tragakanth
e) Begum
122. Which of the following are true
immunization guidelines in Canadian
health system
a) Meninigicocal vaccine for person
touching dirty product
b) Pneumonococcal vaccine
annually for adults and children
c) Tetanus vaccine after 2 years
123.
124.
125. Which is not true about hepatitis
vaccine
a) Prepared from plasma of infected
person
b) Not effective in
immunocompromised patients
126. DOC is in S.meningitis
a) Cefotriaxone
b) Amoxicillin
127. MOA of class I Antiarrhthmia
a) Block voltage gated Na=
channels
128. To compare effectiveness of 2 drugs
for disease
a) Patient record
b) Patient testimonial
c) Patient statement
d) Retrospective comparison
129. Cholesterol to chlorate

a) Epoxidase
b) Hydroxylase
c) Dismutase
d) Aromatase
130. COPD most potent risk factor
a) Smoking history
b) Prolonged asthma
c) Allergy
131. True about GERD treatment except
a) Magnesium antacid cause
constipation
b) PPI are used
c) Antacids are not very effective
132. Treatment of methoteraxate induced
mouth ulcers
a) Folic acid
133. For D3 formation by sunlight the
precursor is
b) Hydrocortisone
c) 7-dihydroxycalciferol
134. Which of the following not used in
allergy treatment
a) Cimetidine
b) All antihistamines
135. MOA of opoids induced emesis
a) Stimulate CTZ centre in brain
136. Celicoxib MOA
a) COX2 inhibitor
137. All cause GIT side effects except
a) Indomethacin
b) ASA
c) Naproxen
d) Celecoxib
138. Weight gain side effect limit its use
as antischizophrenic
a) Mertazapine
b) Sertaline
c) Paroxitine
d) Fluvoxatine
139. Reversible MAO inhibitor is
a) Meclobimide
b) ASA
c) Sertaline
d) Phentolamine
140. DOC in PD except
a) Levodpa/carbidopa
b) Bromocripitine
c) Pergolide
d) Dimenhydramine
141. Benzodiazepine mechanism of action

a) Facilitate GABA action by Cl

channel opening
142. Blood parasite involves
a) Malaria
b) Cholera
c) Traveler diarrhea
143. Thromboembolism
a) It is the floating obstruction in
the blood
144. Following are true about
atherosclerosis
I.
Decrease in cholesterol
II.
Arterial thinning
III.
Increase in vascular
resistance
145.
146.
147.
148. Health at any stage of life depends
on
I.
Accessibility to health
care
II.
Genetic makeup
III.
Educational level of
person
149. There is addition of 10g of 2.9% to
a2g of 1% and 10 g of base.
150.
What is the final percentage
of concentration?
151. What is the normal fasting blood
glucose level
a) 7 mmol/L
152. Which of the following is essential
amino acid
a) Methionine
b) Histadiol
c) Isovaleric acid

153. Which is not involved in statistitics

of clinical trials
a) Alternative hypothesis
b) Null hypothesis
c) Confidence interval
d) Clinical significance
e) Statistical significance
154. If there is a recall of product
pharmacist will do all except
a) Call patients about the recall of
product
b) Display a notice in the hospital
c) Ask the patient about if there is
any change in color of medicine
d) Give patient records to the
recalling company
e) Ask patients to consult physician
155. Counsel insomnia patient
I.
Take nap in afternoon
II.
Exercise daily
III.
Follow routine
156. Stroke risk factor
a) Atrial fibrillation
b) HT
c) DM
d) Seizures
157. A union negotiating the wages,
working hours and conditions on behalf
of pharmacist with company
a) Mediation
b) Bargaining
c) Arbitration
158.
159.
160.
161.
162.
163.
164.
165.
166.
167.
168.