Piperazine Citrate

Piperazine is taken as substitute health care for ascariasis due to Ascaris

lumbricoides and enterobius due to pinworm. Piperazine citrate is a better choice
for treating these diseases/infections in children.
Physicians use piperazine in the treatment of limited intestinal impediment that is
due to Ascaris viruses and this type of situation frequently occurs among kids.
The use of flubendazole, mebendazole,
albendazole and pyrantel pamoate is usually
preferred for treating ascariasis and enterobiasis
as they are effective in single doses.

Mechanism Of Effect & Action

Piperazine can be useful for preventing the reaction of the worms muscular to
acetylcholine by resulting in hyperpolarization of sensors being. This results in a
flaccid paralysis of the worms and when it happens, the worms is dislodged from
the abdominal lumen and thrown stay from our bodies through regular abdominal
peristalsis.
Bio changes made by the drug Piperazine. About
25% of piperazine is metabolized in the liver. It
is nitrosated to form N-mononitrosopiperazine in
gastric juice. It is further metabolized to
NHPYR.

What precautions should be considered

while taking piperazine?
Report has been created on cross-reactivity between ethylenediamine and
piperazine, in which a content is used as a stabilizer in skin medications.
With piperazine, contact allergy can be developed that could be life-threatening in a
person who has impacted with ethylenediamine by external application of by
exposure.
Some unusual negative dermatologic issues also
may happen due to the cross-sensitivity of these
two medicines.

Carcinogenecity & Tumorigenicity

Carcinogenecity
A possibly dangerous nitrosamine mixture has been discovered in stomach juice
and pee of the people who have absorbed therapeutic of piperazine. But the
importance is unidentified for this finding.
Tumorigenicity
There are no research to figure out the tumorgenicity of piperazine.

Pregnant Woman Should Use Piperazine?

If a pregnant woman uses piperazine without her physicians consent, it could
adversely affect her pregnancy. Experts recommend that pregnant woman should use
piperazine after taking consent from her doctor.
Lactating Mothers
If lactating mothers take piperazine, it could distributed into breast milk. However,
issues in human have not be studied.

Blurry vision
Dizziness
Headache
Drowsiness

Tremors
Muscle weakness
Overdose

Piperazine Citrate Used In Treatment Of

Helminthes Infestations
Piperazine Citrate is also used in therapy of helminthes problems for sheep, pets
livestock, kitties and poultry. Major warnings and precautions for the same islarval stages are ineffectively paralyzed and a repetitive treatment is needed in 2-4
weeks.
Piperazine citrate W.S.P dosage for pets: For dogs and cats 128.6 to 185.7 mg. Fr cattle
and sheep and poultry 91.4 mg is recommended.

Heavy dosages may cause emesis, head pressing, incoordination and diarrhea in
cats and dogs. Occasionally the pet may show symptoms like nausea, muscular
tremors or vomiting with overdose.
Piperazine citrate effectively treats ascarid and oxyurid worms, some hookworms
and roundworms.

Reputed Dealer of Piperazine Citrate

Adani Pharmachem Private Limited

Plot No. - 2729 to 2731, Road `I-1 ' - Lodhika GIDC,
Village- Metoda, Taluka- Lodhika,
Dist. - RAJKOT : 360 003. (Gujarat) INDIA

Phone No: - +91 75730 44087

Email ID: - exports@adanipharma.com

Website: http://www.adanipharma.com/contact.html