Compiled General Pathology Answers (2009-2010)

Chapter 1

1. E

2. B

3. C

4. E

5. D: p.13 Robbins

6. D: p.13 PBVD

7. E (PBVD pp 13)
8. B (PBVD pp 35)
9. E (Robbins pp 7)

10. B

11. B

12. A

13. A- RER contain ribosomes (which contain acid- RNA) which is stained by hematoxylin (stains
nucleic acids blue

14. A

15. D

16. D

17. A

18. D

19. E. Correct: Accumulation of lipid breakdown products due to decreased phospholipid synthesis.

20. E

21. E

22. A

23. C

24. D

25. E

26. D
27. B

28. A (Robbins p. 18)

29. E (Robbins p. 19). Cyclosporine targets cyclophilin D, a structural component of the mptp

30. D (Robbins p. 21)

31. C. Robbins 18-19. Ischemia causes reduced cellular glycogen through the increased of anaerobic
glycolysis. Calcium increases through the depletion of ATP à reduced Na/K ATPase.

32. E. Robbins 19. ATPases continue to deplete ATP, phospholipases cause membrane damage,
proteases break down membrane and cytoskeletal proteins, endonucleases cause chromatin and DNA
fragmentation.

33. B. Robbins 25. CCL3 is generated by enzymes, all others are caused by reactive oxygen species.

34. E. Robbins 19.

35. A. Robbins 19. Opening the mitochondrial transition pore causes loss of membrane potential leading
to inability to generate ATP and eventually necrosis. Calcium also activates phospholipases, proteases,
and endonucleases, and ATPases. Increasing membrane permeability also leads to leakage of cytochrome
C and caspases.

36. E. Robbins 24.

37. D. Robbins 24

38. E

39. E

40. D

41. A

42. E (Review)

43. A (Robbins pp 20)

44. B (Robbins pp 20) oxidative enzymes also present in lysosome and cytosol

45. E (Robbins pp 20) Catalase (peroxisomes) and glutathione peroxidase (mitochondrial and cytosol)
convert H2O2 to H2O and O2

46. C (Robbins pp 24)