SALICYLATES (ASPIRIN)

KINETIC
1-ABSORPTION
2-DISTRIBUTION
3-EXCERITION
4-METABOLISM
DYNAMIC
SYSTEMIC ACTION
1-ANTI-PYRETIC
(ND)->HEAT REGULATING CENTER (RESET)
HEAT LOSS(INCREASE)
(TD)->BODY TEMP(INCREASE)
2-ANTI INFLAMMATORY

(H.P.C.K)

-(X)HYALOURANIDASE
-(X)KALLIKAREIN
-(X)CHEMOTAXIS
-(X)PROSTAGLANDINS

DIRECT => (X)C.O.X IRREVERSIBLE

INDIRECT=> (X)PHOSPHOLIPASE A2

3-ANALGESIC
PERIPHERAL ->TISSUE(INFLAMED)->(X)PG
CENTRAL
->SUBCORTICAL SITE->(X)PAIN PATHWAY
4-CVS
(ND)->X
(HD)->SMOOTH M->DIRECT EFFECT->VD PERIPHERAL
(TD)->VMC PARALYSIS+(X)CIRCULATION
5-RESPI
(ND)->
(HD)->
(TD)->
6-G.I.T
CTZ
GASTRIC MUCOSA(IRRITATE)
GASTRIC ULCER+BLEEDING+PAINLESS

7-HEPATIC
BILE VOLUME(INCREASE)
8-RENAL
RBF(DECREASE)
9-BLOOD URIC ACID
(SD) PCT
->RETENTION U.A
(HD) TUBULE->(X)REANSORPTION
10-HEMATOLOGICAL
-G6PD
->MHA
-RHEUMATIC FEVER->LEUCOCYTOSIS(DECREASE)
-(X)PLATELET AGGREGATION [-(X)TXA2-]
-(X)VIT K UTILIZATION = (DICOUMAROL L.A)
-(X)SEDIMENTATION RATE
-BLEEDING TIME
(INCREASE)
-COAGULATION TIME (INCREASE)
11-ENDOCRINE (LD)
ADRENAL CORTEX->ADRENLINE
ADRENAL MEDULLA->ACTH+CORTISOL
12-METABOLIC
CHO( )
(LD) DIABETIC->HYPO-GLYCEMIA
(LD) NORMAL ->HYPER-GLYCEMIA
NITROGEN( )
(LD)
(TD)
TREATEMENT

S A (X) R V F C H (SEE AHMAD (X) READING V FOR

CAPTAIN HUNGGA)

1-STOMACH WASH
2-ALKALINIZATION
3-ANTI CONVULSANT
4-REPLACEMENT
5-VIT K
6-FRESH BLOOD TRANSFUSION
7-CORRECTION ACIDOSIS
8-HAEMODIALYSIS

CONTRAINDICATION

PAP BG (X)AVI

1-PREGNANCY
2-allergy
3-PEPTIC ULCER(ACTIVE)
4-BLEEDING DISEASE
5-GOUT PATIENT(URICOSURIC)
6-(X)ANTI-COAGULANT
7-asthma
8-VIRAL INFECTION+FEVER
9-IDIONCRASY
S.E(7)

(DR MH GTP)

1-DAMAGE (HEPATIC N RENAL)

2-REYE SYNDROME
3-METABOLIC
4-HYPERSENSIVITY(INTOLERANCE)
5-G.I.T
6-TOXICITY
7-PREGNACY (D.A.P.T)
ACUTE TOXICITY
HYPER
1-FLEXIA
2-VENTILATION
3-PYREXIA
4-HYDROSIS
5-ACIDITY
6-GLYCEMIA
HYPO
1-TENSION
2-PROTHROMBINEMIA
CHRONIC TOXICITY
-

USES
LOCAL
SYSTEMIC
1-(SD)
A-PLATELET HYPER-AGGREGAVIBILITY (+) DISEASE
B-PREGNANT(PREECLAMPSIA)
C-HYPERTENSION
D-PATENT DUCTUS ARTERIOSUS(PROMOTE CLOSURE)
E-ALZHEIMER
F-COLORECTAL CANCER INCIDENCE
2-(MD)
A-FEVER N COMMON COLD
B-ANALGESIS
C-RADIATION INDUCE TUMOUR
3-(LD)
A-RHEUMATOID ARTHRITIS
B-RHEUMATIC FEVER (ACUTE)