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The Neuroscience of Mental Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Complexity of the Brain I: Structural . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Complexity of the Brain II: Neurochemical . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Complexity of the Brain III: Plasticity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Imaging the Brain . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Overview of Mental Illness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Manifestations of Mental Illness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Anxiety . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Psychosis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Disturbances of Mood . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Disturbances of Cognition . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Other Symptoms . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Diagnosis of Mental Illness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Epidemiology of Mental Illness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Adults . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Children and Adolescents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Older Adults . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Future Directions for Epidemiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Costs of Mental Illness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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40
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41
42
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48
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Overview of Etiology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Biopsychosocial Model of Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Understanding Correlation, Causation, and Consequences . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Biological Influences on Mental Health and Mental Illness . . . . . . . . . . . . . . . . . . . . . . . . . . .
The Genetics of Behavior and Mental Illness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Infectious Influences . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
PANDAS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Psychosocial Influences on Mental Health and Mental Illness . . . . . . . . . . . . . . . . . . . . . . . . . .
Psychodynamic Theories . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Behaviorism and Social Learning Theory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
The Integrative Science of Mental Illness and Health . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Overview of Development, Temperament, and Risk Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Physical Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Theories of Psychological Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Piaget: Cognitive Developmental Theory . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Erik Erikson: Psychoanalytic Developmental Theory . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
John Bowlby: Attachment Theory of Development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Nature and Nurture: The Ultimate Synthesis . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Overview of Prevention . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62
Definitions of Prevention . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62
Risk Factors and Protective Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 63
Overview of Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Introduction to Range of Treatments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Psychotherapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Psychodynamic Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Behavior Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Humanistic Therapy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Pharmacological Therapies . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Mechanisms of Action . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Complementary and Alternative Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Issues in Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Placebo Response . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Benefits and Risks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Gap Between Efficacy and Effectiveness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Barriers to Seeking Help . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Overview of Mental Health Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73

Overall Patterns of Use . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
History of Mental Health Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 75
&217(176 &217,18('
Overview of Cultural Diversity and Mental Health Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Introduction to Cultural Diversity and Demographics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Coping Styles . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Family and Community as Resources . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Epidemiology and Utilization of Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
African Americans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Asian Americans/Pacific Islanders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Hispanic Americans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Native Americans . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Barriers to the Receipt of Treatment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Help-Seeking Behavior . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Mistrust . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Stigma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Cost . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Clinician Bias . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Improving Treatment for Minority Groups . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Ethnopsychopharmacology . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Minority-Oriented Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Cultural Competence . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Rural Mental Health Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Overview of Consumer and Family Movements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Origins and Goals of Consumer Groups . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Self-Help Groups . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Accomplishments of Consumer Organizations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Family Advocacy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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Overview of Recovery . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
Introduction and Definitions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 97
Impact of the Recovery Concept . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98
Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100
Mental Health and Mental Illness Across the Lifespan . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104
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brain is useless without the sculpting that environment,
experience, and thought itself provides. Thus the brain
is now known to be physically shaped by contributions
from our genes and our experience, working together.
This strengthens the view that mental disorders are both
caused and can be treated by biological and experiential
processes, working together. This understanding has
emerged from the breathtaking progress in modern
neuroscience that has begun to integrate knowledge
from biological and behavioral sciences.
An overview of mental illness follows the section
on modern integrative brain science. The section
highlights topics including symptoms, diagnosis,
epidemiology (i.e., research having to do with the
distribution and determinants of mental disorders in
population groups, including various racial and ethnic
minority groups), and cost, all of which are discussed
in greater and more pointed detail in the chapters that
follow. Etiology is the study of the origins and causes
of disease, and that section reviews research that is
seeking to define, with ever greater precision, the
causes of mental disorders. As will be seen, etiology
research examines fundamental biological, behavioral,
and sociocultural processes, as well as a necessarily
broad array of life events. The section on development
of temperament reveals how mental health science has
attempted over much of the past century to understand
how biological, psychological, and sociocultural factors
meld in health as well as in illness. The chapter then
reviews research approaches to the prevention and
treatment of mental disorders and provides an overview
of mental health services and their delivery. Final
sections cover the growing influence on the mental
vast body of research on mental health and, to an

even greater extent, on mental illness constitutes
the foundation of this Surgeon Generals report. To
understand and better appreciate the content of the
chapters that follow, readers outside the mental health
field may desire some background information. Thus,
this chapter furnishes a primer on topics that the
report addresses.
The chapter begins with an overview of research
under way today that is focused on the neuroscience of
mental health. Modern integrative neuroscience offers
a means of linking research on broad systems level
aspects of brain function with the remarkably detailed
tools and findings of molecular biology. The report
begins with a discussion of the brain because it is
central to what makes us human and provides an
understanding of mental health and mental illness. All
of human behavior is mediated by the brain. Consider,
for example, a memory that most people have from
childhoodthat of learning to ride a bicycle with the
help of a parent or friend. The fear of falling, the
anxiety of lack of control, the reassurances of a loved
one, and the final liberating experience of mastery and
a newly extended universe create an unforgettable
combination. For some, the memories are not good
ones: falling and being chased by dogs have left marks
of anxiety and fear that may last a lifetime. Science is
revealing how the skill learning, emotional overtones,
and memories of such experiences are put together
physically in the brain. The brain and mind are two
sides of the same coin. Mind is not possible without the
remarkable physical complexity that is built into the
brain, but, in addition, the physical complexity of the
31
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in this 3-pound organ reveal little of its complexity. Yet

most organs in the body are composed of only a
handful of cell types; the brain, in contrast, has literally
thousands of different kinds of neurons, each distinct in
terms of its chemistry, shape, and connections
(Figure 2-1 depicts the structural variety of neurons).
To illustrate, one careful, recent investigation of a kind
of interneuron that is a small local circuit neuron in the
retina, called the amacrine cell, found no less than 23
identifiable types.
But this is only the beginning of the brains
complexity.
health field of the need for attention to cultural

diversity, the importance of the consumer movement,
and new optimism about recovery from mental
illnessthat is, the possibility of recovering ones life.
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As befits the organ of the mind, the human brain is the
most complex structure ever investigated by our
science. The brain contains approximately 100 billion
nerve cells, or neurons, and many more supporting
cells, or glia. In and of themselves, the number of cells
Figure 2-1. Structural variety of neurons
Source: Fischbach, 1992, p. 53. (Permission granted: Patricia J. Wynne.)
1
Special thanks to Steven E. Hyman, M.D., Director, National Institute of Mental Health, and Gerald D. Fischbach, M.D., Director,
National Institute of Neurological Diseases and Stroke, for their contributions to this section.
32
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The complexity of the brain is such that a single

neuron may be part of more than one circuit. The
organization of circuits in the brain reveals that the
brain is a massively parallel, distributed information
processor. For example, the circuits involved in vision
receive information from the retina. After initial
processing, these circuits analyze information into
different streams, so that there is one stream of
information describing what the visual object is, and
another stream is concerned with where the object is in
space. The information stream having to do with the
identity of the object is actually broken down into
several more refined parallel streams. One, for
example, analyzes shape while another analyzes color.
Ultimately, the visual world is resynthesized with
information about the tactile world, and the auditory
world, with information from memory, and with
emotional coloration. The massively parallel design is
a great pattern recognizer and very tolerant of failure in
individual elements. This is why a brain of neurons is
still a better and longer-lasting information processor
than a computer.
The specific connectivity of circuits is, to some
degree, stereotyped, or set in expected patterns within
the brain, leading to the notion that certain places in the
brain are specialized for certain functions (Figure 2-3).
Thus, the cerebral cortex, the mantle of neurons with its
enormous surface area increased by outpouchings,
called gyri, and indentations, called sulci, can be
functionally subdivided. The back portion of the
cerebral cortex (i.e., the occipital lobe), for example, is
involved in the initial stages of visual processing. Just
behind the central sulcus is the part of the cerebral
cortex involved in the processing of tactile information
(i.e., parietal lobe). Just in front of the central sulcus is
a part of the cerebral cortex involved in motor behavior
(frontal lobe). In the front of the brain is a region called
the prefrontal cortex, which is involved with some of
the highest integrated functions of the human being,
including the ability to plan and to integrate cognitive
and emotional streams of information.
Beneath the cortex are enormous numbers of axons
sheathed in the insulating substance, myelin. This sub-
The workings of the brain depend on the ability of

nerve cells to communicate with each other.
Communication occurs at small, specialized structures
called synapses. The synapse typically has two parts.
One is a specialized presynaptic structure on a terminal
portion of the sending neuron that contains packets of
signalling chemicals, or neurotransmitters. The second
is a postsynaptic structure on the dendrites of the
receiving neuron that has receptors for the
neurotransmitter molecules.
The typical neuron has a cell body, which contains
the genetic material, and much of the cells energyproducing machinery. Emanating from the cell body are
dendrites, branches that are the most important
receptive surface of the cell for communication. The
dendrites of neurons can assume a great many shapes
and sizes, all relevant to the way in which incoming
messages are processed. The output of neurons is
carried along what is usually a single branch called the
axon. It is down this part of the neuron that signals are
transmitted out to the next neuron. At its end, the axon
may branch into many terminals. (Figure 2-2.)
The usual form of communication involves
electrical signals that travel within neurons, giving rise
to chemical signals that diffuse, or cross, synapses,
which in turn give rise to new electrical signals in the
postsynaptic neuron. Each neuron, on average, makes
more than 1,000 synaptic connections with other
neurons. One type of cella Purkinje cellmay make
between 100,000 and 200,000 connections with other
neurons. In aggregate, there may be between 100
trillion and a quadrillion synapses in the brain. These
synapses are far from random. Within each region of
the brain, there is an exquisite architecture consisting
of layers and other anatomic substructures in which
synaptic connections are formed. Ultimately, the
pattern of synaptic connections gives rise to what are
called circuits in the brain. At the integrative level,
large- and small-scale circuits are the substrates of
behavior and of mental life. One of the most aweinspiring mysteries of brain science is how neuronal
activity within circuits gives rise to behavior and, even,
consciousness.
33
Figure 2-2. How neurons communicate
Source: Fischbach, 1992, p. 52. (Permission granted: Tomo Narashima.)
34
Figure 2-3. The brain: Organ of the mind
Source: Fischbach, 1992, p. 51. (Permission granted: Carol Donner.)
the brain processes information. The white matter is

akin to wiring that conveys information from one
region to another. Gray matter regions include the basal
ganglia, the part of the brain that is involved in the
initiation of motion and thus profoundly affected in
cortical white matter, so named because of its

appearance on freshly cut brain sections, surrounds
deep aggregations of neurons, or gray matter, which,
like the cortex, appears gray because of the presence of
neuronal cell bodies. It is within this gray matter that
35
A neurotransmitter can elicit a biological effect in

the postsynaptic neuron by binding to a protein called
a neurotransmitter receptor. Its job is to pass the
information contained in the neurotransmitter message
from the synapse to the inside of the receiving cell. It
appears that almost every known neurotransmitter has
Parkinsons disease, but that is also involved in the

integration of motivational states and, thus, a substrate
of addictive disorders. Other important gray matter
structures in the brain include the amygdala and the
hippocampus. The amygdala is involved in the
assignment of emotional meaning to events and objects,
and it appears to play a special role in aversive, or
negative, emotions such as fear. The hippocampus
includes, among its many functions, responsibility for
initially encoding and consolidating explicit or episodic
memories of persons, places, and things.
In summary, the organization of the brain at the
cellular level involves many thousands of distinct kinds
of neurons. At a higher integrative level, these neurons
form circuits for information processing determined by
their patterns of synaptic connections. The organization
of these parallel distributed circuits results in the
specialization of different geographic regions of the
brain for different functions. It is important to state at
this point, however, that, especially in younger
individuals, damage to a particular brain region may
yield adaptations that permit circuits spared the damage
and, therefore, other regions of the brain, to pick up
some of the functions that would otherwise have been
lost.
Table 2-1.
Selected neurotransmitters important in

psychopharmacology
Excitatory amino acid

Glutamate
Inhibitory amino acids
Gamma aminobutyric acid
Glycine
Monoamines and related neurotransmitters
Norepinephrine
Dopamine
Serotonin
Histamine
Acetylcholine (quarternary amine)
Purine
Adenosine
Neuropeptides
Opioids
Enkephalins
Beta-endorphin
Dynorphin
&RPSOH[LW\RIWKH%UDLQ,,1HXURFKHPLFDO
Superimposed on this breathtaking structural
complexity is the chemical complexity of the brain. As
described above, electrical signals within neurons are
converted at synapses into chemical signals which then
elicit electrical signals on the other side of the synapse.
These chemical signals are molecules called
neurotransmitters. There are two major kinds of
molecules that serve the function of neurotransmitters:
small molecules, some quite well known, with names
such as dopamine, serotonin, or norepinephrine, and
larger molecules, which are essentially protein chains,
called peptides. These include the endogenous opiates,
Substance P, and corticotropin releasing factor (CRF),
among others. All told, there appear to be more than
100 different neurotransmitters in the brain (Table 2-1
contains a selected list).
Tachykinin
Substance P
Hypothalamic-releasing factors
Corticotropin-releasing hormone
more than one different kind of receptor that can confer

rather different signals on the receiving neuron.
Dopamine has 5 known neurotransmitter receptors;
serotonin has at least 14.
Although there are many kinds of receptors with
many different signaling functions, we can divide most
neurotransmitter receptors into two general classes.
One class of neurotransmitter receptor is called a
ligand-gated channel, where ligand simply means a
36
precise point-to-point communication within the brain

use excitatory or inhibitory neurotransmission.
Examples of such circuits, which are massively
parallel, can be found in the visual and auditory cortex.
Overlying this pattern of precise, rapid (timing in the
range of milliseconds) neurotransmission are the
modulatory systems in the brain that use
norepinephrine, serotonin, and dopamine. In each case,
the neurotransmitter in question is made by a very
small number of nerve cells clustered in a limited
number of areas in the brain. Of the hundred billion
neurons in the brain, only about 500,000, for example,
make dopaminethat is, for every 200,000 cells in the
brain, only one makes dopamine. Even fewer make
norepinephrine. The cell bodies of the dopamine
neurons are clustered in a few brain regions, most
importantly, regions deep in the brain, in the midbrain,
called the substantia nigra, and the ventral tegmental
area. Norepinephrine neurons are made in the nucleus
locus coeruleus even farther down in the brain stem in
a structure called the pons. Serotonin is made by a
somewhat larger number of nuclei but, still, not by
many cells. Nuclei called the raphe nuclei spread along
the brain stem. While each of these neurotransmitters
is made by a small number of neurons with clustered
cell bodies, each sends its axons branching throughout
the brain, so that in each case a very small number of
neurons, which largely appear to fire in unison when
excited, influence almost the entire brain. This is not
the picture of systems that are communicating precise
bits of information about the world but rather are
intrinsic modulatory systems that act via other G
protein-linked receptors to alter the overall
responsiveness of the brain. These neurotransmitters
are responsible for brain states such as degree of
arousal, ability to pay attention, and for putting
emotional color or significance on top of cold cognitive
information provided by precise glutaminergic circuits.
It is no wonder that these modulatory neurotransmitters
and their receptors are critical targets of medications
used to treat mental disordersfor example, the
antidepressant and antipsychotic drugsand also are
the targets of drugs of abuse.
molecule (i.e., a neurotransmitter) that binds to a

receptor. When neurotransmitters interact with this
kind of receptor, a pore within the receptor molecule
itself is opened and positive or negative charges enter
the cell. The entry of positive charge may activate
additional ion channels that allow more positive charge
to enter. At a certain threshold, this causes a cell to fire
an action potentialan electrical event that leads
ultimately to the release of neurotransmitter. By
definition, therefore, receptors that admit positive
charge are excitatory neurotransmitter receptors. The
classic excitatory neurotransmitter receptors in the
brain utilize the excitatory amino acids glutamate and,
to a lesser degree, aspartate as neurotransmitters.
Conversely, inhibitory neurotransmitters act by
permitting negative charges into the cell, taking the cell
farther away from firing. The classic inhibitory
neurotransmitters in the brain are the amino acids
gamma amino butyric acid, or GABA, and, to a lesser
degree, glycine.
Most of the other neurotransmitters in the brain,
such as dopamine, serotonin, and norepinephrine, and
all of the many neuropeptides constitute the second
major class. These are neither precisely excitatory nor
inhibitory but rather act to produce complex
biochemical changes in the receiving cell. Their
receptors do not contain intrinsic ion pores but rather
interact with signaling proteins, called G proteins
found inside the cell membrane. These receptors thus
are called G protein-linked receptors. The details are
less important than understanding the general scheme.
Stimulation of G protein-linked receptors alters the way
in which receiving neurons can process subsequent
signals from glutamate or GABA. To use a metaphor of
a musical instrument, if glutamate, the excitatory
neurotransmitter, is puffing wind into a flute or
clarinet, it is the modulatory neurotransmitters such as
dopamine or serotonin that might be seen as playing the
keys and, thus, altering the melody via G protein-linked
receptors.
The architecture of these systems drives home this
point. The precise brain circuits that carry specific
information about the world and that are involved in
37
&RPSOH[LW\RIWKH%UDLQ,,,3ODVWLFLW\
lions share of the 80,000 or so human genes that are

involved in building a structure so complex as the
brain. Genes are not by themselves the whole story.
Brains are built and changed through life through the
interaction of genes with environment, including
experience. It is true that a set of genes might create
repetitive multiples of one type of unit, yet the brain
appears far more complex than that. It stands to reason
that if 50,000 or 60,000 genes are involved in building
a brain that may have 100 trillion or a quadrillion
synapses, additional information is needed, and that
information comes from the environment. It is this
fundamental realization that is beginning to permit an
understanding of how treatment of mental disorders
workswhether in the form of a somatic intervention
such as a medication, or a psychological talk
therapyby actually changing the brain.
The preceding paragraphs have illustrated the chemical

and anatomic structure of the brain and, in so doing,
provided some picture of its complexity as well as
some picture of its function. The crowning complexity
of the brain, however, is that it is not static. The brain
is always changing. People learn so much and have so
many distinct types of memory: conscious, episodic
memory of the sort that is encoded initially in the
hippocampus; memory of motor programs or
procedures that are encoded in the striatum; emotional
memories that can initiate physiologic and behaviorally
adaptive repertoires encoded, for example, in the
amygdala; and many other kinds. Every time a person
learns something new, whether it is conscious or
unconscious, that experience alters the structure of the
brain. Thus, neurotransmission in itself not only
contains current information but alters subsequent
neurotransmission if it occurs with the right intensity
and the right pattern. Experience that is salient enough
to cause memory creates new synaptic connections,
prunes away old ones, and strengthens or weakens
existing ones. Similarly, experiences as diverse as
stress, substance abuse, or disease can kill neurons, and
current data suggest that new neurons continue to
develop even in adult brains, where they help to
incorporate new memories. The end result is that
information is now routed over an altered circuit. Many
of these changes are long-lived, even permanent. It is in
this way that a person can look back 10 or 20 or 50
years and remember family, a home or school room, or
friends. The general theme is that to really understand
the kind of memoryindeed, any brain functionone
must think at least at two levels: one, the level of
molecular and cellular alterations that are responsible
for remodeling synapses, and, two, the level of
information content and behavior which circuits and
synapses serve.
To summarize this section, scientists are truly
beginning to learn about the structure and function of
the brain. Its awe-inspiring complexity is fully
consistent with the fact that it supports all behavior and
mental life. Implied in the foregoing, is the fact that
brains are built not only by genesand again, it is the
,PDJLQJWKH%UDLQ
There are many exciting developments in brain science.
Of great relevance to the study of mental function and
mental illness is the ability to image the activity of the
living human brain with technologies developed in
recent decades, such as positron emission tomography
scanning or functional magnetic resonance imaging.
Such approaches can exploit surrogates of neuronal
firing such as blood flow and blood oxygenation to
provide maps of activity. As science learns more about
brain circuitry and learns more from cognitive and
affective neuroscience about how to activate and
examine the function of particular brain circuits,
differences between health and illness in the function
of particular circuits certainly will become evident. We
will be able to see the action of psychotropic drugs and,
perhaps most exciting, we will be able to see the impact
of that special kind of learning called psychotherapy,
which works after all because it works on the brain.
Different brain chemicals, brain receptors, and
brain structures will come up in the discussion of
particular illnesses throughout this document. This
section is meant to provide a panoramic, not a detailed,
introduction and also to provide certain overarching
lessons. When something is referred to as biological or
brain-based, that is not shorthand for saying it is
38
of modern science that behavior and our subjective

mental lives reflect the overall workings of the brain.
Thus, symptoms related to behavior or our mental lives
clearly reflect variations or abnormalities in brain
function. On the more difficult side of the ledger are
the terms disorder, disease, or illness. There can be no
doubt that an individual with schizophrenia is seriously
ill, but for other mental disorders such as depression or
attention-deficit/hyperactivity disorder, the signs and
symptoms exist on a continuum and there is no bright
line separating health from illness, distress from
disease. Moreover, the manifestations of mental
disorders vary with age, gender, race, and culture. The
thresholds of mental illness or disorder have, indeed,
been set by convention, but the fact is that this gray
zone is no different from any other area of medicine.
Ten years ago a serum cholesterol of 200 was
considered normal. Today, this same number alarms
some physicians and may lead to treatment. Perhaps
every adult in the United States has some
atherosclerosis, but at what point does this move along
a continuum from normal into the realm of illness?
Ultimately, the dividing line has to do with severity of
symptoms, duration, and functional impairment.
Despite the existence of a gray zone between health
and illness, science can study the mechanisms by which
illness occurs. Indeed, understanding mood regulation
and its abnormalities, for example, proceeds
independently from any set of diagnostic clinical
criteria. Family studies, molecular genetics strategies,
epidemiology, and the tools of clinical investigation
tailored to specific populations are being used to
investigate the mechanisms of mental illness. Specific
manifestations of mental illness will be covered in
succeeding pages.
This overview of mental illness focuses on those
features of the disease process that are most common
and characteristic of these disorders. The chapters that
follow will present specific details about major
categories of mental disorders that occur across the life
span. The purpose here is to provide a framework upon
which subsequent discussions of specific disorders can
rest. The section leads with a descriptive overview of
the cardinal manifestations, signs, and symptoms of
genetic and, thus, predetermined; similarly, references

to psychological or even social phenomena do not
exclude biological processes. The brain is the great
integrator, bringing together genes and environment.
The study of the brain requires reducing problems
initially to bite-sized bits that will allow investigators
to learn something, but ultimately, the agenda of
neuroscience is not reductionist; the goal is to
understand behavior, not to put blinders on and try to
explain it away. As the foregoing discussion illustrates,
the brain also is complex. Thus, having a disease that
affects one or even many critical circuits does not
overthrow, except in extreme cases, such as advanced
Alzheimers disease, all aspects of a person. Typically,
people retain their personality and, in most cases, their
ability to take responsibility for themselves.
In retrospect, early biological models of the mind
seem impoverished and deterministicfor example,
models that held that levels of a neurotransmitter
such as serotonin in the brain were the principal
influence on whether one was depressed or aggressive.
Neuroscience is far beyond that now, working to
integrate information coming bottom-up from genes
and molecules and cells, with information flowing
top-down from interactions with the environment and
experience to the internal workings of the mind and its
neuronal circuits. Ultimately, however, the goal is not
only human self-understanding. In knowing eventually
precisely what goes wrong in what circuits and what
synapses and with what chemical signals, the hope is to
develop treatments with greater effectiveness and with
fewer side effects. Indeed, as the following chapters
indicate, the hope is for cures and ultimately for
prevention. There is every reason to hope that as our
science progresses, we will achieve those goals.
2YHUYLHZRI0HQWDO,OOQHVV
Mental illness is a term rooted in history that refers
collectively to all of the diagnosable mental disorders.
Mental disorders are characterized by abnormalities in
cognition, emotion or mood, or the highest integrative
aspects of behavior, such as social interactions or
planning of future activities. These mental functions
are all mediated by the brain. It is, in fact, a core tenet
39
Table 2-2. Common signs of acute anxiety
mental disorders. It then describes how mental

disorders are diagnosed and classified and provides an
overview of the epidemiology and societal burden of
mental disorders.
0DQLIHVWDWLRQVRI0HQWDO,OOQHVV
Persons suffering from any of the severe mental
disorders present with a variety of symptoms that may
include inappropriate anxiety, disturbances of thought
and perception, dysregulation of mood, and cognitive
dysfunction. Many of these symptoms may be
relatively specific to a particular diagnosis or cultural
influence. For example, disturbances of thought and
perception (psychosis) are most commonly associated
with schizophrenia. Similarly, severe disturbances in
expression of affect and regulation of mood are most
commonly seen in depression and bipolar disorder.
However, it is not uncommon to see psychotic
symptoms in patients diagnosed with mood disorders or
to see mood-related symptoms in patients diagnosed
with schizophrenia. Symptoms associated with mood,
anxiety, thought process, or cognition may occur in any
patient at some point during his or her illness.
&
Feelings of fear or dread
&
Trembling, restlessness, and muscle tension
&
Rapid heart rate
&
Lightheadedness or dizziness
&
Perspiration
&
Cold hands/feet
&
Shortness of breath
pares one to evade or confront a threat in the

environment. The appropriate regulation of anxiety is
critical to the survival of virtually every higher
organism in every environment. However, the
mechanisms that regulate anxiety may break down in a
wide variety of circumstances, leading to excessive or
inappropriate expression of anxiety. Specific examples
include phobias, panic attacks, and generalized anxiety.
In phobias, high-level anxiety is aroused by specific
situations or objects that may range from concrete
entities such as snakes, to complex circumstances such
as social interactions or public speaking. Panic attacks
are brief and very intense episodes of anxiety that often
occur without a precipitating event or stimulus.
Generalized anxiety represents a more diffuse and
nonspecific kind of anxiety that is most often
experienced as excessive worrying, restlessness, and
tension occurring with a chronic and sustained pattern.
In each case, an anxiety disorder may be said to exist if
the anxiety experienced is disproportionate to the
circumstance, is difficult for the individual to control,
or interferes with normal functioning.
In addition to these common manifestations of
anxiety, obsessive-compulsive disorder and posttraumatic stress disorder are generally believed to be
related to the anxiety disorders. The specific clinical
features of these disorders will be described more fully
in the following chapters; however, their relationship to
anxiety warrants mention in the present context. In the
case of obsessive-compulsive disorder, individuals
experience a high level of anxiety that drives their
obsessional thinking or compulsive behaviors. When
such an individual fails to carry out a repetitive
$Q[LHW\
Anxiety is one of the most readily accessible and easily

understood of the major symptoms of mental disorders.
Each of us encounters anxiety in many forms
throughout the course of our routine activities. It may
often take the concrete form of intense fear experienced
in response to an immediately threatening experience
such as narrowly avoiding a traffic accident.
Experiences like this are typically accompanied by
strong emotional responses of fear and dread as well as
physical signs of anxiety such as rapid heart beat and
perspiration. Some of the more common signs and
symptoms of anxiety are listed in Table 2-2. Anxiety is
aroused most intensely by immediate threats to ones
safety, but it also occurs commonly in response to
dangers that are relatively remote or abstract. Intense
anxiety may also result from situations that one can
only vaguely imagine or anticipate.
Anxiety has evolved as a vitally important
physiological response to dangerous situations that pre-
40
unfounded typically fail and may even result in the

further entrenchment of the beliefs.
Hallucinations and delusions are among the most
commonly observed psychotic symptoms. A list of
other symptoms seen in psychotic illnesses such as
schizophrenia appears in Table 2-3. Symptoms of
schizophrenia are divided into two broad classes:
positive symptoms and negative symptoms. Positive
symptoms generally involve the experience of
something in consciousness that should not
normally be present. For example, hallucinations
and delusions represent perceptions or beliefs that
should not normally be experienced. In addition to
hallucinations and delusions, patients with
psychotic disorders such as schizophrenia frequently have marked disturbances in the logical
process of their thoughts. Specifically, psychotic
thought processes are characteristically loose,
disorganized, illogical, or bizarre. These
disturbances in thought process frequently produce
observable patterns of behavior that are also
disorganized and bizarre. The severe disturbances
of thought content and process that comprise the
positive symptoms often are the most recognizable
and striking features of psychotic disorders such as
schizophrenia or manic depressive illness.
behavior such as hand washing or checking, there is an

experience of severe anxiety. Thus while the outward
manifestations of obsessive-compulsive disorder may
seem to be related to other anxiety disorders, there
appears to be a strong component of abnormal
regulation of anxiety underlying this disorder. Posttraumatic stress disorder is produced by an intense and
overwhelmingly fearful event that is often lifethreatening in nature. The characteristic symptoms that
result from such a traumatic event include the persistent
reexperience of the event in dreams and memories,
persistent avoidance of stimuli associated with the
event, and increased arousal.
3V\FKRVLV
Disturbances of perception and thought process fall

into a broad category of symptoms referred to as
psychosis. The threshold for determining whether
thought is impaired varies somewhat with the cultural
context. Like anxiety, psychotic symptoms may occur
in a wide variety of mental disorders. They are most
characteristically associated with schizophrenia, but
psychotic symptoms can also occur in severe mood
disorders.
One of the most common groups of symptoms that
result from disordered processing and interpretation of
sensory information are the hallucinations.
Hallucinations are said to occur when an individual
experiences a sensory impression that has no basis in
reality. This impression could involve any of the
sensory modalities. Thus hallucinations may be
auditory, olfactory, gustatory, kinesthetic, tactile, or
visual. For example, auditory hallucinations frequently
involve the impression that one is hearing a voice. In
each case, the sensory impression is falsely experienced
as real.
A more complex group of symptoms resulting from
disordered interpretation of information consists of
delusions. A delusion is a false belief that an individual
holds despite evidence to the contrary. A common
example is paranoia, in which a person has delusional
beliefs that others are trying to harm him or her.
Attempts to persuade the person that these beliefs are
Table 2-3.
Common manifestations of
schizophrenia
Positive Symptoms
&
Hallucinations
&
Delusions
&
Disorganized thoughts and behaviors
&
Loose or illogical thoughts
&
Agitation
Negative Symptoms
&
Flat or blunted affect
&
Concrete thoughts
&
&
Anhedonia (inability to experience pleasure)

Poor motivation, spontaneity, and initiative
However, in addition to positive symptoms,

patients with schizophrenia and other psychoses
41
Disturbances of mood characteristically

manifest themselves as a sustained feeling of
sadness or sustained elevation of mood. As with
anxiety and psychosis, disturbances of mood may
occur in a variety of patterns associated with
different mental disorders. The disorder most
closely associated with persistent sadness is major
depression, while that associated with sustained
elevation or fluctuation of mood is bipolar disorder.
The most common signs of these mood disorders
are listed in Table 2-4. Along with the prevailing
feelings of sadness or elation, disorders of mood
are associated with a host of related symptoms that
include disturbances in appetite, sleep patterns,
energy level, concentration, and memory.
have been noted to exhibit major deficits in

motivation and spontaneity that are referred to as
negative symptoms. While positive symptoms
represent the presence of something not normally
experienced, negative symptoms reflect the absence
of thoughts and behaviors that would otherwise be
expected. Concreteness of thought represents
impairment in the ability to think abstractly.
Blunting of affect refers to a general reduction in
the ability to express emotion. Motivational failure
and inability to initiate activities represent a major
source of long-term disability in schizophrenia.
Anhedonia reflects a deficit in the ability to
experience pleasure and to react appropriately to
pleasurable situations. Positive symptoms such as
hallucinations are responsible for much of the acute
distress associated with schizophrenia, but negative
symptoms appear to be responsible for much of the
chronic and long-term disability associated with the
disorder.
T he psychotic symptoms represent
manifestations of disturbances in the flow,
processing, and interpretation of information in the
central nervous system. They seem to share an
underlying commonality of mechanism, insofar as
they tend to respond as a group to specific
pharmacological interventions. However, much
remains to be learned about the brain mechanisms
that lead to psychosis.
Table 2-4. Common signs of mood disorders

Symptoms Commonly Associated With
Depression
'LVWXUEDQFHV RI 0RRG
Most of us have an immediate and intuitive

understanding of the notion of mood. We readily
comprehend what it means to feel sad or happy.
These concepts are nonetheless very difficult to
formulate in a scientifically precise and
quantifiable way; the challenge is greater given the
cultural differences that are associated with the
expression of mood. In turn, disorders that impact
on the regulation of mood are relatively difficult to
define and to approach in a quantitative manner.
Nevertheless, dysregulation of mood and the
expression of mood, or affect, represent a major
category among mental disorders.
&
Persistent sadness or despair
&
Insomnia (sometimes hypersomnia)
&
Decreased appetite
&
Psychomotor retardation
&
Anhedonia (inability to experience pleasure)
&
Irritability
&
Apathy, poor motivation, social withdrawal
&
Hopelessness
&
Poor self-esteem, feelings of helplessness
&
Suicidal ideation
Symptoms Commonly Associated With Mania
42
&
Persistently elevated or euphoric mood
&
Grandiosity (inappropriately high self-esteem)
&
Psychomotor agitation
&
Decreased sleep
&
Racing thoughts and distractibility
&
Poor judgment and impaired impulse control
&
Rapid or pressured speech
disorders such as depression. It is not uncommon to

find profound disturbances of cognition in patients
suffering from severe mood disturbances. More
recently, cognitive deficits have been reported in
schizophrenia and now have become a major new
topic of research. Lastly, cognitive impairment
frequently occurs in a host of chemical, metabolic,
and infectious diseases that exert an impact on the
brain.
The manifestations of cognitive impairment can
vary across an extremely wide range, depending on
severity. Short-term memory is one of the earliest
functions to be affected and, as severity increases,
retrieval of more remote memories becomes more
difficult. Attention, concentration, and higher
intellectual functions can be impaired as the
underlying disease process progresses. Language
difficulties range from mild word-finding problems
to complete inability to comprehend or use
language. Functional impairments associated with
cognitive deficits can markedly interfere with the
ability to perform activities of daily living such as
dressing and bathing.
It is not known why diverse functions such as

sleep and appetite should be altered in disorders of
mood. However, depression and mania are typically
associated with characteristic changes in these
basic functions. Mood appears to represent a
complex group of behaviors and responses that
undergo precise and tightly controlled regulation.
Higher organisms that must adapt to changing
environments depend on optimal control of basic
functions such as sleep, appetite, sex, and physical
activity. This regulation must adapt to diurnal and
seasonal changes in the environment. In addition,
more complex behaviors such as exploration,
aggression, and social interaction must also
undergo a similar, perhaps closely linked,
regulation. In humans, these complex behaviors and
their regulation are believed to be associated with
the expression of mood. A depressed mood appears
to reflect a kind of global damping of these
functions, while a manic state may result from an
excessive activation of these same functions. The
mechanisms underlying the diverse changes
associated with the mood disorders are largely
unknown, but their appearance as clusters in
specific disorders along with their collective
response to specific therapeutics suggests a
common mechanistic basis.
2WKHU 6\PSWRPV
Anxiety, psychosis, mood disturbances, and

cognitive impairments are among the most common
and disabling manifestations of mental disorders. It
is important, however, to appreciate that mental
disorders leave no aspect of human experience
untouched. It is beyond the scope of the present
chapter to detail the full spectrum of presentations
of mental disorders. Other common manifestations
include, for example, somatic or other physical
symptoms and impairment of impulse control.
Many of these issues will be touched upon in
subsequent chapters with reference to specific
disorders.
'LVWXUEDQFHV RI &RJQLWLRQ
Cognitive function refers to the general ability to

organize, process, and recall information. Cognitive
tasks may be subdivided into a large number of
more specific functions depending on the nature of
the information remembered and the circumstances
of its recall. In addition, there are many functions
commonly associated with cognition such as the
ability to execute complex sequences of tasks.
Disturbances of cognitive function may occur in a
variety of disorders. Progressive deterioration of
cognitive function is referred to as dementia.
Dementia may be caused by a number of specific
conditions including Alzheimers disease (to be
discussed in subsequent chapters). Impairment of
cognitive function may also occur in other mental
'LDJQRVLVRI0HQWDO,OOQHVV
The foregoing discussion has suggested that the
manifestations of mental disorders fall into a
number of distinct categories such as anxiety,
psychosis, mood disturbance, and cognitive
43
Disorders. Most recently revised in 1994, this

manual now is in its fourth edition (American
Psychiatric Association, 1994, hereinafter cited in
this report as DSM-IV). The first edition was
published in 1952 by the American Psychiatric
Association; subsequent revisions, which were
made on the basis of field trials, analysis of data
sets, and systematic reviews of the research
literature, have sought to gain greater objectivity,
diagnostic precision, and reliability. DSM-IV
organizes mental disorders into 16 major diagnostic
classes listed in Table 2-5. For each disorder within
a diagnostic class, DSM-IV enumerates specific
criteria for making the diagnosis. DSM-IV also lists
diagnostic subtypes for some disorders. A
subtype is a subgroup within a diagnosis that
confers greater specificity. DSM-IV is descriptive
in its listing of symptoms and does not take a
position about underlying causation.
deficits. These categories are broad, heterogeneous,

and somewhat overlapping. Moreover, any
particular patient may manifest symptoms from
more than one of these categories. This is not
unexpected, given the highly complex interactions
that take place among the neurobiological and
behavioral substrates that produce these symptoms.
Despite these confounding difficulties, a systematic
approach to the classification and diagnosis of
mental illness has been developed. Diagnosis is
essential in all areas of health for shaping treatment
and supportive care, establishing a prognosis, and
preventing related disability. Diagnosis also serves
as shorthand to enhance communication, research,
surveillance, and reimbursement.
The diagnosis of mental disorders is often
believed to be more difficult than diagnosis of
somatic, or general medical, disorders, since there
is no definitive lesion, laboratory test, or
abnormality in brain tissue that can identify the
illness. The diagnosis of mental disorders must rest
with the patients reports of the intensity and
duration of symptoms, signs from their mental
status examination, and clinician observation of
their behavior including functional impairment.
These clues are grouped together by the clinician
into recognizable patterns known as syndromes.
When the syndrome meets all the criteria for a
diagnosis, it constitutes a mental disorder. Most
mental health conditions are referred to as
disorders, rather than as diseases, because
diagnosis rests on clinical criteria. The term
disease generally is reserved for conditions with
known pathology (detectable physical change). The
term disorder, on the other hand, is reserved for
clusters of symptoms and signs associated with
distress and disability (i.e., impairment of
functioning), yet whose pathology and etiology are
unknown.
The standard manual used for diagnosis of
mental disorders in the United States is the
Diagnostic and Statistical Manual of Mental
Table 2-5.
Major Diagnostic Classes of Mental

Disorders (DSM-IV)
Disorders usually first diagnosed in infancy,

childhood, or adolescence
Delerium, dementia, and amnestic and other
cognitive disorders
Mental disorders due to a general medical condition
Substance-related disorders
Schizophrenia and other psychotic disorders
Mood disorders
Anxiety disorders
Somatoform disorders
Factitious disorders
Dissociative disorders
Sexual and gender identity disorders
Eating disorders
Sleep disorders
Impulse-control disorders
Adjustment disorders
Personality disorders
44
(SLGHPLRORJ\RI0HQWDO,OOQHVV
DSM-IV and its predecessors 2 represent a

unique approach to diagnosis by a professional
field. No other sphere of health care has created
such an extensive compendium of all of its
disorders with explicit diagnostic criteria. The
World Health Organizations International
Classification of Diseases (10th edition, 1992) is a
valuable compendium of all diseases. Its mental
health categories are expanded upon in DSM-IV.
The International Classification of Diseases (ICD)
is the official classification for mortality and
morbidity statistics for all signatories to theU.N.
Charter establishing the World Health
Organization. ICD-9CM (9th edition, Clinical
Modification, 1991) is still the official
classification for the Health Care Financing
Administration.
Knowledge about diagnosis continues to
evolve. Evolution in the diagnosis of mental
disorders generally reflects greater understanding
of disorders as well as the influence of social
norms. Years ago, for instance, addiction to
tobacco was not viewed as a disorder, but today it
falls under the category of Substance-Related
Disorders. Although DSM-IV strives to cover all
populations, it is not without limitations. The
difficulties encountered in diagnosing mental
disorders in children, older persons, and racial and
ethnic minority groups are discussed later in this
chapter and throughout this report. Diagnosis rests
on clinician judgment about whether clients
symptom patterns and impairments of functioning
meet diagnostic criteria. Cultural differences in
emotional expression and social behavior can be
misinterpreted as impaired if clinicians are not
sensitive to the cultural context and meaning of
exhibited symptoms, a topic discussed later in this
chapter in Overview of Cultural Diversity and
Mental Health Services.
Few families in the United States are untouched by

mental illness. Determining just how many people
have mental illness is one of the many purposes of
the field of epidemiology. Epidemiology is the
study of patterns of disease in the population.
Among the key terms of this discipline,
encountered throughout this report, are incidence,
which refers to new cases of a condition which
occur during a specified period of time, and
prevalence, which refers to cases (i.e., new and
existing) of a condition observed at a point in time
or during a period of time. According to current
epidemiological estimates, at least one in five
people has a diagnosable mental disorder during the
course of a year (i.e., 1-year prevalence).
Epidemiological estimates have shifted over
time because of changes in the definitions and
diagnosis of mental health and mental illness. In
the early 1950s, the rates of mental illness
estimated by epidemiologists were far higher than
those of today. One study, for example, found 81.5
percent of the population of Manhattan, New York,
to have had signs and symptoms of mental distress
(Srole, 1962). This led the authors of the study to
conclude that mental illness was widespread.
However, other studies began to find lower rates
when they used more restrictive definitions that
reflected more contemporary views about mental
illness. Instead of classifying anyone with signs and
symptoms as being mentally ill, this more recent
line of epidemiological research only identified
people as mentally ill if they had a cluster of signs
and symptoms that, when taken together, impaired
peoples ability to function (Pasamanick, 1959;
Weissman et al., 1978). By 1978, the Presidents
Commission on Mental Health (1978) concluded
conservatively that the annual prevalence of
specific mental disorders in the United States was
about 15 percent. This figure comports with recent
estimates of the extent of mental illness in the
population. Even as this figure has become more
sharply delineated, the older and larger estimates
underscore the magnitude of mental distress in the
2
DSM-I (American Psychiatric Association, 1952), DSM-II
(American Psychiatric Association, 1968), DSM-III (American
Psychiatric Association, 1979), and DSM-III-R (American
Psychiatric Association, 1987).
45
Advisory Mental Health Council [NAMHC], 1993).

Most (7 percent of adults) have disorders that
persist for at least 1 year (Regier et al., 1993b;
Regier et al., in press). A subpopulation of 5.4
percent of adults is considered to have a serious
mental illness (SMI) (Kessler et al., 1996). Serious
mental illness is a term defined by Federal
regulations that generally applies to mental
disorders that interfere with some area of social
functioning. About half of those with SMI (or 2.6
percent of all adults) were identified as being even
more seriously affected, that is, by having severe
and persistent mental illness (SPMI) (NAMHC,
1993; Kessler et al., 1996). This category includes
schizophrenia, bipolar disorder, other severe forms
of depression, panic disorder, and obsessivecompulsive disorder. These disorders and the
problems faced by these special populations with
SMI and SPMI are described further in subsequent
chapters. Among those most severely disabled are
the approximately 0.5 percent of the population
who receive disability benefits for mental healthrelated reasons from the Social Security
Administration (NAMHC, 1993).
population, which this report refers to as mental

health problems.
$GXOWV
The current prevalence estimate is that about 20
percent of the U.S. population are affected by
mental disorders during a given year. This estimate
comes from two epidemiologic surveys: the
Epidemiologic Catchment Area (ECA) study of the
early 1980s and the National Comorbidity Survey
(NCS) of the early 1990s. Those surveys defined
mental illness according to the prevailing editions
of the Diagnostic and Statistical Manual of Mental
Disorders (i.e., DSM-III and DSM-III-R). The
surveys estimate that during a 1-year period, 22 to
23 percent of the U.S. adult populationor 44
million peoplehave diagnosable mental disorders,
according to reliable, established criteria. In
general, 19 percent of the adult U.S. population
have a mental disorder alone (in 1 year); 3 percent
have both mental and addictive disorders; and 6
percent have addictive disorders alone. 3
Consequently, about 28 to 30 percent of the
population have either a mental or addictive
disorder (Regier et al., 1993b; Kessler et al., 1994).
Table 2-6 summarizes the results synthesized from
these two large national surveys.
Individuals with co-occurring disorders (about
3 percent of the population in 1 year) are more
likely to experience a chronic course and to utilize
services than are those with either type of disorder
alone. Clinicians, program developers, and policymakers need to be aware of these high rates of
comorbidityabout 15 percent of those with a
mental disorder in 1 year (Regier et al., 1993a;
Kessler et al., 1996).
Based on data on functional impairment, it is
estimated that 9 percent of all U.S. adults have the
mental disorders listed in Table 2-6 and experience
some significant functional impairment (National
&KLOGUHQ DQG $GROHVFHQWV

The annual prevalence of mental disorders in
children and adolescents is not as well documented
as that for adults. About 20 percent of children are
estimated to have mental disorders with at least
mild functional impairment (see Table 2-7). Federal
regulations also define a sub-population of children
and adolescents with more severe functional
limitations, known as serious emotional
disturbance (SED). 4 Children and adolescents with
SED number approximately 5 to 9 percent of
children ages 9 to 17 (Friedman et al., 1996b).
4
The term serious emotional disturbance is used in a variety of
Federal statutes in reference to children under the age of 18 with a
diagnosable mental health problem that severely disrupts their
ability to function socially, academically, and emotionally. The term
does not signify any particular diagnosis; rather, it is a legal term
that triggers a host of mandated services to meet the needs of these
children.
3
Although addictive disorders are included as mental disorders in
the DSM classification system, the ECA and NCS distinguish
between addictive disorders and (all other) mental disorders.
Epidemiologic data in this report follow that convention.
46
Table 2-6. Best estimate 1-year prevalence rates based on ECA and NCS, ages 18%54
Any Anxiety Disorder

Simple Phobia
Social Phobia
Agoraphobia
GAD
Panic Disorder
OCD
PTSD
ECA Prevalence (%)
NCS Prevalence (%)
Best Estimate ** (%)
13.1
8.3
2.0
4.9
(1.5)*
1.6
2.4
(1.9)*
18.7
8.6
7.4
3.7
3.4
2.2
(0.9)*
3.6
16.4
8.3
2.0
4.9
3.4
1.6
2.4
3.6
Any Mood Disorder

MD Episode
Unipolar MD
Dysthymia
Bipolar I
Bipolar II
7.1
6.5
5.3
1.6
1.1
0.6
11.1
10.1
8.9
2.5
1.3
0.2
7.1
6.5
5.3
1.6
1.1
0.6
Schizophrenia
Nonaffective Psychosis
Somatization
ASP
Anorexia Nervosa
Severe Cognitive
Impairment
1.3
&
0.2
2.1
0.1
1.2
&
0.2
&
&
&
&
1.3
0.2
0.2
2.1
0.1
1.2
19.5
23.4
21.0
Any Disorder
*Numbers in parentheses indicate the prevalence of the disorder without any comorbidity. These rates were calculated using the NCS data for
GAD and PTSD, and the ECA data for OCD. The rates were not used in calculating the any anxiety disorder and any disorder totals for the ECA
and NCS columns. The unduplicated GAD and PTSD rates were added to the best estimate total for any anxiety disorder (3.3%) and any disorder
(1.5%).
**In developing best-estimate 1-year prevalence rates from the two studies, a conservative procedure was followed that had previously been used
in an independent scientific analysis comparing these two data sets (Andrews, 1995). For any mood disorder and any anxiety disorder, the lower
estimate of the two surveys was selected, which for these data was the ECA. The best estimate rates for the individual mood and anxiety disorders
were then chosen from the ECA only, in order to maintain the relationships between the individual disorders. For other disorders that were not
covered in both surveys, the available estimate was used.
Key to abbreviations: ECA, Epidemiologic Catchment Area; NCS, National Comorbidity Study; GAD, generalized anxiety disorder; OCD,
obsessive-compulsive disorder; PTSD, post-traumatic stress disorder; MD, major depression; ASP, antisocial personality disorder.
Source: D. Regier, W. Narrow, & D. Rae, personal communication, 1999
47
Table 2-7. Children and adolescents ages 9 to 17

with mental or addictive disorders,*
combined MECA sample
Prevalence (%)
Anxiety disorders
Mood disorders
Disruptive disorders
Substance use disorders
Any disorder
Table 2-8.
13.0
Best estimate prevalence rates based

on Epidemiologic Catchment Area,
age 55+
Prevalence (%)
Any Anxiety Disorder
6.2
10.3
2.0
20.9
* Disorders include diagnosis-specific impairment and

Child Global Assessment Scale 70 (mild global
impairment).
Source: Shaffer et al., 1996
Not all mental disorders identified in childhood

and adolescence persist into adulthood, even
though the prevalence of mental disorders in
children and adolescents is about the same as that
for adults (i.e., about 20 percent of each age
population). While some disorders do continue into
adulthood, a substantial fraction of children and
adolescents recover or grow out of a disorder,
whereas, a substantial fraction of adults develops
mental disorders in adulthood. In short, the nature
and distribution of mental disorders in young
people are somewhat different from those of adults.
11.4
Simple Phobia
7.3
Social Phobia
1.0
Agoraphobia
4.1
Panic Disorder
0.5
Obsessive-Compulsive
Disorder
1.5
Any Mood Disorder
4.4
Major Depressive Episode
3.8
Unipolar Major Depression
3.7
Dysthymia
1.6
Bipolar I
0.2
Bipolar II
0.1
Schizophrenia
0.6
Somatization
0.3
Antisocial Personality Disorder
0.0
Anorexia Nervosa
0.0
Severe Cognitive Impairment
6.6
Any Disorder
19.8
Source: D. Regier, W. Narrow, & D. Rae, personal communication, 1999
2OGHU $GXOWV
epidemiological term for someone who meets the

criteria for a disease or disorder. It is not always
easy to establish a threshold for a mental disorder,
particularly in light of how common symptoms of
mental distress are and the lack of objective,
physical symptoms. It is sometimes difficult to
determine when a set of symptoms rises to the level
of a mental disorder, a problem that affects other
areas of health (e.g., criteria for certain pain
syndromes). In many cases, symptoms are not of
sufficient intensity or duration to meet the criteria
for a disorder and the threshold may vary from
culture to culture.
Diagnosis of mental disorders is made on the
basis of a multidimensional assessment that takes
into account observable signs and symptoms of
The annual prevalence of mental disorders among

older adults (ages 55 years and older) is also not as
well documented as that for younger adults.
Estimates generated from the ECA survey indicate
that 19.8 percent of the older adult population have
a diagnosable mental disorder during a 1-year
period (Table 2-8). Almost 4 percent of older adults
have SMI, and just under 1 percent has SPMI
(Kessler et al., 1996); these figures do not include
individuals with severe cognitive impairments such
as Alzheimers disease.
)XWXUH'LUHFWLRQVIRU(SLGHPLRORJ\
The epidemiology of mental disorders is somewhat
handicapped by the difficulty of identifying a
case of a mental disorder. Case is an
48
&RVWVRI0HQWDO,OOQHVV
illness, the course and duration of illness, response

to treatment, and degree of functional impairment.
One problem has been that there is no clearly
measurable threshold for functional impairments.
Efforts are currently under way in the epidemiology
of mental disorders to create a threshold, or agreedupon minimum level of functional limitation, that
should be required to establish a case (i.e., a
clinically significant condition). Epidemiology
reflecting the state of psychiatric nosology during
the past two decades has focused primarily on
symptom clusters and has not uniformly
appliedor, at times, even measuredthe level of
dysfunction. Ongoing reanalyses of existing
epidemiological data are expected to yield better
understanding of the rates of mental disorder and
dysfunction in the population.
Another limitation of contemporary mental
health knowledge is the lack of standard measures
of need for treatment, particularly those which
are culturally appropriate. Such measures are at the
heart of the public health approach to mental
health. Current epidemiological estimates therefore
cannot definitively identify those who are in need
of treatment. Other estimates presented in Chapter
6 indicate that some individuals with mental
disorders are in treatment and others are not; some
are seen in primary care settings and others in
specialty care. In the absence of valid measures of
need, rates of disorder estimated in epidemiological
surveys serve as an imperfect proxy for the need for
care and treatment (Regier et al., in press).
Subsequent sections of this report reveal the
population basis of our understanding of mental
health. Where appropriate, the report discusses
mental health and illness across the entire
population. At other times, the focus is on care in
specialized mental health settings, primary health
care, schools, the criminal justice system, and even
the streets. A mainstream public health and
population-based perspective demands such a broad
view of mental health and mental illness.
The costs of mental illness are exceedingly high.

Although the question of cost is discussed more
fully in Chapter 6, a few of the central findings are
presented here. The direct costs of mental health
services in the United States in 1996 totaled $69.0
billion. This figure represents 7.3 percent of total
health spending. An additional $17.7 billion was
spent on Alzheimers disease and $12.6 billion on
substance abuse treatment. Direct costs correspond
to spending for treatment and rehabilitation
nationwide.
When economists calculate the costs of an
illness, they also strive to identify indirect costs.
Indirect costs can be defined in different ways, but
here they refer to lost productivity at the
workplace, school, and home due to premature
death or disability. The indirect costs of mental
illness were estimated in 1990 at $78.6 billion
(Rice & Miller, 1996). More than 80 percent of
these costs stemmed from disability rather than
death because mortality from mental disorders is
relatively low.
2YHUYLHZRI(WLRORJ\
The precise causes (etiology) of most mental
disorders are not known. But the key word in this
statement is precise. The precise causes of most
mental disordersor, indeed, of mental health
may not be known, but the broad forces that shape
them are known: these are biological, psychological, and social/cultural factors.
What is most important to reiterate is that the
causes of health and disease are generally viewed
as a product of the interplay or interaction between
biological, psychological, and sociocultural factors.
This is true for all health and illness, including
mental health and mental illness. For instance,
diabetes and schizophrenia alike are viewed as the
result of interactions between biological,
psychological, and sociocultural influences. With
these disorders, a biological predisposition is
necessary but not sufficient to explain their
occurrence (Barondes, 1993). For other disorders,
49
and disease. To many scientists, the model lacks

sufficient specificity to make predictions about the
given cause or causes of any one disorder.
Scientists want to find out what specifically is the
contribution of different factors (e.g., genes,
parenting, culture, stressful events) and how they
operate. But the purpose of the biopsychosocial
model is to take a broad view, to assert that simply
looking at biological factors alonewhich had
been the prevailing view of disease at the time
Engel was writingis not sufficient to explain
health and illness.
According to Engels model, biopsychosocial
factors are involved in the causes, manifestation,
course, and outcome of health and disease,
including mental disorders. The model certainly fits
with common experience. Few people with a
condition such as heart disease or diabetes, for
instance, would dispute the role of stress in
aggravating their condition. Research bears this out
and reveals many other relationships between stress
and disease (Cohen & Herbert, 1996; Baum &
Posluszny, 1999).
One single factor in isolationbiological,
psychological, or socialmay weigh heavily or
hardly at all, depending on the behavioral trait or
mental disorder. That is, the relative importance or
role of any one factor in causation often varies. For
example, a personality trait like extroversion is
linked strongly to genetic factors, according to
identical twin studies (Plomin et al., 1994).
Similarly, schizophrenia is linked strongly to
genetic factors, also according to twin studies (see
Chapter 4). But this does not mean that genetic
factors completely preordain or fix the nature of the
disorder and that psychological and social factors
are unimportant. These social factors modify
expression and outcome of disorders. Likewise,
some mental disorders, such as post-traumatic
stress disorder (PTSD), are clearly caused by
exposure to an extremely stressful event, such as
rape, combat, natural disaster, or concentration
camp (Yehuda, 1999). Yet not everyone develops
PTSD after such exposure. On average, about 9
a psychological or sociocultural cause may be

necessary, but again not sufficient.
As described in the section on modern
neuroscience, the brain and behavior are
inextricably linked by the plasticity of the nervous
system. The brain is the organ of mental function;
psychological phenomena have their origin in that
complex organ. Psychological and sociocultural
phenomena are represented in the brain through
memories and learning, which involve structural
changes in the neurons and neuronal circuits. Yet
neuroscience does not intend to reduce all
phenomena to neurotransmission or to reinterpret
them in a new language of synapses, receptors, and
circuits. Psychological and sociocultural events and
phenomena continue to have meaning for mental
health and mental illness.
Much of the research that is presented in the
remainder of this report draws on theories and
investigations that predate the more modern view
of integrative neuroscience. It is still meaningful,
however, to speak of the interaction of biological
and psychological and sociocultural factors in
health and illness. That is where the overview of
etiology beginswith the biopsychosocial model
of disease, followed by an explanation of important
terms used in the study of etiology. Then, against
the backdrop of the introductory section on brain
and behavior, the following sections address
biological and psychosocial influences on mental
health and mental illness, a separation that reflects
the distinctive research perspectives of past
decades. The overview of etiology draws to a close
with a discussion of the convergence of biological
and psychosocial approaches in the study of mental
health and mental illness.
%LRSV\FKRVRFLDO0RGHORI'LVHDVH
The modern view that many factors interact to
produce disease may be attributed to the seminal
work of George L. Engel, who in 1977 put forward
the Biopsychosocial Model of Disease (Engel,
1977). Engels model is a framework, rather than a
set of detailed hypotheses, for understanding health
50
research, several steps are needed before causation

can be established.
If a correlational study shows that a stressful
event is associated with an increased probability
for depression and that the stress usually precedes
depressions onset, then stress is called a risk
factor for depression. 5 Risk factors are biological,
psychological, or sociocultural variables that
increase the probability for developing a disorder
and antedate its onset (Garmezy, 1983; Werner &
Smith, 1992; Institute of Medicine [IOM], 1994a).
For each mental disorder, there are likely to be
multiple risk factors, which are woven together in
a complex chain of causation (IOM, 1994a). Some
risk factors may carry more weight than others, and
the interaction of risk factors may be additive or
synergistic.
Establishing causation of mental health and
mental illness is extremely difficult, as explained in
Chapter 1. Studies in the form of randomized,
controlled experiments provide the strongest
evidence of causation. The problem is that
experimental research in humans may be
logistically, ethically, or financially impossible.
Correlational research in humans has thus provided
much of what is known about the etiology of mental
disorders. Yet correlational research is not as
strong as experimental research in permitting
inferences about causality. The establishment of a
cause and effect relationship requires multiple
studies and requires judgment about the weight of
all the evidence. Multiple correlational studies can
be used to support causality, when, for example,
evaluating the effectiveness of clinical treatments
(Chambless et al., 1996). But, when studying
etiology, correlational studies are, if possible, best
combined with evidence of biological plausibility
percent do (Breslau et al., 1998), but estimates are

higher for particular types of trauma. For women
who are victims of crime, one study found the
prevalence of PTSD in a representative sample of
women to be 26 percent (Resnick et al., 1993). The
likelihood of developing PTSD is related to
pretrauma vulnerability (in the form of genetic,
biological, and personality factors), magnitude of
the stressful event, preparedness for the event, and
the quality of care after the event (Shalev, 1996).
The relative roles of biological, psychological,
or social factors also may vary across individuals
and across stages of the life span. In some people,
for example, depression arises primarily as a result
of exposure to stressful life events, whereas in
others the foremost cause of depression is genetic
predisposition.
8QGHUVWDQGLQJ&RUUHODWLRQ&DXVDWLRQ
DQG&RQVHTXHQFHV
Any discussion of the etiology of mental health and
mental illness needs to distinguish three key terms:
correlation, causation, and consequences. These
terms are often confused. All too frequently a
biological change in the brain (a lesion) is
purported to be the cause of a mental disorder,
based on finding an association between the lesion
and a mental disorder. The fact is that any simple
associationor correlationcannot and does not,
by itself, mean causation. The lesion could be a
correlate, a cause of, or an effect of the mental
disorder.
When researchers begin to tease apart etiology,
they usually start by noticing correlations. A
correlation is an association or linkage of two (or
more) events. A correlation simply means that the
events are linked in some way. Finding a
correlation between stressful life events and
depression would prompt more research on
causation. Does stress cause depression? Does
depression cause stress? Or are they both caused by
an unidentified factor? These would be the
questions guiding research. But, with correlational
Chapter 4 contains a fuller discussion of the relationship between

stress and depression. In common parlance, stress refers either to the
stressful event or to the individuals response to the event. However,
mental health professionals distinguish the two by referring to the
external events as the stressor (or stressful life event) and to the
individuals response as the stress response.
51
(IOM, 1994b). 6 This means that correlational

findings should fit with biological, chemical, and
physical findings about mechanisms of action
relating to cause and effect.
Biological plausibility is often established in
animal models of disease. That is why researchers
seek animal models in which to study causation. In
mental health research, there are some animal
modelssuch as for anxiety and hyperactivitybut
a major problem is the difficulty of finding animal
models that simulate what is often uniquely human
functioning. The search for animal models,
however, is imperative.
Consequences are defined as the later outcomes
of a disorder. For example, the most serious
consequence of depression in older people is
increased mortality from either suicide or medical
illness (Frasure-Smith et al., 1993, 1995; Conwell,
1996; Penninx et al., 1998). The basis for this
relationship is not fully known. The relationship
between depression and suicide in adolescents is
presented in Chapter 3.
Putting this all together, the biopsychosocial
model holds that biological, psychological, or
social factors may be causes, correlates, and/or
consequences in relation to mental health and
mental illness. A stressful life event, such as
receiving the news of a diagnosis of cancer, offers
a graphic example of a psychological event that
causes immediate biological changes and later has
psychological, biological, and social consequences.
When a patient receives news of the cancer
diagnosis, the brains sensory cortex simultaneously registers the information (a correlate) and
sets in motion biological changes that cause the
heart to pound faster. The patient may experience
an almost immediate fear of death that may later
escalate to anxiety or depression. This certainly has
been established for breast cancer patients
(Farragher, 1998). Anxiety and depression are, in
this case, consequences of the cancer diagnosis, 7

although the exact mechanisms are not understood.
Being anxious or depressed may prompt further
changes in behavior, such as social withdrawal. So
there may be social consequences to the diagnosis
as well. This example is designed to lay out some
of the complexity of the biopsychosocial model
applied to mental health and mental illness.
%LRORJLFDO,QIOXHQFHVRQ0HQWDO+HDOWK
DQG0HQWDO,OOQHVV
There are far-reaching biological and physical
influences on mental health and mental illness. The
major categories are genes, infections, physical
trauma, nutrition, hormones, and toxins (e.g., lead).
Examples have been noted throughout Chapter 1
and earlier in this chapter. This section focuses on
the first two categoriesgenes and infectionsfor
these are among the most exciting and intensive
areas of research relating to biological influences
on mental health and mental illness.
7KH *HQHWLFV RI %HKDYLRU DQG 0HQWDO ,OOQHVV
That genes influence behavior, normal and

abnormal, has long been established (Plomin et al.,
1997). Genes influence behavior across the animal
spectrum, from the lowly fruitfly all the way to
humans. Sorting out which genes are involved and
determining how they influence behavior present
the greatest challenge. Research suggests that many
mental disorders arise in part from defects not in
single genes, but in multiple genes. However, none
of the genes has yet been pinpointed for common
mental disorders (National Institute of Mental
Health [NIMH], 1998).
The human genome contains approximately
80,000 genes that occupy approximately 5 percent
of the DNA sequences of the human genome. By
the spring of 2000, the human genome project will
have provided an initial rough draft version of the
entire sequence of the human genome, and in the
6
Other types of information used to establish cause and effect
relationships are the strength and consistency of the association,
time sequence information, dose-response relationships, and
disappearance of the effect when the cause is removed.
7
Anxiety and depression may in some cases be caused by hormonal
changes related to the tumor itself.
52
this risk is converted into illness by the interaction

of genes with environmental factors. The
implications for science are, first, that no gene is
equivalent to fate for mental illness. This gives us
hope that modifiable environmental risk factors can
eventually be identified and become targets for
prevention efforts. In addition, we recognize that
genes, while significant in their aggregate
contribution to risk, may each contribute only a
small increment, and, therefore, will be difficult to
discover. As a result, however, of the Human
Genome Project, we will know the sequence of
each human gene and the common variants for each
gene throughout the human race. With this
information, combined with modern technologies,
we will in the coming years identify genes that
confer risk of specific mental illnesses.
This information will be of the highest
importance for several reasons. First, genes are the
blueprints of cells. The products of genes, proteins,
work together in pathways or in building cellular
structures, so that finding variants within genes
will suggest pathways that can be targets of
opportunity for the development of new therapeutic
interventions. Genes will also be important clues to
what goes wrong in the brain when a disease
occurs. For example, once we know that a certain
gene is involved in risk of a particular mental
illness such as schizophrenia or autism, we can ask
at what time during the development of the brain
that particular gene is active and in which cells and
circuits the gene is expressed. This will give us
clues to critical times for intervention in a disease
process and information about what it is that goes
wrong. Finally, genes will provide tools for those
scientists who are searching for environmental risk
factors. Information from genetics will tell us at
what age environmental cofactors in risk must be
active, and genes will help us identify
homogeneous populations for studies of treatment
and of prevention.
Heritability refers to how much genetics contributes to the variation of a disease or trait in a
population at a given point in time (Plomin et al.,
ensuing years, gaps in the sequence will be closed,

errors will be corrected, and the precise boundaries
of genes will be identified.
In parallel, clinical medicine is studying the
aggregation of human disease in families. This
effort includes the study of mental illness, most
notably schizophrenia, bipolar disorder (manic
depressive illness), early onset depression, autism,
attention-deficit/hyperactivity disorder, anorexia
nervosa, panic disorder, and a number of other
mental disorders (NIMH, 1998). From studying
how these disorders run in families, and from initial
molecular analyses of the genomes of these
families, we have learned that hereditythat is,
genesplays a role in the transmission of
vulnerability of all the aforementioned disorders
from generation to generation.
But we have also learned that the transmission
of risk is not simple. Certain human diseases such
as Huntingtons disease and cystic fibrosis result
from the transmission of a mutationthat is, a
deleteriously altered gene sequenceat one
location in the human genome. In these diseases, a
single mutation has everything to say about whether
one will get the illness. The transmission of a trait
due to a single gene in the human genome is called
Mendelian transmission, after the Austrian monk,
Gregor Mendel, who was the first to develop
principles of modern genetics and who studied
traits due to single genes. When a single gene
determines the presence or absence of a disease or
other trait, genes are rather easy to discover on the
basis of modern methods. Indeed, for almost all
Mendelian disorders across medicine that affect
more than a few people, the genes already have
been identified.
In contrast to Mendelian disorders, to our
knowledge, all mental illnesses and all normal
variants of behavior are genetically complex. What
this means is that no single gene or even a
combination of genes dictates whether someone
will have an illness or a particular behavioral trait.
Rather, mental illness appears to result from the
interaction of multiple genes that confer risk, and
53
twin does not manifest schizophrenia even though

he or she has the same genes as the affected twin.
This implies that environmental factors exert a
significant role in the onset of schizophrenia.
1997). Once a disorder is established as running in

families, the next step is to determine its
heritability (see below), then its mode of
transmission, and, lastly, its location through
genetic mapping (Lombroso et al., 1994).
One powerful method for estimating heritability
is through twin studies. 8 Twin studies often
compare the frequency with which identical versus
fraternal twins display a disorder. Since identical
twins are from the same fertilized egg, they share
the exact genetic inheritance. Fraternal twins are
from separate eggs and thereby share only 50
percent of their genetic inheritance. If a disorder is
heritable, identical twins should have a higher rate
of concordancethe expression of the trait by both
members of a twin pairthan fraternal twins. Such
studies, however, do not furnish information about
which or how many genes are involved. They just
can be used to estimate heritability. For example,
the heritability of bipolar disorder, according to the
most rigorous twin study, is about 59 percent,
although other estimates vary (NIMH, 1998). The
heritability of schizophrenia is estimated, on the
basis of twin studies, at a somewhat higher level
(NIMH, 1998).
Even with a high level of heritability, however,
it is essential to point out that environmental
factors (e.g., psychosocial environment, nutrition,
health care access) can play a significant role in the
severity and course of a disorder.
Another point is that environmental factors may
even protect against the disorder developing in the
first place. Even with the relatively high heritability of schizophrenia, the median concordance rate
among identical twins is 46 percent 9 (NIMH, 1998),
meaning that in over half of the cases, the second
,QIHFWLRXV ,QIOXHQFHV
It has been known since the early part of the 20th

century that infectious agents can penetrate into the
brain where they can cause mental disorders. A
highly common mental disorder of unknown
etiology at the turn of the century, termed general
paresis, turned out to be a late manifestation of
syphilis. The sexually transmitted infectious
agentTreponema pallidumfirst caused
symptoms in reproductive organs and then,
sometimes years later, migrated to the brain where
it led to neurosyphilis. Neurosyphilis was manifest
by neurological deterioration (including psychosis),
paralysis, and later death. With the wide
availability of penicillin after World War II,
neurosyphilis was virtually eliminated (Barondes,
1993).
Neurosyphilis may be thought of as a disease of
the past (at least in the developed world), but
dementia associated with infection by the human
immunodeficiency virus (HIV) is certainly not.
HIV-associated dementia continues to encumber
HIV-infected individuals worldwide. HIV infection
penetrates into the brain, producing a range of
progressive cognitive and behavioral impairments.
Early symptoms include impaired memory and
concentration, psychomotor slowing, and apathy.
Later symptoms, usually appearing years after
infection, include global impairments marked by
mutism, incontinence, and paraplegia (Navia et al.,
1986). The prevalence of HIV-associated dementia
varies, with estimates ranging from 15 percent to
44 percent of patients with HIV infection (Grant et
al., 1987; McArthur et al., 1993). The high end of
this estimate includes patients with subtle
neuropsychological abnormalities. What is
remarkable about HIV-associated dementia is that
it appears to be caused not by direct infection of
neurons, but by infection of immune cells known as
Establishing that a disorder runs in families could suggest

environmental and/or genetic influences because families share
genes and environment. Comparing identical versus fraternal twins
assumes that their shared environments are about equal, thereby
providing insight about genetic influences. Such comparisons are
further enhanced by studies of twins (identical vs. fraternal)
separated at birth and adopted by different families.
9
The median concordance rate for identical twins is only 14 percent
(NIMH, 1998).
54
may do so indirectly by triggering antibody

formation. How the antibodies are so damaging to
a discrete region of the childs brain and how this
attack ignites OCD-like symptoms are two of the
fundamental questions guiding research.
macrophages that enter the brain from the blood.

The macrophages indirectly cause dysfunction and
death in nearby neurons by releasing soluble toxins
(Epstein & Gendelman, 1993).
Besides HIV-associated dementia and
neurosyphilis, other mental disorders are caused by
infectious agents. They include herpes simplex
encephalitis, measles encephalomyelitis, rabies
encephalitis, chronic meningitis, and subacute
sclerosing panencephalitis (Kaplan & Sadock,
1998). More recently, research has uncovered an
infectious etiology to one form of obsessivecompulsive disorder, as explained below.
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+HDOWKDQG0HQWDO,OOQHVV
This chapter thus far has highlighted some of the
psychosocial influences on mental health and
mental illness. Stressful life events, affect (mood
and level of arousal), personality, and gender are
prominent psychological influences. Social
influences include parents, socioeconomic status,
racial, cultural, and religious background, and
interpersonal relationships. These psychosocial
influences, taken individually or together, are
integrated into many chapters of this report in
discussions of epidemiology, etiology, risk factors,
barriers to treatment, and facilitators to recovery.
Since these psychosocial influences are familiar
to the general reader, detailed description of each
is beyond the scope of this section (with the
exception of cultural influences, which are
discussed in the Overview of Cultural Diversity and
Mental Health Services section). Instead, this
section summarizes the sweeping theories of
individual behavior and personality that inspired a
vast body of psychosocial research: psychodynamic
theories, behaviorism, and social learning theories.
The therapeutic strategies that arose from these
theories, and modifications necessary to make them
relevant to the changing demography of the U.S.
population, are discussed in a later section,
Overview of Treatment.
3$1'$6
In the late 1980s, it was discovered that some
children with obsessive-compulsive disorder (OCD)
experienced a sudden onset of symptoms soon after
a streptococcal pharyngitis (Garvey et al., 1998).
The symptoms were classic for OCDconcerns
about contamination, spitting compulsions, and
extremely excessive hoardingbut the abrupt onset
was unusual. Further study of these children led to
the identification of a new classification of OCD
called PANDAS. This acronym stands for pediatric
autoimmune neuropsychiatric disorders associated
with streptococcal infection. PANDAS are distinct
from classic cases of OCD because of their
episodic clinical course marked by sudden
symptom exacerbation linked to streptococcal
infection, among other unique features. The
exacerbation of symptoms is correlated with a rise
in levels of antibodies that the child produces to
fight the strep infection. Consequently, researchers
proposed that PANDAS are caused by antibodies
against the strep infection that also manage to
attack the basal ganglia region of the childs brain
(Garvey et al., 1998). In other words, the strep
infection triggers the childs immune system to
develop antibodies, which, in turn, may attack the
childs brain, leading to obsessive and compulsive
behaviors. Under this proposal, the strep infection
does not directly induce the condition; rather, it
3V\FKRG\QDPLF 7KHRULHV
Psychodynamic theories of personality assert that

behavior is the product of underlying conflicts over
which people often have scant awareness. Sigmund
Freud (18561939) was the towering proponent of
psychoanalytic theory, the first of the 20th-century
psychodynamic theories. Many of Freuds
55
followers pioneered their own psychodynamic

theories, but this section covers only
psychoanalytic theory. A brief discussion of
Freuds work contributes to an historical
perspective of mental health theory and treatment
approaches.
Freuds theory of psychoanalysis holds two
major assumptions: (1) that much of mental life is
unconscious (i.e., outside awareness), and (2) that
past experiences, especially in early childhood,
shape how a person feels and behaves throughout
life (Brenner, 1978).
Freuds structural model of personality divides
the personality into three partsthe id, the ego,
and the superego. The id is the unconscious part
that is the cauldron of raw drives, such as for sex or
aggression. The ego, which has conscious and
unconscious elements, is the rational and
reasonable part of personality. Its role is to
maintain contact with the outside world in order to
help keep the individual in touch with society. As
such, the ego mediates between the conflicting
tendencies of the id and the superego. The latter is
a persons conscience that develops early in life
and is learned from parents, teachers, and others.
Like the ego, the superego has conscious and
unconscious elements (Brenner, 1978).
When all three parts of the personality are in
dynamic equilibrium, the individual is thought to
be mentally healthy. However, according to
psychoanalytic theory, if the ego is unable to
mediate between the id and the superego, an
imbalance would occur in the form of
psychological distress and symptoms of mental
disorders. Psychoanalytic theory views symptoms
as important only in terms of expression of
underlying conflicts between the parts of
personality. The theory holds that the conflicts
must be understood by the individual with the aid
of the psychoanalyst who would help the person
unearth the secrets of the unconscious. This was the
basis for psychoanalysis as a form of treatment, as
explained later in this chapter.
%HKDYLRULVP DQG 6RFLDO /HDUQLQJ 7KHRU\
Behaviorism (also called learning theory) posits

that personality is the sum of an individuals
observable responses to the outside world
(Feldman, 1997). As charted by J. B. Watson and
B. F. Skinner in the early part of the 20th century,
behaviorism stands at loggerheads with
psychodynamic theories, which strive to understand
underlying conflicts. Behaviorism rejects the
existence of underlying conflicts and an
unconscious. Rather, it focuses on observable,
overt behaviors that are learned from the
environment (Kazdin, 1996, 1997). Its application
to treatment of mental problems, which is discussed
later, is known as behavior modification.
Learning is seen as behavior change molded by
experience. Learning is accomplished largely
through either classical or operant conditioning.
Classical conditioning is grounded in the research
of Ivan Pavlov, a Russian physiologist. It explains
why some people react to formerly neutral stimuli
in their environment, stimuli that previously would
not have elicited a reaction. Pavlovs dogs, for
example, learned to salivate merely at the sound of
the bell, without any food in sight. Originally, the
sound of the bell would not have elicited salvation.
But by repeatedly pairing the sight of the food
(which elicits salvation on its own) with the sound
of the bell, Pavlov taught the dogs to salivate just
to the sound of the bell by itself.
Operant conditioning, a process described and
coined by B. F. Skinner, is a form of learning in
which a voluntary response is strengthened or
attenuated, depending on its association with
positive or negative consequences (Feldman, 1997).
The strengthening of responses occurs by positive
reinforcement, such as food, pleasurable activities,
and attention from others. The attenuation or
discontinuation of responses occurs by negative
reinforcement in the form of removal of a
pleasurable stimulus. Thus, human behavior is
shaped in a trial and error way through positive and
negative reinforcement, without any reference to
inner conflicts or perceptions. What goes on inside
56
to be uncovered about etiology, yet the mental

health field is seen as poised to use the power of
multiple disciplines. The disciplines are urged to
link together the study of the mind and the brain in
the search for understanding mental health and
mental illness (Andreasen, 1997).
This linkage already has been cemented
between cognitive psychology, behavioral
neurology, computer science, and neuroscience.
These disciplines have knit together the field of
cognitive neuroscience (Kosslyn & Shin, 1992).
This new and joint discipline has carved out its
own professional society, journals (Waldrop,
1993), and textbooks (Gazzaniga et al., 1998).
There is movement toward integration of other
disciplines within the field. To promote linkages
between psychiatry and the neurosciences, neuroscientist Eric R. Kandel has furnished a novel
approach. His essay, A New Intellectual Framework for Psychiatry, supplies a set of biological
principles to forge a rapprochementconceptual as
well as practicalbetween the two disciplines
(Kandel, 1998). Integrated approaches are seen as
vital to tackle the monumental complexity of
mental function.
the individual is irrelevant, for humans are equated

with black boxes. Mental disorders represented
maladaptive behaviors that were learned. They
could be unlearned through behavior modification
(behavior therapy) (Kazdin, 1996; 1997).
The movement beyond behaviorism was
spearheaded by Albert Bandura (1969, 1977), the
originator of social learning theory (also known as
social cognitive theory). Social learning theory has
its roots in behaviorism, but it departs in a
significant way. While acknowledging classical and
operant conditioning, social learning theory places
far greater emphasis on a different type of learning,
particularly observational learning. Observational
learning occurs through selectively observing the
behavior of another person, a model. When the
behavior of the model is rewarded, children are
more likely to imitate the behavior. For example, a
child who observes another child receiving candy
for a particular behavior is more likely to carry out
similar behaviors. Social learning theory asserts
that peoples cognitionstheir views, perceptions,
and expectations toward their environmentaffect
what they learn. Rather than being passively
conditioned by the environment, as behaviorism
proposed, humans take a more active role in
deciding what to learn as a result of cognitive
processing. Social learning theory gave rise to
cognitive-behavioral therapy, a mode of treatment
described later in this chapter and throughout this
report.
2YHUYLHZRI'HYHORSPHQW
7HPSHUDPHQWDQG5LVN)DFWRUV
How we come to be the way we are is through the
process of development. Generally defined as the
lifelong process of growth, maturation, and change,
development is the product of the elaborate
interplay of biological, psychological, and social
influences. By studying development, researchers
hope to uncover the origins of both mental health
and mental illness.
This section elaborates and extends concepts
introduced above regarding the fundamental
workings of the brain at different developmental
stages. It then proceeds to explain several seminal
theories of development pioneered by Jean Piaget,
Erik Erikson, and John Bowlby. Their theories
cover cognitive development, personality
development, and social development, respectively,
7KH,QWHJUDWLYH6FLHQFHRI0HQWDO,OOQHVV
DQG+HDOWK
Progress in understanding depression and schizophrenia offers exciting examples of how findings
from different disciplines of the mental health field
have many common threads (Andreasen, 1997).
Despite the differences in terminology and
methodology, the results from different disciplines
have converged to paint a vivid picture of the
nature of the fundamental defects and the regions
of the brain that underlie these defects. Even in the
case of depression and schizophrenia, there is much
57
Physical development of the nervous system

provides the architecture for mental function
(cognition, mood, and intentional behavior). As can
be inferred from the discussion of brain complexity
in the introductory section, nervous system
development is arguably one of the most monumentally complicated developmental achievements.
One hundred billion neurons must form elaborate
and precise arrays of interconnections. Neurons
begin the developmental process as
undifferentiated cells, cells so seemingly
anonymous that they are almost indistinguishable
from other cells in an embryo. On the basis of
genetic and epigenetic 10 influences, the cells must
first specialize, or differentiate, into neurons,
migrate to their final position, and then send their
growing axons (the branch of a neuron that
transmits impulses) to project over long distances
in order to form synapses with distant target cells
(Kandel et al., 1995).
Most neurobiologists are astounded at the level
of precision that neurons achieve in their
interconnections. The process of nervous system
development has been studied at increasingly
complex levelsmolecular, cellular, tissue, and
behavioral levels. Yet, while researchers have
charted many of the behavioral milestones of
development because they are so amenable to
observation and analysis, far less is known about

molecular, cellular, and tissue interactions that
underlie them.
Four overarching findings or organizing
principles have been gleaned from decades of
neuroscience research. The first finding is that the
formation of connections between neurons and their
target cells depends on axons growing along
anatomical pathways that are studded with
signaling molecules, much like landing lights
illuminate the runway for a descending plane. The
second finding is that an axons reaching the
vicinity of, and locating, its correct target cell
depends on diffusable chemical signals being
transmitted from the target cell. The third finding
is that if an axon does not reach its correct target,
it is likely to die. This phenomenon, known as cell
death, or apoptosis, is so common that it affects up
to half of all developing neurons. The brain
overproduces the number of cells it needs, from
which it pares down to only the correct connections
(Kandel et al., 1995). Finally, neuron activity is
essential to strengthening the connections that are
formed. In other words, stimulation from the
environmentwhich is translated into neuron
activityis vital for the forging of normal neural
development (Shatz, 1993; Kandel, 1995). This is
a fundamental principle that is revisited later in this
section. This principle helps to explain why, for
example, babies who are deprived of a stimulating
environment during their first year sometimes
suffer irreparable developmental effects.
Behavior at birth consists of a repertoire of
simple reflexes, that is, inborn neurological
reactions that are involuntary in nature. Two
examples are the sucking reflex and the rooting
reflex, 11 both of which are designed to ensure food
intake. Over time, the infant displays an expanded
repertoire of fine and gross motor skills (e.g.,
crawling, walking) that begin to unfold in the first
few months and year of life. These include the
10
11
although there is some overlap. Their major works,

published in the 1950s and 1960s, were pivotal for
the psychological and social sciences, galvanizing
a huge body of theoretical and empirical research.
However, with the advancements of science and the
diversity of the population, these models may not
apply to all groups without some adaptation for
cultural context. The section concludes with a
reminder that the brain is the great synthesizer of
the many biological, psychological, and sociocultural phenomena that make us who we are.
3K\VLFDO'HYHORSPHQW
Epigenetic influences are those that arise from outside the genes
and lead to emergent, as opposed to predetermined, properties.
Newborns turn their head towards thingstypically the

breastthat touch their cheek.
58
sketches of the developmental theories of Jean

Piaget, Erik Erikson, and John Bowlby; again, these
sketches are provided to afford the reader an
historical perspective of research on psychological
development.
cherished ability to smile, which helps to solidify

a social bond with parents and caregivers. What
begins as a childs biological survival need for
foodevidenced by such behaviors as rooting and
suckingcan turn into a social, interpersonal
experience with the caregiver, as in the smile of an
infant at the sight of a nurturing parent. These
burgeoning motor capabilities are the forerunners
of more complex behavioral and mental functions,
but the actual relationships between early and later
abilities, and their molecular and cellular basis, are
understood only in the most rudimentary terms.
3LDJHW &RJQLWLYH 'HYHORSPHQWDO 7KHRU\
Jean Piaget formulated one of the most influential

theories of cognitive development (Inhelder &
Piaget, 1958). Its focus was on cognitive
(intellectual) development, that is, the processes by
which children come to know and understand the
world. Other aspects of human growth, both
physical and emotional, are beyond the scope of his
theory. Piaget posited that each step of cognitive
development proceeds from the previous step in a
fixed pattern, beginning at birth and ending in the
teen years.
Piaget had a seminal influence on the discipline
of cognitive psychology. Although empirical
research has called into question some of the
specifics of his theories, the broad outlines remain
widely accepted.
7KHRULHVRI3V\FKRORJLFDO'HYHORSPHQW
Theories of human development are grounded in
the developmental perspective. The developmental
perspective takes into account the biological,
social, and psychological environment; their
interaction; and their combined effect upon the
individual throughout the life span.
Developmentalist L. Breger (1974) proposes that
the developmental perspective incorporates three
key precepts:
Behavioral maturation proceeds from the
&
simple to the complex;
Future behaviors, whether temporally near or
&
distant, are a product of their antecedents (prior
responses to the developmental environment);
and
The human response to a particular event or
&
experience often depends on the developmental
stage at which the experience occurs.
Each of these precepts is thought to apply to
neurobiological development, as well as behavioral/psychosocial development. Moreover, each
has implications for whether an individual
experiences either healthful or unhealthful
development that may lead to a mental disorder.
The three precepts are at the heart of each of
the three major mainstream theories of
developmental psychology that have guided
research and increased our understanding of both
normal and abnormal human development across
the life span. The following paragraphs offer brief
(ULN (ULNVRQ 3V\FKRDQDO\WLF 'HYHORSPHQWDO

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The psychoanalytic theory of development is best

exemplified in the work of Erik Erikson, a
psychoanalyst who expanded upon Freuds original
theories of psychosexual development. One of
Eriksons pioneering contributions was that
development unfolded throughout the life span, a
view that has become widely embraced.
Freud postulated that development proceeded
through a series of stages in which children seek
pleasure or gratification from a particular body part
(i.e., the oral, anal, and phallic stage). In contrast,
Eriksons theories of child development focus on
the interrelationship between a developing childs
internal psychosexual development and his or her
more external emotional development, emphasizing
the interpersonal relationships that arise between
the child and parents (Erikson, 1950).
59
attachment of young to their caregivers are seminal

in the drive for survival. Similarly, Bowlby
theorized that for humans, attachment to a
caregiver had a biological basis in the need for
survival (Bowlby, 1951). Moreover, he suggested
that this attachment drive exists alongside the drive
for nutrition and the sex drive, yet distinct and
separate from them. Attachment is seen as the
anchor that enables the developing child to explore
the world.
With the comfort and security of a stable and
routine attachment to the motheror other primary
caregivera child is able to organize other
elements of development in a coherent way. In
contrast, instability in the caregiving relationshipwhether physical distance, erratic patterns of
parental behavior, or even physical or emotional
abusemay interfere with the sense of trust and
security, potentially giving rise to anxiety and
psychological problems later in childhood or even
decades later in life.
Erikson conceived of the life course, from birth

to old age, as a series of eight epigenetic stages
that, as other developmental theories, proceed in a
stepwise fashion, the next dependent upon how
well the previous has been mastered: trust versus
mistrust; autonomy versus shame and doubt;
initiative versus guilt; industry versus inferiority;
identity versus role diffusion; intimacy versus
isolation; generativity versus stagnation; ego
integrity versus despair.
Erikson portrayed each stage as a crisis or
conflict that needed resolution, either at the time or
at a subsequent stage. Each successive stage
presents its own challenges but, at the same time,
offers the opportunity for correction of unresolved
challenges of previous stages. At each stage the
tension was between the psychosocial and
psychosexualthe outward-looking versus inwardlooking perspectives. Psychopathology, in the form
of a mental disorder, would arise if a stage was
ultimately not mastered successfully.
Over the years, Eriksons theory has had great
heuristic value to guide theorists and practitioners
in organizing their approach to mental health and
mental illness. However, his theory does not readily
lend itself to empirical scrutiny. His theory also has
been criticized as reflecting the concerns of male
European culture (where Erikson was born and
trained before moving to the United States) rather
than those of women and other cultures. The need
for cultural sensitivity and competence is discussed
later in this chapter.
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For over a century, an intense debate among
developmentalists and other scientists has pitted
nature (genetic inheritance) against nurture
(environment) as the engine of human development
and behavior. Francis Galton, a 19th-century
geneticist and cousin of Charles Darwin, declared
that there is no escape from the conclusion that
nature prevails enormously over nurture (cited in
Plomin, 1996). As the debate raged, either nature or
nurture gained ascendancy. During the 1940s and
1950s, for example, behaviorism held sway over
American psychology with its argument that
nurture was preeminent.
The pendulum now is coming to rest with the
recognition that behavior is the product of both
nature and nurture (Plomin, 1996). Each
contributes to the development of mental health and
mental illness. Nature and nurture are not
necessarily independent forces but can interact with
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'HYHORSPHQW
Fifty years ago, a new conceptualization of the

psychoanalytic approach to development came into
the lexicon of human development theory. John
Bowlbys reinterpretation of Freudian development
is grounded in both Darwinian evolutionary theory
and animal ethology. The previous work of Konrad
Lorenz and others, who explored the relationship
between other animals and their caregivers,
determined that the bonds of infant care and the
60
connections, while weakened synaptic connections

are eliminated (Shatz, 1993; Kandel et al., 1995).
For example, kittens deprived of visual experience
early in life sustain permanent disruption to
synapses in parts of their visual cortex (Hubel &
Wiesel, 1970).
Later in the course of development, established
patterns of connections still can be altered by the
environmentthrough learning. Studies in a
variety of animal models have found that certain
forms of learning lead to changes in the structure
and function of neurons. With long-term
memorythe long-term storage of learned
informationthese changes take the form of an
enhanced number of synaptic connections and
increased gene expression (Kandel et al., 1995).
Increased gene expression appears to be for
synthesis of new proteins needed for the structural
changes occurring at the synapse (Bailey & Kandel,
1993).
Researchers continue to probe for changes in
the brain associated with mental disorders. They
have found, for instance, that repeated stress from
the environment affects the hippocampus, an area
of the brain located deep within the cerebral
hemispheres. Research in animals has shown that
repeated stress triggers atrophy of dendrites of
certain types of neurons in a segment of the
hippocampus (Sapolsky, 1996; McEwen, 1998).
Similarly, imaging studies in humans suggest that
stress-related disorders (e.g., post-traumatic stress
disorder) induce possibly irreversible atrophy of
the hippocampus (McEwen & Magarinos, 1997).
Anxiety disorders also alter neuroendocrine
systems (Sullivan et al., 1998). These are some of
the tantalizing ways in which nurture influences
nature.
The mental health field is far from a complete
understanding of the biological, psychological, and
sociocultural bases of development, but developpment clearly involves interplay among these
influences. Understanding the process of development requires knowledge, ranging from the most
fundamental levelthat of gene expression and
one another: nature can influence nurture, and

nurture can influence nature (Plomin, 1996).
Studies comparing identical and fraternal twins
have shed light on the contributions of nature and
nurture. These studies show that for many
behavioral traits, as well as mental disorders, there
is a noticeable heritable component (see earlier
discussion of heritability). Yet even with the most
highly heritable traits or conditions, identical twins
who share the same genetic endowment display
marked differences. Identical twins, for example,
are concordant for schizophrenia in 46 percent of
pairs (NIMH, 1998), meaning that more than 50
percent of pairs are not concordant. Something yet
unknown about the environment protects against
the development of schizophrenia in genetically
identical individuals (Plomin, 1996).
How do nature and nurture interact? This
question cannot be directly answered by twin
studies. Animal models have proven to be fertile
ground for study of the mechanismsat the
molecular and cellular levelby which nature and
nurture interact. As reviewed earlier, research in
different animal models has established that the
environment can alter the structure and function of
the central nervous system (Baily & Kandel, 1993).
This holds true not only during early development,
but also into adulthood. Nurture influences nature,
right down to detectable changes in the brain.
During development of the nervous system,
each neuron forms myriad intricate synaptic
connections with other neurons, the outcome of the
interaction of genes and the environment described
above. In this case, the environment is a very
general termit denotes the local extracellular
environment surrounding the growing neuron, as
well as what we traditionally think of as the
environment (sensory environment, psychosocial
environment, diet, etc.). When a neuron forms a
synapse with its target cell, the pattern of activity,
usually furnished by external environmental
stimulation, strengthens or weakens the developing
synapse. Only strengthened synaptic connections
survive early development to form enduring
61
Rigorous scientific trials have documented

successful prevention programs in such areas as
dysthymia and major depressive disorder (Munoz et
al., 1987; Clarke et al., 1995), conduct problems
(Berrento-Clement et al., 1984), and risky
behaviors leading to HIV infection (Kalichman et
al., in press) and low birthweight babies (Olds et
al., 1986). Much progress also has been made to
prevent the occurrence of lead poisoning, which, if
unchecked, can lead to serious and persistent
cognitive deficits in children (Centers for Disease
Control and Prevention, 1991; Pirkle et al., 1994).
Lastly, historical milestones in prevention of
mental illness led to the successful eradication of
neurosyphilis, pellagra, and measles encephalomyelitis (measles invasion of the brain) in the
developed world.
interactions between molecules and cellsall the

way up to the highest levels of cognition, memory,
emotion, and language. The challenge requires
integration of concepts from many different
disciplines. A fuller understanding of development
is not only important in its own right, but it is
expected to pave the way for our ultimate
understanding of mental health and mental illness
and how different factors shape their expression at
different stages of the life span.
2YHUYLHZRI3UHYHQWLRQ
The field of public health has long recognized the
imperative of prevention to contain a major health
problem (IOM, 1988). The principles of prevention were first applied to infectious diseases in
the form of mass vaccination, water safety, and
other forms of public hygiene. As successes
amassed, prevention came to be applied to other
areas of health, including chronic diseases (IOM,
1994a). A landmark report published by the
Institute of Medicine in 1994 extended the concept
of prevention to mental disorders (IOM, 1994a).
Reducing Risks for Mental Disorders evaluated the
body of research on the prevention of mental
disorders, offered new definitions of prevention,
and provided recommendations on Federal policies
and programs, among other goals.
Preventing an illness from occurring is
inherently better than having to treat the illness
after its onset. In many areas of health, increased
understanding of etiology and the role of risk and
protective factors in the onset of health problems
has propelled prevention. In the mental health field,
however, progress has been slow because of two
fundamental and interrelated problems: for most
major mental disorders, there is insufficient
understanding about etiology and/or there is an
inability to alter the known etiology of a particular
disorder. While these have stymied the development of prevention interventions, some successful
strategies have emerged in the absence of a full
understanding of etiology.
'HILQLWLRQVRI3UHYHQWLRQ
The term prevention has different meanings to
different people. It also has different meanings to
different fields of health. The classic definitions
used in public health distinguish between primary
prevention, secondary prevention, and tertiary
prevention (Commission on Chronic Illness, 1957).
Primary prevention is the prevention of a disease
before it occurs; secondary prevention is the
prevention of recurrences or exacerbations of a
disease that already has been diagnosed; and
tertiary prevention is the reduction in the amount of
disability caused by a disease to achieve the highest
level of function.
The Institute of Medicine report on prevention
identified problems in applying these definitions to
the mental health field (IOM, 1994a). The problems
stemmed mostly from the difficulty of diagnosing
mental disorders and from shifts in the definitions
of mental disorders over time (see Diagnosis of
Mental Illness). Consequently, the Institute of
Medicine redefined prevention for the mental
health field in terms of three core activities:
prevention, treatment, and maintenance (IOM,
1994a). Prevention, according to the IOM report, is
similar to the classic concept of primary prevention
62
developmental phase or a new stressor in ones life,

and they can reside within the individual, family,
community, or institutions. Some risks such as
gender and family history are fixed; that is, they are
not malleable to change. Other risk factors such as
lack of social support, inability to read, and
exposure to bullying can be altered by strategic and
potent interventions (Coie & Krehbiel, 1984;
Silverman, 1988; Olweus, 1991; Kellam & Rebok,
1992). Current research is focusing on the interplay
between biological risk factors and psychosocial
risk factors and how they can be modified. As
explained earlier, even with a highly heritable
condition such as schizophrenia, concordance
studies show that in over half of identical twins, the
second twin does not have schizophrenia. This
suggests the possibility of modifying the
environment to eventually prevent the biological
risk factor (i.e., the unidentified genes that
contribute to schizophrenia) from being expressed.
Prevention not only focuses on the risks
associated with a particular illness or problem but
also on protective factors. Protective factors
improve a persons response to some environmental
hazard resulting in an adaptive outcome (Rutter,
1979). Such factors, which can reside with the
individual or within the family or community, do
not necessarily foster normal development in the
absence of risk factors, but they may make an
appreciable difference on the influence exerted by
risk factors (IOM, 1994a). There is much to be
learned in the mental health field about the role of
protective factors across the life span and within
families as well as individuals. The potential for
altering these factors in intervention studies is
enormous. The construct of resilience is related
to the concept of protective factors, but it focuses
more on the ability of a single individual to
withstand chronic stress or recover from traumatic
life events. There are many different perceptions of
what constitutes resilience or competence,
another related term. Despite the increasing
popularity of these ideas, virtually no intervention
from public health; it refers to interventions to

ward off the initial onset of a mental disorder.
Treatment refers to the identification of individuals
with mental disorders and the standard treatment
for those disorders, which includes interventions to
reduce the likelihood of future co-occurring
disorders. And maintenance refers to interventions
that are oriented to reduce relapse and recurrence
and to provide rehabilitation. (Maintenance
incorporates what the public health field
traditionally defines as some forms of secondary
and all forms of tertiary prevention.)
The Institute of Medicines new definitions of
prevention have been very important in
conceptualizing the nature of prevention activities
for mental disorders; however, the terms have not
yet been universally adopted by mental health
researchers. As a result, this report strives to use
the terms employed by the researchers themselves.
To avoid confusion, the report furnishes the
relevant definition along with study descriptions.
When the term prevention is used in this
report without a qualifying term, it refers to the
prevention of the initial onset of a mental disorder
or emotional or behavioral problem, including
prevention of comorbidity. First onset corresponds
to the initial point in time when an individuals
mental health problems meet the full criteria for a
diagnosis of a mental disorder.
5LVN)DFWRUVDQG3URWHFWLYH)DFWRUV
The concepts of risk and protective factors, risk
reduction, and enhancement of protective factors
(also sometimes referred to as fostering resilience)
are central to most empirically based prevention
programs. Risk factors are those characteristics,
variables, or hazards that, if present for a given
individual, make it more likely that this individual,
rather than someone selected at random from the
general population, will develop a disorder
(Garmezy, 1983; Werner & Smith, 1992; IOM,
1994a). To qualify as a risk factor the variable must
antedate the onset of the disorder. Yet risk factors
are not static. They can change in relation to a
63
et al., 1991). The accumulation of risk factors

usually increases the likelihood of onset of
disorder, but the presence of protective factors can
attenuate this to varying degrees.
The concept of accumulation of risks in
pathways that accentuate other risks has led
prevention researchers to the concept of breaking
the chain at its weakest links (Robins, 1970; IOM,
1994a). In other words, some of the risks, even
though they contribute significantly to onset, may
be less malleable than others to intervention. The
preventive strategy is to change the risks that are
most easily and quickly amenable to intervention.
For example, it may be easier to prevent a child
from being disruptive and isolated from peers by
altering his or her classroom environment and
increasing academic achievement than it is to
change the home environment where there is severe
marital discord and substance abuse.
Because mental health is so intrinsically
related to all other aspects of health, it is
imperative when providing preventive interventions
to consider the interactions of risk and protective
factors, etiological links across domains, and
multiple outcomes. For example, chronic illness,
unemployment, substance abuse, and being the
victim of violence can be risk factors or mediating
variables for the onset of mental health problems
(Kaplan et al., 1987). Yet some of the same factors
also can be related to the consequences of mental
health problems (e.g., depression may lead to
substance abuse, which in turn may lead to lung or
liver cancer).
studies have been conducted that test the outcomes

of resilience variables (Grover, 1998).
Preventive researchers use risk status to
identify populations for intervention, and then they
target risk factors that are thought to be causal and
malleable and target protective factors that are to
be enhanced. If the interventions are successful, the
amount of risk decreases, protective factors
increase, and the likelihood of onset of the
potential problem also decreases. The risks for
onset of a disorder are likely to be somewhat
different from the risks involved in relapse of a
previously diagnosed condition. This is an
important distinction because at-risk terminology is
used throughout the mental health intervention
spectrum. The optimal treatment protocol for an
individual with a serious mental condition aims to
reduce the length of time the disorder exists, halt a
progression of severity, and halt the recurrence of
the original disorder, or if not possible, to increase
the length of time between episodes (IOM, 1994a).
To do this requires an assessment of the
individuals specific risks for recurrence.
Many mental health problems, especially in
childhood, share some of the same risk factors for
initial onset, so targeting those factors can result in
positive outcomes in multiple areas. Risk factors
that are common to many disorders include
individual factors such as neurophysiological
deficits, difficult temperament, chronic physical
illness, and below-average intelligence; family
factors such as severe marital discord, social
disadvantage, overcrowding or large family size,
paternal criminality, maternal mental disorder, and
admission into foster care; and community factors
such as living in an area with a high rate of
disorganization and inadequate schools (IOM,
1994a). Also, some individual risk factors can lead
to a state of vulnerability in which other risk
factors may have more effect. For example, low
birthweight is a general risk factor for multiple
physical and mental outcomes; however, when it is
combined with a high-risk social environment, it
more consistently has poorer outcomes (McGauhey
2YHUYLHZRI7UHDWPHQW
,QWURGXFWLRQWR5DQJHRI7UHDWPHQWV
Mental disorders are treatable, contrary to what
many think. 12 An armamentarium of efficacious
treatments is available to ameliorate symptoms. In
12
About 40 percent of those surveyed thought that they didnt think

anyone could help as a reason for not seeking mental health
treatment (Sussman et al., 1987).
64
3V\FKRWKHUDS\
fact, for most mental disorders, there is generally

not just one but a range of treatments of proven
efficacy. Most treatments fall under two general
categories, psychosocial and pharmacological.13
Moreover, the combination of the twoknown as
multimodal therapycan sometimes be even more
effective than each individually (see Chapter 3).
The evidence for treatment being more effective
than placebo is overwhelming, as documented in
the main chapters of this report (Chapters 3 through
5). The degree of effectiveness tends to vary,
depending on the disorder and the target population
(e.g., older adults with depression). What is
optimal for one disorder and/or age group may not
be optimal for another. Further, treatments
generally need to be tailored to the client and to
client preferences.
The inescapable point is that studies
demonstrate conclusively that treatment is more
effective than placebo. Placebo (an inactive form of
treatment) in both pharmacological and psychotherapy studies has a powerful effect in its own
right, as this section later explains. Placebo is more
effective than no treatment. Therefore, to capitalize
on the placebo response, people are encouraged to
seek treatment, even if the treatment is not as
optimal as that described in this report.
If treatment is so effective, then why are so few
people receiving it? Studies reveal that less than
one-third of adults with a diagnosable mental
disorder, and even a smaller proportion of children,
receive any mental health services in a given year.
This section of the chapter strives to explain why
by examining the types of barriers that prevent
people from seeking help. But the chapter first
covers some general points about psychological and
pharmacological therapies. It also discusses why
therapies that work so well in research settings do
not work as well in practice.
Psychotherapy is a learning process in which

mental health professionals seek to help individuals
who have mental disorders and mental health
problems. It is a process that is accomplished
largely by the exchange of verbal communication,
hence it often is referred to as talk therapy.
Many of the theories undergirding each orientation
to psychotherapy were summarized earlier in this
chapter.
Participants in psychotherapy can vary in age
from the very young to the very old, and problems
can vary from mental health problems to disabling
and catastrophic mental disorders. Although people
often are seen individually, psychotherapy also can
be done with couples, families, and groups. In each
case, participants present their problems and then
work with the psychotherapist to develop a more
effective means of understanding and handling
their problems. This report focuses on individual
psychotherapy and also mentions couples therapy
and various forms of family interventions,
particularly psycho-educational approaches.
Although not discussed in the report, group
psychotherapy is effective for selected individuals
with some mood disorders, anxiety disorders,
schizophrenia, personality disorders, and for mental
health problems seen in somatic illness (Yalom,
1995; Kanas, in press).
Estimates of the number of orientations to
psychotherapy vary from a very small number to
well over 400. The larger estimate generally refers
to all the variations of the three major orientations,
that is, psychodynamic, behavioral, and humanistic.
Each orientation falls under the more general
conceptual category of either action or reflection.
Psychodynamic orientations are the oldest.
They place a premium on self-understanding, with
the implicit (or sometimes explicit) assumption that
increased self-understanding will produce salutary
changes in the participant. Behavioral orientations
are geared toward action, with a clear attempt to
mobilize the resources of the patient in the
direction of change, whether or not there is any
13
Other treatments are electroconvulsive therapy (Chapters 4 and 5) and

some types of surgery.
65
understand the origin of actions that are troubling

so that they can be corrected.
For some psychodynamic approaches, such as
the classical Freudian approach, the focus is on the
individual and the experiences the person had in the
early years that give shape to current behavior,
even beyond the awareness of the patient. For
other, more contemporary approaches, such as
interpersonal therapy, the focus is on the
relationship between the person and others. First
developed as a time-limited treatment for midlife
depression, interpersonal therapy focuses on grief,
role disputes, role transitions, and interpersonal
deficits (Klerman et al., 1984). The goal of
interpersonal therapy is to improve current
interpersonal skills. The therapist takes an active
role in teaching patients to evaluate their
interactions with others and to become aware of
self-isolation and interpersonal difficulties. The
therapist also offers advice and helps the patient to
make decisions.
understanding of the etiology of the problem.

Humanistic orientations aim toward increased selfunderstanding, often in the direction of personal
growth, but use treatment techniques that often are
much more active than are likely to be employed by
the psychodynamic clinician.
While the following paragraphs focus on
psychodynamic, behavioral, and humanistic
orientations, they also discuss interpersonal therapy
and cognitive-behavioral therapy as outgrowths of
psychodynamic and behavioral therapy, respectively. Psychodynamic, interpersonal, and cognitivebehavioral therapy are most commonly the focus of
treatment research reported throughout this report.
3V\FKRG\QDPLF 7KHUDS\
The first major approach to psychotherapy was

developed by Sigmund Freud and is called
psychoanalysis (Horowitz, 1988). Since its origin
more than a century ago, psychoanalysis has
undergone many changes. Today, Freudian (or
classical) psychoanalysis is still practiced, but
other variations have been developedego
psychology, object relations theory, interpersonal
psychology, and self-psychology, each of which
can be grouped under the general term
psychodynamic (Horowitz, 1988). The
psychodynamic therapies, even though they differ
somewhat in theory and approach, all have some
concepts in common. With each, the role of the past
in shaping the present is emphasized, so it is
important, in understanding behavior, to understand
its origins and how people come to act and feel as
they do. A second critical concept common to all
psychodynamic approaches is the belief in the
unconscious, so that there is much that influences
our behavior of which we are not aware. This
makes the process of understanding more difficult,
as we often act for reasons that we cannot state, and
these reasons often are linked to previous
experiences. Thus, an important part of
psychodynamic psychotherapy is to make the
unconscious conscious or to help the patient
%HKDYLRU 7KHUDS\
A second major approach to psychotherapy is

known as behavior modification or behavior
therapy (Kazdin, 1996, 1997). It focuses on current
behavior rather than on early patterns of the
patient. In its earlier form, behavior therapy dealt
exclusively with what people did rather than what
they thought or felt. The general principles of
learning were applied to the learning of maladaptive as well as adaptive behaviors. Thus, if a person
could be conditioned to act in a functional way,
there was no reason why the same principles of
conditioning could not be employed to help the
person unlearn dysfunctional behavior and learn to
replace it with more functional behavior. The role
of the environment was very important for behavior
therapists, because it provided the positive and
negative reinforcements that sustained or
eliminated various behaviors. Therefore, ways of
shaping that environment to make it more
responsive to the needs of the individual were
important in behavior therapy.
66
owes its origins as a treatment to the clientcentered therapy that was originated by Carl
Rogers, and the theory can be traced to
philosophical roots beginning with the 19th century
philosopher, Soren Kierkegaard. The central focus
of humanistic therapy is the immediate experience
of the client. The emphasis is on the present and the
potential for future development rather than on the
past, and on immediate feelings rather than on
thoughts or behaviors. It is rooted in the everyday
subjective experience of the person seeking
assistance and is much less concerned with mental
illness than it is with human growth.
One critical aspect of humanistic treatment is
the relationship that is forged between the
therapist, who in some ways serves as a guide in an
exploration of self-discovery, and the client, who is
seeking greater knowledge of the self and an
expansion of inherent human potential. The focus
on the self and the search for self-awareness is akin
to psychodynamic psychotherapy, while the
emphasis on the present is more similar to behavior
therapy.
Although it is possible to describe distinctive
orientations to psychotherapy, as has been done
above, most psychotherapists describe themselves
as eclectic in their practice, rather than as adherents
to any single approach to treatment. As a result,
there is a growing development referred to as
psychotherapy integration (Wolfe & Goldfried,
1988). It strives to capture what is best about each
of the individual approaches. Psychotherapy
integration includes various attempts to look
beyond the confines of any single orientation but
rather to see what can be learned from other
perspectives. It is characterized by an openness to
various ways of integrating diverse theories and
techniques. Psychotherapy also should be modified
to be culturally sensitive to the needs of racial and
ethnic minorities (Acosta et al., 1982; Sue et al.,
1994; Lopez, in press).
The scientific evidence on efficacy presented in
this report, however, is focused primarily on
specific, standardized forms of psychotherapy.
More recently, there has been a significant

addition to the interests and activities of behavior
therapists. Although behavior continued to be
important in relation to reinforcements, cognitionswhat the person thought about, perceived,
or interpreted what was transpiringwere also
seen as important. This combined emphasis led to
a therapeutic variant known as cognitivebehavioral therapy, an approach that incorporates
cognition with behavior in understanding and
altering the problems that patients present (Kazdin,
1996).
Cognitive-behavioral therapy draws on
behaviorism as well as cognitive psychology, a
field devoted to the scientific study of mental
processes, such as perceiving, remembering,
reasoning, decisionmaking, and problem solving.
The use of cognition in cognitive-behavioral
therapy varies from attending to the role of the
environment in providing a model for behavior, to
the close study of irrational beliefs, to the
importance of individual thought processes in
constructing a vision of the surrounding world. In
each case, it is critical to study what the individual
in therapy thinks and does and less important to
understand the past events that led to that pattern of
thinking and doing. Cognitive-behavioral therapy
strives to alter faulty cognitions and replace them
with thoughts and self-statements that promote
adaptive behavior (Beck et al., 1979). For instance,
cognitive-behavioral therapy tries to replace selfdefeatist expectations (I cant do anything right)
with positive expectations (I can do this right).
Cognitive-behavioral therapy has gained such
ascendancy as a means of integrating cognitive and
behavioral views of human functioning that the
field is more frequently referred to as cognitivebehavioral therapy rather than behavior therapy
(Kazdin, 1996).
+XPDQLVWLF 7KHUDS\
The third wave of psychotherapy is referred to

variously as humanistic (Rogers, 1961), existential
(Yalom, 1980), experiential, or Gestalt therapy. It
67
3KDUPDFRORJLFDO7KHUDSLHV
body to produce therapeutic effects. Pharmacotherapies that act in similar ways are grouped
together into broad categories (e.g., stimulants,
antidepressants). Within each category are several
chemical classes. The individual pharmacotherapies
within a chemical class share similar chemical
structures. Table 2-9 presents several common
categories and classes, along with their indication,
that is, their clinical use.
Many pharmacotherapies for mental disorders
have as their initial action the alterationeither
increase or decreasein the amount of a
neurotransmitter. Neurotransmitter levels can be
altered by pharmacotherapies in myriad ways:
pharmacotherapies can mimic the action of the
neurotransmitter in cell-to-cell signaling; they can
block the action of the neurotransmitter; or they
can alter its synthesis, breakdown (degradation),
release, or reuptake, among other possibilities
(Cooper et al., 1996).
Neurotransmitters generally are concentrated in
separate brain regions and circuits. Within the cells
that form a circuit, each neurotransmitter has its
own biochemical pathway for synthesis,
degradation, and reuptake, as well as its own
specialized molecules known as receptors. At the
time of neurotransmission, when a traveling signal
reaches the tip (terminal) of the presynaptic cell,
the neurotransmitter is released from the cell into
the synaptic cleft. It migrates across the synaptic
cleft in less than a millisecond and then binds to
receptors situated on the membrane of the
postsynaptic cell. The neurotransmitters binding to
the receptor alters the shape of the receptor in such
a way that the neurotransmitter can either excite the
postsynaptic cell, and thereby transmit the signal to
this next cell, or inhibit the receptor, and thereby
block signal transmission. The neurotransmitters
action is terminated either by enzymes that degrade
it right there, in the synaptic cleft, or by transporter
proteins that return unused neurotransmitter back to
the presynaptic neuron for reuse, a recycling
process known as reuptake. The widely prescribed
class of antidepressants referred to as the selective
The past decade has seen an outpouring of new

drugs introduced for the treatment of mental
disorders (Nemeroff, 1998). New medications for
the treatment of depression and schizophrenia are
among the achievements stoked by research
advances in both neuroscience and molecular
biology. Through the process known as rational
drug design, researchers have become increasingly
sophisticated at designing drugs by manipulating
their chemical structures. Their goal is to create
more effective therapeutic agents, with fewer side
effects, exquisitely targeted to correct the
biochemical alterations that accompany mental
disorders.
The process was not always so rational. Many
of the older pharmacotherapies (drug treatments)
that had been introduced by 1960 had been
discovered largely by accident. Researchers
studying drugs for completely different purposes
serendipitously found them to be useful for treating
mental disorders (Barondes, 1993). Thanks to their
willingness to follow up on unexpected leads, drugs
such as chlorpromazine (for psychosis), lithium
(for bipolar disorder), and imipramine (for
depression) became available. The advent of
chlorpromazine in 1952 and other neuroleptic drugs
was so revolutionary that it was one of the major
historical forces behind the deinstitutionalization
movement that is discussed later in this chapter.
The past generation of pharmacotherapies, once
shown to be safe and effective, was introduced to
the market generally before their mechanism of
action was understood. Years of research after their
introduction revealed how many of them work
therapeutically. Knowledge about their actions has
had two cardinal consequences: it helped probe the
etiology of mental disorders, and it ushered in the
next generation of pharmacotherapies that are more
selective in their mechanism of action.
0HFKDQLVPV RI $FWLRQ
The mechanism of action refers to how a

pharmacotherapy interacts with its target in the
68

Table 2-9. Selected types of pharmacotherapies
Category and Class
Example(s) of Clinical Use
Antipsychotics (neuroleptics)
Typical antipsychotics*
Atypical antipsychotics**
Schizophrenia, psychosis
Antidepressants
Selective serotonin
reuptake inhibitors
Tricyclic and heterocyclic
antidepressants***
Monoamine oxidase inhibitors
Depression, anxiety
Stimulants
Attention-deficit/hyperactivity disorder
Antimanic
Lithium
Anticonvulsants
Thyroid supplementation
Mania
Antianxiety (anxiolytics)
Benzodiazepines
Antidepressants
-Adrenergic-blocking drugs
Anxiety
Cholinesterase inhibitors
Alzheimers disease
* Also known as first-generation antipsychotics, they include these chemical classes: phenothiazines (e.g., chlorpromazine),
butyrophenones (e.g., haloperidol), and thioxanthenes (Dixon et al., 1995).
** Also known as second-generation antipsychotics, they include these chemical classes: dibenzoxazepine (e.g., clozapine),
thienobenzodiazepine (e.g., olanzapine), and benzisoxazole (e.g., risperidone).
*** Include imipramine and amitriptyline.
Source: Perry et al., 1997
postsynaptic receptors, so-called down-regulation

that parallels the time course of clinical effect in
patients (Schatzberg & Nemeroff, 1998). Some of
the secondary effects of reuptake inhibitors may be
mediated by the activation of intraneuronal second
messenger proteins which result from the
stimulation of postsynaptic receptors (Schatzberg
& Nemeroff, 1998).
Receptors for each transmitter come in
numerous varieties. Not only are there several types
of receptor for each neurotransmitter, but there may
be many subtypes. For serotonin, for example, there
are seven types of receptors, designated 5-HT 15HT 7, and seven receptor subtypes, totaling 14
separate receptors (Schatzberg & Nemeroff, 1998).
The pace at which receptors are identified has
serotonin reuptake inhibitors primarily block the

action of the transporter protein for serotonin, thus
leaving more serotonin to remain at the synapse
(Schloss & Williams, 1998). Depression is thought
to be reflected in decreased serotonin transmission,
so one rationale for this class of antidepressants is
to boost the level of serotonin (see Chapter 4).
Although the effects of reuptake inhibitors on
neurotransmitter concentrations in the synapse
occur with the first dose, therapeutic benefit
typically lags behind by days or weeks. This
observation has spurred considerable recent
research on chronic and downstream actions of
psychotropics, particularly antidepressants. For
example, in animal models the repeated
administration of nearly all antidepressants is
associated with a reduction in the number of
69
maintaining mental health or treating mental

disorders. In many cases, preparations are not
standardized and consist of a variable mixture of
substances, any of which may be the active
ingredient(s). Purity, bioavailability, amount and
timing of doses, and other factors that are
standardized for traditional pharmaceutical agents
prior to testing cannot be taken for granted with
natural products. Current regulations in the United
States classify most complementary and alternative
treatments as food supplements, which are not
subject to premarketing approval of the Food and
Drug Administration.
At present, no conclusions about the role, if
any, of complementary and alternative treatments
in mental health or illness can be accepted with
certainty, as very few claims or studies meet
acceptable scientific standards. With funding from
government and private industry, controlled clinical
trials are under way, including the use of St. Johns
wort (Hypericum perforatum) as a treatment for
depression, and omega-3 fatty acids (fish oils) as a
mood stabilizer in bipolar depression. In addition,
it is important for clinicians and investigators to
account for any herbs or natural products being
taken by their patients or research subjects that
might interact with traditional treatments.
become so dizzying that these figures are likely to

be obsolete by the time this paragraph is read.
A pharmacotherapy typically interacts with a
receptor in either one of two waysas an agonist
or as an antagonist. 14 When a pharmacotherapy acts
as an agonist, it mimics the action of the natural
neurotransmitter. When a pharmacotherapy acts as
an antagonist, it inhibits, or blocks, the neurotransmitters action, often by binding to the
receptor and preventing the natural transmitter from
binding there. An antagonist disrupts the action of
the neurotransmitter.
The diversity of receptors presents vast
opportunities for drug development. Through
rational drug design, pharmacotherapies have
become increasingly selective in their actions.
Generally speaking, the more selective the
pharmacotherapys action, the more targeted it is to
one receptor rather than another, the narrower its
spectrum of action, and the fewer the side effects.
Conversely, the broader the pharmacotherapys
action, the less targeted to a receptor type or
subtype, the broader the effects, and the broader the
side effects (Minneman, 1994). However, the
interaction among neurotransmitter systems in the
brain renders some of the apparent distinctions
among medications more apparent than real. Thus,
despite differential initial actions on neurotransmitters, both serotonin and norepinephrine
reuptake blockers have similar biochemical effects
after chronic dosing (Potter et al., 1985).
,VVXHVLQ7UHDWPHQW
The foregoing section has furnished an overview of
the types and nature of mental health treatment.
The resounding message, which is echoed
throughout this report, is that a range of efficacious
treatments is available. The following material
deals with four issues surrounding treatmentthe
placebo response, benefits and risks, the gap between how well treatments work in clinical trials
versus in the real world, and the constellation of
barriers that hinder people from seeking mental
health treatment.
&RPSOHPHQWDU\ DQG $OWHUQDWLYH 7UHDWPHQW
Recent interest in the health benefits of a plethora

of natural products has engendered claims related
to putative effects on mental health. These have
ranged from reports of enhanced memory in people
taking the herb, ginseng, to the use of the St. Johns
wort flowers as an antidepressant (see Chapter 4).
There are major challenges to evaluating the
role of complementary and alternative treatments in
3ODFHER 5HVSRQVH
Recognized since antiquity, the placebo effect

refers to the powerful role of patients attitudes and
14
There are certainly exceptions to this general rule. Some

pharmacotherapies work as partial agonists and partial antagonists
simultaneously.
70
perceptions that help them improve and recover

from health problems. Hippocrates established the
therapeutic principle of physicians laying their
hands in a reassuring manner to draw on the inner
resources of the patient to fight disease.
Technically speaking, the placebo effect refers to
treatment responses in the placebo group, responses
that cannot be explained on the basis of active
treatment (Friedman et al., 1996a). A placebo is an
inactive treatment, either in the form of an inert pill
for studying a new drug treatment or an inactive
procedure for studying a psychological therapy.
The effects of active treatment are often compared
with a control group that receives a pharmacological or psychological placebo.
It is not unusual for a placebo effect to be found
in up to 50 percent of patients in any study of a
medical treatment (Schatzberg & Nemeroff, 1998).
For example, about 30 percent of patients typically
respond to a placebo in a clinical trial of a new
antidepressant (see Chapter 4). The rate is even
higher for an antianxiety agent (an anxiolytic)
(Schweizer & Rickels, 1997). The placebo effect is
of such import that a placebo group or other control
group 15 is mandated by the Food and Drug
Administration in clinical trials of a new
pharmacotherapy to establish its efficacy prior to
marketing (Friedman et al., 1996a). If the
pharmacotherapy is not statistically superior to the
control, efficacy cannot be established. It is
somewhat more difficult to fashion an analog of an
inert pill in the testing of new and experimental
psychological therapies. Psychological studies can
employ a psychological placebo in the form of a
treatment known to be ineffectual. Or they can
employ a comparison group, which receives an
alternative psychological therapy. Some treatment
studies employ both a psychological placebo, as
well as a comparison group. 16
The basis of the placebo response is not fully

known, but there are thought to be many possible
reasons. These reasons, which relate to attributes of
the disorder or the disease, the patient, and the
treatment setting, include spontaneous remission,
personality variables (e.g., social acquiescence),
patient expectations, attitudes of and compassion
by clinicians, and receiving treatment in a
specialized setting (Schweizer & Rickels, 1997). In
studies of postoperative pain, the placebo response
is mediated by patients production of endogenous
pain-killing substances known as endorphins
(Levine et al., 1978).
%HQHILWV DQG 5LVNV
Throughout this report, currently accepted

treatments for mental disorders will be described.
Except where otherwise indicated, the efficacy of
these interventions has been documented in
multiple controlled, clinical trials published in the
peer-reviewed literature. In some cases, these have
been supplemented by expert consensus reports or
practice guidelines.
Most studies of efficacy of specific treatments
for mental disorders have been highly structured
clinical trials, performed on individuals with a
single disorder, in good physical health. While
necessary and important, these trials do not always
generalize easily to the wider population, which
includes many individuals whose mental disorder is
accompanied by another mental or somatic disorder
and/or alcohol or substance abuse, and who may be
taking other medications. Moreover, children,
adolescents, and the elderly are excluded from
many clinical trials, 17 as are those in certain
settings, such as nursing homes. Newer, more
generalizable studies are being undertaken to
psychological placebo or to another treatment (Chambless et al.,

1998).
15
When it is unethical to deprive patients of treatment, such as the

case with AIDS, conventional treatment is given as the control.
17
In March 1998, the NIH issued a policy guideline stating that

NIH-funded investigators will be expected to include children in
clinical trials, which normally would involve adults only, when
there is sound scientific rationale and in the absence of a strong
justification to the contrary.
16
The criteria developed by a division of the American

Psychological Association for establishing treatment efficacy call
for the experimental treatment to be statistically superior to pill or
71
some degree of gap is widely recognized. The

question is, why?
Efficacy studies test whether treatment works
under ideal circumstances. They typically exclude
patients with other mental or somatic disorders. In
the past, they typically have examined relatively
homogeneous populations, usually white males.
Furthermore, efficacy studies are carried out by
highly trained specialists following strict protocols
that require frequent patient monitoring. Finally,
participation in efficacy studies is often free of
charge to patients.
It is not surprising that the reasons commonly
cited to explain the discrepancy between efficacy
and effectiveness focus on the practicalities and
constraints imposed by the real world. In real-world
settings, patients often are more heterogeneous and
ethnically diverse, are beset by comorbidity (more
than one mental or somatic disorder), 18 are often
less compliant, and are seen more often in general
medical rather than specialty settings; providers are
less inclined to adequately monitor and standardize
treatment; and cost pressures exist on both patients
and providers, depending on the nature of the
financing of care (Dixon et al., 1995; Wells &
Sturm, 1996). This constellation of real-world
constraints appears to explain the gap.
address these shortcomings of the scientific

literature (Lebowitz & Rudorfer, 1998).
Pending the results of these newer studies, it is
important, for clinical decisionmakers to review the
current best evidence for the efficacy of treatments.
People with mental disorders and their health
providers should consider all possible options and
carefully weigh the pros and cons of each, as well
as the possibility of no treatment at all, before
deciding upon a course of action. Such an informed
consent process entails the calculation of a
"benefit-to-risk ratio" for each available treatment
option. Most medications or somatic treatments
have side effects, for example, but a likelihood of
significant clinical benefit often overrides sideeffects in support of a treatment recommendation.
*DS %HWZHHQ (IILFDF\ DQG (IIHFWLYHQHVV
Mental health professionals have long observed

that treatments work better in the clinical research
trial setting as opposed to typical clinical practice
settings. The diminished level of treatment
effectiveness in real-world settings is so
perceptible that it even has a name, the efficacyeffectiveness gap. Efficacy is the term for what
works in the clinical trial setting, and effectiveness
is the term for what works in typical clinical
practice settings. The efficacy-effectiveness gap
applies to both pharmacological therapies and to
psychotherapies (Munoz et al., 1994; Seligman,
1995). The gap is not unique to mental health, for
it is found with somatic disorders too.
The magnitude of the gap can be surprisingly
high. With schizophrenia medications, one review
article found that, in clinical trials, the use of
traditional antipsychotic medications for
schizophrenia was associated with an average
annual relapse rate of about 23 percent, whereas the
same medications used in clinical practice carried
a relapse rate of about 50 percent (Dixon et al.,
1995). The magnitude of the gap found in this study
may not apply to other medications and other
disorders, much less to psychological therapies.
Studies of real-world effectiveness are scarce. Yet
%DUULHUV WR 6HHNLQJ +HOS
Most people with mental disorders do not seek

treatment, according to figures presented in the
next section of this chapter and in Chapter 6. This
general statement applies to adults and older adults
and to parents and guardians who make treatment
decisions for children with mental disorders. There
is a multiplicity of reasons why people fail to seek
treatment for mental disorders but few detailed
studies. The barriers to treatment fall under several
umbrella categories: demographic factors, patient
attitudes toward a service system that often
18
Having a second disorder increases the possibility of drug

interactions, which may translate into reduced dosing. Comorbidity
is discussed throughout this report.
72
2YHUYLHZRI0HQWDO+HDOWK6HUYLFHV
neglects the special needs of racial and ethnic

minorities, financial, and organizational.
Several demographic factors predispose people
against seeking treatment. African Americans,
Hispanics (Sussman et al., 1987; Gallo et al.,
1995), and poor women (Miranda & Green, 1999)
are less inclined than non-Hispanic
whitesparticularly femalesto seek treatment.
Common patient attitudes that deter people from
seeking treatment are not having the time, fear of
being hospitalized, thinking that they could handle
it alone, thinking that no one could help, and
stigma (being too embarrassed to discuss the
problem) (Sussman et al., 1987). Above all, the
cost of treatment is the most prevalent deterrent to
seeking care, according to a large study of
community residents (Sussman et al., 1987). Cost
is a major determinant of seeking treatment even
among people with health insurance because of
inferior coverage of mental health as compared
with health care in general. Finally, the
organizational barriers include fragmentation of
services and lack of availability of services
(Horwitz, 1987). Members of racial and ethnic
minority groups often perceive that services offered
by the existing system do not or will not meet their
needs, for example, by taking into account their
cultural or linguistic practices. These particular
barriers are discussed in greater depth with respect
to minority groups (later in this chapter) and with
respect to different ages (Chapters 3 to 5).
Demographic, attitudinal, financial, and
organizational barriers operate at various points
and to various degrees. Seeking treatment is
conceived of as a complex process that begins with
an individual or parent recognizing that thinking,
mood, or behaviors are unusual and severe enough
to require treatment; interpreting symptoms as a
medical or mental health problem; deciding
whether or not to seek help and from whom;
receiving care; and, lastly, evaluating whether
continuation of treatment is warranted (Sussman et
al., 1987).
Over the past three centuries, the complex

patchwork of mental health services in the United
States has become so fragmented that it is referred
to as the de facto mental health system (Regier et
al., 1993b). Its shape has been determined by many
heterogeneous factors rather than by a single
guiding set of organizing principles. The de facto
system has been characterized as having distinct
sectors, financing, duration of care, and settings
(see Figure 2-4).
The four sectors of the system are the specialty
mental health sector, the general medical/primary
care sector, the human services sector, and the
voluntary support network sector. Specialty mental
health services include services provided by
specialized mental health professionals (e.g.,
psychologists, psychiatric nurses, psychiatrists, and
psychiatric social workers) and the specialized
offices, facilities, and agencies in which they work.
Specialty services were designed expressly for the
provision of mental health services. The general
medical/primary care sector consists of health care
professionals (e.g., family physicians, nurse
practitioners, internists, pediatricians, etc.) and
the settings (i.e., offices, clinics, and hospitals) in
which they work. These settings were designed for
the full range of health care services, including, but
not specialized for, the delivery of mental health
services. The human services sector consists of
social welfare, criminal justice, educational,
religious, and charitable services. The voluntary
support network refers to self-help groups and
organizations. These are groups devoted to
education, communication, and support, all of
which extend beyond formal treatment.
Financing of the de facto system refers to the
payer of services. The system is often described as
being divided into a public (i.e., government) and
a private sector. The term public sector refers
both to services directly operated by government
agencies (e.g., state and county mental hospitals)
and to services financed with government resources
73
includes brief treatment-oriented services. Longterm care includes residential care as well as some
treatment services. Residential care is often
referred to as custodial, when supervised living
predominates over active treatment.
The settings for care and treatment include
institutional, community-based, and home-based.
The former refers to facilities, particularly public
mental hospitals and nursing homes, which usually
are seen by patients and families as large,
regimented, and impersonal. They often are
removed from the community by distance and
frequency of contact with friends and family. In
contrast, community-based services are close to
where patients or clients live. Services are typically
provided by community agencies and organizations.
Home-based services include informal supports
provided in an individuals residence.
(e.g., Medicaid, a Federal-State program for

financing health care services for people who are
poor and disabled, and Medicare, a Federal health
insurance program primarily for older Americans
and people who retired early due to disability).
Publicly financed services may be provided by
private organizations. The term private sector
refers both to services directly operated by private
agencies and to services financed with private
resources (e.g., employer-provided insurance).
The duration of care is divided between
services for the treatment of acute conditions and
those devoted to the long-term care of chronic (i.e.,
severe and persistent) conditions, such as
schizophrenia, bipolar disorder, and Alzheimers
disease. The former, provided in psychiatric
hospitals, psychiatric units in general hospitals, and
in beds scattered in general hospital wards,
74
percent). The distribution of those who do and do

not currently meet diagnostic criteria for a mental
disorder is similar to that for adults (Figure 2-6).
Chapter 6 examines the impact of recent

changes in financing and organizing services on
access and quality of care. Many of these issues
also are addressed in Chapters 3 to 5, where they
are discussed in the context of care and treatment at
each stage of the life cycle. The following material
provides general information on current patterns of
use and focuses on the historical origins of mental
health services.
+LVWRU\RI0HQWDO+HDOWK6HUYLFHV
The history of mental health services in the United
States has been chronicled by historian Gerald N.
Grob in a series of landmark books from which this
account is drawn (Grob, 1983, 1991, 1994). The
origins of the mental health services system
coincide with the colonial settlement of the United
States. Individuals with mental illness were cared
for at home until urbanization induced state
governments to confront a problem that had been
relegated largely to families. The states response
was to build institutions, known first as asylums
and later as mental hospitals. When the
Pennsylvania Hospital opened in Philadelphia in
the mid-18th century, it had provisions for
individuals with mental illness housed in its
basement. Also in the mid-18th century, colonial
Virginia was the first state to build an asylum for
mentally ill citizens, which it constructed in its
capital at Williamsburg. If not cared for at home or
in asylums, those with mental illness were likely to
be found in jails, almshouses, work houses, and
other institutions. By the time of the Revolutionary
War, the beginnings were in place for each of the
four sectors of the de facto mental health system.
The origins of treatment for mental illness in
the general medical/primary care sector can be
traced to the Pennsylvania Hospital. The origins of
specialty mental health care can be traced to the
Williamsburg asylum. Home care, the most
common response to mental illness, probably
became a part of the voluntary support network,
whereas the human services sector was by far the
most common organized or institutional response,
by placing individuals in almshouses (homes for
the poor) and work houses. The first form of treatmentknown as moral treatmentwas not given
until the very end of the 18th century, after the
Revolutionary War.
2YHUDOO3DWWHUQVRI8VH
According to recent national surveys (Regier et al,
1993b; Kessler et al., 1996), a total of about 15
percent of the U.S. adult population use mental
health services in any given year. Eleven percent
receive their services from either the general
medical care sector or the specialty mental health
sector, in roughly equal proportions. In addition,
about 5 percent receive care from the human
services sector, and about 3 percent receive care
from the voluntary support network. (The overlap
across these latter two sectors accounts for these
figures totaling more than 15 percent.)
Slightly more than half of the 15 percent of the
adult population that use mental health services
have a diagnosable mental or addictive disorder (8
percent), while the remaining portion has a mental
health problem (7 percent). Bearing in mind that 28
percent of the population have a diagnosable
mental or substance abuse disorder, only about
one-third with a diagnosable mental disorder
receives treatment in 1 year (Figure 2-5). In short,
this translates to the majority of those with
a diagnosable mental disorder not receiving
treatment.
Similarly, about 21 percent of the child and
adolescent population use mental health services
annually. Nine percent receive care from the health
care sector, almost exclusively from the specialty
mental health sector. Seventeen percent of the child
and adolescent population receive care from the
human services sector, mostly in the school system,
yet there is much overlap with the health sector
(again accounting for the sum being more than 21
75
76
77
welfare institutions. State Care Acts were passed

between 1894 and World War I. These acts
centralized financial responsibility for the care of
individuals with mental illness in every state
government. Local government took the
opportunity to send everyone with a mental illness,
including dependent older citizens, to the state
asylums. Dementia was redefined as a mental
illness, although only some of the older residents
were demented. For the past century the states have
carried this responsibility at very low cost, in spite
of the magnitude of the task.
The reformers of the mental hygiene period,
who formed the National Committee on Mental
Hygiene (now the National Mental Health
Association [NMHA]), called for an expansion of
the new science, particularly of neuropathology, in
asylums, which were renamed mental hospitals.
They also called for psychopathic hospitals and
clinics to bring the new science to patients in
smaller institutions associated with medical
schools. They opened several psychiatric units in
general hospitals to move mental health care into
the mainstream of health care. The mental
hygienists believed in the principles of early
treatment and expected to prevent chronic mental
illness. To support this effort, they advocated for
outpatient treatment to identify early cases of
mental disorder and to follow discharged
inpatients.
Treatments were not effective. Early treatment
was no more successful in preventing patients from
becoming chronically ill in the early 20th century
than it was in the early years of the previous
century. At best, the hospitals provided humane
custodial care; at worst, they neglected or abused
the patients. Length of stay did begin to decline for
newly admitted inpatients, but older, long-stay
patients filled public asylums. The financial
problems and overcrowding deepened during the
Depression and during World War II.
Enthusiasm for early interventions, developed
by military mental health services during World
War II, brought a new sense of optimism about
An era of moral treatment was introduced

from Europe at the turn of the 19th century,
representing the first of four reform movements in
mental health services in the United States
(Morrissey & Goldman, 1984; Goldman &
Morrissey, 1985) (Table 2-10).
The first reformers, including Dorothea Dix and
Horace Mann, imported the idea that mental illness
could be treated by removing the individual to an
asylum to receive a mix of somatic and psychosocial treatments in a controlled environment
characterized by moral sensibilities. The term
moral had a connotation different from that of
today. It meant the return of the individual to
reason by the application of psychologically
oriented therapy19 (Grob, 1994). The moral treatment period was characterized by the building of
private and public asylums. Almost every state had
an asylum dedicated to the early treatment of
mental illness to restore mental health and to keep
patients from becoming chronically ill. Moral
treatment accomplished the former objective, but it
could not prevent chronicity.
Shortly after the Civil War, the failures of the
promise of early treatment were recognized and
asylums were built for untreatable, chronic
patients. The quality of care deteriorated in public
institutions, where overcrowding and underfunding
ran rampant. A new reform movement, devoted to
mental hygiene, began late in the 19th century. It
combined the newly emerging concepts of public
health (which at the time was referred to as
hygiene), scientific medicine, and social
progressivism. Although the states built the public
asylums, local government was expected to pay for
each episode of care. To avoid the expense, many
communities continued to use local almshouses and
jails. Asylums could not maintain their budgets,
care deteriorated, and newspaper exposs revealed
inhuman conditions both in asylums and local
19
According to a student of the originator of moral treatment,

Philippe Pinel, moral treatment is the application of the faculty of
intelligence and of the emotions in the treatment of mental
alienation (Grob, 1994).
78
Table 2-10. Historical reform movements in mental health treatment in the United States
Reform Movement
Era
Setting
Focus of Reform
Moral Treatment
1800%1850
Asylum
Humane, restorative treatment
Mental Hygiene
1890%1920
Mental hospital and clinic
Prevention, scientific
orientation
Community Mental Health
1955%1970
Community mental health center
Deinstitutionalization,
social integration
Community support
Mental illness as a social welfare

problem (e.g., housing, employment)
Community Support
1975%present
Sources: Morrissey & Goldman, 1984; Goldman & Morrissey, 1985
of psychiatric units in general hospitals, and

ultimately paid for many rehabilitation services for
individuals with severe and persistent mental
disorders.
The dual policies of community care and
deinstitutionalization, however, were implemented
without evidence of effectiveness of treatments and
without a social welfare system attuned to the
needs of hundreds of thousands of individuals with
disabling mental illness. Housing, support services,
community treatment approaches, vocational
opportunities, and income supports for those unable
to work were not universally available in the
community. Neither was there a truly welcoming
spirit of community support for returning mental
patients. Many discharged mental patients found
themselves in welfare and criminal justice
institutions, as had their predecessors in earlier
eras; some became homeless or lived in regimented
residential (e.g., board and care) settings in the
community.
The special needs of individuals with severe
and persistent mental illness were not being met
(General Accounting Office, 1977; Turner &
TenHoor, 1978). Early treatment did not prevent
disability, although new approaches to treatment
would eventually reduce morbidity and improve
quality of life. A fourth reform era (1975present),
called the community support movement, grew
treatment by the middle of the 20th century. Again,

early treatment of mental disorders was
championed and a new concept was born,
community mental health. The NMHA figured
prominently in this reform, along with the Group
for the Advancement of Psychiatry. Borrowing
some ideas from the mental hygienists and
capitalizing on the advent of new drugs for treating
psychosis and depression, community mental health
reformers argued that they could bring mental
health services to the public in their communities.
They suggested that long-term institutional care in
mental hospitals had been neglectful, ineffective,
even harmful. The joint policies of community
care and deinstitutionalization led to dramatic
declines in the length of hospital stay and the
discharge of many patients from custodial care in
hospitals.
Concomitantly, these policies led to the
expansion of outpatient services in the community,
particularly in federally funded community mental
health centers. Federal legislation beginning in the
mid-1960s fueled this expansion through grants to
centers and then through the inclusion of some
(albeit limited) mental health benefits in Medicare
and Medicaid. The latter was particularly
important, because it stimulated the transfer of
many long-term inpatients from public mental
hospitals to nursing homes, encouraged the opening
79
many diverse functions. Unfortunately for those

individuals with the most complex needs, and who
often have the fewest financial resources, the
system is fragmented and difficult to use to meet
those needs effectively. Efforts at integrating the
service system and tailoring it to those with the
greatest needs are discussed, by age group, in
subsequent chapters of the report. Many problems
remain, including the lack of health insurance by 16
percent of the U.S. population, underinsurance for
mental disorders even among those who have health
insurance, access barriers to members of many
racial and ethnic groups, discrimination, and the
stigma about mental illness, which is one of the
factors that impedes help-seeking behavior.
directly out of the community mental health

movement. This new reform movement called for
an end to viewing and responding to chronic mental
disorder only as the object of neglect, by favoring
acute treatment and prevention. Reformers
advocated for developing community support
systems, with an expanded vision of care and
treatment as encompassing the social welfare needs
of individuals with disabling mental illness. The
emphasis favored the view that individuals could
once again become citizens of their community, if
given support and access to mainstream resources
such as housing and vocational opportunities
(Goldman, 1998). At first, mental health treatments
were deemphasized in favor of social supports, but
newer medications, such as SSRIs and novel antipsychotic drugs, and more effective psychosocial
interventions, such as assertive community
treatment for schizophrenia (Chapter 4), facilitated
the objectives of community support and recovery
in the community.
The voluntary support network expanded with
an emphasis on recovery, a concept introduced
by service users, or consumers, who began to take
an active role in their own care and support and in
making policy. From their inception in the late
1970s, family organizations, such as the National
Alliance for the Mentally Ill and the Federation of
Families, advocated for services for individuals
who are most impaired. As discussed later in this
chapter, consumers, who also call themselves
survivors, have formed their own networks for
support and advocacy and work with other
advocacy groups such as the National Mental
Health Association and the Bazelon Center for
Mental Health Law.
The de facto mental health system is complex
because it has metamorphosed over time under the
influence of a wide array of factors, including
reform movements and their ideologies, financial
incentives based on who would pay for what kind
of services, and advances in care and treatment
technology. Each factor has been important in its
own way. The hybrid system that emerged serves
2YHUYLHZRI&XOWXUDO'LYHUVLW\DQG
0HQWDO+HDOWK6HUYLFHV
The U.S. mental health system is not well equipped
to meet the needs of racial and ethnic minority
populations. Racial and ethnic minority groups are
generally considered to be underserved by the
mental health services system (Neighbors et al.,
1992; Takeuchi & Uehara, 1996; Center for Mental
Health Services [CMHS], 1998). A constellation of
barriers deters ethnic and racial minority group
members from seeking treatment, and if individual
members of groups succeed in accessing services,
their treatment may be inappropriate to meet their
needs.
Awareness of the problem dates back to the
1960s and 1970s, with the rise of the civil rights
and community mental health movements (Rogler
et al., 1987) and with successive waves of
immigration from Central America, the Caribbean,
and Asia (Takeuchi & Uehara, 1996). These
historical forces spurred greater recognition of the
problems that minority groups confront in relation
to mental health services.
Research documents that many members of
minority groups fear, or feel ill at ease with, the
mental health system (Lin et al., 1982; Sussman et
al., 1987; Scheffler & Miller, 1991). These groups
experience it as the product of white, European
80
racial or ethnic minorities and considerable

diversity within each of the four groupings listed
above. The representation of the four officially
designated groups in the U.S. population in 1999 is
as follows: African Americans constitute the
largest group, at 12.8 percent of the U.S.
population; followed by Hispanics (11.4 percent),
Asian/Pacific Islanders (4.0 percent), and American
Indians (0.9 percent) (U.S. Census Bureau, 1999).
Hispanic Americans are among the fastest-growing
groups. Because their population growth outpaces
that of African Americans, they are projected to be
the predominant minority group (24.5 percent of
the U.S. population) by the year 2050 (CMHS,
1998).
Racial and ethnic populations differ from one
another and from the larger society with respect to
culture. The term culture is used loosely to
denote a common heritage and set of beliefs,
norms, and values. The cultures with which
members of minority racial and ethnic groups
identify often are markedly different from
industrial societies of the West. The phrase
cultural identity specifies a reference groupan
identifiable social entity with whom a person
identifies and to whom he or she looks for
standards of behavior (Cooper & Denner, 1998). Of
course, within any given group, an individuals
cultural identity may also involve language,
country of origin, acculturation, 21 gender, age,
cl ass, religious/spiritual beliefs, sexual
orientation 22, and physical disabilities (Lu et al.,
1995). Many people have multiple ethnic or
cultural identities.
The historical experiences of ethnic and
minority groups in the United States are reflected
culture, shaped by research primarily on white,

European populations. They may find only
clinicians who represent a white middle-class
orientation, with its cultural values and beliefs, as
well as its biases, misconceptions, and stereotypes
of other cultures.
Research and clinical practice have propelled
advocates and mental health professionals to press
for linguistically and culturally competent
services to improve utilization and effectiveness
of treatment for different cultures. Culturally
competent services incorporate respect for and
understanding of, ethnic and racial groups, as well
as their histories, traditions, beliefs, and value
systems (CMHS, 1998). Without culturally
competent services, the failure to serve racial and
ethnic minority groups adequately is expected to
worsen, given the huge demographic growth in
these populations predicted over the next decades
(Takeuchi & Uehara, 1996; CMHS, 1998;
Snowden, 1999).
This section of the chapter amplifies these
major conclusions. It explains the confluence of
clinical, cultural, organizational, and financial
reasons for minority groups being underserved by
the mental health system. The first task, however,
is to explain which ethnic and racial groups
constitute underserved populations, to describe
their changing demographics, and to define the
term culture and its consequences for the mental
health system.
,QWURGXFWLRQWR&XOWXUDO'LYHUVLW\DQG
'HPRJUDSKLFV
The Federal government officially designates four
major racial or ethnic minority groups in the United
States: African American (black), Asian/Pacific
Islander, Hispanic American (Latino), 20 and Native
American/American Indian/Alaska Native/Native
Hawaiian (referred to subsequently as American
Indians) (CMHS, 1998). There are many other
21
Acculturation refers to the social distance separating members

of an ethnic or racial group from the wider society in areas of beliefs
and values and primary group relations (work, social clubs, family,
friends) (Gordon, 1964). Greater acculturation thus reflects greater
adoption of mainstream beliefs and practices and entry into primary
group relations.
20
22
The term Latino(a) refers to all persons of Mexican, Puerto

Rican, Cuban, or other Central and South American or Spanish
origin (CMHS, 1998).
Research is emerging on the importance of tailoring services to

the special needs of gay, lesbian, and bisexual mental health service
users (Cabaj & Stein, 1996).
81
mental health services. These include coping styles

and ties to family and community, discussed below.
in differences in economic, social, and political

status. The most measurable difference relates to
income. Many racial and ethnic minority groups
have limited financial resources. In 1994, families
from these groups were at least three times as likely
as white families to have incomes placing them
below the Federally established poverty line. The
disparity is even greater when considering extreme
povertyfamily incomes at a level less than half of
the poverty thresholdand is also large when
considering children and older persons (OHare,
1996). Although some Asian Americans are
somewhat better off financially than other minority
groups, they still are more than one and a half times
more likely than whites to live in poverty. Poverty
disproportionately affects minority women and
their children (Miranda & Green, 1999). The
effects of poverty are compounded by differences
in total value of accumulated assets, or total wealth
(OHare et al., 1991).
Lower socioeconomic statusin terms of
income, education, and occupationhas been
strongly linked to mental illness. It has been known
for decades that people in the lowest
socioeconomic strata are about two and a half times
more likely than those in the highest strata to have
a mental disorder (Holzer et al., 1986; Regier et al.,
1993b). The reasons for the association between
lower socioeconomic status and mental illness are
not well understood. It may be that a combination
of greater stress in the lives of the poor and greater
vulnerability to a variety of stressors leads to some
mental disorders, such as depression. Poor women,
for example, experience more frequent, threatening,
and uncontrollable life events than do members of
the population at large (Belle, 1990). It also may be
that the impairments associated with mental
disorders lead to lower socioeconomic status
(McLeod & Kessler, 1990; Dohrenwend, 1992;
Regier et al., 1993b).
Cultural identity imparts distinct patterns of
beliefs and practices that have implications for the
willingness to seek, and the ability to respond to,
&RSLQJ 6W\OHV
Cultural differences can be reflected in differences

in preferred styles of coping with day-to-day
problems. Consistent with a cultural emphasis on
restraint, certain Asian American groups, for
example, encourage a tendency not to dwell on
morbid or upsetting thoughts, believing that
avoidance of troubling internal events is warranted
more than recognition and outward expression
(Leong & Lau, 1998). They have little willingness
to behave in a fashion that might disrupt social
harmony (Uba, 1994). Their emphasis on willpower
is similar to the tendency documented among
African Americans to minimize the significance of
stress and, relatedly, to try to prevail in the face of
adversity through increased striving (Broman,
1996).
Culturally rooted traditions of religious beliefs
and practices carry important consequences for
willingness to seek mental health services. In many
traditional societies, mental health problems can be
viewed as spiritual concerns and as occasions to
renew ones commitment to a religious or spiritual
system of belief and to engage in prescribed
religious or spiritual forms of practice. African
Americans (Broman, 1996) and a number of ethnic
groups (Lu et al., 1995), when faced with personal
difficulties, have been shown to seek guidance from
religious figures. 23
Many people of all racial and ethnic
backgrounds believe that religion and spirituality
favorably impact upon their lives and that wellbeing, good health, and religious commitment or
faith are integrally intertwined (Taylor, 1986;
Priest, 1991; Bacote, 1994; Pargament, 1997).
Religion and spirituality are deemed important
because they can provide comfort, joy, pleasure,
and meaning to life as well as be means to deal
23
Of the 15 percent of the U.S. population that use mental health

services in a given year, about 2.8 percent receive care only from
members of the clergy (Larson et al., 1988).
82
sometimes reflect comprehensive systems of belief,

typically emphasizing a need for a balance between
opposing forces (e.g., yin/yang, hot-cold theory)
or the power of supernatural forces (Cheung &
Snowden, 1990). Belief in indigenous disorders and
adherence to culturally rooted coping practices are
more common among older adults and among
persons who are less acculturated. It is not well
known how applicable DSM-IV diagnostic criteria
are to culturally specific symptom expression and
culture-bound syndromes.
with death, suffering, pain, injustice, tragedy, and

stressful experiences in the life of an individual or
family (Pargament, 1997). In the family/community-centered perception of mental illness held
by Asians and Hispanics, religious organizations
are viewed as an enhancement or substitute when
the family is unable to cope or assist with the
problem (Acosta et al., 1982; Comas-Diaz, 1989;
Cook & Timberlake, 1989; Meadows, 1997).
Culture also imprints mental health by
influencing whether and how individuals
experience the discomfort associated with mental
illness. When conveyed by tradition and sanctioned
by cultural norms, characteristic modes of
expressing suffering are sometimes called idioms
of distress (Lu et al., 1995). Idioms of distress
often reflect values and themes found in the
societies in which they originate.
One of the most common idioms of distress is
somatization, the expression of mental distress in
terms of physical suffering. Somatization occurs
widely and is believed to be especially prevalent
among persons from a number of ethnic minority
backgrounds (Lu et al., 1995). Epidemiological
studies have confirmed that there are relatively
high rates of somatization among African
Americans (Zhang & Snowden, in press). Indeed,
somatization resembles an African American folk
disorder identified in ethnographic research and is
linked to seeking treatment (Snowden, 1998).
A number of idioms of distress are well
recognized as culture-bound syndromes and have
been included in an appendix to DSM-IV. Among
culture-bound syndromes found among some Latino
psychiatric patients is ataque de nervios, a
syndrome of uncontrollable shouting, crying,
trembling, and aggression typically triggered by a
stressful event involving family. . . (Lu et al.,
1995, p. 489). A Japanese culture-bound syndrome
has appeared in that countrys clinical modification
of ICD-10 (WHO International Classification of
Diseases, 10th edition, 1993). Taijin kyofusho is an
intense fear that ones body or bodily functions
give offense to others. Culture-bound syndromes
)DPLO\DQG&RPPXQLW\DV5HVRXUFHV
Ties to family and community, especially strong in
African, Latino, Asian, and Native American
communities, are forged by cultural tradition and
by the current and historical need to assist arriving
immigrants, to provide a sanctuary against
discrimination practiced by the larger society, and
to provide a sense of belonging and affirming a
centrally held cultural or ethnic identity.
Among Mexican-Americans (del Pinal &
Singer, 1997) and Asian Americans (Lee, 1998)
relatively high rates of marriage and low rates of
divorce, along with a greater tendency to live in
extended family households, indicate an orientation
toward family. Family solidarity has been invoked
to explain relatively low rates among minority
groups of placing older people in nursing homes
(Short et al., 1994).
The relative economic success of Chinese,
Japanese, and Korean Americans has been
attributed to family and communal bonds of
association (Fukuyama, 1995). Community
organizations and networks established in the
United States include rotating credit associations
based on lineage, surname, or region of origin.
These organizations and networks facilitate the
startup of small businesses.
There is evidence of an African American
tradition of voluntary organizations and clubs often
having political, economic, and social functions
and affiliation with religious organizations
(Milburn & Bowman, 1991). African Americans
83
standing of the prevalence of mental disorders

among minority groups in the United States. 24
Nationwide studies conducted many years ago
overlooked institutional populations, which are
disproportionately represented by minority groups.
Treatment utilization information on minority
groups in relation to whites is more plentiful, yet,
a clear understanding of health seeking behavior in
various cultures is lacking.
The following paragraphs reveal that disparities
abound in treatment utilization: some minority
groups are underrepresented in the outpatient
treatment population while, at the same time,
overrepresented in the inpatient population.
Possible explanations for the differences in utilization are discussed in a later section.
and other racial and ethnic minority groups have

drawn upon an extended family tradition in which
material and emotional resources are brought to
bear from a number of linked households.
According to this literature, there is (a) a high
degree of geographical propinquity; (b) a strong
sense of family and familial obligation; (c) fluidity
of household boundaries, with greater willingness
to absorb relatives, both real and fictive, adult and
minor, if need arises; (d) frequent interaction with
relatives; (e) frequent extended family gettogethers for special occasions and holidays; and
(f) a system of mutual aid (Hatchett & Jackson,
1993, p. 92).
Families play an important role in providing
support to individuals with mental health problems.
A strong sense of family loyalty means that, despite
feelings of stigma and shame, families are an early
and important source of assistance in efforts to
cope, and that minority families may expect to
continue to be involved in the treatment of a
mentally ill member (Uba, 1994). Among Mexican
American families, researchers have found lower
levels of expressed emotion and lower levels of
relapse (Karno et al., 1987). Other investigators
have demonstrated an association between family
warmth and a reduced likelihood of relapse (Lopez
et al., in press).
$IULFDQ $PHULFDQV
The prevalence of mental disorders is estimated to
be higher among African Americans than among
whites (Regier et al., 1993a). This difference does
not appear to be due to intrinsic differences
between the races; rather, it appears to be due to
socioeconomic differences. When socioeconomic
factors are taken into account, the prevalence
difference disappears. That is, the socioeconomic
status-adjusted rates of mental disorder among
African Americans turn out to be the same as those
of whites. In other words, it is the lower
socioeconomic status of African Americans that
places them at higher risk for mental disorders
(Regier et al., 1993a).
African Americans are underrepresented in
some outpatient treatment populations, but overrepresented in public inpatient psychiatric care in
relation to whites (Snowden & Cheung, 1990;
(SLGHPLRORJ\ DQG 8WLOL]DWLRQ RI 6HUYLFHV

One of the best ways to identify whether a minority
group has problems accessing mental health
services is to examine their utilization of services
in relation to their need for services. As noted
previously, a limitation of contemporary mental
health knowledge is the lack of standard measures
of need for treatment and culturally appropriate
assessment tools. Minority group members needs,
as measured indirectly by their prevalence of
mental illness in relation to the U.S. population,
should be proportional to their utilization, as
measured by their representation in the treatment
population. These comparisons turn out to be
exceedingly complicated by inadequate under-
24
In spring 2000, survey field work begins on an NIMH-funded

study of the prevalence of mental disorders, mental health
symptoms, and related functional impairments in African
Americans, Caribbean blacks, and non-Hispanic whites. The study
will examine the effects of psychosocial factors and race-associated
stress on mental health, and how coping resources and strategies
influence that impact. The study will provide a database on mental
health, mental disorders, and ethnicity and race. James Jackson,
Ph.D., University of Michigan, is principal investigator.
84
Finally, African Americans are more likely than

whites to use the emergency room for mental health
problems (Snowden, in press-a). Their overreliance
on emergency care for mental health problems is an
extension of their overreliance on emergency care
for other health problems. The practice of using the
emergency room for routine care is generally
attributed to a lack of health care providers in the
community willing to offer routine treatment to
people without insurance (Snowden, in press-a).
Snowden, in press-b). Their underrepresentation in

outpatient treatment varies according to setting,
type of provider, and source of payment. The racial
gap between African Americans and whites in
utilization is smallest, if not nonexistent, in community-based programs and in treatment financed
by public sources, especially Medicaid (Snowden,
1998) and among older people (Padgett et al.,
1995). The underrepresentation is largest in
privately financed care, especially individual
outpatient practice, paid for either by fee-forservice arrangements or managed care. As a result,
underrepresentation in the outpatient setting occurs
more among working and middle-class African
Americans, who are privately insured, than among
the poor. This suggests that socioeconomic
standing alone cannot explain the problem of
underutilization (Snowden, 1998).
African Americans are, as noted above,
overrepresented in inpatient psychiatric care
(Snowden, in press-b). Their rate of utilization of
psychiatric inpatient care is about double that of
whites (Snowden & Cheung, 1990). This difference
is even higher than would be expected on the basis
of prevalence estimates. Overrepresentation is
found in hospitals of all types except private
psychiatric hospitals. 25 While difficult to explain
definitively, the problem of overrepresentation in
psychiatric hospitals appears more rooted in
poverty, attitudes about seeking help, and a lack of
community support than in clinician bias in
diagnosis and overt racism, which also have been
implicated (Snowden, in press-b). This line of
reasoning posits that poverty, disinclination to seek
help, and lack of health and mental health services
deemed appropriate, and responsive, as well as
community support, are major contributors to
delays by African Americans in seeking treatment
until symptoms become so severe that they warrant
inpatient care.
$VLDQ $PHULFDQV3DFLILF ,VODQGHUV
The prevalence of mental illness among Asian

Americans is difficult to determine for
methodological reasons (i.e., population sampling).
Although some studies suggest higher rates of
mental illness, there is wide variance across
different groups of Asian Americans (Takeuchi &
Uehara, 1996). It is not well known how applicable
DSM-IV diagnostic criteria are to culturally
specific symptom expression and culture-bound
syndromes. With respect to treatment-seeking
behavior, Asian Americans are distinguished by
extremely low levels at which specialty treatment
is sought for mental health problems (Leong & Lau,
1998). Asian Americans have proven less likely
than whites, African Americans, and Hispanic
Americans to seek care. One national sample
revealed that Asian Americans were only a quarter
as likely as whites, and half as likely as African
Americans and Hispanic Americans, to have sought
outpatient treatment (Snowden, in press-a). Asian
Americans/Pacific Islanders are less likely than
whites to be psychiatric inpatients (Snowden &
Cheung, 1990). The reasons for the underutilization
of services include the stigma and loss of face over
mental health problems, limited English
proficiency among some Asian immigrants,
different cultural explanations for the problems,
and the inability to find culturally competent services. These phenomena are more pronounced for
recent immigrants (Sue et al., 1994).
25
African Americans are overrepresented among persons

undergoing involuntary civil commitment (Snowden, in press-b).
85
dependence appear also to be especially

problematic, occurring at perhaps twice the rate of
occurrence found in any other population group.
Relatedly, suicide occurs at alarmingly high levels.
(Indian Health Service, 1997). Among Native
American veterans, post-traumatic stress disorder
has been identified as especially prevalent in
relation to whites (Manson, 1998). In terms of
patterns of utilization, Native Americans are
overrepresented in psychiatric inpatient care in
relation to whites, with the exception of private
psychiatric hospitals (Snowden & Cheung, 1990;
Snowden, in press-b).
+LVSDQLF $PHULFDQV
Several epidemiological studies revealed few

differences between Hispanic Americans and
whites in lifetime rates of mental illness (Robins &
Regier, 1991; Vega & Kolody, 1998). A recent
study of Mexican Americans in Fresno County,
California, found that Mexican Americans born in
the United States had rates of mental disorders
similar to those of other U.S. citizens, whereas
immigrants born in Mexico had lower rates (Vega
et al., 1998a). A large study conducted in Puerto
Rico reported similar rates of mental disorders
among residents of that island, compared with those
of citizens of the mainland United States (Canino et
al., 1987).
Although rates of mental illness may be similar
to whites in general, the prevalence of particular
mental health problems, the manifestation of
symptoms, and help-seeking behaviors within
Hispanic subgroups need attention and further
research. For instance, the prevalence of depressive
symptomatology is higher in Hispanic women
(46%) than men (almost 20%); yet, the known risk
factors do not totally explain the gender difference
(Vega et al., 1998a; Zunzunegui et al., 1998).
Several studies indicate that Puerto Rican and
Mexican American women with depressive
symptomatology are underrepresented in mental
health services and overrepresented in general
medical services (Hough et al., 1987; Sue et al.,
1991, 1994; Duran, 1995; Jimenez et al., 1997).
%DUULHUVWRWKH5HFHLSWRI7UHDWPHQW
The underrepresentation in outpatient treatment of
racial and ethnic minority groups appears to be the
result of cultural differences as well as financial,
organizational, and diagnostic factors. The service
system has not been designed to respond to the
cultural and linguistic needs presented by many
racial and ethnic minorities. What is unresolved are
the relative contribution and significance of each
factor for distinct minority groups.
+HOS6HHNLQJ %HKDYLRU
Among adults, the evidence is considerable that

persons from minority backgrounds are less likely
than are whites to seek outpatient treatment in the
specialty mental health sector (Sussman et al.,
1987; Gallo et al., 1995; Leong & Lau, 1998;
Snowden, 1998; Vega et al., 1998a, 1998b; Zhang
et al., 1998). This is not the case for emergency
department care, from which African Americans
are more likely than whites to seek care for mental
health problems, as noted above. Language, like
economic and accessibility differences, can play an
important role in why people from other cultures do
not seek treatment (Hunt, 1984; Comas-Diaz, 1989;
Cook & Timberlake, 1989; Taylor, 1989).
1DWLYH $PHULFDQV
American Indians/Alaska Natives have, like Asian

Americans and Pacific Islanders, been studied in
few epidemiological surveys of mental health and
mental disorders. The indications are that
depression is a significant problem in many
American Indian/Alaska Native communities
(Nelson et al., 1992). One study of a Northwest
Indian village found rates of DSM-III-R affective
disorder that were notably higher than rates
reported from national epidemiological studies
(Kinzie et al., 1992). Alcohol abuse and
0LVWUXVW
The reasons why racial and ethnic minority groups

are less apt to seek help appear to be best studied
86
discrimination has affected their ability to trust a

white majority population (Herring, 1994;
Thompson, 1997).
among African Americans. By comparison with

whites, African Americans are more likely to give
the following reasons for not seeking professional
help in the face of depression: lack of time, fear of
hospitalization, and fear of treatment (Sussman et
al., 1987). Mistrust among African Americans may
stem from their experiences of segregation, racism,
and discrimination (Primm et al., 1996; Priest,
1991). African Americans have experienced racist
slights in their contacts with the mental health
system, called microinsults by Pierce (1992).
Some of these concerns are justified on the basis of
research, cited below, revealing clinician bias in
overdiagnosis of schizophrenia and underdiagnosis
of depression among African Americans.
Lack of trust is likely to operate among other
minority groups, according to research about their
attitudes toward government-operated institutions
rather than toward mental health treatment per se.
This is particularly pronounced for immigrant
families with relatives who may be undocumented,
and hence they are less likely to trust authorities
for fear of being reported and having the family
member deported. People from El Salvador and
Argentina who have experienced imprisonment or
watched the government murder family members
and engage in other atrocities may have an
especially strong mistrust of any governmental
authority (Garcia & Rodriguez, 1989). Within the
Asian community, previous refugee experiences of
groups such as Vietnamese, Indochinese, and
Cambodian immigrants parallel those experienced
by Salvadoran and Argentine immigrants. They,
too, experienced imprisonment, death of family
members or friends, physical abuse, and assault, as
well as new stresses upon arriving in the United
States (Cook & Timberlake, 1989; Mollica, 1989).
American Indians past experience in this
country also imparted lack of trust of government.
Those living on Indian reservations are particularly
fearful of sharing any information with white
clinicians employed by the government. As with
African Americans, the historical relationship of
forced control, segregation, racism, and
6WLJPD
The stigma of mental illness is another factor

preventing African Americans from seeking
treatment, but not at a rate significantly different
from that of whites. Both African American and
white groups report that embarrassment hinders
them from seeking treatment (Sussman et al.,
1987). In general, African Americans tend to deny
the threat of mental illness and strive to overcome
mental health problems through self-reliance and
determination (Snowden, 1998). Stigma, denial,
and self-reliance are likely explanations why other
minority groups do not seek treatment, but their
contribution has not been evaluated empirically,
owing in part to the difficulty of conducting this
type of research. One of the few studies of Asian
Americans identified the barriers of stigma,
suspiciousness, and a lack of awareness about the
availability of services (Uba, 1994). Cultural
factors tend to encourage the use of family,
traditional healers, and informal sources of care
rather than treatment-seeking behavior, as noted
earlier.
&RVW
Cost is yet another factor discouraging utilization

of mental health services (Chapter 6). Minority
persons are less likely than whites to have private
health insurance, but this factor alone may have
little bearing on access. Public sources of insurance
and publicly supported treatment programs fill
some of the gap. Even among working class and
middle-class African Americans who have private
health insurance, there is underrepresentation of
African Americans in outpatient treatment
(Snowden, 1998). Yet studies focusing only on
poor women, most of whom were members of
minority groups, have found cost and lack of
insurance to be barriers to treatment (Miranda &
Green, 1999). The discrepancies in findings suggest
87
African Americans were less likely than others to

have received treatment that conformed to
recommended practices (Lehman & Steinwachs,
1998). Inferior treatment outcomes are widely
assumed but are difficult to prove, especially
because of sampling, questionnaire, and other
design issues, as well as problems in studying
patients who drop out of treatment after one session
or who otherwise terminate prematurely. In a
classic study, 50 percent of Asian Americans versus
30 percent of whites dropped out of treatment early
(Sue & McKinney, 1975). However, the disparity in
dropout rates may have abated more recently
(OSullivan et al., 1989; Snowden et al., 1989).
One of the few studies of clinical outcomes, a preversus post-treatment study, found that African
Americans fared more poorly than did other
minority groups treated as outpatients in the Los
Angeles area (Sue et al., 1991). Earlier studies from
the 1970s and 1980s had given inconsistent results
(Sue et al., 1991).
that much research remains to be performed on the

relative importance of cost, cultural, and
organizational barriers, and poverty and income
limitations across the spectrum of racial and ethnic
and minority groups.
&OLQLFLDQ %LDV
Advocates and experts alike have asserted that bias

in clinician judgment is one of the reasons for
overutilization of inpatient treatment by African
Americans. Bias in clinician judgment is thought to
be reflected in overdiagnosis or misdiagnosis of
mental disorders. Since diagnosis is heavily reliant
on behavioral signs and patients reporting of the
symptoms, rather than on laboratory tests, clinician
judgment plays an enormous role in the diagnosis
of mental disorders. The strongest evidence of
clinician bias is apparent for African Americans
with schizophrenia and depression. Several studies
found that African Americans were more likely
than were whites to be diagnosed with
schizophrenia, yet less likely to be diagnosed with
depression (Snowden & Cheung, 1990; Hu et al.,
1991; Lawson et al., 1994).
In addition to problems of overdiagnosis or
misdiagnosis, there may well be a problem of
underdiagnosis among minority groups, such as
Asian Americans, who are seen as problem-free
(Takeuchi & Uehara, 1996). The presence and
extent of this type of clinician bias are not known
and need to be investigated.
(WKQRSV\FKRSKDUPDFRORJ\
There is mounting awareness that ethnic and

cultural influences can alter an individuals
responses to medications (pharmacotherapies). The
relatively new field of ethnopsychopharmacology
investigates cultural variations and differences that
influence the effectiveness of pharmacotherapies
used in the mental health field. These differences
are both genetic and psychosocial in nature. They
range from genetic variations in drug metabolism to
cultural practices that affect diet, medication
adherence, placebo effect, and simultaneous use of
traditional and alternative healing methods (Lin et
al., 1997). Just a few examples are provided to
illustrate ethnic and racial differences.
Pharmacotherapies given by mouth usually
enter the circulation after absorption from the
stomach. From the circulation they are distributed
throughout the body (including the brain for
psychoactive drugs) and then metabolized, usually
in the liver, before they are cleared and eliminated
from the body (Brody, 1994). The rate of
,PSURYLQJ7UHDWPHQWIRU0LQRULW\
*URXSV
The previous paragraphs have documented
underutilization of treatment, less help-seeking
behavior, inappropriate diagnosis, and other
problems that have beset racial and ethnic minority
groups with respect to mental health treatment.
This kind of evidence has fueled the widespread
perception of mental health treatment as being
uninviting, inappropriate, or not as effective for
minority groups as for whites. The Schizophrenia
Patient Outcome Research Team demonstrated that
88
Psychosocial factors also can play an important

role in ethnic variation. Compliance with dosing
may be hindered by communication difficulties;
side effects can be misinterpreted or carry different
connotations; some groups may be more responsive
to placebo treatment; and reliance on psychoactive
traditional and alternative healing methods (such as
medicinal plants and herbs) may result in
interactions with prescribed pharmacotherapies.
The result could be greater side effects and
enhanced or reduced effectiveness of the
pharmacotherapy, depending on the agents involved
and their concentrations (Lin et al., 1997). Greater
awareness of ethnopsychopharmacology is
expected to improve treatment effectiveness for
racial and ethnic minorities. More research is
needed on this topic across racial and ethnic
groups.
metabolism affects the amount of the drug in the

circulation. A slow rate of metabolism leaves more
drug in the circulation. Too much drug in the
circulation typically leads to heightened side
effects. A fast rate of metabolism, on the other
hand, leaves less drug in the circulation. Too little
drug in the circulation reduces its effectiveness.
There is wide racial and ethnic variation in drug
metabolism. This is due to genetic variations in
drug-metabolizing enzymes (which are responsible
for breaking down drugs in the liver). These genetic
variations alter the activity of several drugmetabolizing enzymes. Each drug-metabolizing
enzyme normally breaks down not just one type of
pharmacotherapy, but usually several types. Since
most of the ethnic variation comes in the form of
inactivation or reduction in activity in the enzymes,
the result is higher amounts of medication in the
blood, triggering untoward side effects.
For example, 33 percent of African Americans
and 37 percent of Asians are slow metabolizers of
several antipsychotic medications and
antidepressants (such as tricyclic antidepressants
and selective serotonin reuptake inhibitors) (Lin et
al., 1997). This awareness should lead to more
cautious prescribing practices, which usually entail
starting patients at lower doses in the beginning of
treatment. Unfortunately, just the opposite typically
had been the case with African American patients
and antipsychotic drugs. Clinicians in psychiatric
emergency services prescribed more oral doses and
more injections of antipsychotic medications to
African American patients (Segel et al., 1996). The
combination of slow metabolism and overmedication of antipsychotic drugs in African Americans
can yield very uncomfortable extrapyramidal 26 side
effects (Lin et al., 1997). These are the kinds of
experiences that likely contribute to the mistrust of
mental health services reported among African
Americans (Sussman et al., 1987).
0LQRULW\2ULHQWHG 6HUYLFHV
Through employment of minority practitioners and

the creation of specialized minority-oriented
programs, community-based, publicly supported
mental health programs have achieved greater
minority representation than are found in other
mental health settings (Snowden, 1999). Mental
health care providers who are themselves from
ethnic minority backgrounds are especially likely to
treat ethnic minority clients and have been found to
enjoy good success in retaining them in treatment
(Sue et al., 1991).
The character of the mental health program in
which treatment is provided has proven particularly
important in encouraging minority mental health
service use. Research has shown that programs that
specialize in serving identified minority
communities have been successful in encouraging
minorities to enter and remain in treatment (Yeh et
al., 1994; Snowden et al., 1995; Takeuchi et al.,
1995; Snowden & Hu, 1996). Modeled on programs
successfully targeting groups of recent immigrants
and refugees, minority-oriented programs appear to
succeed by maintaining active, committed
relationships with community institutions and
26
Dystonia (brief or prolonged contraction of muscles), akathisia

(an urge to move about constantly), or parkinsonism (tremor and
rigidity) (Perry et al., 1997).
89
leaders and making aggressive outreach efforts; by

maintaining a familiar and welcoming atmosphere;
and by identifying and encouraging styles of
practice best suited to the problems particular to
racial and ethnic minority group members. A
challenge for such programs is to meet specialized
sociocultural needs for clients from various
backgrounds. The track record of minority-oriented
programs at improving treatment outcomes is not
yet clear for adults but appears to be positive for
children and adolescents (Yeh et al., 1994).
There is a specialized system of care for Native
Americans that provides mental health treatment.
The Indian Health Service (IHS) includes a Mental
Health Programs Branch; it offers mental health
treatment intended to be culturally appropriate.
Urban Indian Health Programs also provide for
mental health treatment. The IHS Alcoholism/Substance Abuse Program Branch sponsors
services on reservations and in urban communities
through contracts with service providers. Most
mental health programs in the IHS focus on
screening and treatment in primary care settings.
Due to budgetary restraints, IHS is able to provide
only limited medical, including mental health,
coverage of Native American peoples (Manson,
1998).
Many tribes have moved toward selfdetermination and, as a result, toward assuming
direct control of local programs. When surveyed,
these tribal health programs reported providing
mental health care in a substantial number of
instances, although questions remain about the
nature and scope of services. Finally, the
Department of Veterans Affairs and many state and
local authorities provide specialized mental health
programming targeting persons of Native American
heritage (Manson, 1998). Little is known about the
levels and types of care provided under any of these
arrangements.
&XOWXUDO &RPSHWHQFH
Advocates and policymakers have called for all

mental health practitioners to be culturally
competent: to recognize and to respond to cultural
concerns of ethnic and racial groups, including
their histories, traditions, beliefs, and value
systems (CMHS, 1998).
Cultural competence is one approach to helping
mental health service systems and professionals
create better services and ensure their adequate
utilization by diverse populations (Cross et al.,
1989). It is defined as a set of behaviors, attitudes,
and policies that come together in a system or
agency or among professionals that enables that
system, agency, or professionals to work
effectively in cross-cultural situations (Cross et al.,
1989). This is especially important because most
mental health providers are not racial and ethnic
minority group members (Hernandez et al., 1998).
Using the term competence places the
responsibility on the mental health services
organization and all of its employees, challenging
them all to become part of a process of providing
culturally appropriate services. This approach
emphasizes understanding the importance of
culture and building service systems that recognize,
incorporate, practice, and value cultural diversity.
There is no single prescribed method for
accomplishing cultural competence. It begins with
respect, and not taking an ethnocentric perspective
about behavior, values, or beliefs. Three possible
methods are to render mainstream treatments more
inviting and accessible to minority groups through
enhanced communication and greater awareness; to
select a traditional therapeutic approach according
to the perceived needs of the minority group; or to
adapt available therapeutic approaches to the needs
of the minority group (Rogler et al., 1987). One
effort to promote cultural competence has been
directed toward mental health services systems
and programs. The Center for Mental Health
Services has developed, with national input, a
preliminary set of performance indicators for
cultural competence by which service and
90
This capacity has a dual advantage. The

practitioner comes to understand the problem as it
is experienced and understood by the patient and,
in so doing, gains otherwise inaccessible
information on personal and social reality for the
patient, as well as a sense of trust and credibility.
At the same time the practitioner is able to plan for
and implement an appropriate intervention. It is
through a facility and a willingness to switch from
a professional orientation to that of the client and
his or her cultural group that the clinician is best
able to implement guidelines for cultural
competence such as those specified in DSM-IV
(Mezzich et al., 1996).
In the end, to be culturally competent is to
deliver treatment that is equally effective to all
sociocultural groups. The treatments provided must
not only be efficacious (based on clinical research),
but also effective in community delivery. The
delivery of effective treatments is complicated
because most research on efficacy has been
conducted on predominantly white populations.
This suggests the importance of both efficacy and
effectiveness studies on racial and ethnic
minorities.
At present, there is scant knowledge about
treatment effectiveness according to race, culture,
or ethnicity (Snowden & Hu, 1996). Rarely has
research evaluating standard forms of treatment
examined differential effectiveness. In fact, the
American Psychological Associations Division of
Clinical Psychology Task Force, which tried to
identify the efficacy of different psychotherapeutic
treatments, could not find a single rigorous study of
treatment efficacy published on ethnic minority
clients (Chambless et al., 1996). Nor have studies
been carried out on the efficacy of proposed
cultural adaptations of treatment in comparison
with standard alternatives. Only as more knowledge
is gained will it become possible to mount a fullfledged and appropriate response to racial and
ethnic differences in the provision of mental health
care.
funding organizations might be judged. Cultural

competence in this context includes consultation
with cross-cultural experts and training of staff, a
capacity to provide services in languages other than
English, and the monitoring of caseloads to ensure
proportional racial and ethnic representation. The
ultimate test of any performance indicator will be
documented by improvements in care and treatment
of ethnic and racial minorities.
Another response has been to develop
guidelines that more directly convey variations
believed necessary in the course of clinical
practice. An appendix to DSM-IV presents
clinicians with an Outline for Cultural Formulation.
The guidelines are intended as a supplement to
standard diagnosis, for use in multicultural environments and for the provision of a systematic review
of the individuals cultural background, the role of
the cultural context in the expression and
evaluation of symptoms and dysfunction, and the
effect that cultural differences may have on the
relationship between the individual and the
clinician (DSM-IV).
The Outline for Cultural Formulation covers
several areas. It calls for an assessment of cultural
identity, including degree of involvement with
alternative cultural reference groups; cultural
explanations of illness; cultural factors related to
stresses, supports, and level of functioning and
disability (e.g., religion, kin networks); differences
in culture or social status between patient and
clinician and possible barriers (e.g., communication, trust); and overall cultural assessment.
Others have focused attention on the process by
which mental health practitioners must engage,
assess, and treat patients and on understanding how
cultural differences might affect that process
(Lopez et al., in press). Viewed from this
perspective, the task is to maintain two points of
viewthat of the cultural group and that of
evidence-based mental health practiceand
strategically integrate them with the aim of valuing
and utilizing culture, context, and practice in a way
that promotes mental health.
91
5XUDO0HQWDO+HDOWK6HUYLFHV
Mental health services in rural areas cannot achieve

certain economies of scale, and some state-of-the
art services (e.g., assertive community treatment)
are inefficient to deliver unless there is a critical
mass of patients. Informal supports and indigenous
healers assume more importance in rural mental
health care.
Rural mental health concerns are being raised
nationally (Rauch, 1997; Ciarlo, 1998; Beeson et
al., 1998). Model programs offer new designs for
services (Mohatt & Kirwan, 1995), particularly
through the integration of mental health and
primary care (Bird et al., 1995, 1998; Size, 1998).
Newer technology, such as advanced telecommunications in the form of telemental health,
may improve rural access to expertise from
professionals located in urban areas (Britain, 1996;
La Mendola, 1997; Smith & Allison, 1998).
Internet access, videoconferencing, and various
computer applications offer an opportunity to
enhance the quality of care in rural mental health
services.
The differences between rural and urban communities present another source of diversity in mental
health services. People in rural America encounter
numerous barriers to the receipt of effective
services. Some barriers are geographic, created by
the problem of delivering services in less densely
populated rural areas and even more sparsely
populated frontier areas. Some barriers are
cultural, insofar as rural America reflects a range
of cultures and life styles that are distinct from
urban life. Urban culture and its approach to
delivering mental health services dominate mental
health services (Beeson et al., 1998).
Rural America is shrinking in size and political
influence (Danbom, 1995; Dyer, 1997). As a
consequence, rural mental health services do not
figure prominently in mental health policy (Ahr &
Holcomb, 1985; Kimmel, 1992). Furthermore, rural
economies are in decline, and the population is
decreasing in most areas (yet expanding rapidly in
a few boom areas) (Hannan, 1998). Rural America
is no longer a stable or homogeneous environment.
The farm crisis of the 1980s unleashed a period of
economic hardship and rapid social change,
adversely affecting the mental health of the
population (Ortega et al., 1994; Hoyt et al., 1995).
Policies and programs designed for urban
mental health services often are not appropriate for
rural mental health services (Beeson et al., 1998).
Beeson and his colleagues (1998) list a host of
important differences that should be considered in
designing rural mental health services. In an era of
specialized services, rural mental health relies
heavily on primary medical care and social
services. Stigma is particularly intense in rural
communities, where anonymity is difficult to
maintain (Hoyt et al., 1997). In an era of expanding
private mental health services, rural mental health
services have been predominantly publicly funded.
Consumer and family involvement in advocacy,
characteristic of urban and suburban areas, is rare
in rural America. The supply of services and
providers is limited, so choice is constrained.
2YHUYLHZRI&RQVXPHUDQG)DPLO\
0RYHPHQWV
Since the late 1970s, mental health services
continue to be transformed by the growing
influence of consumer and family organizations
(Lefley, 1996). Through strong advocacy, consumer
and family organizations have gained a voice in
legislation and policy for mental health service
delivery. Organizations representing consumers and
family members, though divergent in their
historical origins and philosophy, have developed
some important, overlapping goals: overcoming
stigma and preventing discrimination, promoting
self-help groups, and promoting recovery from
mental illness (Frese, 1998).
This section covers the history, goals, and
impact of consumer and family organizations,
whereas the next section covers the process of
recovery from mental illness. With literally
hundreds of grassroots consumer organizations
across the United States, no single organization
92
Groups of patients saw themselves as having been

rejected by society and robbed of power and
control over their lives. To surmount what they saw
as persecution, they began to advocate for selfdetermination and basic rights (Chamberlin, 1990;
Frese & Davis, 1997). The posture of these early
groups was decidedly militant against psychiatry,
against laws favoring involuntary commitment, and
often against interventions such as electroconvulsive therapy and antipsychotic medications (Lefley,
1996; Frese, 1998). Groups called Alliance for the
Liberation of Mental Patients, the Insane Liberation
Front, and Project Release met in homes and
churches, drawing their membership from those
with firsthand experiences with the mental health
system. Largely unfunded, they sustained their
membership by providing peer support, education
about services in the community, and advocacy to
help members access services and to press for
reforms (Furlong-Norman, 1988).
The book On Our Own (1978) by former patient
Judi Chamberlin was a benchmark in the history of
the consumer movement. Consumers and others
were able to read in the mainstream press what it
was like to have experienced the mental health
system. For many consumers, reading this book was
the beginning of their involvement in consumer
organizations (Van Tosh & del Vecchio, in press).
Early consumer groups, although geographically
dispersed, voluntary, and independent, were linked
through the newsletter Madness Network News,
which continued publication from 1972 to 1986.
During the same era, the Conference on Human
Rights and Against Psychiatric Oppression was
established and met annually from 1973 through
1985 (Chamberlin, 1990). In 1978, early consumer
groups gained what they perceived as their first
official acknowledgment from the highest levels of
government. The Presidents Commission on
Mental Health stated that . . . groups composed of
individuals with mental or emotional problems are
being formed all over the United States
(Presidents Commission on Mental Health, 1978,
pp. 1415). To date, racial and ethnic minority
speaks for all consumers or all families. In fact,

even the term consumer is not uniformly
accepted. Despite the heterogeneity, these
organizations typically offer some combination of
advocacy and self-help groups (Lefley, 1996).
Many users of mental health services refer
to themselves as consumers. The lexicon is
complicated by objections to the term consumer.
To some, being a consumer erroneously signifies
that service users have the power to choose services
most suitable to their needs. Those who object
contend that consumers have neither choices,
leverage, nor power to select services. Instead,
some consumers refer to themselves as survivors
or ex-patients to denote that they have survived
what they experienced as oppression by the mental
health system (Chamberlin & Rogers, 1990). This
distinction can best be understood in its historical
context.
2ULJLQVDQG*RDOVRI&RQVXPHU*URXSV
The consumer movement arose as a protest in the
1970s by former patients of mental hospitals. Their
antecedents trace back to the 19th century, when a
handful of individuals recovered enough to write
exposs expressing their outrage at the indignities
and abuses inside mental hospitals. The most
persuasive former patient was Clifford Beers,
whose classic book, A Mind That Found Itself
(1908), galvanized the mental hygiene reform
movement (Grob, 1994). Beers was among the
founders of the National Committee on Mental
Hygiene, an advocacy group that later was renamed
the National Mental Health Association. This group
focuses on linking citizens and mental health
professionals in broad-based prevention of mental
illness.
With the advent of deinstitutionalization in the
1950s, increasing numbers of former patients of
mental hospitals began to forge informal ties in the
community. By the 1960s, the civil rights movement inspired former patients to become better
organized into what was then coined the mental
patients liberation movement (Chamberlin, 1995).
93
self-help groups began to flourish and more

moderate viewpoints became represented. Self-help
groups assume three different postures toward
health professionals: the separatist model, the
supportive model that allows professionals to aid in
auxiliary roles, and partnership models in which
professionals act as leaders alongside patients
(Chamberlin, 1978; Emerick, 1990). The focus of
groups varies, with some groups united on the basis
of diagnosis, such as Schizophrenics Anonymous
and the National Depressive and Manic-Depressive
Association, whereas others are more broad based.
Chamberlins influential book and another book
by former patients, Reaching Across (Zinman et al.,
1987), explained to consumers how to form selfhelp groups. These books also extended the concept
of self-help more broadly into the provision of
consumer-run services as alternatives (as opposed
to adjuncts) to mental health treatment (Lefley,
1996).
Programs entirely run by consumers include
drop-in centers, case management programs,
outreach programs, businesses, employment and
housing programs, and crisis services (Long & Van
Tosh, 1988; National Resource Center on
Homelessness and Mental Illness, 1989; Van Tosh
& del Vecchio, in press). Drop-in centers are places
for consumers to obtain social support and
assistance with problems. Although research is
limited, the efficacy of consumer-run services is
discussed in Chapter 4.
Consumer positions also are being incorporated
into more conventional mental health servicesas
job coaches and case manager extenders, among
others. The rationale for employing consumers in
service deliveryin consumer-run or conventional
programsis to benefit those hired and those
served. Consumers who are hired obtain
employment, enhance self-esteem, gain work
experience and skills, and sensitize other service
providers to the needs of people with mental
disorders. Consumers who are served may be more
receptive to care and have role models engaged in
their care (Mowbray et al., 1996).
group members are underrepresented within the

consumer movement proportionate to their growing
representation in the U.S. population. There is a
need for more outreach and involvement of
consumers representing the special concerns of
racial and ethnic minorities.
The advocacy positions of consumers have
dealt with the role of involuntary treatment, selfmanaged care, the role of consumers in research,
the delivery of services, and access to mental health
services. By 1985, consumer views became so
divergent that two groups emerged: The National
Association of Mental Patients 27 and the National
Mental Health Consumers Association. The former
opposed all forms of involuntary treatment,
supported the prohibition of electroconvulsive
therapy, and rejected psychotropic medications and
hospitalization. The latter organization held more
moderate views for improving rather than
eschewing the mental health service system
(Lefley, 1996; Frese, 1998). Both groups eventually
disbanded, but the differences of opinion that they
reflected became deeply entrenched.
6HOI+HOS *URXSV
Self-help refers to groups led by peers to promote

mutual support, education, and growth (Lefley,
1996). Self-help is predicated on the belief that
individuals who share the same health problem can
help themselves and each other to cope with their
condition. The self-help approach enjoys a long
history, most notably with the formation of
Alcoholics Anonymous in 1935 (IOM, 1990). Over
time, the self-help approach has been brought to
virtually every conceivable health condition.
Since the 1970s, many mental health consumer
groups emphasized self-help as well as advocacy
(Chamberlin, 1995), although to different degrees.
Self-help for recovering mental patients initially
emphasized no involvement with mental health
professionals. Over time the numbers and types of
27
Later renamed the National Association of Psychiatric Survivors

(Chamberlin, 1995).
94
$FFRPSOLVKPHQWVRI&RQVXPHU
2UJDQL]DWLRQV
consumer affairs are generally staffed by

consumers to support consumer empowerment and
self-help in their particular states. A recent survey
of state mental health authorities identified 27
states as having paid positions for consumers in
central offices (Geller et al., 1998). In 1995, the
Federal Center for Mental Health Services hired its
first consumer affairs specialist.
The consumer movement also has had a
substantial influence on increasing the utilization
of consumers as employees in the traditional mental
health system, as well as in other human service
agencies (Specht, 1988; U.S. Department of
Education, 1990; Schlageter, 1990; Interagency
Council on the Homeless, 1991). Consumers are
being hired at all levels in the mental health
system, ranging from case manager aides to
management positions in national advocacy
organizations, as well as state and Federal
governmental agencies.
Finally, consumers continue to be involved in
research in several ways: as participants of clinical
research; as respondents who are asked questions
about conditions in their life; as partners in some
aspect of the planning, designing, and conducting
of the research project with professional
researchers in control; and as independent
researchers who conduct, analyze the data, and
publish the results of the research project
(Campbell et al., 1993). The past decade has
witnessed the blossoming of a vibrant consumer
research agenda and the growing belief that
consumer involvement in research and evaluation
holds great promise for system reform, quality
improvement, and outcome measurement (Campbell
et al., 1993; Campbell, 1997). In an effort to
enhance the active role of consumers and others in
the research process, the National Institute of
Mental Health is developing a systematic means of
including public participants in the initial review of
grant applications in the areas of clinical treatment
and services research. This innovation follows up
on a recommendation made by the Institute of
Consumer organizations have had measurable

impact on mental health services, legislation, and
research. One of their greatest contributions has
been the organization and proliferation of self-help
groups and their impact on the lives of thousands of
consumers of mental health services. In 1993, a
collaborative survey found that 46 state mental
health departments funded 567 self-help groups and
agencies for persons with mental disabilities and
their family members (National Association of
State Mental Health Program Directors, 1993). A
nationwide directory lists all 50 states and the
District of Columbia as having 235 different mental
health consumer organizations (South Carolina
SHARE, 1995).
On a systems level, the consumer movement has
substantially influenced mental health policy to
tailor services to consumer needs. This influence is
described by consumers and researchers as
empowerment. A concept from the social
sciences, empowerment has come to be defined by
mental health researchers as gaining control over
ones life in influencing the organizational and
societal structures in which one lives (Segal et al.,
1995).
Consumers are now involved in all aspects of
the planning, delivery, and evaluation of mental
health services, and in the protection of individual
rights. One prominent example is the passage of
Public Law 102-321, which established mental
health planning councils in every state. Planning
councils are required to have membership from
consumers and families. Having a planning council
so constituted is required for the receipt of Federal
block grant funds for mental health services. Other
Federal legislation required the establishment of
protection and advocacy agencies for patients
rights in every state (Chamberlin & Rogers, 1990;
Lefley, 1996).
Another significant development has been the
establishment of offices of consumer affairs in
many state mental health authorities. Offices of
95
NAMI was created as a grassroots organization

in 1979 by a small cadre of families in Madison,
Wisconsin. Since then, its membership has
skyrocketed to 208,000 in all 50 states (NAMI,
1999). NAMIs principal goal is to advocate for
improved services for persons with severe and
per s i s t ent mental illnes s for example,
schizophrenia and bipolar disorder. Its sole
emphasis on the most severely affected consumers
distinguishes it from most other consumer and
family organizations. Another NAMI goal is to
transform public attitudes and reduce stigma by
emphasizing the biological basis of serious mental
disorders, as opposed to poor parenting (Frese,
1998; NAMI, 1999). Correspondingly, NAMI
advocates for intensification of research in the
neurosciences. Through state and local affiliates,
NAMI operates a network of family groups for selfhelp and education purposes.
NAMIs accomplishments are formidable. The
organization has become a powerful voice for the
expansion of community-based services to fulfill
the vision of the community support reform
movement. NAMI has successfully pressed for
Federal legislation for family membership in state
mental health planning boards. It is a prime force
behind congressional legislation for parity in the
financing of mental health services. It also has
made substantial inroads in the training of mental
health professionals to sensitize them to the
predicament of the chronically mentally ill. It has
promoted psychoeducation, specific information
to family members, usually in small-group settings,
about schizophrenia and about strategies for
dealing with relatives with schizophrenia (Lamb,
1994). Finally, NAMI has successfully lobbied for
increased Federal research funding, and it has set
up private research foundations (Lefley, 1996).
Similarly, advocacy by parents on behalf of
children with serious emotional or behavioral
disturbances has had a compelling impact.
Advocacy for children was electrified by the
publication of Jane Knitzers 1982 book,
Unclaimed Children; shortly afterward, the
Medicine and Committee for the Study of the

Future of Public Health (1988).
)DPLO\$GYRFDF\
The family movement has experienced spectacular
growth and influence since its beginnings in the
late 1970s (Lefley, 1996). Although several
advocacy and professional organizations speak to
the needs of families, the family movement is
principal l y r epr es ented by three large
organizations. They are the National Alliance for
the Mentally Ill (NAMI), the Federation of Families
for Childrens Mental Health (FFCMH), and the
National Mental Health Association (NMHA).
NAMI serves families of adults with chronic mental
illness, whereas the Federation serves children and
youth with emotional, behavioral, or mental
disorders. NMHA serves a broad base of family
members and other supporters of children and
adults with mental disorders and mental health
problems. Though the target populations are
different, these organizations are similar in their
devotion to advocacy, family support, research, and
public awareness.
Fragmentation and lack of availability of
services were motivating forces behind the
establishment of the family movement.
Deinstitutionalization, in particular, was a cogent
impetus f o r t h e f o r ma t i on of NAMI.
Deinstitutionalization of the mentally ill left
families in the unexpected position of having to
assume care for their adult children, a role for
which they were ill prepared. Another motivating
force behind the family movement was the past
tendency by the mental health establishment to
blame parents for the mental illness in children
(Frese, 1998). The cause of schizophrenia, for
example, h a d b e e n a t t r ibuted to the
schizophrenogenic mother, who was cold and
aloof, according to a reigning but now discredited
view of etiology. Similarly, parents were viewed as
partly to blame for children with serious emotional
or behavioral disturbances (Melaville & Asayesh
1993; Friesen & Stephens, 1998).
96
possibility of recovering function (Harding et al.,

1992). Promoting recovery became a rallying point
and common ground for the consumer and family
movements (Frese, 1998).
The concept of recovery is having substantial
impact on consumers and families, mental health
research, and service delivery. Before describing
that impact, this section first turns to an
introduction and definitions.
National Mental Health Association (NMHA)

issued Invisible Children (NMHA, 1983), followed
by A Guide for Advocates to All Systems Failure
(NMHA, 1993). Knitzer chronicled the plight of
families in trying to access care from disparate and
uncoordinated public agencies, many of which
blamed or ignored parents. NMHA, a pioneer in the
mental health advocacy field, assumed a pivotal
role in strengthening the child mental health
movement in the 1980s and early 1990s. Over time,
the Federation of Families for Childrens Mental
Health has become another focal point for families,
championing family participation and support in
systems of care and access to services. The
Federations chapters across the United States offer
self-help, education, and networking (FFCMH,
1999). Through the efforts of these groups and
individuals, among the most noteworthy
accomplishments of the family movement has been
the emergence of family participation in
decisionmaking about care for children, one of the
decisive historical shifts in service delivery in the
past 20 years.
,QWURGXFWLRQDQG'HILQLWLRQV
Recovery is a concept introduced in the lay
writings of consumers beginning in the 1980s. It
was inspired by consumers who had themselves
recovered to the extent that they were able to write
about their experiences of coping with symptoms,
getting better, and gaining an identity (Deegan,
1988; Leete, 1989). Recovery also was fueled by
longitudinal research uncovering a more positive
course for a significant number of patients with
severe mental illness (Harding et al., 1992),
although findings across several studies were
variable (Harrow et al., 1997) (see discussion in
Chapter 4).
Recovery is variously called a process, an
outlook, a vision, a guiding principle. There is
neither a single agreed-upon definition of recovery
nor a single way to measure it. But the overarching
message is that hope and restoration of a
meaningful life are possible, despite serious mental
illness (Deegan, 1988; Anthony, 1993; Stocks,
1995; Spaniol et al., 1997). Instead of focusing
primarily on symptom relief, as the medical model
dictates, recovery casts a much wider spotlight on
restoration of self-esteem and identity and on
attaining meaningful roles in society.
Written testimonials by former mental patients
have appeared for centuries. These writings,
according to historian of medicine Roy Porter,
shore up that sense of personhood and identity
which they feel is eroded by society and
psychiatry (Porter, 1987). What distinguishes the
contemporary wave of writings is their critical
mass, organizational backing, and freedom of
2YHUYLHZRI5HFRYHU\
Until recently, some severe mental disorders were
generally considered to be marked by lifelong
deterioration. Schizophrenia, for instance, was seen
by the mental health profession as having a
uniformly downhill course (Harding et al., 1992).
At the beginning of the 20th century, the leading
psychiatrist of the era, Emil Kraepelin, judged the
outcome of schizophrenia to be so dismal that he
named the disorder dementia praecox, or
premature dementia. Negative conceptions of
severe mental illness, perpetuated in textbooks for
decades by Kraepelins original writings, dampened
consumers and families expectations, leaving
them without hope. A turnabout in attitudes came
as a result of the consumer movement and self-help
activities. They mobilized a shift toward a more
positive set of consumer attitudes and selfperceptions. Research provided a scientific basis
for and supported a more optimistic view of the
97
expression from outside the confines of the

institution. Deinstitutionalization, the emergence of
community supports and psychosocial rehabilitation, and the growth of the consumer and family
advocacy movements all paved the way for
recovery to take hold (Anthony, 1993).
The concept of recovery continues to be defined
in the writings of consumers (see Figure 2-7).
These lay writings offer a range of possible
definitions, many of which seek to discover
meaning, purpose, and hope from having mental
illness (Lefley, 1996). The definitions do not,
however, imply full recovery, in which full
functioning is restored and no medications are
needed. Instead they suggest a journey or process,
not a destination or cure (Deegan, 1997). One of
the most prominent professional proponents of
recovery, William A. Anthony, crystallized consumer writings on recovery with the following
definition:
. . . a person with mental illness can
recover even though the illness is not
cured . . . . [Recovery] is a way of living
a satisfying, hopeful, and contributing life
even with the limitations caused by illness.
Recovery involves the development of new
meaning and purpose in ones life as one
grows beyond the catastrophic effects of
mental illness (Anthony, 1993).
It is important to point out that consumers see
a distinction between recovery and psychosocial
rehabilitation. The latter, which is discussed more
extensively in Chapter 4, refers to professional
mental health services that bring together
approaches from the rehabilitation and the mental
health fields (Cook et al., 1996). These services
combine pharmacological treatment, skills training,
and psychological and social support to clients and
families in order to improve their lives and
functional capacities. Recovery, by contrast, does
not refer to any specific services. Rather, according
to the writings of pioneering consumer Patricia
Deegan, recovery refers to the lived experience
Figure 2-7. Definitions of recovery from

consumer writings
Recovery is a process, a way of life, an attitude,

and a way of approaching the days challenges. It
is not a perfectly linear process. At times our
course is erratic and we falter, slide back, regroup
and start again. . . .The need is to meet the
challenge of the disability and to re-establish a
new and valued sense of integrity and purpose
within and beyond the limits of the disability; the
aspiration is to live, work, and love in a community
in which one makes a significant contribution
(Deegan, 1988, p. 15).
One of the elements that makes recovery possible
is the regaining of ones belief in oneself
(Chamberlin, 1997, p. 9).
Having some hope is crucial to recovery; none of
us would strive if we believed it a futile effort. . .I
believe that if we confront our illnesses with
courage and struggle with our symptoms
persistently, we can overcome our handicaps to
live independently, learn skills, and contribute to
society, the society that has traditionally
abandoned us (Leete, 1989, p. 32).
A recovery paradigm is each persons unique
experience of their road to recovery. . . .My
recovery paradigm included my re-connection
which included the following four key ingredients:
connection, safety, hope, and acknowledgment of
my spiritual self (Long, 1994, p. 4).
To return renewed with an enriched perspective of
the human condition is the major benefit of
recovery. To return at peace, with yourself, your
experience, your world, and your God, is the major
joy of recovery (Granger, 1994, p. 10).
of gaining a new and valued sense of self and of

purpose (Deegan, 1988).
,PSDFWRIWKH5HFRYHU\&RQFHSW
The impact of the recovery concept is felt most by
consumers and families. Consumers and families
are energized by the message of hope and selfdetermination. Having more active roles in
98
their success in dealing with a mental illness. They

included medication, community support/case
management, self-will/self-monitoring, vocational
activity (including school), and spirituality
(Sullivan, 1994). Other researchers, also using
semistructured interviews, suggested that the
rediscovery and reconstruction of a sense of self
were important to recovery (Davidson & Strauss,
1992).
These early forays by researchers set the stage
for consumer-driven research efforts to identify
some of the aspects of recovery. A group of
consumers with consultant researchers developed
the Empowerment Scale (Rogers et al., 1997). After
testing a 28-item scale on members of six self-help
programs in six states, factor analysis revealed the
underlying dimensions of empowerment to be
(1) self-efficacyself-esteem; (2) power-powerlessness ; (3) community activism; (4) righteous anger;
and (5) optimismcontrol over the future. Other
instruments, found to have consistency and
construct validity, are the Personal Empowerment
Scale, the Organizational Empowerment Scale, and
the Extra-Organizational Empowerment Scale
(Segal et al., 1995).
Mental health services continue to be refined
and shaped by the consumer and recovery
emphasis. The most tangible changes in services
come from assertive community treatment and
psychosocial and vocational rehabilitation, which
emphasize an array of approaches to maximize
functioning and promote recovery. Consumer
interest in self-help and recovery has stimulated the
proliferation of interventions for what has been
called illness management or self-managed
care for relapse prevention of psychotic
symptoms. Illness management training programs
now teach individuals to identify early warning
signs of relapse and to develop strategies for their
prevention. All of these transformations in service
delivery and research affirming their benefits are
discussed at length in Chapter 4.
Champions of recovery assert that its greatest
impact will be on mental health providers and the
treatment, research, social and vocational

functioning, and personal growth strikes a
responsive cord. Consumers harboring more
optimistic attitudes and expectations may improve
the course of their illness, based on related research
from the field of psychosocial and vocational
rehabilitation (see Chapter 4). Yet direct empirical
support for the salutary, long-term effect of
positive expectations, on both consumers and
families, is still in its infancy (Lefley, 1997).
The recovery concept likewise is having a
bearing on mental health research and services.
Researchers are beginning to study consumer
attitudes and behavior to attempt to identify the
elements contributing to recovery. Though still at
an early stage, research is being driven by
consumer perspectives on recovery. Consumers
assert that the recovery process is governed by
internal factors (their psychological perceptions
and expectations), external factors (social
supports), and the ability to self-manage care, all of
which interact to give them mastery over their
lives. The first systematic efforts to define
consumer perceptions of recovery was conducted
by consumers. The Well-Being Project, sponsored
by the California Department of Mental Health,
was a landmark effort in which mental health
consumers conducted a multifaceted study to define
and explore factors promoting or deterring the wellbeing of persons diagnosed with serious mental
illness (Campbell & Schraiber, 1989). Using
quantitative survey research, focus groups, and oral
histories, Campbell (1993) arrived at a definition of
recovery that incorporates good health, good food,
and a decent place to live, all supported by an
adequate income that is earned through meaningful
work. We need adequate resources and a satisfying
social life to meet our desires for comfort and
intimacy. Well-being is enriched by creativity, a
satisfying spiritual and sexual life, and a sense of
happiness (p. 28).
Through semistructured interviews with
consumers about recovery, a subsequent study
identified the most common factors associated with
99
example, on the complex neurochemical activity

that occurs within individual nerve cells, or
neurons, to process information; on the properties
and roles of proteins that are expressed, or
produced, by a persons genes; and on the
interaction of genes with diverse environmental
influences. All of these activities now are
understood, with increasing clarity, to underlie
learning, memory, the experience of emotion, and,
when these processes go awry, the occurrence of
mental illness or a mental health problem.
Equally important to the mental health field is
top-down research; here, as the term suggests, the
aim is to understand the broader behavioral context
of the brains cellular and molecular activity and to
learn how individual neurons work together in
well-delineated neural circuits to perform mental
functions.
Effective Treatments. As information accumulates about the basic workings of the brain, it is the
task of translational research to transfer new
knowledge into clinically relevant questions and
targets of research opportunityto discover, for
example, what specific properties of a neural
circuit might make it receptive to a safer, more
effective medications. To elaborate on this
example, theories derived from knowledge about
basic brain mechanisms are being wedded more
closely to brain imaging tools such as functional
Magnetic Resonance Imaging (MRI) that can
observe actual brain activity. Such a collaboration
would permit investigators to monitor the specific
protein molecules intended as the targets of a
new medication to treat a mental illness or, indeed,
to determine how to optimize the effect on the brain
of the learning achieved through psychotherapy.
In its entirety, the new integrative neuroscience of mental health offers a way to
circumvent the antiquated split between the mind
and the body that historically has hampered mental
health research. It also makes it possible to
examine scientifically many of the important
psychological and behavioral theories regarding
normal development and mental illness that have
future design of the service system. They envision

services being structured to be recovery-oriented to
ensure that recovery takes place. They envision
mental health professionals believing in and
supporting consumers in their quest to recover. In
a groundbreaking article, William A. Anthony
described recovery as a guiding vision that pulls
the field of services into the future. A vision is not
reflective of what we are currently achieving, but
of what we hope for and dream of achieving.
Visionary thinking does not raise unrealistic
expectations. A vision begets not false promises but
a passion for what we are doing.
&RQFOXVLRQV
The past 25 years have been marked by several
discrete, defining trends in the mental health field.
These have included:
1. The extraordinary pace and productivity of
scientific research on the brain and behavior;
2. The introduction of a range of effective
treatments for most mental disorders;
3. A dramatic transformation of our societys
approaches to the organization and financing of
mental health care; and
4. The emergence of powerful consumer and
family movements.
Scientific Research. The brain has emerged as
the central focus for studies of mental health and
mental illness. New scientific disciplines,
technologies, and insights have begun to weave a
seamless picture of the way in which the brain
mediates the influence of biological, psychological,
and social factors on human thought, behavior, and
emotion in health and in illness. Molecular and
cellular biology and molecular genetics, which are
complemented by sophisticated cognitive and
behavioral science, are preeminent research
disciplines in the contemporary neuroscience of
mental health. These disciplines are affording
unprecedented opportunities for bottom-up
studies of the brain. This term refers to research
that is examining the workings of the brain at the
most fundamental levels. Studies focus, for
100
greater coordination among these settings and

systems.
Consumer and Family Movements. The emergence of vital consumer and family movements
promises to shape the direction and complexion of
mental health programs for many years to come.
Although divergent in their historical origins and
philosophy, organizations representing consumers
and family members have promoted important,
often overlapping goals and have invigorated the
fields of research as well as treatment and service
delivery design. Among the principal goals shared
by much of the consumer movement are to
overcome stigma and prevent discrimination in
policies affecting persons with mental illness; to
encourage self-help and a focus on recovery from
mental illness; and to draw attention to the special
needs associated with a particular disorder or
disability, as well as by age or gender or by the
racial and cultural identity of those who have
mental illness.
Chapter 2 of the report was written to provide
background information that would help persons
from outside the mental health field better
understand topics addressed in subsequent chapters
of the report. Although the chapter is meant to
serve as a mental health primer, its depth of
discussion supports a range of conclusions:
1. The multifaceted complexity of the brain is
fully consistent with the fact that it supports all
behavior and mental life. Proceeding from an
acknowledgment that all psychological
experiences are recorded ultimately in the brain
and that all psychological phenomena reflect
biological processes, the modern neuroscience
of mental health offers an enriched
understanding of the inseparability of human
experience, brain, and mind.
2. Mental functions, which are disturbed in mental
disorders, are mediated by the brain. In the
process of transforming human experience into
physical events, the brain undergoes changes in
its cellular structure and function.
been developed in years past. The unswerving goal

of mental health research is to develop and refine
clinical treatments as well as preventive interventions that are based on an understanding of
specific mechanisms that can contribute to or lead
to illness but also can protect and enhance mental
health.
Mental health clinical research encompasses
studies that involve human participants, conducted,
for example, to test the efficacy of a new treatment.
A noteworthy feature of contemporary clinical
research is the new emphasis being placed on
studying the effectiveness of interventions in actual
practice settings. Information obtained from such
studies increasingly provides the foundation for
services research concerned with the cost, costeffectiveness, and deliverability of interventions
and the designincluding economic considerationsof service delivery systems.
Organization and Financing of Mental Health
Care. Another of the defining trends has been the
transformation of the mental illness treatment and
mental health services landscapes, including
increased reliance on primary health care and other
human service providers. Today, the U.S. mental
health system is multifaceted and complex,
comprising the public and private sectors, general
health and specialty mental health providers, and
social services, housing, criminal justice, and
educational agencies. These agencies do not always
function in a coordinated manner. Its configuration
reflects necessary responses to a broad array of
factors including reform movements, financial
incentives based on who pays for what kind of
services, and advances in care and treatment
technology. Although the hybrid system that exists
today serves diverse functions well for many
people, individuals with the most complex needs
and the fewest financial resources often find the
system fragmented and difficult to use. A challenge
for the Nation in the near-term future is to speed
the transfer of new evidence-based treatments and
prevention interventions into diverse service
delivery settings and systems, while ensuring
101
must be designed and delivered in a manner

that is sensitive to the perspectives and needs
of racial and ethnic minorities.
11. The consumer movement has increased the
involvement of individuals with mental
disorders and their families in mutual support
services, consumer-run services, and advocacy.
They are powerful agents for changes in service
programs and policy.
12. The notion of recovery reflects renewed
optimism about the outcomes of mental illness,
including that achieved through an individuals
own self-care efforts, and the opportunities
open to persons with mental illness to
participate to the full extent of their interests in
the community of their choice.
3. Few lesions or physiologic abnormalities define

the mental disorders, and for the most part their
causes remain unknown. Mental disorders,
instead, are defined by signs, symptoms, and
functional impairments.
4. Diagnoses of mental disorders made using
specific criteria are as reliable as those for
general medical disorders.
5. About one in five Americans experiences a
mental disorder in the course of a year.
Approximately 15 percent of all adults who
have a mental disorder in one year also
experiences a co-occurring substance (alcohol
or other drug) use disorder, which complicates
treatment.
6. A range of treatments of well-documented
efficacy exists for most mental disorders. Two
broad types of intervention include psychosocial treatmentsfor example, psychotherapy or counselingand psychopharmacologic treatments; these often are most
effective when combined.
7. In the mental health field, progress in
developing preventive interventions has been
slow because, for most major mental disorders,
there is insufficient understanding about
etiology (or causes of illness) and/or there is an
inability to alter the known etiology of a
particular disorder. Still, some successful
strategies have emerged in the absence of a full
understanding of etiology.
8. About 10 percent of the U.S. adult population
uses mental health services in the health sector
in any year, with another 5 percent seeking
such services from social service agencies,
schools, religious, or self-help groups. Yet
critical gaps exist between those who need
service and those who receive service.
9. Gaps also exist between optimally effective
treatment and what many individuals receive in
actual practice settings.
10. Mental illness and less severe mental health
problems must be understood in a social and
cultural context, and mental health services
0HQWDO+HDOWKDQG0HQWDO,OOQHVV$FURVV
WKH/LIHVSDQ
The Surgeon Generals report takes a lifespan
approach to its consideration of mental health and
mental illness. Three chapters that address,
respectively, the periods of childhood and
adolescence, adulthood, and later adult life
beginning somewhere between ages 55 and 65,
capture the contributions of research to the breadth,
depth, and vibrancy that characterize all facets of
the contemporary mental health field.
The disorders featured in depth in Chapters 3,
4, and 5 were selected on the basis of the frequency
with which they occur in our society, and the
clinical, societal, and economic burden associated
with each. To the extent that data permit, the report
takes note of how gender and culture, in addition to
age, influence the diagnosis, course, and treatment
of mental illness. The chapters also note the
changing role of consumers and families, with
attention to informal support services (i.e., unpaid
services), with which many consumers are
comfortable and upon which they depend for
information. Persons with mental illness and, often,
their families welcome a proliferating array of
support servicessuch as self-help programs,
family self-help, crisis services, and advocacy
102
focuses on mental disorders in childhood and

adolescence and what can be done to prevent or
treat these conditions and on the design and
operation of service settings best suited to the
needs experienced by children.
For about one in five Americans, adulthooda
time for achieving productive vocations and for
sustaining close relationships at home and in the
communityis interrupted by mental illness.
Understanding why and how mental disorders occur
in adulthood, often with no apparent portents of
illness in earlier years, draws heavily on the full
panoply of research conducted under the aegis of
the mental health field. In years past, the onset, or
occurrence, of mental illness in the adult years, was
attributed principally to observable phenomena
for example, the burden of stresses associated with
career or family, or the inheritance of a disease
viewed to run in a particular family. Such
explanations now may appear naive at best.
Contemporary studies of the brain and behavior
are racing to fill in the picture by elucidating
specific neurobiological and genetic mechanisms
that are the platform upon which a persons life
experiences can either strengthen mental health or
lead to mental illness. It now is recognized that
factors that influence brain development prenatally
may set the stage for a vulnerability to illness that
may lie dormant throughout childhood and
adolescence. Similarly, no single gene has been
found to be responsible for any specific mental
disorder; rather, variations in multiple genes
contribute to a disruption in healthy brain function
that, under certain environmental conditions,
results in a mental illness. Moreover, it is now
recognized that socioeconomic factors affect
individuals vulnerability to mental illness and
mental health problems. Certain demographic and
economic groups are more likely than others to
experience mental health problems and some
mental disorders. Vulnerability alone may not be
sufficient to cause a mental disorder; rather, the
causes of most mental disorders lie in some
that help them cope with the isolation, family

disruption, and possible loss of employment and
housing that may accompany mental disorders.
Support services can help to dissipate stigma and to
guide patients into formal care as well.
Mental health and mental illness are dynamic,
ever-changing phenomena. At any given moment,
a persons mental status reflects the sum total of
that individuals genetic inheritance and life
experiences. The brain interacts with and respondsboth in its function and in its very
structureto multiple influences continuously,
across every stage of life. At different stages,
variability in expression of mental health and
mental illness can be very subtle or very pronounced. As an example, the symptoms of
separation anxiety are normal in early childhood
but are signs of distress in later childhood and
beyond. It is all too common for people to
appreciate the impact of developmental processes
in children, yet not to extend that conceptual
understanding to older people. In fact, people
continue to develop and change throughout life.
Different stages of life are associated with
vulnerability to distinct forms of mental and
behavioral disorders but also with distinctive
capacities for mental health.
Even more than is true for adults, children must
be seen in the context of their social
environmentsthat is, family and peer group, as
well as that of their larger physical and cultural
surroundings. Childhood mental health is expressed
in this context, as children proceed along the arc of
development. A great deal of contemporary
research focuses on developmental processes, with
the aim of understanding and predicting the forces
that will keep children and adolescents mentally
healthy and maintain them on course to become
mentally healthy adults. Research also focuses on
identifying what factors place some at risk for
mental illness and, yet again, what protects some
children but not others despite exposure to the
same risk factors. In addition to studies of normal
development and of risk factors, much research
103
care provider training properly emphasizes skills

required to differentiate accurately the causes of
cognitive, emotional, and behavioral symptoms that
may, in some instances, rise to the level of mental
disorders, and in other instances be expressions of
unmet general medical needs.
As the life expectancy of Americans continues
to extend, the sheer numberalthough not necessarily the proportionof persons experiencing
mental disorders of late life will expand, confronting our society with unprecedented challenges in
organizing, financing, and delivering effective
mental health services for this population. An
essential part of the needed societal response will
include recognizing and devising innovative ways
of supporting the increasingly more prominent role
that families are assuming in caring for older,
mentally impaired and mentally ill family members.
combination of genetic and environmental factors,

which may be biological or psychosocial.
The fact that many, if not most, people have
experienced mental health problems that mimic or
even match some of the symptoms of a diagnosable
mental disorder tends, ironically, to prompt many
people to underestimate the painful, disabling
nature of severe mental illness. In fact,
schizophrenia, mood disorders such as major
depression and bipolar illness, and anxiety often
are devastating conditions. Yet relatively few
mental illnesses have an unremitting course marked
by the most acute manifestations of illness; rather,
for reasons that are not yet understood, the
symptoms associated with mental illness tend to
wax and wane. These patterns pose special
challenges to the implementation of treatment plans
and the design of service systems that are optimally
responsive to an individuals needs during every
phase of illness. As this report concludes,
enormous strides are being made in diagnosis,
treatment, and service delivery, placing the
productive and creative possibilities of adulthood
within the reach of persons who are encumbered by
mental disorders.
Late adulthood is when changes in health status
may become more noticeable and the ability to
compensate for decrements may become limited. As
the brain ages, a persons capacity for certain
mental tasks tends to diminish, even as changes in
other mental activities prove to be positive and
rewarding. Well into late life, the ability to solve
novel problems can be enhanced through training in
cognitive skills and problem-solving strategies.
The promise of research on mental health
promotion notwithstanding, a substantial minority
of older people are disabled, often severely, by
mental disorders including Alzheimers disease,
major depression, substance abuse, anxiety, and
other conditions. In the United States today, the
highest rate of suicidean all-too-common
consequence of unrecognized or inappropriately
treated depressionis found in older males. This
fact underscores the urgency of ensuring that health
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Overview of Mental Illness . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Overview of Development, Temperament, and Risk Factors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Overview of Mental Health Services . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 73

Overview of Consumer and Family Movements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

vast body of research on mental health and, to an

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in this 3-pound organ reveal little of its complexity. Yet

health field of the need for attention to cultural

Figure 2-1. Structural variety of neurons

Source: Fischbach, 1992, p. 53. (Permission granted: Patricia J. Wynne.)

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The complexity of the brain is such that a single

The workings of the brain depend on the ability of

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Figure 2-2. How neurons communicate

Source: Fischbach, 1992, p. 52. (Permission granted: Tomo Narashima.)

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Figure 2-3. The brain: Organ of the mind

Source: Fischbach, 1992, p. 51. (Permission granted: Carol Donner.)

the brain processes information. The white matter is

cortical white matter, so named because of its

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A neurotransmitter can elicit a biological effect in

Parkinsons disease, but that is also involved in the

Selected neurotransmitters important in

Excitatory amino acid

more than one different kind of receptor that can confer

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precise point-to-point communication within the brain

molecule (i.e., a neurotransmitter) that binds to a

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lions share of the 80,000 or so human genes that are

The preceding paragraphs have illustrated the chemical

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of modern science that behavior and our subjective

genetic and, thus, predetermined; similarly, references

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Table 2-2. Common signs of acute anxiety

mental disorders. It then describes how mental

Feelings of fear or dread

Trembling, restlessness, and muscle tension

Rapid heart rate

pares one to evade or confront a threat in the

Anxiety is one of the most readily accessible and easily

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unfounded typically fail and may even result in the

behavior such as hand washing or checking, there is an

Disturbances of perception and thought process fall

Disorganized thoughts and behaviors

Loose or illogical thoughts

Flat or blunted affect

Anhedonia (inability to experience pleasure)

However, in addition to positive symptoms,

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Disturbances of mood characteristically

have been noted to exhibit major deficits in

Table 2-4. Common signs of mood disorders

Most of us have an immediate and intuitive

Persistent sadness or despair

Insomnia (sometimes hypersomnia)

Anhedonia (inability to experience pleasure)

Apathy, poor motivation, social withdrawal

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