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1 - LYMPHATIC FILARIASIS
Lymphatic filariasis is a helminthiasis transmitted by mosquitoes belonging to several genera.
These are tropical diseases whose chronic manifestations result from obstruction of the lymph
ducts by adult filariae [1].
1.1 - TREATMENT OPTIONS
Antiparasite treatment is first and foremost indicated for asymptomatic patients with
microfilaraemia and patients with initial-stage clinically manifest disease. Whatever the
antifilarian agent used, treatment must be given at a distance from an acute infection.
The recommended treatment regimen with diethylcarbamazine is one 6 mg/kg dose every three
months. Courses of 10 to 21 days of diethylcarbamazine at a dose gradually incremented to reach
6 mg/kg a day are indicated for patients with tropical pulmonary eosinophilia or who also present
with loa loa filariasis or hypersensitivity to diethylcarbamazine.
Ivermectin may be used at a dose of 200 g/kg for six months [1]. The number of courses given
depends on the clinical and biological course of the disease.
Doxycycline cures the disease permanently. It is prescribed at a dose of 200 mg/day for 6 weeks
followed by a course of ivermectin, repeated 3 to 6 months later.
Treatment for an acute manifestation is symptomatic, combining rest, wet bandages, pain relief
and antibiotics, etc.
In patients with chronic-stage disease, antifilarian treatment may be of use if the lesions are
relatively recent since regression is still achievable. Some simple measures will help prevent the
onset of acute infectious flares which aggravate lymphoedema or elephantiasis: the interdigital
spaces must be kept scrupulously clean and cracked or broken skin must be treated with local
antiseptics, antibiotics and/or antifungal agents. Acute infection must always be treated with
antibiotics. Physical treatments (drainage) and binding can be used to help reduce swelling.
Surgery is mainly indicated for elephantiasis of the genitals.
On an individual level, prevention consists in avoiding mosquito bites. Mass
treatment campaigns in endemic zones are the best option for rapidly reducing the
incidence of lymphatic filariasis. The worldwide lymphatic filariasis reduction
program was launched in 2000 and covers 51 countries. Treatment consists of an
annual 200-400 g/kg dose of ivermectin combined with 400 mg albendazole. In loa
loa free areas, DEC can be given alone or at a dose of 6 mg/kg in combination with
400 mg albendazole. The courses of treatment must be given for at least 5
years. Annual courses of ivermectin (400 g/kg) or a combination of ivermectin (400
g/kg)-diethylcarbamazine (6 mg/kg) may be used [1].
http://www.therapeutique-dermatologique.org/spip.php?article1508
Doxycycline
Pronunciation
Generic Name: doxycycline (DOX i SYE kleen)
Brand Names: Acticlate, Adoxa, Alodox, Avidoxy, Doryx, Monodox, Morgidox, NicAzel Doxy
30, Ocudox Convenience Kit, Oracea, Oraxyl, Targadox, Vibramycin
What is doxycycline?
Doxycycline is a tetracycline antibiotic. It fights bacteria in the body.
Doxycycline is used to treat many different bacterial infections, such as acne, urinary tract
infections, intestinal infections, eye infections, gonorrhea, chlamydia, periodontitis (gum
disease), and others.
Doxycycline is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. It
will not treat facial redness caused by rosacea.
Some forms of doxycycline are used to prevent malaria, to treat anthrax, or to treat infections
caused by mites, ticks, or lice.
https://www.drugs.com/doxycycline.html
If you don't have bacterial infections (such as those listed above), skip
taking the Bactrim. However, suggest you keep a supply of this antibiotic
on hand for infections that may develop from die-off after starting drug
treatment.
Morgellons: Since Bactrim heals skin & soft tissue infections, recommend
taking it during first 4 wks of above drug treatment to enhance healing of
parasitic die-off in Morgellons sores & lesions.
When finished taking the Bactrim, I then took Doxycycline, 100mg, twice
daily, for 6 weeks.
Doxycycline enhances the synergistic & antiparasitic effects of
Ivermectin & results in higher cure rates. It's a key element in
treatment of Strongyloides, Filariasis, & Morgellons. If treating those
infections, do not skip taking this drug.
If Bactrim or other antibiotics are not taken for bacterial infections,
then start taking Doxycline at the beginning of parasite drug treatment.
Do not take Bactrim (or other antibiotics) & Doxycycline together or
during the same time period. Finish the dosage cycle of one
antibiotic before starting the next antibiotic.
Bactrim DS/Sulfamethoxazole-Trimethoprim/SMZ-TMP): (For
Morgellons & Bacterial Infections) First 4 wks of parasite drug treatment: 1
tablet*, twice daily, evenly spaced 12 hours apart, with 8oz water. If unsure of
sulfa drug allergy, take gradual dose increases: 1/2 tablet first day, 1
tablet second day, 1-1/2 tablet third day, & 2 tablets daily thereafter. This slow
"ramp-up" dosage method generally prevents allergic reaction.
*Two tablet sizes are available: Bactrim 400/80mg (Regular Strength) & Bactrim
DS 800/160mg (Double Strength). There are 61 brands of Bactrim
(Sulfamethoxazole-Trimethoprim, SMZ-TMP): http://www.druginfosys.com/AlterBrandResult.aspx?
code=9406&packing=13859
trial study: 25 received DEC (300 mg) combined with a placebo, and 19 received DEC (300 mg)
combined with doxycycline (200 mg). The incidences of adverse reactions to standard treatment
were lower in the doxycycline group (45.5%) than in the placebo group (58.8%). Severe
reactions occurred only in the placebo group (3 of 25 subjects). The severity of adverse reactions
was significantly lower in the doxycycline group (mean score 0.45) than in the placebo group
(mean score 1.17). The levels of IL-6 and Wolbachia DNA in the plasma were significantly
lower in the doxycycline group. The filarial antigen levels were significantly lower in the
doxycycline group at months 6 after treatment.
http://www.ncbi.nlm.nih.gov/pubmed/21073054
Doxycycline was used to treat LF in 51 patients in Ghana. The antibiotic not only
killed the worm but also provided relief from symptoms. Lymphatic Filariasis (LF)
http://www.medindia.net/news/view_news_main.asp?x=14571
http://www.medplusmart.com/drugsCategory/MEDICINES/Anthelmintics/10074/1009
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http://www.medplusmart.com/drugsCategory/MEDICINES/Anthelmintics/10074/1009
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http://www.medplusmart.com/product/LIZA-DEC-TABLET/LIZA0003
LIZA DEC TABLET
Mfg:
CASSEL PHARMA
(Other Products from CASSEL PHARMA)
Comp:
Diethylcarbamazine 150 MG+Levocetirizine 2.5 MG
Form:
TABLET
Pack Size:
10 (Units)
MRP (per pack) :
Rs. 31.90
Comp:
Diethylcarbamazine 150 MG
Form:
TABLET
Pack Size:
10 (Units)
MRP (per pack) :
Rs. 37.90
Comp:
Chlorpheniramine maleate 2 MG+Diethylcarbamazine 100 MG
Form:
TABLET
Pack Size:
10 (Units)
MRP (per pack) :
Rs. 13.00