Curriculum Framework

Principles of the Biomedical Sciences Unit 3 Lesson 2

Established
Goals

Desired Results (stage 1)

Transfer
Students will be able to independently use their learning to
T1 Analyze how a change in a DNA sequence impacts the structure and function of a protein.
Meaning
UNDERSTANDINGS: Students will understand that
ESSENTIAL QUESTIONS: Students will keep considering
U1 - Proteins are produced through the processes of
Q1 What is the relationship between DNA and proteins?
transcription and translation.
Q2 How do changes in DNA sequences relate to genetic diseases?
U2 - Changes in the genetic material may cause changes in the
structure and function of a protein and consequently the traits of
an organism.
Acquisition
KNOWLEDGE: Students will
SKILLS: Students will
K1 - Recognize that the sequence of nucleotides in DNA
S1 - Demonstrate transcription and translation to create a simulated
determines the sequence of amino acids in a protein. U1, U2
protein. U1, U2
K2 - Explain the process of protein synthesis. U1
S2 - Analyze the effect that base pair mutations have on a simulated
K3 - Explain how changes in the b-globin protein are due to the
protein. U1, U2
mutation associated with sickle cell disease. U2
S3 - Manipulate computer simulated proteins to visualize the
interactions between amino acids and analyze protein structural
changes. U1, U2

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Curriculum Framework PBS Unit 3 Lesson 3.2 Page 1
Format guided by: Wiggins, G. & McTighe, J. (2011). The understanding by design guide to creating high quality units. Alexandria. VA: ASCD

Students will demonstrate

knowledge and skills by
Learning about process of protein
synthesis (A3.2.1)

Evidence (stage 2)
Assessments for
Learning

Students will

1. Use resources to create a concept

map detailing the process of
protein synthesis.

Investigating the impact of DNA

mutations, which can lead to genetic
diseases (A3.2.2)
Students will
1. Complete a virtual
transcription/translation
exercise
2. Build a model detailing the
process of protein synthesis
3. Examine the impact of
mutations and the cause of
sickle cell anemia

Examining of the impact of DNA

mutations on protein structure and
function (A3.2.3)
Students will
1. Watch a video detailing DNA
mutations and the resulting

1. The teacher will

review with the
concept maps
and give
feedback.
2. The conclusion
questions will be
reviewed.
1. The teacher will
review the model
and give
feedback.
2. The conclusion
questions will be
reviewed.

Assessments of Learning
1. Students will complete the
concept maps.
2. They will answer the
conclusion questions.

Learning Plan (stage 3)

Activities (A), Projects

(P), and Problems (B)
A 3.2.1
A 3.2.2
A 3.2.3

Knowledge and Skills

K1, K2
K1, K2, S1, S2
K1, K3, S2, S3

1. Students will explain the

process protein synthesis
and the impact of
mutations to their group
members.
2. They will build the protein
synthesis model.
3. Students will answer all
conclusion questions.

1. Teacher will
review the
students
responses and
give feedback.

1. Students will record their

observations.
2. They will answer all the
conclusion questions.

2. The conclusion
Project Lead The Way, Inc. Copyright 2013
Curriculum Framework PBS Unit 3 Lesson 3.2 Page 2
Format guided by: Wiggins, G. & McTighe, J. (2011). The understanding by design guide to creating high quality units. Alexandria. VA: ASCD

genetic diseases.
2. Investigate the chemical
properties of amino acids
(hydrophobic vs hydrophilic)
and how they impact the
proteins structure.

questions will be
reviewed.

Project Lead The Way, Inc. Copyright 2013

Curriculum Framework PBS Unit 3 Lesson 3.2 Page 3
Format guided by: Wiggins, G. & McTighe, J. (2011). The understanding by design guide to creating high quality units. Alexandria. VA: ASCD