Alzheimer

,

. ,
,

cdalla@med.uoa.gr



35 . (140.000 )
2050 -> 1 85 (106 )

4
$340 . .

.
1% 65 .
65 74 3%. 75 84
19%.
47% 85 .

 ......100
- ;
- A
- ;
- A

- ;
- A,
- ;
-A, ...
- ;
- A

- .
D
?
1911: Alois Alzheimer

, .
Kraepelin

-,
, A
D Alzheimer. Alzheimer
( )
....
(miliary foci
) (
).

N :

 : 100 ...
-
(.. )

I/II

III/IV

(
Meynert)

V/VI

au
P

APP
(BACE-1)

C99

P PP
P

au

()

()

P
P

P
P PP

au
P
P


( 2004):
-
- NMDA ( )
-

50% .

( 6 ).
, ( )
/ , ,
.

N =
M =
ACh =

ACh

ACh

6
4
2
0
-2
-4
-6
-8
-10
-12
-14
-16

T:
T 1/2= 35 (, )
4-
P450

CYP1A2.
.
( ). .

,
, ,

T1/2 70

P450
CYP3A CYP2D6

. N (17%), (17%), (10%)
(8%), (8%)

t1/2 1.5

P450
,
N , , ,

: 1
,


NMDA

(): ,
,

()
COX 2 ,

secretases,

, (.. ),
tau
, ,
3 , (Zn/Cu),
(, ..)

,
-

(
au, )

 Morris Water Maze