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B cells
ll
Lecture #2
Ralph Feuer
Medical Microbiology (BIOL 584)
Spring 2012
B Cells
Humoral immunity
Generate antibodies
Antibody-secreting
y
g plasma
p m B
cells survive in the bone
marrow for long periods
Immunoglobulins
Immuno lobulins
Fc fragment
Fc region
Responsible for
complement activation
Mediates binding to
phagocyte receptors
during opsonization
Transcription
p
of
f the
recombined gene
RNA processing (splicing)
Translation of heavy chain
protein
Mechanisms of Diversity in
A ti
R
t
Antigen
Receptors
Diversity is increased by
Different Ig heavy and light
chains
Anergy
Ap pt sis
Apoptosis
Plasma B cells
Memory B cells
Immunoglobulin Isotypes
Different classes of
immunoglobulins
and
, , , ,
IgG
I
G
IgE
IgD (not show)
IgM (pentamers)
IgA
g (dimers)
( m rs)
IgA
IgD
IgE
IgM
IgG
Dimer
Mucosal immunity
Neonatal passive immunity
N B cell
Nave
ll antigen
ti
receptor
t
Pentamer
Nave B cell antigen receptor
Complement Activation
O s i ti
Opsonization
Complement Activation
Ab-dependent cell-mediated cytoxicity
Neonatal immunity
Feedback inhibition of B cells
Isotype
yp Switching
g
B cells are activated via their CD40 and IL-4 receptors (both modulated by
T helper cells)
Without opsonization,
phagocytes have
diffi lt iingesting
difficulty
ti a
bacterium
Like a slippery
pp y fish
Complement Proteins
Have a role in both non-specific
p f and specific
p f defenses
f
T-Independent
T
Independent Production of Antibodies
Chemoattraction
Selectins
Integrins