Académique Documents
Professionnel Documents
Culture Documents
Pathophysiology
Seizures are defined as paroxysmal events of transitory alteration
in consciousness or other signs or symptoms that can be due to
brain dysfunction. Epileptic seizures are seizure events that are
caused by excessive, abnormally synchronized, localized or widely
distributed neuronal electrical discharges3. The paroxysmal
depolarization shift (PDS) is the pathophysiological cellular
phenomenon that underlies all types of epileptic seizures. PDSs
are cellular events in which rapidly repetitive action potentials are
not followed by the usual refractory period, thereby generating a
prolonged membrane depolarization .When a PDS occurs as an
abnormally prolonged run of action potentials during sustained
membrane depolarization in a single neuron, it will increased
glutamate (Na+) concentration which is associated with influx of
DH.
Epilepsy.
Engl
Med