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Physiology 1
LECTURE 3 NOTES
By Dr. Tom Madayag
Genetic Control of Protein Synthesis, Cell Function, and
Cell Reproduction
https://www.youtube.com/watch?v=zwibgNGe4aY
Nucleotides
o Organized to form two strands of DNA
o Ten pairs of nucleotides are present in each full turn of the helix
o Components
1. Phosphoric acid
2. Sugar called deoxyribose
3. Four nitrogenous bases
Adenine
Guanine
PURINE
Thymine
Cytosine
Pyrimidin
4. Hydrogen bonds hold two respective DNA strands
Each purine base always bonds with a pyrimidine base
1. ADENINE TO THYMINE
2. GUANINE TO CYTOSINE
3. Remember: Apple to Tree; Car to Garage
Genetic Code
o IF DNA is split, purine & pyrimidine project to each side
o These projecting bases form the genetic code
o Genetic code consist of triplets of bases
o The DNA code in the cell nucleus is transferred to the RNA code in the
cell cytoplasm in the process called transcription
o The RNA in turn diffuses to the cytoplasmic compartment where it
controls protein synthesis
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https://www.youtube.com/watch?v=zFVH9SqtJCM
https://www.youtube.com/watch?v=pNVPB6NFIZU
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3
6. Micro RNA (miRNA)- single stranded RNA molecules of 21 to 23
nucleotides that can regulate gene transcription and translation
Translation
https://www.youtube.com/watch?v=8dsTvBaUMvw
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CELL REPRODUCTION
https://www.youtube.com/watch?v=JcZQkmooyPk
4
3. Anaphase
Two chromatids of each chromosome are pulled apart at
the centromere
The 46 pairs of chromatids are separated forming two
separate sets of 46 daughter chromosomes
Remember this stage by remembering A representing
AWAY
4. Telophase
Two sets of daughter chromosomes are pushed
completely apart
Mitotic apparatus dissolves
New nuclear membrane develops around each set of
chromosomes
Cell pinches in two caused by formation of aa contractile
ring (composed of actin and myosin)
Remember this stage by remembering T representing
TWO
Control of Cell Growth and Cell Reproduction
Some cells reproduce all the time (blood-forming cells of bone marrow, skin)
Some cells do not reproduce (except during fetal life)
o Neurons
o Most striated muscle cells
Insufficiency of some cells cause them to grow
o Example: liver--- transplant
Control of cell growth
o Growth factors
o Contact inhibition- stop growing when there I no space
o When own secretions of the cells collect (negative feedback control)
Telomeres
o Region of repetitive nucleotide sequences at each end of a chromatid
o Serve as protective caps that prevent chromosome from deteriorating
during cell division
o With each cell division, the copied DNA loses nucleotides at the
telomere region
o Explanation of aging
o Telomere erosion can also be caused by diseases
o Telomerase activity adds bases to allow more generations of cells can
be produced (stem cells of bone marrow, skin)
Apoptosis
o Programmed cell death
o When cells are no longer needed or become a threat to the organism
Cancer
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https://www.youtube.com/watch?v=8LhQllh46yI