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"I propose to gather data linking loss of mass on drying with solvent selection for filtration
and washing, this in turn will be linked with the friability of the dried particles and this then
correlated with the solubility of the substrate in the selected wash solvent. The initial program
of work will be a wide selection of pure solvents, the substrate will be paracetamol, chosen to
be compatible with a larger program of work, this will allow the effect of particle size to be
explored as a categorical variable; micronized, typical crystalline and granular. If time allows
we will select a small group of solvent pairs and investigate the effect of making a solvent
switch between a primary solvent and secondary wash solvent on the tendency for the
particles to granulate on drying. This work fits into a bigger program of work on isolation
shown in the image below. The data gathered should form the basis of a paper on wash
solvent selection, it may not be a world changing publication but it will feed into a wash
solvent selection algorithm and so is likely to lead impact."
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