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Clinical assessment of bad breath: current

concepts
M Rosenberg
J Am Dent Assoc 1996;127;475-482

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ARTICLE 1

CLINICAL ASSESSMENT OF BAD BREATH:


CURRENT CONCEPTS

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MEL ROSENBERG, PH.D.

..l ... Ot is likely that the majority of adults suffer from bad breath at
least occasionally.' Since bad breath usually comes from the mouth
Bad breath typically originates in itself, the dentist should be the first professional whom individuals
the mouth, often from the back turn to for help.2 In recent years, there has been a growing aware-
of the tongue. Nasal problems
ness that bad breath is a problem that the dental profession should
recognize and address. Hundreds-perhaps thousands-of U.S.
also can cause bad breath; odor dentists currently advertise breath freshening as part of their clini-
generated in this manner can be cal services. Dentists and their staff members also may suffer from
easily distinguished from mouth
this problem, to the dismay of their patients.2
Together with the growing interest of dental practitioners in bad
odor by comparing the odor exit- breath diagnosis and treatment, there has been an increase in re-
ing the mouth and nose. In most search activity in this field, reflected in two recent international
cases, good professional oral
workshops dedicated solely to this subject (First International
Workshop on Oral Malodor, Herzliya, Israel, April 1993; Second
care combined with a daily regi- World Workshop on Oral Malodor, Leuven, Belgium, October 1995).
men of oral hygiene-including This article summarizes general concepts related to bad breath.
interdental cleaning, deep
Since the main clinical challenges for the practitioner are deciding
whether a given complaint of bad breath is justified and whether
tongue cleaning and optional the odor originates in the mouth or elsewhere, this article empha-
use of an efficacious mouth- sizes diagnostic modalities.
rinse-will lead to improvement. HISTORY AND FOLKLORE
This article discusses common Bad breath has been recorded in the literature for thousands of
causes of oral malodor as well years. The problem is discussed at length in the Jewish Talmud,3 as
as methods to assess the extent
well as by Greek and Roman writers.4 Islam also stresses fresh
breath in the context of good oral hygiene. The prophet Mohammed
of the problem. is said to have thrown a congregant from the mosque for having the
smell of garlic on his breath.3
Ancient folk remedies abound which are still in use. In the Bible,
the book of Genesis mentions ladanum (mastic), a resin derived
from the Pistacia lentiscus tree (Figure 1) which has been used in
Mediterranean countries for breath freshening for thousands of
years. Other folk cures include parsley (Italy), cloves (Iraq), guava

JADA, Vol. 127, April 1996 475


_ UNICAl PRBACIIC

the patient's mouth with that to be even more malodorous.10


exiting the nose. If the odor is Several studies have docu-
primarily from the mouth, an mented the presence of three
oral origin may be inferred.7 potential periodontopathogens
In people with rigorous oral (Treponema denticola, Porphy-
hygiene, clean and intact denti- romonas gingivalis, and Bacte-
tion and a healthy periodon- roides forsythus) on the tongue
tium, the source of bad breath dorsum, using the BANA test
is likely to be the back of the (Knowell Therapeutic Tech-
tongue.79 Although the anterior nologies, Inc.)."'-13 Data from
part of the tongue usually these studies suggested- that
smells (a simple test is to lick these pathogens are signifi-
one's wrist, waiting a few sec- cantly associated with the level
onds until it dries, and then of whole mouth odor. Odor from
smell the area6), the main the posterior dorsal surface of
source of odor is usually farther the tongue even may be present
back in the posterior region.7 in preschool children.'4
The posterior area of the dorsal As with other body odors, bad

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surface can be readily assessed breath usually is generated by
Figure 1. Gum mastic, an an- by a gentle but thorough scrap- bacteria. Putrefaction is
cient Mediterranean remedy for ing using a disposable plastic thought to occur under anaero-
bad breath, Is still chewed for spoon.9 Afterward, the spoon bic conditions, involving a range
this purpose.
can be smelled to compare the of gram-negative microorgan-
peels (Thailand) and eggshells odor with the overall mouth isms, including species of
(China).5 odor. Fusobacterium, Haemophilus,
Modem literature on bad In many cases, a yellowish Veillonella, T. denticola and P.
breath dates back to a mono- discharge is collected on the gingivalis.'5"6 Although gram-
graph published by Howe in the spoon (Figure 2). Although positive bacteria usually do not
19th century.6 Experimental there is no direct evidence, this produce odor under laboratory
research on the subject dates discharge is probably postna- conditions,'5 one research group
back more than 60 years.7'8 sal drip.9 Postnasal drip is ex- has recently suggested that pro-
Since the 1960s, the preeminent tremely common and may not teolysis by gram-positive
researcher in this field has been be indicative of any frank nasal Stomatococcus mucilaginus con-
Dr. Joseph Tonzetich of the infection or other pathological tributes to subsequent malodor
University of British Columbia. condition.6 Although the post- at the dorsal tongue.17
Among other findings, Tonzetich nasal drip might not smell Any oral site in which micro-
and co-workers established that when it first reaches the tongue bial accumulation and putrefac-
oral malodor is associated with (M. Littner,
the presence of volatile sulfur D.M.D., and M. TABLE i
compounds, primarily hydrogen Rosenberg,
sulfide and methylmercaptan.' Ph.D., unpub-
lished data,
THE ROLE OF THE ORAL 1994), it can
CAVITY
subsequently
In as many as 85 percent of pa- be putrefied by
tients with bad breath, the odor the abundant
originates in the mouth.'4'6'8'9 tongue micro-
Several indications can suggest biota.
that the problem arises from In patients
the mouth (Table 1). The sim- with periodon-
plest way to distinguish oral tal disease, the
from non-oral etiologies is to tongue has
compare the smell coming from been reported

476 JADA, Vol. 127, April 1996


CLINICAL PRACTICE

terial mouthrinse (such as chlor-


hexidine-containing mouth-
rinses, wich have been shown
in several studies: to reduce
odor levels significantly
[P< .001] for long periods fol-
lowng wuse). If malodor is sig-
iiificantly reduced with this reg-
Mien, then an oral origin may
be inferred.

TAOfAL SOURCES OF

Among non-oral etiologies of


bad breath, the nasal passages
predominate. In such cases, the
telltale odor can be smelled
most strongly from the nose,

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Figure 2. A simple test for dlagnosing oral malodor Involves scraping rather than the mouth. Nasal
the posterior part of the tongue dorsum with a plastic spoon. Odor odor may be indicative of a
from the spoon often closely resembles the overall mouth odor and frank nasal infection, such as
Is frequently accompanled by a yellowlsh discharge, pr-obably post-
nasal drip. sinusitis, or a problem affecting
airflow or mucous secretions,
tion can occur are suspect.' In after fasting), bad breath in- such as polyps. In some cases,
addition to the most common in- creases. Conversely, mastica- craniofacial anomalies, such as
traoral sites of malodor produc- tion increases saliva flow, with cleft palate, may be involved.23
tion (the tongue, interdental concomitant cleansing of the The tendency of very young
and subgingival areas) other oral cavity and reduction in children to insert foreign bodies
foci may include faulty restora- malodor.12"9 Despite these com- into their nostrils is a common
tions (such as overhanging res- mon observations, the data of cause of offensive odor that
torations and leaking crowns), two clinical studies did not sup- comes from the nose yet ap-
sites of food impaction and ab- port any association between pears to emanate from the en-
scesses. Caries usually is not salivary flow rate and malodor tire body.9 Typical nasal mal-
particularly malodorous, unless levels in the populations stud- odor usually has a slightly
large enough to entrap food.2 ied.202' Moreover, patients with cheesy character and differs ap-
Dentures are another impor- xerostomia do not seem to have preciably from other types of
tant cause of oral malodor, par- higher-than-normal oral mal- bad breath.9
ticularly if they are worn over- odor levels (L. Sreebny, D.D.S., The role of tonsils in chronic
night. Usually the odor has a Ph.D., personal communication, bad breath is not at all clear. A
somewhat sweet but unpleasant 1995). One possible explanation transient odor associated with
character and is readily identifi- could be that malodor arises tonsil infections in children is
able,9 especially if the dentures primarily in an alkaline mi- common. Occasionally, tonsils
are placed in a plastic bag and croenvironment,'5 whereas the emit a foul-smelling exudate
smelled following several min- saliva of people with xerostomia when pressed, although they
utes (Y. Kaufman, D.M.D., M. often is acidic (L. Sreebny, appear normal on visual exami-
Rosenberg, Ph.D., unpublished D.D.S., Ph.D., personal commu- nation.23 In some individuals,
data, 1988). nication, 1995). Additional stud- the tonsillar crypts develop con-
Saliva also affects bad ies should be carried out to ad- cretions called tonsilloliths
breath. In the individual, bad dress this apparent paradox. (Figure 3) which migrate to the
breath levels during the day are When the oral etiology of the tongue's surface. These stones
inversely related to saliva odor can not be identified, the are usually several millimeters
flow.'8"19 When saliva flow is low- patient can rinse and gargle for in diameter, rough-edged and
est (for example, during sleep or a week with a potent antibac- white or yellowish. Although

JADA, Vol. 127, April 1996 477


_CLINICAL PRACTICE-

a hundred tempts at objectivity. Interest-


years to mask ingly, in another study, self-
their bad estimates of bad breath by fe-
breath, 725 a male subjects complaining of
practice that oral malodor were significantly
creates an odor higher than corresponding self-
in its own right. scores given by the male sub-
Cigarette odor jects (P < .001), whereas actual
can linger for odor scores of the judge re-
more than a vealed that the men had signifi-
day after smok- cantly higher levels of bad breath
ing. In some than the women (P < .001)9
cases, one can Whatever the underlying rea-
Figure 3. An assortment of tonsilloliiths collected detect the odor
from a single patient. sons, our insensitivity to our
of cigarette own bad breath can have grave
the stones themselves have a smoke on the breath of people consequences. People may
foul odor, particularly when who do not smoke but are con- spend their entire lives un-
pressed, they do not appear to tinually exposed to the smoke of aware that their breath is offen-

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be a significant source of bad others (M. Rosenberg, Ph.D., sive. Conversely, many others
breath.9 unpublished data, 1995). suffer from halitophobia, a
Many non-oral diseases, in- highly exaggerated fear that
cluding bronchial and lung in- THE BAD BREATH
PARADOX they suffer from bad breath.:'
fections, kidney failure, various People with halitophobia often
carcinomas, metabolic dysfunc- People often are unaware of avoid social situations and are
tions and biochemical disorders, their own bad breath.2389 Our continually preoccupied with
can result in bad breath,24 but inability to smell our own oral concealing the perceived odor by
all these diseases taken to- malodor has been attributed to frequent toothbrushing, contin-
gether affect a very small per- adaptation or dulling of sensa- uous gum chewing and candy
centage of people experiencing tion resulting from continual sucking, keeping a safe distance
oral malodor. One interesting exposure. or "talking sideways."9 They are
rare metabolic condition that We recently addressed this often secretive about this fear,
leads to a perception on the part question in a study in which 52 and in many cases, refrain from
of the patient of a foul fishy people attempted to score the discussing the problem, even
odor or taste is trimethylamin- level of the malodor coming with family members. During
uria.2 An acetone smell to the from their whole mouth, dorsal consultation, they may even
breath was once considered a tongue and saliva.28 In the first break into tears. One individual
diagnostic indication for uncon- two instances, participants ap- recently described the problem
trolled diabetes, but very few peared completely unable to as a "nightmare." Another said
cases are detected in this man- score their own smells objective- that the fear of having bad
ner (C. Hollenberg, M.D., per- ly. In the case of saliva, some breath "controls my soul." A
sonal communication, 1990). objectivity was evident. In all third spoke of feeling "defiled."'
Contrary to common think- cases, participants tended to In extreme cases, people with
ing, bad breath originating in score their own malodors ac- halitophobia are driven to social
the gastrointestinal tract is con- cording to preconceived notions. isolation, may have their teeth
sidered to be extremely rare.',`,` Based on the results of this extracted and occasionally even
The esophagus is normally col- study, it appears although the commit suicide."'
lapsed and closed, and although participants had the physiologi- What factors may predispose
the occasional belch may carry cal capability of smelling their certain people to be overly con-
odor up from the stomach, the own oral odors (shown by their cerned regarding bad breath? In
possibility of air escaping conti- semiobjective scoring of their some instances on questioning,
nously is remote. own saliva malodor), their per- patients may recall from child-
Interestingly, people have ception of how bad their breath hood that someone in the imme-
smoked cigarettes for more than should smell confounded at- diate family (usually a parent)

478 JADA, Vol. 127, April 1996


CLINICAL PRACTICE-

suffered from bad breath. Thus, women who complained of bad improve the association be-
the patient upon reaching breath, 25 rated their own tween sulfide monitor levels
adulthood may develop a con- breath as a 5 ("the most foul and odor judge scores. For ex-
cern of having inherited this odor imaginable") on a scale of 0 ample, in two studies, the asso-
trait. Advertisements on bad to 5, although corresponding ciation between volatile sulfur
breath may elicit unwarranted judge scores ranged from 0 to levels (as determined by the
concerns in suggestible individ- 3.5.9 For this reason, it is impor- sulfide monitor) and odor judge
uals. Others may notice a bad tant to ask the patient to bring scores was improved when
taste in their mouth and as- along a confidant, usually a car- BANA test results were fac-
sume (correctly or incorrectly) ing spouse or other family mem- tored into the regression analy-
that it must be related to bad ber. The confidant can provide a sis.12,3 In a third investigation,
breath. Some patients recall more objective picture of BANA scores were associated
having been told once in their whether the patient actually with floss odor (scored by an in-
distant past that they had bad suffers from bad breath and to vestigator after proximal dental
breath and have continued to what extent. Also, since bad floss passage) (P = .001) and
worry about it ever since. Fi- breath can vary with the time of were reduced after chlorhexi-
nally, as mentioned above, indi- day (as an inverse function of dine rinsing.20 Although such

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viduals with malodorous tonsil- saliva flow, which drastically quantitative and semiquantita-
loliths may falsely infer that decreases at night) and day of tive measurements can assist in
they have awful breath.9 the month (worsening immedi- testing for improvement follow-
ately prior to and during men- ing treatment, they do not obvi-
CLINICAL DIAGNOSIS struation),29 the odor present at ate the need for the clinician to
Complaints of bad breath the consultation may or may actually smell the breath ema-
should be taken seriously by the not be similar to the odor at nating from the patient's
dental practitioner, regardless other times. The confidant can mouth, nose and tongue.
of whether they appear justi- help determine whether the In an influential study pub-
fied.2 When a patient expresses odor present at the time of the lished in 1967, Tonzetich and co-
concern about his or her breath, consultation is typical in quality workers argued that bad breath
it is important to set up a spe- and intensity to the odor which derives exclusively from sulfur-
cial appointment for an assess- is generally present.9 containing volatiles.30 They
ment. The patient should be based this on the observation
instructed to refrain from INSTRUMENTAL that other volatiles tested did
ANALYSIS
drinking, eating, chewing, rins- not escape from the saliva into
ing, gargling and smoking for at Bad breath has been attributed the air. However, Kleinberg and
least two hours before the ap- to volatile sulphur compounds, Codipilly have recently shown
pointment. Patients also should primarily hydrogen sulfide and that when the skin dries out,
avoid using scented lipstick, af- methylmercaptan.1 The level of non-sulfur-containing gases,
tershave and perfume on the intraoral VSC can be estimated such as cadaverine, putrescine,
day of the consultation. Malodor chairside, using portable sulfide skatole, indole, butyric acid and
examinations should not be per- monitors (Interscan Corp.).2 isovaleric acid, can be released
formed on patients taking an- Several studies have shown over time.15 Similarly, the mal-
tibiotics.2 that sulfide monitor readings odor of an extract of putrefied
The initial challenge is to de- are sensitive to reductions in saliva placed on the skin lingers
termine whether the patient's mouth odor levels following use for more than two hours (M.
complaint is well-founded or of efficacious mouthrinses. 18-20 Rosenberg, Ph.D., 0. Ilan, M.Sc.,
has been blown out of propor- Associations comparing sulfide unpublished observation, 1995).
tion. Although a personal and monitor results and odor scores The implication is that when
medical history can provide im- recorded by judges are signifi- saliva dries out on oral surfaces,
portant clues (for example, al- cant (coefficient correlations a range of VSC and other vola-
lergies, sinusitis, mouth breath- ranging from about 0.45 to 0.65, tiles are released. This is in
ing, polyps), self-reports of bad P < .001 in various studies) and agreement with the observation
breath are notoriously subjec- are relatively reproducible.3 that bad breath increases when
tive. For example, among 88 Additional tests may further the mouth is dry.18"l9

JADA, Vol. 127, April 1996 479


-CLINICAL PRBACICE

TABLE 2 - periodontal- breath odor. In one study, par-


type odor (all ticipants who flossed had signif-
too familiar to icantly less mouth odor
practicing den- (P = .016), saliva odor (P < .001)
tists), which and salivary cadaverine levels
usually comes (P = .011) than those who did
from subgingi- not.32 Furthermore, one year
val areas and after the initial oral malodor ex-
interdental amination, the percentage of
spaces; participants who flossed their
- characteris- teeth rose from 31 percent to 65
tic nasal odor percent.33 Other interdental
(which can be cleaners (such as toothpicks)
easily identified also can be effective in identify-
on the breath ing and cleaning sites of odor
Results in our laboratory exiting the nose); production.
show correlations between sali- - denture odor (readily smelled Gentle but effective deep

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vary levels of cadaverine and by placing the dentures a plas- tongue cleaning should become
oral malodors.3' When sulfide tic bag for several minutes); a part of the daily hygiene rou-
monitor scores and salivary ca- - smoker's breath. tine. Dental product manufac-
daverine levels are both con- With practice and experience, turers have developed a variety
sidered, the correlation with these odors become distinct and of tongue scrapers in recent
odor judge scores increases sig- recognizable, even when found years (Figure 4). Cleaning the
nificantly.3' Unfortunately, ca- in various combinations. tongue also can be performed by
daverine is difficult to assess in In some cases, although little brushing with any toothbrush
the dental clinic. However, as odor appears on the breath that minimizes gagging reflex.
mentioned above, BANA testing when the patient breathes out To prevent tongue odor, the
of samples obtained from vari- through the mouth, the odor be- tongue should be cleaned in a
ous intraoral sites'2"3'2' and per- comes evident when the patient gentle but thorough manner.
haps other tests such as the starts speaking (M. Rosenberg, The patient should be reminded
Oratest-which was the only Ph.D., E. Leib, D.M.D., unpub- that the posterior portion of the
test other than volatile sulfide lished observation, 1995). Thus, tongue is the least accessible
levels to show significant associ- in addition to asking the subject but usually smells the worst.7-9
ations with bad breath in chil- to breathe out through the Even patients with significant
dren'4-can be useful. Someday mouth and nose, we now rou- gagging reflex can get used to
in the not-too-distant future, tinely ask the patient to count cleaning the back of the tongue
electronic "noses" that distin- out loud to 20, and we smell the with some practice.
guish between different kinds of breath while the patient counts. Since bad breath is worse
smells may be available for bad when the mouth dries out (for
breath testing. Eventually, indi- TREATMENT example, at night or when fast-
viduals may be able to breathe The best way to treat bad ing), patients should be encour-
into their telephone mouthpiece breath is to motivate patients to aged to drink ample amounts of
or other device and receive an practice good oral hygiene and water. Chewing gum also is
"on-line" breath analysis. to ensure that their dentition is helpful in reducing bad breath
For now, clinicians interested properly maintained."2 While during the day, although it
in diagnosing bad breath must patients often balk at using should be chewed for only a few
still rely on their noses to dis- dental floss, once the connection minutes at a time to avoid tem-
tinguish the main types of oral is made between flossing and poromandibular joint problems.2
odors (Table 2). These include fresh breath, compliance im- Many people continue to
- odor from the posterior tongue proves.2 Having patients smell have malodor of oral origin,
dorsum (can easily be recognized the floss after each use is a good even after maintaining good
by smelling a spoon after scrap- way to illustrate the importance oral hygiene. In such instances,
ing the tongue); of regular flossing in improving rinsing and gargling with an ef-

480 JADA, Vol. 127, April 1996


CLINICAl PRACTICEm

ficacious mouthwash may be sitivity and tact.


advised. The best time to use a One possibility is
mouthwash is probably before to make an
bedtime, since residue of the oblique, general-
mouthrinse may remain in the ized comment
mouth for a longer period and about the con-
have a greater effect, and bacte- nection between
rial activity leading to bad oral hygiene and
breath is greatest at night, bad breath. For
when saliva flow is lowest.1 example, the
Patients should be advised, dental profes-
however, that many mouth- sional might ask,
washes contain components "Did you know
that may have a non-beneficial that people who Figure 4. A variety of tongue scraper are current-
effect on soft oral tissues (inclu- don't floss their iy available for cleaning the tongue dorsum.
ding alcohol, sodium dodecyl teeth daily may
sulfate, strong oxidizing suffer from bad breath?" The separate appointment and

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agents). patient might then ask, "Are should be encouraged to bring
Although consultation and you implying that I have bad along a confidant-a family
treatment may result in a dra- breath?" The dentist or hygien- member or a close friend.
matic reduction in bad breath, ist could then respond, "If you - Because of the difficulty in-
patients may find it difficult to don't clean your teeth and herent in smelling our own
sense the improvement them- tongue properly, you might." breath, many people harbor
selves (A. Fleming, Ph.D., per- Certainly, it is difficult to tell grossly exaggerated concerns
sonal communication, 1990). patients, friends and associates about their breath, while others
This problem can be addressed that they suffer from this prob- remain unaware that they suf-
with the help of the confidant, lem. However, at the very least, fer from halitosis.
who can help monitor changes we should be prepared to tell - Although correlative, quanti-
over time. In those cases in the ones we love and care for if tative measurement techniques
which the odor (or the subjec- they suffer from bad breath, are available and helpful, the
tive complaint) persists, the pa- and to hope that, if necessary, clinician also should make a dif-
tient should be referred to a they will reciprocate in kind. ferential judgment by actually
physician for further assess- smelling the odor emanating
ment. SUMMARY from the patient's mouth and
Several of the central concepts nose.
BEING in the diagnosis and treatment
FRANK - In most cases, bad breath
ABOUT BAD of oral malodor are as follows: can be ameliorated by proper
BREATH - Bad breath is a common con- dental care, oral hygiene, deep
Should a den- dition that usually originates in tongue cleaning and, if neces-
tist tell a pa- the mouth itself and rarely sary, rinsing with an effective
tient with bad comes from the gastrointestinal mouthwash.
Dr. Rosenberg Is an
breath that he tract. - If the problem (or the pa-
assoclate professor, or she suffers - The dentist has the primary tient's perception of the prob-
The Maurice and from the prob- responsibility for diagnosing lem) persists, the patient should
Gabriela Gold-
schloger School of
lem, even when and treating bad breath. be referred promptly for appro-
Dontal Medicine the patient - The posterior area of the priate medical care. .
and the Department
of Human Micro-
does not com- dorsal tongue is the most fre-
biology, Sackder plain? Dis- quently overlooked source of Dr. Rosenberg's e-mail address is
School of Medicine, cussing this ob- oral malodor. It can be sampled "melrose@post.tau.ac.il".
Tel Aviv University,
Ramat Aviv, Tel Aviv servation is an by scraping the surface with a Tel Aviv University's home page posts no-
tices about research related to bad breath at
69978, Israel. Ad- onerous but plastic spoon. "http://www.tau.ac.il/-melrose/Welcome.html".
dress reprint re-
quests to Dr.
important task - Patients complaining of bad
The author thanks Rellu Samuel for assis-
Rosenberg. requiring sen- breath should be assigned a tance in the photography of the figures.

JADA, Vol. 127, April 1996 481


-CLINICAL PRACTICE-

1. Tonzetich J. Production and origin of oral 18. Tonzetich J. Oral malodour: an indicator
More than malodor: a review of mechanisms and methods
of analysis. J Periodontol 1977;48(1):13-20.
of health status and oral cleanliness. Int Dent
J 1977;98:309-19.
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just safe 3. Rosenberg M. Bad breath: Research per-
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82.
Tel Aviv University;1995:1-12. 20. Rosenberg M, Kulkarni GV, Bosy A,
and 4. Geist H. Halitosis in ancient literature.
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McCulloch CA. Reproducibility and sensitivity
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40.
21. Bosy A, Kulkarni GV, Rosenberg M,
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___D)A\____
ACCEPTED
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Dental Israeli malodor clinic. In: Rosenberg M, ed. Periodontol 1992;63:39-43.
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studies. But it's your assurance of tal disease. In: Rosenberg M, ed. Bad breath: versity; 1995:175-88.
much more... research perspectives. Tel Aviv, Israel: Ramot 24. Attia EL, Marshall KG. Halitosis. Can
Publishing-Tel Aviv University; 1995:87-108. Med Assoc J 1982;126:1281-5.
11. De Boever EH, Loesche WJ. Assessing 25. Preti G, Clark L, Cowart BJ, et al. Non-
the contribution of anaerobic microflora of the oral etiologies of oral malodor and altered
* Verification of Claims. The ad- tongue to oral malodor. JADA 1995;126:1384- chemosensation. J Periodontol 1992;63:790-6.
vertising claims of any product bear- 93. 26. Hawxhurst DC. Offensive breath. Dent
12. De Boever EH, De Uzeda M, Loesche Register 1873;27:104-10.
ing the ADA Seal are reviewed by WJ. Relationship between volatile sulfur com- 27. Spouge JD. Halitosis: a review of its
the American Dental Association. pounds, BANA-hydrolyzing bacteria and gin- causes and treatment. Dent Pract 1964;14:-
Only those claims that can be sup- gival health in patients with and without 307-17.
complaints of oral malodor. J Clin Dent 28. Rosenberg M, Kozlovsky A, Gelernter I,
ported by appropriate clinical studies 1994;4(4):114-9. et al. Self estimation of oral malodor. J Dent
and scientific data are allowed to ap- 13. Kozlovsky A, Gordon D, Gelernter I, Res 1995;1577-82.
pear in conjunction with the Seal. Loesche WJ, Rosenberg M. Correlation be- 29. Tonzetich J, Preti G, Huggins GR.
This is your assurance against mis- tween the BANA test and oral malodor pa- Changes in concentration of volatile sulphur
leading or untrue statements concern- rameters. J Dent Res 1994;73:1036-42. compounds of mouth air during the menstrual
14. Shimonov R. Oral malodor in children. cycle. J Int Med Res 1978;6:245-56.
ing a product, its use, safety and effi- Tel Aviv, Israel: University of Tel Aviv; 1996. 30. Tonzetich J, Eigen E, King WJ, Weiss S.
cacy. Thesis. Volatility as a factor in the inability of certain
15. Kleinberg I, Codipilly M. The biological amines and indole to increase the odor of sali-
basis of oral malodor formation. In: Rosen- va. Arch Oral Biol 1967;12:1167-75.
* Proper Labeling. Products award- berg M, ed. Bad breath: research perspec- 31. Goldberg S, Kozlovsky A, Gordon D,
ed the ADA Seal must present a true tives. Tel Aviv, Israel: Ramot Publishing-Tel Gelernter I, Sintov A, Rosenberg M.
and accurate portrayal of intended Aviv University;1995:13-39. Cadaverine as a putative component of oral
use and efficacy on the label. Any 16. Persson S, Claesson R, Carlsson J. The malodor. J Dent Res 1994;73:1168-72.
capacity of subgingival microbiotas to produce 32. Gordon D. Correlation between BANA
label claims must be supported by volatile sulfur compounds in human serum. test and parameters of bad breath. Tel Aviv,
appropriate clinical studies and scien- Oral Microbiol Immunol 1989;4:169-72. Israel: University of Tel Aviv; 1993. Thesis.
tific data. 17. Greenman J, El-Maaytah MA, Hartley 33. Wind Y. Improvement in periodontal pa-
MG, McAloon S. Proteolytic activity of Stoma- rameters following bad breath examination.
tococcus mucilaginus. Second World Work- Tel Aviv, Israel: University of Tel Aviv; 1995.
* Continuing Research. The ADA shop on Oral Malodor. Oct. 20, 1995; Leuven, Thesis.
supports ongoing research in the field Belgium.
of dental practice, practice manage-
ment and product safety and effec-
tiveness. Such dedication has helped
to promote the art and science of
dentistry and to achieve dentistry's
goal of self-regulation.
* Numerous Experts. It takes 165
professional dental consultants, 17
scientific council members and 11
staff scientists to proclaim oral care
products safe, effective and worthy
of the ADA Seal.

482 JADA, Vol. 127, April 1996

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