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2009 UpToDate

Properties of statins
Variable

Atorvastatin

Fluvastatin

Lovastatin

Pravastatin

Rosuvastatin

Simvastatin

LDL
cholesterol
reductions
(dose range,
mg)

38-54 percent
(10-80)

17-33
percent
(20-80)

29-48
percent
(20-80)

19-40 percent
(10-40)

52-63 percent
(10-40)

28-48 percent
(10-80)

Elimination
half-life, hours

15-30

0.5-2.3

2.9

1.3-2.8

19

2-3

Bioavailability,
percent

12

19-29

18

20

Protein
binding,
percent

80-90

>99

>95

43-55

88

94-98

Solubility

Lipophilic

Lipophilic

Lipophilic

Hydrophilic

Hydrophilic

Lipophilic

Cytochrome
450
metabolism
and lsozyme

3A4

2C9

3A4

Limited 2C9

3A4, 3A5

Active
metabolites

Yes

No

Yes

No

No

Yes

Effect of food
on absorption
of drug

None

Negligible

Increased
absorption

Decreased
absorption

None

None

Optimal time
of
administration

Evening

Bedtime

With meals
(morning
and evening)

Bedtime

Anytime

Evening

Renal
excretion of
absorbed
dose, percent

<6

10

20

10

13

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