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A. TEST BLUEPRINT
TOPIC
Bioenergetics & Biological Oxidation
RECALL
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UNDERSTANDING
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ANALYSIS
A. rho factor
C. tata box
B. sigma factor
D. hogness box
Reference: Murray, R.K., et. al., Harper's Illustrated Biochemistry, 26 th ed., p. 342.
19. The noncoding sequence in mRNA is called:
A. exon
C. cistron
B. muton
D. intron
Reference: Murray, R.K., et. al., Harper's Illustrated Biochemistry, 26 th ed., p. 341.
20. The adapter molecule during translation is:
A . tRNA
C. rRNA
B. mRNA
D. DNA
Reference: Murray, R.K., et. al., Harper's Illustrated Biochemistry, 26 th ed., p. 355.
B. GMP
D. ADP
Reference: Murray, R.K., et. al., Harper's Illustrated Biochemistry, 26 th ed., p. 293.
26. Which enzyme participates in both salvage and de novo synthesis of purine and
pyrimidine nucleotides?
A. Adenosine phosphoribosyl transferase
B. xanthine oxidase
C. phosphoribosyl phosphate synthetase
D. phosphoribosyl phosphate amidotransferase
Reference: Murray, R.K., et. al., Harper's Illustrated Biochemistry, 26 th ed., p. 294.
27. The primary product of purine catabolism is:
A. xanthine
C. uric acid
B. urea
D. hypoxanthine
Reference: Murray, R.K., et. al., Harper's Illustrated Biochemistry, 26 th ed., p.299.
28. The salvage pathway of purine nucleotide is described as:
A. utilizing amphibolic intermediates.
B. is less active than the de novo synthesis
C. is catalyzed by phosphoribosyl transferase
D. requiring more energy than the de novo pathway
Reference: Murray, R.K., et. al., Harper's Illustrated Biochemistry, 26 th ed., p. 294.
29. Which molecule is NOT a monomer of ribonucleic acids?
A. adenine
C. cytidine
B. thymine
D. uridine
Reference: Murray, R.K., et. al., Harper's Illustrated Biochemistry, 26 th ed., p. 303.
30. The Watson - Crick model of DNA is described as:
A. A right handed double helix with the bases directed inwards
A. containing 12 base pairs
B. having a pitch of 33A
C. the A DNA
Reference: Murray, R.K., et. al., Harper's Illustrated Biochemistry, 26 th ed., p. 305.
31. The discontinuous polymerization of DNA results in the synthesis of:
A. Okazaki fragments
C. exons
B. RNA
D. introns
Reference: Murray, R.K., et. al., Harper's Illustrated Biochemistry, 26 th ed., p. 330.
52. Complete oxidation of a saturated 21-carbon fatty acid yields how many molecules of ATP?
A. 161
C. 165
B. 163
D. 167
Reference: Champe, P. C., et. al., Biochemistry, 2nd ed., p. 185.
53. Carbohydrate digestion stops temporarily in the stomach because:
A. carbohydrates are already digested upon reaching the stomach.
B. the low gastric pH inactivates amylase.
C. there are no digestive enzymes in the stomach.
D. the stomach lacks the activators for amylase.
Reference: Murray, R. K., et. al., Harpers Biochemistry, 25 th ed., p. 662.
54. Which glycolytic reaction step reoxidizes NADH 2 to NAD+ and reduces pyruvate to lactate?
A. Glyceraldehyde 3-phosphate dehydrogenase reaction
B. Pyruvate kinase reaction
C. Lactate dehydrogenase reaction
D. Phosphofructokinase reaction
Reference: Murray, R. K., et. al., Harpers Biochemistry, 25th ed., p. 194.
55. Which of the following compounds are involved in storing energy?
A. Glycogen
C. ATP
B. Triacylglycerol
D. A and B
Reference: Murray, R. K., et. al, Illustrated Biochemistry, 26 th ed., pp. 458-460.
56. Glucose absorption from the intestinal mucosal cell is characterized as:
A. an energy-independent carrier mediated system.
B. a co-transport system with sodium.
C. transport of glucose along concentration gradient.
D. passive diffusion of glucose across the intestinal epithelial cell.
Reference: Murray, R. K., et. al., Harpers Biochemistry, 25 th ed., p. 667.
57. Glucose is a precursor of ribose and deoxyribose moieties of nucleotides and
deoxynucleotides via which of the following pathways?
A. Uronic acid pathway
C. Pentose phosphate pathway
B. Glucose-Alanine Cycle
D. Polyol pathway
Reference: Champe, P. C., et. al., Biochemistry, 2nd ed., p. 42.
58. Which of the following is TRUE of gluconeogenesis?
A. It results to a net synthesis of ATP.
B. Acetyl CoA can be converted to glucose.
C. Muscles and brain can contribute to blood glucose.
D. The pathway is stimulated by decreased AMP levels.
Reference: Murray, R. K. et. al., Harpers Biochemistry, 25 th ed.,. pp. 208-215.
59. Which of the following enzymes do not catalyze a rate-controlling step in the citric acid
cycle?
A. Fumarase
C. Citrate synthase
B. Isocitrate dehydrogenase
D. -ketoglutarate dehydrogenase
Reference: Murray, R. K., et. al., Harpers Biochemistry, 25th ed., pp184-186.
60. Which enzyme reverses the hexokinase reaction in the liver during fasting to liberate free
glucose into the blood?
A. Glucose 6-phosphatase
C. Pyruvate carboxylase
B. PEP carboxykinase
D. Fructose 1,6-bisphosphatase
Reference: Murray, R. K. et. al., Illustrated Biochemistry, 26 th ed., pp. 119-120.
61. Insulin stimulates which of the following metabolic pathways?
A. Glycogenolysis
C. Gluconeogenesis
B. Glycolysis
D. Lipolysis
Reference: Murray, R.K., et. al., Illustrated Biochemistry, 26th ed., p. 156.
62. Which is NOT an intermediate of the Krebs Cycle?
A. Isocitrate
C. Succinate
B. Pyruvate
D. Malate
Reference: Murray, R.K., et. al., Illustrated Biochemistry, 26 th ed., pp. 130-132.
63. The process by which ATP is formed as a result of the transfer of electrons from NADH or
FADH2 to oxygen by a series of electron carriers is called:
A. substrate level phosphorylation
C. phosphorylation of an enzyme
B. oxidative phosphorylation
D. dephosphorylation of an enzyme
Reference: Murray, R.K., et. al., Illustrated Biochemistry, 26th ed., p. 94.
64. Which of the following vitamins acts as a carrier of carbon dioxide in most carboxylation
reactions?
A. Thiamine
C. Biotin
B. Cobalamin
D. Folic acid
Reference: Murray, R. K., et. al., Illustrated Biochemistry, 26 th ed., p. 494.
65. The fat soluble vitamin under current investigation for its cardioprotective properties is:
A. Vit. A
C. Vit. E
B. Vit. D
D. Vit. K
Reference: Champe, P. C., et. al., Biochemistry, 2nd ed., p. 315.
66. The active form of vitamin D is:
A. 7-dehydrocholesterol
C. 1,25-dihydrocholecalciferol
B. cholecalciferol
D. 24,25-dihydroxycholecalciferol
Reference: Champe, P. C., et. al, Biochemistry, 2nd ed., p. 335.
67. The effects of vitamin A may include all of the following EXCEPT:
A. prevention of anemia.
C. the visual cycle
B. serving as an antioxidant
D. induction of certain cancers
Reference: Champe, P. C. et. al., Biochemistry, 2nd ed., pp. 330-332.
68. This mineral ion is a necessary co-factor in all reactions where ATP participates:
A. Cu+2
C. Fe+2
+2
B. Mn
D. Mg+2
Reference: Berg, J. M., et. al., Biochemistry, 5 th ed., p. 254.
69. The second messenger of glucagon is:
A. cyclic AMP
C. cyclic GMP
B. Tyrosine kinase
D. Calcium
Reference: Murray, R. K., et. al., Harpers Biochemistry, 25 th ed., p. 535.
70. Which of the following hormones activates the hormone response element?
A. Thyroxine
C. Glucagon
B. Epinephrine
D. Growth hormone
Reference: Murray, R. K., et. al., Harpers Biochemistry, 25 th ed., p. 537.
71. A hormone which is virilizing and can stimulate somatic growth is:
A. Estrogen
C. Progesterone
B. Androgen
D. Prolactin
Reference: Murray, R. K., et. al., Harpers Biochemistry, 25thed., p. 598.
72. The following is NOT a cholesterol derived hormone:
A. Thyroxine
C. Androgens
B. Calcitriol
D. Estrogens
Reference: Murray, R. K, et. al., Harpers Biochemistry, 25 th ed., 535.
73. Intracellular calcium is mobilized ion the cytoplasm by this PIP 2-derived second messenger:
A. Protein kinase C
C. Inositol diphosphate
B. Inositol triphosphate
D. Phosphatidylinositol
Reference: Murray, R. K., et. al., Harpers Biochemistry, 25 th ed., p. 546.
74. A transducing protein found in cell membranes which when actrivated after hormone
receptor interaction activates the adenylate cyclase system:
A. Ubiquitin
C. G-protein
B. Calmodulin
D. Protein kinase
Reference: Murray, R. K., et. al. Illustrated Biochemistry, 26th ed., pp. 458-460.
75. The most significant source of stored energy in the human body is:
A. Liver glycogen
C. Adipose tissue fats
B. Muscle proteins
D. Brain glucose
Reference: Campbell, M. K., Bichemistry, 3rd ed., p. 574.
ed., p. 724.
97. The lipoxygenase pathway of unsaturated fatty acids directs to the formation of:
A. Prostaglandins
C. Thromboxanes
B. Leukotrienes
D. Prostacyclins
Reference: Champe, P. C., Harve, R. A., Biochemistry, 2 nd ed., p 187.
98. Which is NOT a function of cholesterol?
A. Synthesis of cell membranes.
C. Precursor of steroid hormones.
B. Synthesis of Vitamin A.
D. Precursor of bile salts.
Reference: Murray, R. K., et. al., Illustrated Biochemistry, 26 th ed., p. 219.
99. Megaloblastic anemia is caused by lack of:
A. Panthothenic acid
C. Pyridoxine
B. Folic acid
D. Ascorbic acid
Reference: Champe, P. C., Harvey, R. A., Biochemistry, 2nd ed., p. 326.
100. A smoker who complains of soft swollen gums and loose teeth is deficient in Vitamin C and
therefore has impaired:
A. hydroxylation of proline.
B. hydroxylation of dopamine -hydroxylase.
C. degradation of tyrosine.
D. hydroxylation of bile acids.
Reference: Champe, P. C., Harvey, R. A., Biochemistry, 2nd ed., p. 40.