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Toxins 2016, 8(3), 60; doi:10.3390/toxins8030060

Review
Open Access
A Review of Bioinsecticidal Activity of Solanaceae Alkaloids

Szymon Chowaski 1,*, Zbigniew Adamski 1,2,*, Pawe Marciniak 1, Grzegorz Rosiski 1,
Ender Bykgzel 3, Kemal Bykgzel 4, Patrizia Falabella 5, Laura Scrano 6, Emanuela
Ventrella 5, Filomena Lelario 5 and Sabino A. Bufo 5
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Department of Animal Physiology and Development, Faculty of Biology, Adam Mickiewicz

University, Umultowska 89 Str., Pozna, 61-614, Poland
Electron and Confocal Microscope Laboratory, Faculty of Biology, Adam Mickiewicz
University, Umultowska 89 Str., Pozna, 61-614, Poland
Department of Molecular Biology and Genetics, Faculty of Arts and Science, Bulent Ecevit
University, Zonguldak, 67100, Turkey
Department of Biology, Faculty of Arts and Science, Bulent Ecevit University, Zonguldak,
67100, Turkey
Department of Science, University of Basilicata, Via dellAteneo Lucano 10, Potenza, 85100,
Italy
Department of European Culture, University of Basilicata, Via S. Rocco 1, Matera, 75100, Italy
* Correspondence: Tel.: +48-8295-925 (S.C.); +48-8295-646 (Z.A.)

Academic Editor: Kevin Welch
Received: 29 November 2015 / Accepted: 24 February 2016 / Published: 1 March 2016

Abstract: Only a small percentage of insect species are pests. However, pest species cause
significant losses in agricultural and forest crops, and many are vectors of diseases.
Currently, many scientists are focused on developing new tools to control insect
populations, including secondary plant metabolites, e.g., alkaloids, glycoalkaloids,
terpenoids, organic acids and alcohols, which show promise for use in plant protection.
These compounds can affect insects at all levels of biological organization, but their action
generally disturbs cellular and physiological processes, e.g., by altering redox balance,
hormonal regulation, neuronal signalization or reproduction in exposed individuals.
Secondary plant metabolites cause toxic effects that can be observed at both lethal and
sublethal levels, but the most important effect is repellence. Plants from the Solanaceae
family, which contains numerous economically and ecologically important species, produce
various substances that affect insects belonging to most orders, particularly herbivorous
insects and other pests. Many compounds possess insecticidal properties, but they are also
classified as molluscides, acaricides, nematocides, fungicides and bactericides. In this
paper, we present data on the sublethal and lethal toxicity caused by pure metabolites and
crude extracts obtained from Solanaceae plants. Pure substances as well as water and/or
alcohol extracts cause lethal and sublethal effects in insects, which is important from the
economical point of view. We discuss the results of our study and their relevance to plant
protection and management.
Keywords: insect physiology; pest control; bioinsecticides; Solanaceae secondary plant
metabolites
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1. Introduction
Humanity faces many problems that arise from its rapidly
increasing population and one is the provision of the population

with good quality food that is accessible for all [1]. There are
various strategies that may be used to increase crop yield and
improve food production, but various problems remain. Among
them, the destruction of crops by pests is one of the most difficult,
especially in developing countries, and although pests make up
only a small percentage of insects, they cause significant losses to

agricultural and forest crops, such as contributing to 20% annual
loss of cereal crops [2]. The most voracious of the insect pests are
Lepidoptera larvae, which have huge nutritional needs and are thus
the most detrimental to food production [3]. For example, the
diamondback moth, Plutella xylostella (L.), which is one of the major
pests of Brassicaceae crop plants, causes annual losses of between

USD 1.3 billion and USD 2.3 billion [4]. Moreover, many insect
species are vectors of diseases that lead to millions of human
deaths each year [3]. For example, malaria, which is transmitted by
mosquitoes, kills over 600 thousand people annually around the
world [5]. Therefore, the search for effective tools to control insect
populations is one of the most intensively developing fields of
research. Presently, the most common way to control insect pests is
through the use of synthetic pesticides, but they negatively impact
the natural environment [6]. These compounds have a wide

spectrum of activities against diverse groups of insects and can
almost completely remove pests from agroecosystems. However,
although the immediate impacts and high efficiency of synthetic
insecticides seem positive, there is no way to limit their action to
only agricultural areas. The negative effects of synthetic
insecticides are due to their insufficient selectivity, accumulation in
the environment and food chains, long persistence, disturbance of
the balance of ecosystems [7,8], and high socio-economic costs
(poisoning as well as water and food contamination) [9,10] as well

as the development of resistance in pest species [11]. Additionally,
more selective pesticides are more expensive, so the inexpensive,
nonselective pesticides are primarily used in developing countries

[12]. These problems have forced humankind to search for
alternatives to these compounds, and the demands of agriculture
include inexpensive insecticides that cause the least amount of
damage to the environment.
Integrated pest management (IPM) involves various plant
protection strategies with an emphasis on a variety of biological

control agents such as predatory animals, plant-derived
substances, crop rotation and mechanical damage to pests. The use
of highly toxic insecticides must be limited, so substances with

lower toxicity should be used first. Such a strategy may
significantly decrease the amount of pesticides released to the
environment, although chemical approaches are and will continue
to be a very important component of crop protection.
Are there any alternatives to synthetic insecticides? Among other
candidates, secondary plant metabolites, such as alkaloids,
glycoalkaloids, terpenoids, organic acids or alcohols, are regarded
as promising sources of plant-protecting substances [13,14]. These
compounds are produced by a variety of plant species in

practically all their organs, and they are one of the most important
lines of plant defense against pests. The range of cellular targets for
these substances is very wide and covers metabolic pathways,

macromolecules (e.g., proteins or nucleic acids) and organelles
(e.g., biological membranes or nuclei) and they affect the
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functioning of entire organism

as when they bind to receptors, and
impair nervous system function (for
review, see Wink [15]).
More
importantly, especially in developing
countries, effective biological controls

are cost-effective. For example, on
average, pesticides provide about $4
in benefits for every dollar invested in

pesticide control. Furthermore, pest
control using biological agents is
more profitable, ranging from $30 to
$100 for each dollar invested [16].
The increase in the content of
secondary metabolites in plant organs

is a common effect of pest invasion,
and it can be said that plants use these
compounds as chemical weapons [17].
The strategies vary; these compounds
can lower the attractiveness of a plant
to insects, make a plant unpalatable

[18], or attract insects to poison them,
i.e., a lure-and-kill strategy [19], etc.
However, the primary result is a
reduction in the attractiveness of
plants to insects. Additionally, the
short half-life of natural insecticides

in the environment is one of their
most important attributes [11,20], and
due to pleiotropy and their broad

physiological activity, pests do not
easily develop resistance to them. One
of the reasons is that biopesticides

usually have multiple modes of action
due to their complex chemical
composition, so insects are affected by
many different compounds, which
reduces the probability of developing
resistance to all the chemicals [19].
The evolutionary co-existence of
plants and insects has led to the
development
of
complicated
interactions among these two groups
of organisms including the abovementioned repellence and acute
toxicity of natural insecticides that
also affect plant pollination and insect
reproduction and can be acquired and

used by herbivorous insects against
predators and parasitoids (for a
review, see Ibanez,
Despres [14]).
The
secondary
Gallet
and
metabolites
produced by plants have a wide

spectrum of activity; they affect
insects at the cellular, tissue and
organismal level. In general, their

action disturbs the cellular and
physiological processes responsible
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for
maintain
ing
homeost
asis, and
they can
provoke
sublethal
changes
within
various
tissues
and
organs,
which
can
ultimatel
y lead to
death.
However
,
secondar
y
metabolit
es
also
have
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implicati
ons, such
as
reduced
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viability
or
deformiti
es
in
parental
and filial
generatio
ns.
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addition,
these
compoun
ds
reduce
the
number
of
individu
als
in
populati
ons both
directly
(as
a
result of
death)
but also,
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References
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Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
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Metabolites as
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Acknowledgments
References
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References
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References
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Acknowledgments
References
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Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
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Directions
Acknowledgments
References
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18-09-2016 09:55
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Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
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Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
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Metabolites as
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References
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References
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18-09-2016 09:55
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Metabolites
Metabolites as
Directions
Acknowledgments
References
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Metabolites as
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Acknowledgments
References
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Metabolites
Metabolites as
Directions
Acknowledgments
References
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Metabolites as
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References
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18-09-2016 09:55
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Metabolites as
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Acknowledgments
References
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References
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18-09-2016 09:55
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Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
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Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
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Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
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Acknowledgments
References
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18-09-2016 09:55
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Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
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Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
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Metabolites
Metabolites as
Directions
Acknowledgments
References
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p
r
o
t
e
c
t
i
o
n
;
m
o
r
e
a
n
d
m
o
r
e
o
f
t
h
e
s
e
c
o
m
p
o
u
n
d
s
,
o
r
18-09-2016 09:55
30 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
m
i
x
t
u
r
e
s
o
f
t
h
e
s
e
c
o
m
p
o
u
n
d
s
,
a
r
e
b
e
i
n
g
i
d
e
n
t
i
f
i
e
d
a
s
p
e
s
t
c
o
n
t
r
o
l
a
g
e
18-09-2016 09:55
31 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
t
s
,
e
s
p
e
c
i
a
l
l
y
a
g
a
i
n
s
t
i
n
s
e
c
t
s
,
f
u
n
g
i
a
n
d
m
i
t
e
s
[
3
3
]
.
e
c
o
n
d
a
r
y
m
e
t
18-09-2016 09:55
32 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
b
o
l
i
t
e
s
c
a
n
b
e
c
l
a
s
s
i
f
i
e
d
a
c
c
o
r
d
i
n
g
t
o
t
h
e
i
r
c
h
e
m
i
c
a
l
s
t
r
u
c
t
u
r
e
,
c
o
18-09-2016 09:55
33 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
m
p
o
s
i
t
i
o
n
,
s
o
l
u
b
i
l
i
t
y
i
n
d
i
f
f
e
r
e
n
t
s
o
l
v
e
n
t
s
,
o
r
o
n
t
h
e
b
a
s
i
s
o
f
t
h
e
i
r
18-09-2016 09:55
34 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
y
n
t
h
e
s
i
s
p
a
t
h
w
a
y
.
A
s
i
m
p
l
e
c
l
a
s
s
i
f
i
c
a
t
i
o
n
,
b
a
s
e
d
o
n
c
h
e
m
i
c
a
l
s
t
r
u
c
18-09-2016 09:55
35 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
u
r
e
,
i
n
c
l
u
d
e
s
t
h
r
e
e
m
a
i
n
g
r
o
u
p
s
:
t
e
r
p
e
n
e
s
(
c
o
m
p
o
s
e
d
a
l
m
o
s
t
e
n
t
i
r
e
l
18-09-2016 09:55
36 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
o
f
c
a
r
b
o
n
a
n
d
h
y
d
r
o
g
e
n
a
n
d
i
n
c
l
u
d
i
n
g
p
l
a
n
t
v
o
l
a
t
i
l
e
s
,
c
a
r
d
i
a
c
g
l
y
c
o
18-09-2016 09:55
37 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
i
d
e
s
,
c
a
r
o
t
e
n
o
i
d
s
a
n
d
s
t
e
r
o
l
s
)
,
p
h
e
n
o
l
i
c
s
(
w
i
t
h
t
h
e
c
o
m
m
o
n
f
e
a
t
u
r
e
18-09-2016 09:55
38 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
f
h
a
v
i
n
g
o
n
e
o
r
m
o
r
e
p
h
e
n
o
l
r
i
n
g
s
a
n
d
i
n
c
l
u
d
i
n
g
p
h
e
n
o
l
i
c
a
c
i
d
s
,
c
o
u
m
a
18-09-2016 09:55
39 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
i
n
s
,
f
l
a
v
o
n
o
i
d
s
,
t
a
n
n
i
n
s
a
n
d
l
i
g
n
i
n
)
,
a
n
d
n
i
t
r
o
g
e
n
c
o
n
t
a
i
n
i
n
g
c
o
m
18-09-2016 09:55
40 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
p
o
u
n
d
s
(
e
x
t
r
e
m
e
l
y
d
i
v
e
r
s
e
,
i
n
c
l
u
d
i
n
g
a
l
k
a
l
o
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d
s
a
n
d
g
l
u
c
o
s
i
n
o
l
a
t
e
s
18-09-2016 09:55
41 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
)
.
l
k
a
l
o
i
d
s
a
r
e
t
h
e
m
o
s
t
c
o
m
m
o
n
b
i
o
l
o
g
i
c
a
l
l
y
a
c
t
i
v
e
c
o
m
p
o
u
n
d
s
w
i
t
h
i
18-09-2016 09:55
42 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
t
h
e
S
o
l
a
n
a
c
e
a
e
f
a
m
i
l
y
,
a
n
d
t
h
e
y
a
r
e
s
t
r
o
n
g
l
y
p
h
y
s
i
o
l
o
g
i
c
a
l
l
y
a
c
t
i
v
18-09-2016 09:55
43 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
i
n
m
a
m
m
a
l
s
,
i
n
c
l
u
d
i
n
g
h
u
m
a
n
s
.
T
h
e
e
f
f
e
c
t
s
o
f
t
h
e
s
e
p
l
a
n
t
s
c
a
n
r
a
n
g
e
f
18-09-2016 09:55
44 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
o
m
b
e
i
n
g
s
t
i
m
u
l
a
t
o
r
y
,
i
.
e
.
,
n
a
r
c
o
t
i
c
,
t
o
t
o
x
i
c
a
n
d
c
a
n
c
a
u
s
e
d
e
a
t
h
,
e
18-09-2016 09:55
45 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
v
e
n
i
n
v
e
r
y
l
o
w
d
o
s
e
s
[
3
4
,
3
5
,
3
6
]
.
T
o
m
a
t
o
a
n
d
p
o
t
a
t
o
a
r
e
t
h
e
b
e
s
t
k
n
o
w
n
a
18-09-2016 09:55
46 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
d
m
o
s
t
w
i
d
e
l
y
u
s
e
d
p
l
a
n
t
s
i
n
t
h
i
s
g
r
o
u
p
,
a
n
d
t
h
e
y
c
o
n
s
t
i
t
u
t
i
v
e
l
y
s
y
n
t
18-09-2016 09:55
47 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
h
e
s
i
z
e
l
o
w
l
e
v
e
l
s
o
f
m
a
n
y
d
i
f
f
e
r
e
n
t
g
l
y
c
o
a
l
k
a
l
o
i
d
s
.
H
o
w
e
v
e
r
,
u
n
d
e
r
s
18-09-2016 09:55
48 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
r
e
s
s
(
e
.
g
.
,
t
h
e
e
m
e
r
g
e
n
c
e
o
f
h
e
r
b
i
v
o
r
e
s
)
,
t
h
e
y
i
n
c
r
e
a
s
e
t
h
e
s
y
n
t
h
e
s
18-09-2016 09:55
49 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
s
o
f
t
h
e
s
e
c
o
m
p
o
u
n
d
s
,
a
n
d
i
n
t
h
e
c
a
s
e
o
f
p
o
t
a
t
o
(
S
o
l
a
n
u
m
t
u
b
e
r
o
s
u
m
)
,
g
18-09-2016 09:55
50 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
y
c
o
a
l
k
a
l
o
i
d
s
f
u
n
c
t
i
o
n
a
s
n
a
t
u
r
a
l
d
e
f
e
n
s
e
s
u
b
s
t
a
n
c
e
s
a
g
a
i
n
s
t
p
a
t
h
o
18-09-2016 09:55
51 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
e
n
s
a
n
d
i
n
s
e
c
t
s
[
3
7
]
.
T
h
e
c
o
m
m
o
n
p
o
t
a
t
o
c
o
n
t
a
i
n
s
t
w
o
m
a
j
o
r
t
o
x
i
c
s
t
e
r
18-09-2016 09:55
52 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
i
d
a
l
g
l
y
c
o
a
l
k
a
l
o
i
d
s
,
s
o
l
a
n
i
n
e
a
n
c
h
a
c
o
n
i
n
e
,
w
h
i
c
h
a
r
e
b
i
o
s
y
n
18-09-2016 09:55
53 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
h
e
t
i
c
a
l
l
y
d
e
r
i
v
e
d
f
r
o
m
c
h
o
l
e
s
t
e
r
o
l
,
[
3
8
]
a
n
d
b
o
t
h
a
r
e
n
o
r
m
a
l
l
y
p
r
e
s
18-09-2016 09:55
54 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
n
t
i
n
t
u
b
e
r
s
i
n
s
m
a
l
l
a
m
o
u
n
t
s
(
<
5
m
g
/
1
0
0
g
o
f
t
u
b
e
r
f
r
e
s
h
w
e
i
g
h
t
)
.
T
h
e
s
18-09-2016 09:55
55 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
n
a
t
u
r
a
l
t
o
x
i
c
a
n
t
s
(
s
t
r
e
s
s
m
e
t
a
b
o
l
i
t
e
s
)
h
a
v
e
i
n
s
e
c
t
i
c
i
d
a
l
a
n
d
f
u
n
g
18-09-2016 09:55
56 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
c
i
d
a
l
p
r
o
p
e
r
t
i
e
s
a
n
d
b
e
c
a
u
s
e
n
a
t
u
r
a
l
l
y
o
c
c
u
r
r
i
n
g
p
e
s
t
i
c
i
d
e
s
a
r
e
o
f
18-09-2016 09:55
57 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
e
n
s
y
n
t
h
e
s
i
z
e
d
w
h
e
n
p
l
a
n
t
s
a
r
e
u
n
d
e
r
s
t
r
e
s
s
,
i
n
j
u
r
e
d
p
l
a
n
t
t
i
s
s
u
e
s
i
18-09-2016 09:55
58 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
s
t
i
g
a
t
e
t
h
e
s
y
n
t
h
e
s
i
s
o
f
h
i
g
h
e
r
c
o
n
c
e
n
t
r
a
t
i
o
n
s
o
f
t
h
e
s
e
c
o
m
p
o
u
n
d
s
.
18-09-2016 09:55
59 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
H
l
y
w
k
a
e
t
a
l
.
[
3
9
]
f
o
u
n
d
t
h
a
t
t
u
b
e
r
s
f
r
o
m
p
l
a
n
t
s
s
u
b
j
e
c
t
e
d
t
o
d
e
f
o
l
i
a
t
18-09-2016 09:55
60 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
o
n
b
y
t
h
e
C
o
l
o
r
a
d
o
p
o
t
a
t
o
b
e
e
t
l
e
(
L
e
p
t
i
n
o
t
a
r
s
a
d
e
c
e
m
l
i
n
e
a
t
a
S
a
y
)
c
o
18-09-2016 09:55
61 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
t
a
i
n
e
d
h
i
g
h
e
r
g
l
y
c
o
a
l
k
a
l
o
i
d
c
o
n
c
e
n
t
r
a
t
i
o
n
s
t
h
a
n
t
u
b
e
r
s
f
r
o
m
c
o
n
t
r
18-09-2016 09:55
62 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
l
p
l
a
n
t
s
.
I
n
a
d
d
i
t
i
o
n
,
p
o
t
a
t
o
e
s
t
h
a
t
h
a
v
e
b
e
e
n
e
x
p
o
s
e
d
t
o
l
i
g
h
t
i
n
t
h
e
18-09-2016 09:55
63 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
i
e
l
d
o
r
d
u
r
i
n
g
s
t
o
r
a
g
e
m
a
y
b
e
c
o
m
e
g
r
e
e
n
d
u
e
t
o
a
n
a
c
c
u
m
u
l
a
t
i
o
n
o
f
c
h
l
o
18-09-2016 09:55
64 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
o
p
h
y
l
l
,
w
h
i
c
h
m
a
y
a
f
f
e
c
t
o
n
l
y
t
h
e
s
u
r
f
a
c
e
(
p
e
e
l
)
o
r
m
a
y
e
x
t
e
n
d
i
n
t
o
t
h
18-09-2016 09:55
65 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
f
l
e
s
h
.
E
x
p
o
s
u
r
e
t
o
l
i
g
h
t
i
s
o
n
l
y
o
n
e
o
f
t
h
e
s
t
r
e
s
s
f
a
c
t
o
r
s
a
f
f
e
c
t
i
n
g
p
18-09-2016 09:55
66 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
t
a
t
o
t
u
b
e
r
s
;
o
t
h
e
r
p
r
e
o
r
p
o
s
t
h
a
r
v
e
s
t
s
t
r
e
s
s
f
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m
e
c
h
18-09-2016 09:55
67 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
n
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a
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18-09-2016 09:55
68 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
p
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[
3
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s
18-09-2016 09:55
69 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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o
18-09-2016 09:55
70 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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G
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o
18-09-2016 09:55
71 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
l
k
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c
o
18-09-2016 09:55
72 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
t
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x
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t
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18-09-2016 09:55
73 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
74 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
h
e
p
o
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t
o
,
w
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[
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c
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t
i
v
18-09-2016 09:55
75 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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s
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s
t
h
18-09-2016 09:55
76 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
n
o
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s
[
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2
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1
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l
k
a
18-09-2016 09:55
77 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
o
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n
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t
18-09-2016 09:55
78 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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g
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18-09-2016 09:55
79 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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d
b
y
p
18-09-2016 09:55
80 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
a
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d
18-09-2016 09:55
81 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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p
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18-09-2016 09:55
82 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
m
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d
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k
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18-09-2016 09:55
83 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
,
a
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18-09-2016 09:55
84 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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18-09-2016 09:55
85 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
,
c
o
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[
4
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]
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h
e
18-09-2016 09:55
86 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
b
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s
18-09-2016 09:55
87 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
m
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l
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n
t
18-09-2016 09:55
88 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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n
a
l
k
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18-09-2016 09:55
89 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
p
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o
18-09-2016 09:55
90 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
d
s
,
g
l
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w
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r
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18-09-2016 09:55
91 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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t
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18-09-2016 09:55
92 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
a
n
d
d
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[
3
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]
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d
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18-09-2016 09:55
93 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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n
m
18-09-2016 09:55
94 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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t
h
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n
3
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18-09-2016 09:55
95 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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f
a
m
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l
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s
[
4
3
]
.
T
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18-09-2016 09:55
96 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
)
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a
18-09-2016 09:55
97 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
h
e
d
a
t
t
h
e
3
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4
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]
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18-09-2016 09:55
98 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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t
y
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,
18-09-2016 09:55
99 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
D
x
y
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s
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d
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18-09-2016 09:55
100 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
a
g
l
y
c
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e
s
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18-09-2016 09:55
101 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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f
p
s
18-09-2016 09:55
102 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
103 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
a
t
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p
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b
18-09-2016 09:55
104 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
s
e
d
o
n
t
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c
18-09-2016 09:55
105 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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18-09-2016 09:55
106 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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18-09-2016 09:55
107 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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18-09-2016 09:55
108 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
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18-09-2016 09:55
109 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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18-09-2016 09:55
110 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
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18-09-2016 09:55
111 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
112 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
113 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
114 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
115 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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18-09-2016 09:55
116 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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18-09-2016 09:55
117 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
.
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18-09-2016 09:55
118 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
m
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18-09-2016 09:55
119 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
120 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
121 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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18-09-2016 09:55
122 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
123 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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18-09-2016 09:55
124 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
)
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18-09-2016 09:55
125 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
126 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
127 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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18-09-2016 09:55
128 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
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18-09-2016 09:55
129 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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4
18-09-2016 09:55
130 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
7
]
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18-09-2016 09:55
131 of 1060
Abstract
Introduction
Metabolites
[
4
8
]
.
Metabolites as
Figure
1.
Structure
of
the
major
Directions
Acknowledgments
glycoalkalo
ids of the
potato,
References
eggplant
and
tomato:
aglycones
(a)
and
carbohydra
te moieties
(b).
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18-09-2016 09:55
132 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
133 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
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18-09-2016 09:55
134 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
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18-09-2016 09:55
135 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
h
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h
l
18-09-2016 09:55
136 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
c
k
s
a
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a
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[
4
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]
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18-09-2016 09:55
137 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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o
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18-09-2016 09:55
138 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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k
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18-09-2016 09:55
139 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
m
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c
o
m
18-09-2016 09:55
140 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
p
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d
s
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18-09-2016 09:55
141 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
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18-09-2016 09:55
142 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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18-09-2016 09:55
143 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
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18-09-2016 09:55
144 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
145 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
B
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18-09-2016 09:55
146 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
147 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
148 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
149 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
150 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
151 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
152 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
153 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
154 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
155 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
156 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
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18-09-2016 09:55
157 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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18-09-2016 09:55
158 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
159 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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18-09-2016 09:55
160 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
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18-09-2016 09:55
161 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
k
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18-09-2016 09:55
162 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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18-09-2016 09:55
163 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
164 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
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18-09-2016 09:55
165 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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18-09-2016 09:55
166 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
167 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
168 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
169 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
170 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
171 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
172 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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18-09-2016 09:55
173 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
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18-09-2016 09:55
174 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
175 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
176 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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18-09-2016 09:55
177 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
x
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18-09-2016 09:55
178 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
179 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
180 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
.
V
e
r
y
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n
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c
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18-09-2016 09:55
181 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
e
r
v
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d
,
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18-09-2016 09:55
182 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
-
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18-09-2016 09:55
183 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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18-09-2016 09:55
184 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
l
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)
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18-09-2016 09:55
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Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
f
p
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18-09-2016 09:55
186 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
187 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
a
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d
18-09-2016 09:55
188 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
v
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18-09-2016 09:55
189 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
i
n
s
e
c
t
s
,
p
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18-09-2016 09:55
190 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
h
a
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18-09-2016 09:55
191 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
o
n
f
e
c
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s
a
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d
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2
)
.
18-09-2016 09:55
192 of 1060
Figure 2.
A range of
Abstract
Introduction
toxic
effects of
Solanaceae
Metabolites
metabolite
s
on
various
Metabolites as
Directions
levels of
biological
organizati
Acknowledgments
on.
References
Table 1.
Reported
acute
and
subacute
effects of
Solanacea
e
pure
compou
nds on
insects.
Table
2.
Report
ed
acute
and
subacu
te
effects
of
Solanac
eae
extract
s
on
insects.
f
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t
s
18-09-2016 09:55
193 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
e
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18-09-2016 09:55
194 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
195 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
h
a
n
p
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d
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s
18-09-2016 09:55
196 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
s
[
5
4
,
5
5
]
.
T
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l
18-09-2016 09:55
197 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
a
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5
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,
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d
18-09-2016 09:55
198 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
s
t
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18-09-2016 09:55
199 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
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18-09-2016 09:55
200 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
201 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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m
18-09-2016 09:55
202 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
s
t
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m
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i
18-09-2016 09:55
203 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
a
l
p
o
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n
t
o
f
v
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w
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s
t
18-09-2016 09:55
204 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
o
l
u
t
i
o
n
.
A
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p
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r
18-09-2016 09:55
205 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
a
s
e
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n
s
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s
.
A
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c
o
18-09-2016 09:55
206 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
s
e
q
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e
,
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i
n
t
18-09-2016 09:55
207 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
h
e
e
x
p
o
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e
d
a
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s
,
s
u
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a
g
e
18-09-2016 09:55
208 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
t
s
s
h
o
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d
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s
.
S
18-09-2016 09:55
209 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
c
o
n
d
a
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p
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18-09-2016 09:55
210 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
c
e
d
b
y
p
l
a
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t
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a
18-09-2016 09:55
211 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
v
e
s
o
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n
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s
.
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s
t
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t
i
n
18-09-2016 09:55
212 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
t
h
e
i
r
a
n
t
i
f
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d
a
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n
f
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L
.
18-09-2016 09:55
213 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
e
c
e
m
l
i
n
e
a
t
a
,
T
r
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t
a
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m
(
H
e
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)
,
H
e
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p
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a
r
m
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g
e
r
a
18-09-2016 09:55
214 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
(
H
u
b
n
e
r
)
a
n
d
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1
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b
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e
2
)
.
H
o
18-09-2016 09:55
215 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
w
e
v
e
r
,
h
e
r
b
i
v
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l
s
p
r
o
d
18-09-2016 09:55
216 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
c
e
d
b
y
p
l
a
n
t
s
.
H
o
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t
a
l
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18-09-2016 09:55
217 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
218 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
219 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
220 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
221 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
222 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
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18-09-2016 09:55
223 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
224 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
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18-09-2016 09:55
225 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
226 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
227 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
228 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
229 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
230 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
231 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
232 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
233 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
234 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
235 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
236 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
237 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
238 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
239 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
240 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
241 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
242 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
243 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
244 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
245 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
246 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
247 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
248 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
249 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
250 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
251 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
252 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
253 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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18-09-2016 09:55
254 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
255 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
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18-09-2016 09:55
256 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
257 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
258 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
259 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
260 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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18-09-2016 09:55
261 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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18-09-2016 09:55
262 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
263 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
264 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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18-09-2016 09:55
265 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
266 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
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18-09-2016 09:55
267 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
268 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
269 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
270 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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18-09-2016 09:55
271 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
m
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m
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18-09-2016 09:55
272 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
273 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
l
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18-09-2016 09:55
274 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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18-09-2016 09:55
275 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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4
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]
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18-09-2016 09:55
276 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
277 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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18-09-2016 09:55
278 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
279 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
280 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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18-09-2016 09:55
281 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
282 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
283 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
284 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
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18-09-2016 09:55
285 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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18-09-2016 09:55
286 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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18-09-2016 09:55
287 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
288 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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18-09-2016 09:55
289 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
290 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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18-09-2016 09:55
291 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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l
s
t
r
a
t
e
g
i
e
s
[
6
8
]
.
e
s
e
c
o
n
d
c
e
l
l
u
l
a
r
m
e
t
a
b
o
l
i
c
p
a
t
h
w
a
y
t
h
18-09-2016 09:55
292 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
t
i
s
a
f
f
e
c
t
e
d
b
y
a
v
a
r
i
e
t
y
o
f
a
l
l
e
l
o
c
h
e
m
i
c
a
l
s
,
i
n
c
l
u
d
i
n
g
a
l
k
a
l
o
i
d
s
,
18-09-2016 09:55
293 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
s
t
h
e
a
n
t
i
o
x
i
d
a
n
t
s
y
s
t
e
m
.
A
l
k
a
l
o
i
d
s
,
a
f
t
e
r
p
e
n
e
t
r
a
t
i
n
g
a
n
o
r
g
a
n
i
s
m
18-09-2016 09:55
294 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
,
l
e
a
d
t
o
t
h
e
g
e
n
e
r
a
t
i
o
n
o
f
r
e
a
c
t
i
v
e
o
x
y
g
e
n
s
p
e
c
i
e
s
(
R
O
S
)
,
w
h
i
c
h
c
a
u
s
e
18-09-2016 09:55
295 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
x
i
d
a
t
i
v
e
s
t
r
e
s
s
t
h
a
t
r
e
s
u
l
t
s
i
n
p
r
o
c
e
s
s
e
s
s
u
c
h
a
s
t
h
e
p
e
r
o
x
i
d
a
t
i
o
n
o
18-09-2016 09:55
296 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
m
e
m
b
r
a
n
e
l
i
p
i
d
s
,
t
h
e
d
i
s
r
u
p
t
i
o
n
o
f
m
i
t
o
c
h
o
n
d
r
i
a
l
m
e
m
b
r
a
n
e
p
o
t
e
n
t
i
18-09-2016 09:55
297 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
l
o
r
p
r
o
t
e
i
n
d
a
m
a
g
e
.
T
h
e
g
e
n
e
r
a
t
i
o
n
o
f
R
O
S
p
r
o
m
o
t
e
s
a
n
t
i
o
x
i
d
a
n
t
m
e
c
h
18-09-2016 09:55
298 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
n
i
s
m
s
s
u
c
h
a
s
t
h
e
a
c
t
i
v
a
t
i
o
n
o
f
t
h
e
a
n
t
i
o
x
i
d
a
n
t
e
n
z
y
m
e
s
g
l
u
t
a
t
h
i
o
n
e
18-09-2016 09:55
299 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
S
t
r
a
n
f
e
r
a
s
e
(
G
S
T
)
,
c
a
t
a
l
a
s
e
o
r
s
u
p
e
r
o
x
i
d
e
d
i
s
m
u
t
a
s
e
[
6
9
]
.
e
c
e
n
t
l
18-09-2016 09:55
300 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
,
w
e
r
e
p
o
r
t
e
d
t
h
a
t
d
i
e
t
a
r
y
s
o
l
a
n
i
n
e
t
r
e
a
t
m
e
n
t
s
i
n
f
l
u
e
n
c
e
t
h
e
b
i
o
l
18-09-2016 09:55
301 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
g
i
c
a
l
f
i
t
n
e
s
s
o
f
w
a
x
m
o
t
h
,
G
a
l
l
e
r
i
a
m
e
l
l
o
n
e
l
l
a
(
L
.
)
,
l
a
r
v
a
e
[
2
3
,
6
9
]
18-09-2016 09:55
302 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
,
a
n
d
t
h
e
m
e
c
h
a
n
i
s
m
a
p
p
e
a
r
s
t
o
b
e
r
e
l
a
t
e
d
t
o
t
h
e
e
f
f
e
c
t
s
o
s
o
l
a
n
i
n
e
18-09-2016 09:55
303 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
n
d
u
c
e
d
o
x
i
d
a
t
i
v
e
s
t
r
e
s
s
o
n
t
h
e
a
n
t
i
o
x
i
d
a
n
t
s
y
s
t
e
m
s
,
a
s
s
h
o
w
n
b
y
t
h
e
i
18-09-2016 09:55
304 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
f
l
u
e
n
c
e
o
f
t
h
i
s
g
l
y
c
o
a
l
k
a
l
o
i
d
o
n
m
a
l
o
n
d
i
a
l
d
e
h
y
d
e
(
M
D
A
)
a
n
d
p
r
o
t
e
i
n
18-09-2016 09:55
305 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
a
r
b
o
n
y
l
(
P
C
O
)
c
o
n
t
e
n
t
s
,
c
h
a
n
g
e
s
i
n
G
S
T
e
n
z
y
m
e
a
c
t
i
v
i
t
y
,
a
n
d
d
e
c
l
i
n
e
18-09-2016 09:55
306 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
i
n
i
m
p
o
r
t
a
n
t
l
i
f
e
-
t
a
b
l
e
p
a
r
a
m
e
t
e
r
s
.
L
i
p
i
d
p
e
r
o
x
i
d
a
t
i
o
n
a
n
d
p
r
o
t
e
i
18-09-2016 09:55
307 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
c
a
r
b
o
n
y
l
a
t
i
o
n
l
e
v
e
l
s
,
a
s
m
e
a
s
u
r
e
d
b
y
M
D
A
a
n
d
P
C
O
c
o
n
c
e
n
t
r
a
t
i
o
n
s
,
v
a
18-09-2016 09:55
308 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
y
a
c
r
o
s
s
t
i
s
s
u
e
s
a
n
s
o
l
a
n
i
n
e
c
o
n
c
e
n
t
r
a
t
i
o
n
s
,
r
e
s
p
e
c
t
i
v
e
l
y
.
B
a
s
18-09-2016 09:55
309 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
d
o
n
s
t
u
d
i
e
s
o
f
i
n
s
e
c
t
s
p
e
c
i
e
s
e
x
p
o
s
e
d
t
o
p
r
o
o
x
i
d
a
n
t
a
l
l
e
l
o
c
h
e
m
i
c
a
18-09-2016 09:55
310 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
s
[
7
0
,
7
1
,
7
2
,
7
3
]
,
w
e
c
a
n
s
p
e
c
u
l
a
t
e
t
h
a
t
t
h
e
s
o
l
a
n
i
n
e
i
n
d
u
c
e
d
M
D
A
a
18-09-2016 09:55
311 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
d
P
C
O
c
o
n
t
e
n
t
i
n
t
h
e
m
i
d
g
u
t
a
n
d
f
a
t
b
o
d
y
f
o
l
l
o
w
e
d
f
r
o
m
R
O
S
p
r
o
d
u
c
t
i
o
n
a
18-09-2016 09:55
312 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
d
r
e
d
u
c
e
d
n
o
n
e
n
z
y
m
a
t
i
c
p
r
o
t
e
c
t
i
o
n
f
r
o
m
p
r
o
o
x
i
d
a
n
t
s
d
u
r
i
n
g
e
x
p
o
s
18-09-2016 09:55
313 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
r
e
t
o
s
o
l
a
n
i
n
e
.
D
e
c
r
e
a
s
e
d
G
S
T
a
c
t
i
v
i
t
i
e
s
i
n
t
h
e
f
a
t
b
o
d
y
a
n
d
i
n
c
r
e
a
18-09-2016 09:55
314 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
e
d
G
S
T
a
c
t
i
v
i
t
i
e
s
i
n
m
i
d
g
u
t
t
i
s
s
u
e
a
r
e
c
o
n
s
i
s
t
e
n
t
w
i
t
h
i
n
c
r
e
a
s
e
d
r
a
t
18-09-2016 09:55
315 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
s
o
f
a
d
a
p
t
i
v
e
m
e
t
a
b
o
l
i
c
r
e
s
p
o
n
s
e
s
t
o
e
l
e
v
a
t
e
d
l
i
p
i
d
p
e
r
o
x
i
d
a
t
i
o
n
a
n
18-09-2016 09:55
316 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
p
r
o
t
e
i
n
o
x
i
d
a
t
i
o
n
[
2
3
]
.
H
o
w
e
v
e
r
,
t
h
e
m
i
d
g
u
t
s
e
e
m
s
t
o
b
e
r
e
l
a
t
i
v
e
l
y
r
18-09-2016 09:55
317 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
s
i
s
t
a
n
t
t
o
v
a
r
i
o
u
s
x
e
n
o
b
i
o
t
i
c
s
,
a
n
d
w
e
p
r
e
v
i
o
u
s
l
y
s
h
o
w
e
d
t
h
a
t
m
i
d
g
u
18-09-2016 09:55
318 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
c
e
l
l
s
p
r
e
s
e
n
t
a
l
o
w
e
r
l
e
v
e
l
o
f
m
a
l
f
o
r
m
a
t
i
o
n
s
,
w
i
t
h
a
l
o
w
e
r
i
n
c
r
e
a
s
e
i
18-09-2016 09:55
319 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
a
n
t
i
o
x
i
d
a
n
t
e
n
z
y
m
e
a
c
t
i
v
i
t
i
e
s
,
t
h
a
n
t
h
e
f
a
t
b
o
d
y
,
w
h
i
c
h
s
h
o
w
e
d
m
u
c
h
18-09-2016 09:55
320 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
m
o
r
e
i
n
t
e
n
s
i
v
e
m
a
l
f
o
r
m
a
t
i
o
n
s
,
e
v
e
n
t
h
o
u
g
h
t
h
e
a
c
t
i
v
i
t
y
o
f
t
h
e
a
n
t
i
o
x
18-09-2016 09:55
321 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
d
a
n
t
e
n
z
y
m
e
s
w
a
s
h
i
g
h
e
r
t
h
a
n
i
n
t
h
e
g
u
t
[
2
3
]
.
W
e
t
h
i
n
k
t
h
a
t
t
h
i
s
p
h
e
n
o
m
18-09-2016 09:55
322 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
n
o
n
i
s
c
o
n
n
e
c
t
e
d
t
o
t
h
e
r
e
l
a
t
i
v
e
l
y
s
h
o
r
t
e
x
p
o
s
u
r
e
t
i
m
e
t
o
x
e
n
o
b
i
o
t
i
c
18-09-2016 09:55
323 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
i
n
m
o
v
i
n
g
f
o
o
d
a
n
d
t
h
e
r
a
p
i
d
t
r
a
n
s
f
e
r
a
c
r
o
s
s
t
h
e
g
u
t
t
o
o
t
h
e
r
o
r
g
a
n
s
.
18-09-2016 09:55
324 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
h
e
m
e
c
h
a
n
i
s
m
o
f
d
a
m
a
g
e
m
a
y
b
e
a
q
u
a
n
t
i
t
a
t
i
v
e
i
s
s
u
e
i
n
w
h
i
c
h
t
h
e
a
m
o
u
n
t
s
18-09-2016 09:55
325 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
f
p
r
o
o
x
i
d
a
n
t
s
i
n
t
h
e
d
i
e
t
s
a
p
p
e
a
r
t
o
o
v
e
r
t
a
k
e
t
h
e
p
r
o
t
e
c
t
i
v
e
m
e
c
h
a
n
18-09-2016 09:55
326 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
s
m
s
,
l
e
a
d
i
n
g
t
o
l
o
n
g
t
e
r
m
o
x
i
d
a
t
i
v
e
s
t
r
e
s
s
.
H
o
w
e
v
e
r
,
K
r
i
s
h
n
a
n
a
n
d
S
18-09-2016 09:55
327 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
h
n
a
l
[
7
2
]
d
i
d
n
o
t
o
b
s
e
r
v
e
s
i
g
n
i
f
i
c
a
n
t
a
l
t
e
r
a
t
i
o
n
s
t
o
a
n
t
i
o
x
i
d
a
n
t
d
e
18-09-2016 09:55
328 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
e
n
s
e
s
y
s
t
e
m
s
i
n
t
h
e
g
u
t
o
f
S
p
o
d
o
p
t
e
r
a
l
i
t
t
o
r
a
l
i
s
e
x
p
o
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18-09-2016 09:55
329 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
330 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
331 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
332 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
333 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
334 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
335 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
336 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
337 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
338 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
339 of 1060
Abstract
Introduction
Metabolites
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Directions
Acknowledgments
References
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18-09-2016 09:55
340 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
341 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
342 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
343 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
344 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
345 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
346 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
347 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
348 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
349 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
350 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
351 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
352 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
353 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
354 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
355 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
356 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
357 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
358 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
359 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
360 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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18-09-2016 09:55
361 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
362 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
363 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
364 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
365 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
366 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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b
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f
f
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c
t
s
,
a
18-09-2016 09:55
367 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
d
a
l
t
h
o
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g
h
a
c
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c
t
i
o
n
o
18-09-2016 09:55
368 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
h
a
r
v
e
s
t
e
d
p
l
a
n
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s
a
g
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r
y
i
m
p
18-09-2016 09:55
369 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
r
t
a
n
t
.
S
u
c
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f
f
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a
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s
i
n
e
x
p
o
s
18-09-2016 09:55
370 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
d
p
o
p
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l
a
t
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s
b
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.
F
o
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x
a
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p
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e
,
a
d
e
c
r
e
a
s
18-09-2016 09:55
371 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
i
n
t
h
e
n
u
m
b
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f
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g
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e
n
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x
t
g
e
18-09-2016 09:55
372 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
e
r
a
t
i
o
n
,
s
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p
e
s
t
s
18-09-2016 09:55
373 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
n
c
r
e
a
s
e
s
,
w
h
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c
h
m
a
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.
M
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l
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d
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s
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o
f
t
e
n
w
e
a
18-09-2016 09:55
374 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
k
e
r
,
c
a
n
n
o
t
s
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c
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f
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p
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d
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t
o
r
s
,
a
n
d
18-09-2016 09:55
375 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
r
e
m
o
r
e
s
u
s
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p
t
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a
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s
.
F
u
r
t
h
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r
m
o
r
e
,
w
e
18-09-2016 09:55
376 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
k
e
f
f
e
c
t
s
o
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s
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r
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d
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n
v
i
r
o
n
18-09-2016 09:55
377 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
m
e
n
t
a
l
c
o
n
d
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t
i
o
n
s
.
H
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n
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s
m
a
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p
l
a
y
i
m
p
o
18-09-2016 09:55
378 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
t
a
n
t
r
o
l
e
s
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s
p
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n
t
h
e
u
s
18-09-2016 09:55
379 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
o
f
t
h
e
c
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e
m
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l
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n
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,
w
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l
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d
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h
i
g
h
c
o
n
c
e
18-09-2016 09:55
380 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
t
r
a
t
i
o
n
s
,
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s
p
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s
p
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e
s
.
18-09-2016 09:55
381 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
s
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m
p
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t
a
n
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c
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a
l
a
n
d
s
u
b
18-09-2016 09:55
382 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
e
t
h
a
l
e
f
f
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c
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s
;
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o
u
s
18-09-2016 09:55
383 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
f
f
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c
t
s
a
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e
s
t
h
a
t
m
18-09-2016 09:55
384 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
y
a
c
t
s
y
n
e
r
g
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s
t
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c
a
l
l
y
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d
f
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H
e
l
i
x
a
s
p
18-09-2016 09:55
385 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
r
s
a
s
n
a
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l
s
,
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w
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f
f
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t
i
v
e
18-09-2016 09:55
386 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
y
t
h
a
n
s
o
l
u
t
i
o
n
s
o
f
p
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g
l
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k
a
l
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d
s
[
1
5
7
]
.
S
y
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r
g
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s
m
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s
n
o
t
l
i
m
i
18-09-2016 09:55
387 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
e
d
t
o
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n
c
r
e
a
s
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b
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o
m
p
o
n
e
n
t
18-09-2016 09:55
388 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
o
f
e
x
t
r
a
c
t
s
.
T
a
k
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l
.
[
1
5
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]
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o
m
p
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n
e
n
18-09-2016 09:55
389 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
s
i
s
a
l
s
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b
e
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t
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.
M
o
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o
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,
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n
d
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v
i
d
18-09-2016 09:55
390 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
a
l
c
o
m
p
o
u
n
d
s
c
a
n
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v
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b
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a
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l
y
[
1
5
9
]
.
F
o
r
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n
s
18-09-2016 09:55
391 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
a
n
c
e
C
h
a
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g
[
18-09-2016 09:55
392 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
2
5
,
1
0
1
,
1
1
2
,
1
6
0
]
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2
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,
2
3
,
2
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]
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a
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f
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c
t
i
18-09-2016 09:55
393 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
n
a
n
d
a
l
t
e
r
e
n
z
y
m
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[
2
3
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]
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s
[
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1
3
]
,
b
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t
t
h
e
18-09-2016 09:55
394 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
m
o
u
n
t
o
f
e
a
c
h
o
f
t
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e
f
f
e
c
t
v
18-09-2016 09:55
395 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
r
i
e
s
[
1
6
0
]
.
T
h
e
s
a
m
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s
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o
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v
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d
w
h
e
n
18-09-2016 09:55
396 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
S
o
l
a
n
u
m
s
p
p
.
e
x
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1
3
3
,
1
4
5
,
1
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8
,
1
4
9
,
1
5
2
]
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b
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t
a
u
t
h
o
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s
18-09-2016 09:55
397 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
s
u
a
l
l
y
r
e
p
o
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o
n
l
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s
a
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s
c
o
n
s
i
d
18-09-2016 09:55
398 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
r
e
d
t
h
e
m
o
s
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p
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.
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u
s
s
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t
a
n
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s
p
r
18-09-2016 09:55
399 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
s
e
n
t
i
n
e
x
t
r
a
c
t
s
m
a
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n
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x
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c
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f
f
e
c
t
s
.
o
x
18-09-2016 09:55
400 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
c
i
t
y
t
e
s
t
s
o
f
p
l
a
n
t
e
x
t
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s
o
f
s
e
a
r
c
h
18-09-2016 09:55
401 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
n
g
f
o
r
n
e
w
,
a
c
t
i
v
e
s
u
b
s
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d
a
n
d
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s
e
d
c
o
m
m
e
r
18-09-2016 09:55
402 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
i
a
l
l
y
i
n
t
h
e
f
u
t
u
r
e
.
T
h
e
s
t
a
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d
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p
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d
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a
d
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t
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h
e
d
i
s
c
o
v
e
18-09-2016 09:55
403 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
y
o
f
n
e
w
i
n
s
e
c
t
i
c
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d
e
s
c
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s
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s
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n
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s
s
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e
p
s
.
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,
18-09-2016 09:55
404 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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f
18-09-2016 09:55
405 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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18-09-2016 09:55
406 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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18-09-2016 09:55
407 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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18-09-2016 09:55
408 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
409 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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g
18-09-2016 09:55
410 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
411 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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t
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18-09-2016 09:55
412 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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18-09-2016 09:55
413 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
414 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
415 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
416 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
m
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18-09-2016 09:55
417 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
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18-09-2016 09:55
418 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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18-09-2016 09:55
419 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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18-09-2016 09:55
420 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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18-09-2016 09:55
421 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
N
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18-09-2016 09:55
422 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
423 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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18-09-2016 09:55
424 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
v
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18-09-2016 09:55
425 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
426 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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18-09-2016 09:55
427 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
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18-09-2016 09:55
428 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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n
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18-09-2016 09:55
429 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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.
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18-09-2016 09:55
430 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
w
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s
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18-09-2016 09:55
431 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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n
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18-09-2016 09:55
432 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
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d
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18-09-2016 09:55
433 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
g
a
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c
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18-09-2016 09:55
434 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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t
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18-09-2016 09:55
435 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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s
18-09-2016 09:55
436 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
437 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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H
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18-09-2016 09:55
438 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
v
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n
d
18-09-2016 09:55
439 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
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p
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d
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l
l
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18-09-2016 09:55
440 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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e
d
,
t
h
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18-09-2016 09:55
441 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
442 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
443 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
444 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
445 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
446 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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N
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18-09-2016 09:55
447 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
x
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18-09-2016 09:55
448 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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18-09-2016 09:55
449 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
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18-09-2016 09:55
450 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
451 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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p
l
18-09-2016 09:55
452 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
453 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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l
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18-09-2016 09:55
454 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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t
18-09-2016 09:55
455 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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F
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18-09-2016 09:55
456 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
,
o
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D
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18-09-2016 09:55
457 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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r
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18-09-2016 09:55
458 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
s
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d
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o
n
o
18-09-2016 09:55
459 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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18-09-2016 09:55
460 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
461 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
,
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t
o
18-09-2016 09:55
462 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
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s
18-09-2016 09:55
463 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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H
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18-09-2016 09:55
464 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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s
18-09-2016 09:55
465 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
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18-09-2016 09:55
466 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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,
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18-09-2016 09:55
467 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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s
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18-09-2016 09:55
468 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
469 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
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18-09-2016 09:55
470 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
471 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
472 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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m
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18-09-2016 09:55
473 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
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,
18-09-2016 09:55
474 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
h
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S
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o
m
18-09-2016 09:55
475 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
m
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s
18-09-2016 09:55
476 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
e
p
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t
h
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,
S
18-09-2016 09:55
477 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
l
a
n
u
m
,
L
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c
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g
g
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e
r
18-09-2016 09:55
478 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
,
a
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18-09-2016 09:55
479 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
.
T
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18-09-2016 09:55
480 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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.
T
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t
18-09-2016 09:55
481 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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m
y
18-09-2016 09:55
482 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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s
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18-09-2016 09:55
483 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
p
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18-09-2016 09:55
484 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
485 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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18-09-2016 09:55
486 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
d
H
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18-09-2016 09:55
487 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
h
s
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18-09-2016 09:55
488 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
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G
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z
18-09-2016 09:55
489 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
R
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s
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s
k
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c
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18-09-2016 09:55
490 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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k
g
18-09-2016 09:55
491 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
l
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n
d
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k
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18-09-2016 09:55
492 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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d
s
o
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L
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S
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n
o
,
18-09-2016 09:55
493 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
E
m
a
n
u
e
l
l
a
V
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F
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B
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18-09-2016 09:55
494 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
t
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o
n
t
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l
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C
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l
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18-09-2016 09:55
495 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
s
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I
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18-09-2016 09:55
496 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
s
h
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d
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o
18-09-2016 09:55
497 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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n
t
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18-09-2016 09:55
498 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
d
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P
18-09-2016 09:55
499 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
a
c
t
i
c
e
:
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o
18-09-2016 09:55
500 of 1060
n
;
Abstract
F
A
O
Introduction
Metabolites
:
R
o
Metabolites as
Directions
m
e
,
Acknowledgments
I
t
a
References
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2
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18-09-2016 09:55
501 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
e
:
D
a
m
a
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o
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P
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h
18-09-2016 09:55
502 of 1060
o
l
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
3.
a
r
]
N
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.
M
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:
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18-09-2016 09:55
503 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
h
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s
p
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t
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f
18-09-2016 09:55
504 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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s
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18-09-2016 09:55
505 of 1060
C
r
Abstract
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s
s
Introduction
Metabolites
R
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]
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References
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d
]
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18-09-2016 09:55
506 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
D
.
;
S
h
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;
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o
18-09-2016 09:55
507 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
t
h
e
w
o
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l
m
a
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:
18-09-2016 09:55
508 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
P
l
u
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e
l
l
i
d
a
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)
:
J
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2
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1
18-09-2016 09:55
509 of 1060
2
,
Abstract
1
0
5
Introduction
Metabolites
,
1
1
Metabolites as
Directions
1
5
Acknowledgments
1
1
2
References
9
.
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P
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5.
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]
W
H
O
.
W
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l
18-09-2016 09:55
510 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
M
a
l
a
r
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a
R
e
p
o
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t
2
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3
;
W
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O
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:
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18-09-2016 09:55
511 of 1060
,
2
Abstract
0
1
3
Introduction
Metabolites
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.
1
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2
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5
References
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18-09-2016 09:55
512 of 1060
N
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Abstract
w
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n
Introduction
Metabolites
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2
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D
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d
18-09-2016 09:55
513 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
r
e
c
t
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m
p
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o
f
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:
A
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o
18-09-2016 09:55
514 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
r
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e
a
g
r
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.
2
0
0
8
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6
4
,
1
0
6
18-09-2016 09:55
515 of 1060
Abstract
1
0
7
Introduction
Metabolites
3
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Metabolites as
Directions
G
o
o
Acknowledgments
g
l
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References
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C
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s
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f
]
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P
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18-09-2016 09:55
516 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
517 of 1060
Abstract
Introduction
Metabolites
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18-09-2016 09:55
518 of 1060
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18-09-2016 09:55
519 of 1060
Abstract
Introduction
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18-09-2016 09:55
520 of 1060
Abstract
Introduction
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18-09-2016 09:55
522 of 1060
Abstract
Introduction
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523 of 1060
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18-09-2016 09:55
524 of 1060
Abstract
Introduction
Metabolites
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18-09-2016 09:55
525 of 1060
Abstract
Introduction
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Acknowledgments
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18-09-2016 09:55
526 of 1060
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18-09-2016 09:55
527 of 1060
Abstract
Introduction
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18-09-2016 09:55
528 of 1060
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References
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18-09-2016 09:55
529 of 1060
Abstract
Introduction
Metabolites
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18-09-2016 09:55
530 of 1060
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18-09-2016 09:55
531 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
References
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18-09-2016 09:55
532 of 1060
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18-09-2016 09:55
533 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
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18-09-2016 09:55
534 of 1060
Abstract
Introduction
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Acknowledgments
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18-09-2016 09:55
535 of 1060
Abstract
Introduction
Metabolites
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Directions
Acknowledgments
References
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18-09-2016 09:55
536 of 1060
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Acknowledgments
References
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18-09-2016 09:55
537 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
538 of 1060
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18-09-2016 09:55
539 of 1060
Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
540 of 1060
Abstract
Introduction
Metabolites
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541 of 1060
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18-09-2016 09:55
542 of 1060
Abstract
Introduction
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References
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18-09-2016 09:55
543 of 1060
Abstract
Introduction
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Acknowledgments
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18-09-2016 09:55
544 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
545 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
References
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18-09-2016 09:55
546 of 1060
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18-09-2016 09:55
547 of 1060
Abstract
Introduction
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References
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18-09-2016 09:55
548 of 1060
Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
549 of 1060
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18-09-2016 09:55
550 of 1060
Abstract
Introduction
Metabolites
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Directions
Acknowledgments
References
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18-09-2016 09:55
551 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
References
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18-09-2016 09:55
552 of 1060
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Introduction
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18-09-2016 09:55
553 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
554 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
555 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
556 of 1060
o
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Abstract
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Introduction
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18-09-2016 09:55
557 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
558 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
559 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
560 of 1060
o
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1
3
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2
9
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18-09-2016 09:55
561 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
562 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
563 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
564 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
565 of 1060
b
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Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
24.
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18-09-2016 09:55
566 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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18-09-2016 09:55
567 of 1060
o
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Abstract
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Introduction
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References
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18-09-2016 09:55
568 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
569 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
s
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18-09-2016 09:55
570 of 1060
C
r
Abstract
o
s
s
Introduction
Metabolites
R
e
f
Metabolites as
Directions
Acknowledgments
References
26.
C
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a
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C
.
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A
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R
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18-09-2016 09:55
571 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
l
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18-09-2016 09:55
572 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
m
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18-09-2016 09:55
573 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
,
D
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t
y
o
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18-09-2016 09:55
574 of 1060
8
,
Abstract
1
7
2
Introduction
Metabolites
1
7
Metabolites as
Directions
5
.
[
Acknowledgments
G
o
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References
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l
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S
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27.
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]
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;
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V
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;
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18-09-2016 09:55
575 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
,
P
.
T
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e
p
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a
t
18-09-2016 09:55
576 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
v
e
t
o
c
h
e
m
i
c
a
l
i
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s
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)
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A
18-09-2016 09:55
577 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
e
v
i
e
w
.
J
.
V
e
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t
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r
B
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e
D
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s
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P
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M
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]
18-09-2016 09:55
578 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
28.
L
e
e
,
M
.
R
.
S
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V
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.
J
.
R
18-09-2016 09:55
579 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
.
C
o
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l
.
P
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s
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]
18-09-2016 09:55
580 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
29.
L
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e
,
M
.
R
.
T
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e
S
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s
E
18-09-2016 09:55
581 of 1060
d
i
Abstract
n
b
.
Introduction
Metabolites
2
0
0
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Directions
6
,
3
Acknowledgments
6
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1
References
6
2
1
6
9
.
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P
l
a
18-09-2016 09:55
582 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
t
s
o
u
r
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e
s
o
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U
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o
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g
18-09-2016 09:55
583 of 1060
l
e
Abstract
S
c
h
Introduction
Metabolites
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a
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Directions
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]
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Acknowledgments
C
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References
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s
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]
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P
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]
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;
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,
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D
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s
i
18-09-2016 09:55
584 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
585 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
r
a
L
e
o
n
e
.
B
i
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.
A
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H
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18-09-2016 09:55
586 of 1060
o
s
Abstract
s
R
e
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
32.
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]
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a
i
18-09-2016 09:55
587 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
s
,
L
.
;
L
o
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m
i
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a
l
18-09-2016 09:55
588 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
p
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d
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b
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:
A
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5
3
4
7
18-09-2016 09:55
589 of 1060
.
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Abstract
G
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Introduction
Metabolites
g
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e
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References
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]
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18-09-2016 09:55
590 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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18-09-2016 09:55
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18-09-2016 09:55
592 of 1060
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18-09-2016 09:55
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18-09-2016 09:55
595 of 1060
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18-09-2016 09:55
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18-09-2016 09:55
597 of 1060
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18-09-2016 09:55
599 of 1060
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18-09-2016 09:55
600 of 1060
Abstract
Introduction
Metabolites
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18-09-2016 09:55
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18-09-2016 09:55
602 of 1060
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18-09-2016 09:55
603 of 1060
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18-09-2016 09:55
604 of 1060
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Introduction
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18-09-2016 09:55
605 of 1060
Abstract
Introduction
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Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
606 of 1060
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18-09-2016 09:55
607 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
References
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18-09-2016 09:55
608 of 1060
Abstract
Introduction
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Acknowledgments
References
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18-09-2016 09:55
609 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
610 of 1060
Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
611 of 1060
Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
612 of 1060
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18-09-2016 09:55
613 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
614 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
615 of 1060
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18-09-2016 09:55
616 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
617 of 1060
Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
References
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M
.
F
.
,
W
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18-09-2016 09:55
618 of 1060
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References
43.
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18-09-2016 09:55
619 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
620 of 1060
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18-09-2016 09:55
621 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
622 of 1060
Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
References
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18-09-2016 09:55
623 of 1060
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References
45.
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18-09-2016 09:55
624 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
References
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18-09-2016 09:55
625 of 1060
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18-09-2016 09:55
626 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
References
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.
;
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18-09-2016 09:55
627 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
References
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18-09-2016 09:55
628 of 1060
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References
47.
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18-09-2016 09:55
629 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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18-09-2016 09:55
630 of 1060
G
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Abstract
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Metabolites
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18-09-2016 09:55
631 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
632 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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18-09-2016 09:55
633 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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18-09-2016 09:55
634 of 1060
M
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Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
References
49.
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]
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18-09-2016 09:55
635 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
636 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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9
18-09-2016 09:55
637 of 1060
Abstract
1
4
0
Introduction
Metabolites
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.
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Metabolites as
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Acknowledgments
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References
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18-09-2016 09:55
638 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
639 of 1060
c
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Abstract
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m
i
Introduction
Metabolites
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18-09-2016 09:55
640 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
;
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18-09-2016 09:55
641 of 1060
Abstract
5
0
.
Introduction
Metabolites
[
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r
18-09-2016 09:55
642 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
p
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;
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G
.
18-09-2016 09:55
643 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
A
.
,
E
d
.
;
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:
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18-09-2016 09:55
644 of 1060
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Introduction
Metabolites
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S
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Acknowledgments
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r
References
53.
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.
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18-09-2016 09:55
645 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
t
s
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18-09-2016 09:55
646 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
e
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18-09-2016 09:55
647 of 1060
e
d
Abstract
.
E
F
Introduction
Metabolites
S
A
J
Metabolites as
Directions
.
2
0
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0
8
,
References
6
9
1
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,
18-09-2016 09:55
648 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
J
.
A
.
;
K
e
m
p
e
r
,
J
.
;
T
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,
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.
;
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o
,
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.
;
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.
P
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18-09-2016 09:55
649 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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18-09-2016 09:55
650 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
r
e
g
a
t
a
(
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18-09-2016 09:55
651 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
e
s
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)
(
H
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9
8
6
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3
1
9
18-09-2016 09:55
652 of 1060
Abstract
3
2
8
Introduction
Metabolites
.
[
G
Metabolites as
Directions
o
o
g
Acknowledgments
l
e
S
References
c
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]
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,
P
.
L
.
N
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t
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e
18-09-2016 09:55
653 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
s
p
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s
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l
o
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i
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a
l
18-09-2016 09:55
654 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
o
n
t
r
o
l
a
n
d
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s
i
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s
.
I
18-09-2016 09:55
655 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
B
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t
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P
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A
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l
t
18-09-2016 09:55
656 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
r
e
;
U
p
a
d
h
y
a
y
,
R
.
K
.
,
M
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k
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r
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.
G
.
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.
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d
s
.
;
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p
r
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n
g
e
r
S
c
18-09-2016 09:55
657 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
e
n
c
e
&
B
u
s
i
n
e
s
s
M
e
d
i
a
N
e
w
Y
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:
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Y
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A
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0
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1
.
[
G
o
o
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S
c
h
o
l
18-09-2016 09:55
658 of 1060
a
r
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
56.
E
v
a
n
g
e
l
i
s
t
a
,
W
.
S
.
;
S
a
n
t
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s
,
R
.
L
.
;
T
o
r
r
e
s
,
J
.
B
.
;
Z
a
n
u
n
c
i
o
,
J
.
C
.
E
18-09-2016 09:55
659 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
f
e
c
t
o
f
g
o
s
s
y
p
o
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o
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s
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y
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o
p
h
a
g
o
u
18-09-2016 09:55
660 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
s
t
i
n
k
b
u
g
P
o
d
i
s
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s
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s
(
D
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)
.
R
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.
B
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s
.
E
n
t
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m
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l
.
2
0
1
1
,
5
18-09-2016 09:55
661 of 1060
5
,
Abstract
2
6
7
Introduction
Metabolites
2
7
Metabolites as
Directions
1
.
[
Acknowledgments
G
o
o
References
g
l
e
S
c
h
o
l
a
r
]
[
C
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s
R
57.
e
f
]
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m
p
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l
l
,
B
.
C
.
;
D
u
f
f
e
y
,
S
.
18-09-2016 09:55
662 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
S
.
A
l
l
e
v
i
a
t
i
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o
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s
i
t
o
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d
,
H
y
18-09-2016 09:55
663 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
p
o
s
o
t
e
r
e
x
i
g
u
a
e
,
b
y
p
h
y
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o
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s
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d
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t
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o
s
t
,
H
e
l
i
o
t
h
i
s
z
e
18-09-2016 09:55
664 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
.
J
.
C
h
e
m
.
E
c
o
l
.
1
9
8
1
,
7
,
9
2
7
9
4
6
.
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]
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P
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M
18-09-2016 09:55
665 of 1060
e
d
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
58.
H
o
r
i
,
M
.
;
N
a
k
a
m
u
r
a
,
H
.
;
F
u
j
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i
,
Y
.
;
S
u
z
u
k
i
,
Y
.
;
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a
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18-09-2016 09:55
666 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
667 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
668 of 1060
Abstract
Introduction
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Directions
Acknowledgments
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18-09-2016 09:55
669 of 1060
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Introduction
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Acknowledgments
References
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18-09-2016 09:55
670 of 1060
Abstract
Introduction
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18-09-2016 09:55
671 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
References
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18-09-2016 09:55
672 of 1060
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18-09-2016 09:55
673 of 1060
Abstract
Introduction
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18-09-2016 09:55
674 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
675 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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.
18-09-2016 09:55
676 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
677 of 1060
Abstract
Introduction
Metabolites
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Directions
Acknowledgments
References
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18-09-2016 09:55
678 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
679 of 1060
o
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18-09-2016 09:55
680 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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;
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18-09-2016 09:55
681 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
682 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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18-09-2016 09:55
683 of 1060
c
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9
Introduction
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2
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6
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18-09-2016 09:55
684 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
685 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
686 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
687 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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d
h
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e
s
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J
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S
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18-09-2016 09:55
688 of 1060
l
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Abstract
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Introduction
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]
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Acknowledgments
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18-09-2016 09:55
689 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
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18-09-2016 09:55
690 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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c
t
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p
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18-09-2016 09:55
691 of 1060
i
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Abstract
c
h
e
Introduction
Metabolites
m
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Metabolites as
Directions
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l
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Acknowledgments
B
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References
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9
9
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3
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65.
18-09-2016 09:55
692 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
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r
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b
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-
18-09-2016 09:55
693 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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l
t
i
n
g
h
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18-09-2016 09:55
694 of 1060
l
e
Abstract
S
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h
Introduction
Metabolites
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a
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Directions
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[
Acknowledgments
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66.
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18-09-2016 09:55
695 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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S
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n
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f
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18-09-2016 09:55
696 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
a
t
i
o
n
o
f
p
l
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18-09-2016 09:55
697 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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r
c
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18-09-2016 09:55
698 of 1060
g
l
Abstract
e
S
c
Introduction
Metabolites
h
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l
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Directions
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Acknowledgments
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References
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18-09-2016 09:55
699 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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m
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k
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M
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18-09-2016 09:55
700 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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o
x
i
c
i
t
y
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f
i
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p
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a
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18-09-2016 09:55
701 of 1060
2
0
Abstract
0
5
,
Introduction
Metabolites
4
9
,
Metabolites as
Directions
1
3
1
Acknowledgments
1
5
References
8
.
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18-09-2016 09:55
702 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
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l
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n
g
w
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R
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s
18-09-2016 09:55
703 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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b
y
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h
e
p
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a
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18-09-2016 09:55
704 of 1060
Abstract
9
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Introduction
Metabolites
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18-09-2016 09:55
705 of 1060
Abstract
Introduction
Metabolites
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Directions
Acknowledgments
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18-09-2016 09:55
706 of 1060
Abstract
Introduction
Metabolites
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Directions
Acknowledgments
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18-09-2016 09:55
707 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
708 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
709 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
710 of 1060
P
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18-09-2016 09:55
711 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
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18-09-2016 09:55
712 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
713 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
714 of 1060
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18-09-2016 09:55
715 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
716 of 1060
1
5
Abstract
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Introduction
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18-09-2016 09:55
717 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
.
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18-09-2016 09:55
718 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
719 of 1060
s
i
Abstract
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.
Introduction
Metabolites
2
0
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Acknowledgments
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18-09-2016 09:55
720 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
721 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
722 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
74.
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]
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18-09-2016 09:55
723 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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M
.
;
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L
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18-09-2016 09:55
724 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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t
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g
18-09-2016 09:55
725 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
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A
.
S
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.
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18-09-2016 09:55
726 of 1060
h
o
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r
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i
18-09-2016 09:55
727 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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.
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;
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18-09-2016 09:55
728 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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8
18-09-2016 09:55
729 of 1060
5
2
Abstract
3
8
Introduction
Metabolites
6
0
.
Metabolites as
Directions
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G
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.
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;
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18-09-2016 09:55
730 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
l
a
,
P
.
;
A
h
n
,
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.
S
.
;
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;
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i
v
i
18-09-2016 09:55
731 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
y
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m
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o
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l
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L
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m
c
h
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n
e
n
18-09-2016 09:55
732 of 1060
s
e
Abstract
M
i
l
Introduction
Metabolites
l
e
r
Metabolites as
Directions
.
A
s
Acknowledgments
i
a
n
References
J
.
C
h
e
m
.
2
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M
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a
18-09-2016 09:55
733 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
a
n
,
P
.
V
.
;
D
e
v
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,
K
.
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s
f
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m
S
o
18-09-2016 09:55
734 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
a
n
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m
t
r
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o
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18-09-2016 09:55
735 of 1060
.
C
Abstract
a
n
c
Introduction
Metabolites
e
r
L
Metabolites as
Directions
e
t
t
Acknowledgments
.
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9
References
9
6
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R
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78.
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]
F
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e
d
18-09-2016 09:55
736 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
n
,
M
.
C
h
e
m
i
s
t
r
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a
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k
a
l
o
i
d
s
18-09-2016 09:55
737 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
p
r
o
d
u
c
e
d
b
y
e
g
g
p
l
a
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t
s
,
p
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,
a
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.
J
.
A
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.
F
o
o
d
C
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m
.
2
18-09-2016 09:55
738 of 1060
0
1
Abstract
5
,
6
Introduction
Metabolites
3
,
3
Metabolites as
Directions
3
2
3
Acknowledgments
3
3
References
3
7
.
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G
o
o
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79.
e
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]
K
e
u
k
e
n
s
,
18-09-2016 09:55
739 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
E
.
A
.
;
d
e
V
r
i
j
e
,
T
.
;
v
a
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d
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n
B
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m
,
C
.
;
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e
W
a
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,
P
.
;
P
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m
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,
H
.
H
.
;
T
h
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e
l
18-09-2016 09:55
740 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
,
F
.
;
C
h
u
p
i
n
,
V
.
;
J
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,
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.
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.
;
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18-09-2016 09:55
741 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
l
k
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l
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.
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9
9
5
,
18-09-2016 09:55
742 of 1060
1
2
Abstract
4
0
,
Introduction
Metabolites
2
1
6
Metabolites as
Directions
2
2
Acknowledgments
8
.
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References
G
o
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;
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s
,
18-09-2016 09:55
743 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
H
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;
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.
;
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;
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o
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18-09-2016 09:55
744 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
h
e
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18-09-2016 09:55
745 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
b
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p
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2
18-09-2016 09:55
746 of 1060
0
0
Abstract
7
,
4
Introduction
Metabolites
5
,
1
Metabolites as
Directions
9
1
8
Acknowledgments
1
9
References
2
7
.
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.
18-09-2016 09:55
747 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
;
H
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M
.
;
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;
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18-09-2016 09:55
748 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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a
,
J
.
;
K
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18-09-2016 09:55
749 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
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l
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s
d
18-09-2016 09:55
750 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
p
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18-09-2016 09:55
751 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
752 of 1060
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18-09-2016 09:55
753 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
754 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
755 of 1060
r
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Abstract
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Introduction
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18-09-2016 09:55
756 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
L
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;
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18-09-2016 09:55
757 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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S
.
;
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18-09-2016 09:55
758 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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t
o
18-09-2016 09:55
759 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
m
e
n
t
a
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s
o
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18-09-2016 09:55
760 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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c
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s
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p
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18-09-2016 09:55
761 of 1060
r
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Abstract
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C
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Introduction
Metabolites
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References
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;
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,
S
.
I
.
;
18-09-2016 09:55
762 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
K
i
m
,
C
.
S
.
N
i
t
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e
18-09-2016 09:55
763 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
p
e
p
p
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r
(
C
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p
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e
r
,
18-09-2016 09:55
764 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
L
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r
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o
m
y
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2
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7
18-09-2016 09:55
765 of 1060
1
,
Abstract
4
2
1
Introduction
Metabolites
4
2
Metabolites as
Directions
6
.
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Acknowledgments
G
o
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References
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l
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s
,
G
.
F
.
;
18-09-2016 09:55
766 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
K
a
m
m
i
n
g
a
,
K
.
;
S
n
y
d
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r
,
J
.
C
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W
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m
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a
18-09-2016 09:55
767 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
d
c
o
w
p
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a
a
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18-09-2016 09:55
768 of 1060
[
G
Abstract
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Introduction
Metabolites
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Acknowledgments
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;
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,
18-09-2016 09:55
769 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
.
;
I
n
b
a
r
,
M
.
;
I
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t
18-09-2016 09:55
770 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
s
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d
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18-09-2016 09:55
771 of 1060
3
1
Abstract
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2
7
Introduction
Metabolites
9
1
Metabolites as
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2
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0
Acknowledgments
4
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G
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C
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18-09-2016 09:55
772 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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m
a
,
A
.
;
R
e
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M
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;
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;
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i
18-09-2016 09:55
773 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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e
z
D
i
a
z
,
R
.
;
R
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.
S
18-09-2016 09:55
774 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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d
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k
18-09-2016 09:55
775 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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l
o
i
d
s
.
J
.
C
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.
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18-09-2016 09:55
776 of 1060
e
f
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Introduction
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Metabolites as
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Acknowledgments
References
88.
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]
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;
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.
18-09-2016 09:55
777 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
;
S
h
a
w
,
T
.
E
.
;
W
a
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18-09-2016 09:55
778 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
s
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18-09-2016 09:55
779 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
780 of 1060
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18-09-2016 09:55
781 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
782 of 1060
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18-09-2016 09:55
783 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
;
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o
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18-09-2016 09:55
784 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
785 of 1060
e
s
Abstract
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1
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Introduction
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18-09-2016 09:55
786 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
787 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
788 of 1060
i
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Abstract
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Introduction
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18-09-2016 09:55
789 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
790 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
791 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
792 of 1060
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18-09-2016 09:55
793 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
794 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
795 of 1060
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18-09-2016 09:55
796 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
797 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
798 of 1060
,
2
Abstract
Introduction
Metabolites
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18-09-2016 09:55
799 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
800 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
801 of 1060
c
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Abstract
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18-09-2016 09:55
802 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
803 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
804 of 1060
7
,
Abstract
1
8
1
Introduction
Metabolites
1
8
Metabolites as
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;
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18-09-2016 09:55
805 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
q
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z
,
A
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;
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H
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18-09-2016 09:55
806 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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3
18-09-2016 09:55
807 of 1060
6
9
Abstract
3
7
Introduction
Metabolites
4
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Acknowledgments
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18-09-2016 09:55
808 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
p
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18-09-2016 09:55
809 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
810 of 1060
[
G
Abstract
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Introduction
Metabolites
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.
18-09-2016 09:55
811 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
L
.
D
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18-09-2016 09:55
812 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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L
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18-09-2016 09:55
813 of 1060
0
0
Abstract
1
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2
Introduction
Metabolites
7
,
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1
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Acknowledgments
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1
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.
18-09-2016 09:55
814 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
;
G
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A
18-09-2016 09:55
815 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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p
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18-09-2016 09:55
816 of 1060
,
5
Abstract
5
,
2
Introduction
Metabolites
1
7
Metabolites as
Directions
2
2
2
Acknowledgments
.
[
G
References
o
o
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e
S
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F
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E
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;
C
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e
l
l
,
18-09-2016 09:55
817 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
.
L
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;
D
u
k
e
,
S
.
O
.
N
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.
M
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.
C
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e
18-09-2016 09:55
818 of 1060
m
.
Abstract
2
0
0
Introduction
Metabolites
9
,
1
Metabolites as
Directions
7
,
4
Acknowledgments
0
2
2
References
4
0
3
4
.
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102.
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]
S
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a
18-09-2016 09:55
819 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
a
v
e
l
a
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,
N
.
;
I
n
b
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,
M
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;
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.
;
D
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,
M
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;
W
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M
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;
I
z
h
a
k
i
,
I
.
T
h
18-09-2016 09:55
820 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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f
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s
.
J
.
18-09-2016 09:55
821 of 1060
C
h
Abstract
e
m
.
Introduction
Metabolites
E
c
o
Metabolites as
Directions
l
.
2
Acknowledgments
0
0
6
References
,
3
2
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4
9
5
9
.
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103.
18-09-2016 09:55
822 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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,
A
.
;
P
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k
,
C
.
W
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;
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:
18-09-2016 09:55
823 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
D
e
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s
.
J
18-09-2016 09:55
824 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
.
I
n
s
e
c
t
P
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s
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.
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P
u
18-09-2016 09:55
825 of 1060
b
M
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
104.
e
d
]
u
m
a
r
,
P
.
;
R
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;
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;
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T
.
;
P
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,
S
.
18-09-2016 09:55
826 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
D
i
f
f
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s
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b
i
18-09-2016 09:55
827 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
v
o
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s
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d
18-09-2016 09:55
828 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
t
o
r
.
P
L
o
S
O
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2
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9
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]
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P
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M
e
d
]
18-09-2016 09:55
829 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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M
a
r
e
g
g
i
a
n
i
,
G
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;
P
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c
o
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o
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;
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;
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;
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,
M
18-09-2016 09:55
830 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
.
C
.
;
B
e
n
e
d
e
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-
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O
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;
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A
.
S
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d
a
n
t
a
c
t
i
v
18-09-2016 09:55
831 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
t
y
o
f
w
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t
h
a
n
o
l
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M
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d
o
m
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s
t
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c
a
18-09-2016 09:55
832 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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J
.
N
a
t
.
P
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d
.
2
0
0
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b
18-09-2016 09:55
833 of 1060
M
e
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
106.
d
]
M
a
r
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g
g
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i
,
G
.
;
P
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;
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S
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;
T
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M
.
C
18-09-2016 09:55
834 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
.
;
B
e
n
e
d
e
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D
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;
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;
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R
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f
T
r
18-09-2016 09:55
835 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
b
o
l
i
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m
c
a
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e
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a
o
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g
a
18-09-2016 09:55
836 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
i
f
o
l
i
a
w
i
t
h
a
n
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i
d
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s
.
J
.
A
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F
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2
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0
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0
7
.
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G
o
o
g
l
18-09-2016 09:55
837 of 1060
e
S
Abstract
c
h
o
Introduction
Metabolites
l
a
r
Metabolites as
Directions
]
[
C
Acknowledgments
r
o
s
References
s
R
e
f
]
[
P
u
b
M
e
d
107.
H
a
r
t
l
,
M
.
;
G
i
r
i
,
A
.
P
.
;
K
a
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r
,
H
.
;
B
a
l
d
18-09-2016 09:55
838 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
w
i
n
,
I
.
T
.
S
e
r
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a
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m
n
i
18-09-2016 09:55
839 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
g
r
u
m
a
g
a
i
n
s
t
g
e
n
e
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t
g
r
o
w
t
h
18-09-2016 09:55
840 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
n
d
d
e
v
e
l
o
p
m
e
n
t
.
P
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2
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]
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C
18-09-2016 09:55
841 of 1060
r
o
Abstract
s
s
R
Introduction
Metabolites
e
f
]
Metabolites as
Directions
[
P
u
Acknowledgments
b
M
e
References
108.
d
]
G
u
n
t
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r
,
C
.
;
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,
A
.
;
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z
,
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.
;
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s
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i
l
l
a
18-09-2016 09:55
842 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
,
A
.
;
F
e
r
r
e
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r
a
,
F
.
;
M
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d
s
o
n
p
o
p
18-09-2016 09:55
843 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
a
t
o
a
p
h
i
d
,
M
a
c
r
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:
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.
2
0
0
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2
6
,
18-09-2016 09:55
844 of 1060
1
1
Abstract
1
3
Introduction
Metabolites
1
1
2
Metabolites as
Directions
1
.
[
Acknowledgments
G
o
o
References
g
l
e
S
c
h
o
l
a
r
]
[
C
r
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s
s
R
109.
e
f
]
L
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a
m
p
a
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y
,
V
.
;
S
o
l
a
n
k
i
,
18-09-2016 09:55
845 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
V
.
R
.
;
A
n
u
r
a
d
h
a
,
D
.
L
.
;
S
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a
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a
i
n
s
t
l
a
18-09-2016 09:55
846 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
t
i
n
s
t
a
r
l
a
r
v
a
e
o
f
T
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.
J
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E
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.
Z
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.
S
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d
.
2
0
1
4
,
18-09-2016 09:55
847 of 1060
2
,
Abstract
1
1
8
Introduction
Metabolites
1
2
Metabolites as
Directions
0
.
[
Acknowledgments
G
o
o
References
g
l
e
S
c
h
o
l
a
110.
r
]
M
u
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u
,
B
.
;
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p
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e
b
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m
,
S
.
W
.
;
K
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m
,
Z
.
18-09-2016 09:55
848 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
;
C
o
l
l
,
M
.
T
o
m
a
t
o
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t
s
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e
,
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f
18-09-2016 09:55
849 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
u
e
n
c
e
t
h
e
p
e
r
f
o
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m
a
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a
o
p
e
18-09-2016 09:55
850 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
c
u
l
e
l
l
a
(
L
e
p
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:
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)
.
B
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E
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l
.
R
e
s
.
2
0
0
6
,
9
6
,
18-09-2016 09:55
851 of 1060
1
7
Abstract
Introduction
Metabolites
7
8
.
Metabolites as
Directions
[
G
o
Acknowledgments
o
g
l
References
e
S
c
h
o
l
a
r
]
[
C
r
o
s
s
R
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f
]
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P
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b
M
111.
e
d
]
F
r
a
g
o
y
i
a
n
n
i
s
,
D
.
A
.
18-09-2016 09:55
852 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
;
M
c
K
i
n
l
a
y
,
R
.
G
.
;
D
M
e
l
l
o
,
J
.
P
.
F
.
S
t
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s
o
f
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18-09-2016 09:55
853 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
854 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
855 of 1060
,
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18-09-2016 09:55
856 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
857 of 1060
Abstract
Introduction
Metabolites
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Directions
Acknowledgments
References
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18-09-2016 09:55
858 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
References
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18-09-2016 09:55
859 of 1060
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18-09-2016 09:55
860 of 1060
Abstract
Introduction
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18-09-2016 09:55
861 of 1060
Abstract
Introduction
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18-09-2016 09:55
862 of 1060
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18-09-2016 09:55
863 of 1060
Abstract
Introduction
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Acknowledgments
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18-09-2016 09:55
864 of 1060
Abstract
Introduction
Metabolites
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Directions
Acknowledgments
References
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18-09-2016 09:55
865 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
866 of 1060
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18-09-2016 09:55
867 of 1060
Abstract
Introduction
Metabolites
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Directions
Acknowledgments
References
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18-09-2016 09:55
868 of 1060
Abstract
Introduction
Metabolites
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Directions
Acknowledgments
References
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18-09-2016 09:55
869 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
870 of 1060
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18-09-2016 09:55
871 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
872 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
873 of 1060
e
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Introduction
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18-09-2016 09:55
874 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
875 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
876 of 1060
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Acknowledgments
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118.
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18-09-2016 09:55
877 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
878 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
879 of 1060
.
2
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Introduction
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r
18-09-2016 09:55
880 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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G
.
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;
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18-09-2016 09:55
881 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
882 of 1060
s
.
Abstract
P
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Introduction
Metabolites
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;
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18-09-2016 09:55
883 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
h
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18-09-2016 09:55
884 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
l
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18-09-2016 09:55
885 of 1060
R
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18-09-2016 09:55
886 of 1060
Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
References
,
A
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18-09-2016 09:55
887 of 1060
Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
References
o
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18-09-2016 09:55
888 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
889 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
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18-09-2016 09:55
890 of 1060
o
l
Abstract
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Introduction
Metabolites
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C
r
Metabolites as
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Acknowledgments
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;
18-09-2016 09:55
891 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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a
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n
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,
R
.
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18-09-2016 09:55
892 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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d
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18-09-2016 09:55
893 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
y
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:
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.
P
a
18-09-2016 09:55
894 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
r
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s
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o
l
.
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s
.
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18-09-2016 09:55
895 of 1060
b
M
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
123.
e
d
]
I
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;
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.
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18-09-2016 09:55
896 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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.
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4
18-09-2016 09:55
897 of 1060
,
1
Abstract
2
1
Introduction
Metabolites
1
2
8
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Directions
.
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References
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18-09-2016 09:55
898 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
a
,
P
.
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18-09-2016 09:55
899 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
900 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
.
J
.
E
c
o
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.
E
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.
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18-09-2016 09:55
901 of 1060
u
b
Abstract
M
e
d
Introduction
Metabolites
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Directions
Acknowledgments
References
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l
a
n
g
o
,
G
.
;
R
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,
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.
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.
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.
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.
;
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18-09-2016 09:55
902 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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A
.
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18-09-2016 09:55
903 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
p
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18-09-2016 09:55
904 of 1060
o
g
Abstract
l
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S
Introduction
Metabolites
c
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o
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Directions
l
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]
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126.
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;
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o
18-09-2016 09:55
905 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
p
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.
;
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18-09-2016 09:55
906 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
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18-09-2016 09:55
907 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
e
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)
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.
P
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.
S
18-09-2016 09:55
908 of 1060
c
i
Abstract
.
R
e
Introduction
Metabolites
v
.
R
Metabolites as
Directions
e
s
.
Acknowledgments
2
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1
References
3
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5
4
.
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G
.
;
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a
18-09-2016 09:55
909 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
,
A
.
A
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;
K
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;
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g
d
18-09-2016 09:55
910 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
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e
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r
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e
18-09-2016 09:55
911 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
c
t
o
r
A
n
o
p
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e
l
e
s
s
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.
R
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1
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9
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7
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7
2
6
18-09-2016 09:55
912 of 1060
.
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Abstract
G
o
o
Introduction
Metabolites
g
l
e
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Acknowledgments
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,
18-09-2016 09:55
913 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
P
.
;
G
o
p
a
l
a
k
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d
l
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18-09-2016 09:55
914 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
l
e
i
c
a
c
i
d
s
i
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o
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L
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n
.
)
S
c
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r
a
d
.
P
a
r
18-09-2016 09:55
915 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
s
i
t
o
l
.
R
e
s
.
2
0
0
8
,
1
0
3
,
1
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3
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.
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]
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P
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b
18-09-2016 09:55
916 of 1060
M
e
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
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]
A
b
b
a
s
i
p
o
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r
,
H
.
;
M
a
h
m
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M
.
;
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a
r
,
F
.
;
H
o
s
s
e
i
n
p
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r
,
18-09-2016 09:55
917 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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H
.
B
i
o
a
c
t
i
v
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L
.
(
S
o
l
a
18-09-2016 09:55
918 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
a
c
e
a
e
)
,
a
g
a
i
n
s
t
T
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(
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:
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e
b
r
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o
n
i
d
a
e
)
18-09-2016 09:55
919 of 1060
.
T
Abstract
u
r
k
Introduction
Metabolites
.
J
.
Metabolites as
Directions
A
g
r
Acknowledgments
.
F
o
References
r
e
s
t
.
2
0
1
1
,
3
5
,
6
2
3
6
2
9
.
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o
o
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l
e
S
c
h
o
l
130.
a
r
]
M
e
h
r
a
b
a
18-09-2016 09:55
920 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
,
M
.
;
B
a
n
d
a
n
i
,
A
.
R
.
;
S
a
a
d
a
t
i
,
F
.
;
M
a
h
m
u
d
v
a
n
d
,
M
.
a
m
y
l
a
s
e
a
c
t
i
v
i
t
y
18-09-2016 09:55
921 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
o
f
s
t
o
r
e
d
p
r
o
d
u
c
t
s
i
n
s
e
c
t
s
a
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d
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s
i
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i
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y
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e
d
i
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i
n
a
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p
l
a
n
t
e
x
t
r
18-09-2016 09:55
922 of 1060
a
c
Abstract
t
s
.
Introduction
Metabolites
J
.
A
Metabolites as
Directions
g
r
i
Acknowledgments
c
.
S
References
c
i
.
T
e
c
h
n
o
l
.
2
0
1
1
,
1
3
,
1
1
7
3
1
1
8
2
.
[
G
o
o
g
l
e
S
c
h
o
l
a
131.
r
]
18-09-2016 09:55
923 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
C
a
s
t
i
l
l
o
,
L
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;
G
o
n
z
a
l
e
z
C
o
l
o
m
a
,
A
.
;
G
o
n
z
a
l
e
z
,
A
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;
D
i
a
z
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M
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n
t
o
s
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E
18-09-2016 09:55
924 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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A
l
o
n
s
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P
a
z
,
E
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;
B
a
s
s
a
g
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d
a
,
M
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J
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R
o
s
s
i
n
i
,
C
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S
c
r
e
e
n
i
n
g
o
f
u
r
u
g
u
a
y
18-09-2016 09:55
925 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
n
p
l
a
n
t
s
f
o
r
d
e
t
e
r
r
e
n
t
a
c
t
i
v
i
t
y
a
g
a
i
n
s
t
i
n
s
e
c
t
s
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I
n
d
.
C
r
o
p
s
P
r
o
d
.
2
0
18-09-2016 09:55
926 of 1060
0
9
Abstract
,
2
9
Introduction
Metabolites
,
2
3
Metabolites as
Directions
Acknowledgments
4
0
.
References
[
G
o
o
g
l
e
S
c
h
o
l
a
r
]
[
C
r
o
s
s
R
e
f
]
[
P
u
b
M
132.
e
d
]
S
i
n
g
h
,
A
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;
B
h
18-09-2016 09:55
927 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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t
t
a
c
h
a
r
y
a
,
K
.
;
C
h
a
n
d
r
a
,
G
.
E
f
f
i
c
a
c
y
o
f
N
i
c
o
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i
a
n
a
p
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18-09-2016 09:55
928 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
929 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
930 of 1060
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18-09-2016 09:55
931 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
932 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
933 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
934 of 1060
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18-09-2016 09:55
935 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
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18-09-2016 09:55
936 of 1060
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18-09-2016 09:55
937 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
938 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
939 of 1060
Abstract
3
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Metabolites
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18-09-2016 09:55
940 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
941 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
942 of 1060
4
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18-09-2016 09:55
943 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
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18-09-2016 09:55
944 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
945 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
946 of 1060
b
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Introduction
Metabolites
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Acknowledgments
References
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18-09-2016 09:55
947 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
948 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
949 of 1060
[
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Introduction
Metabolites
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18-09-2016 09:55
950 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
951 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
952 of 1060
Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
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953 of 1060
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18-09-2016 09:55
954 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
955 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
956 of 1060
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18-09-2016 09:55
957 of 1060
Abstract
Introduction
Metabolites
Metabolites as
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Acknowledgments
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18-09-2016 09:55
958 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
959 of 1060
Abstract
Introduction
Metabolites
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Acknowledgments
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18-09-2016 09:55
960 of 1060
c
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18-09-2016 09:55
961 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
962 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
963 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
964 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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18-09-2016 09:55
965 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
143.
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18-09-2016 09:55
966 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
t
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18-09-2016 09:55
967 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
h
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18-09-2016 09:55
968 of 1060
0
7
Abstract
,
2
,
Introduction
Metabolites
5
5
2
Metabolites as
Directions
5
5
Acknowledgments
4
.
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References
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o
o
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]
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18-09-2016 09:55
969 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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E
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;
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18-09-2016 09:55
970 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
971 of 1060
7
,
Abstract
1
7
,
Introduction
Metabolites
3
8
9
Metabolites as
Directions
3
9
Acknowledgments
4
.
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References
G
o
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;
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R
a
h
18-09-2016 09:55
972 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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n
,
A
.
;
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,
A
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;
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;
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a
18-09-2016 09:55
973 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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,
G
.
;
M
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c
18-09-2016 09:55
974 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
i
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a
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p
l
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q
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f
a
18-09-2016 09:55
975 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
c
i
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t
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s
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.
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o
18-09-2016 09:55
976 of 1060
g
l
Abstract
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S
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Introduction
Metabolites
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Acknowledgments
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;
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.
18-09-2016 09:55
977 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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o
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q
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l
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a
18-09-2016 09:55
978 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
e
x
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s
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a
18-09-2016 09:55
979 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
:
C
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18-09-2016 09:55
980 of 1060
a
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Introduction
Metabolites
r
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s
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Directions
s
R
e
Acknowledgments
References
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]
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;
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18-09-2016 09:55
981 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
m
a
r
,
T
.
;
M
o
h
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d
,
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.
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;
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;
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o
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.
;
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s
18-09-2016 09:55
982 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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e
l
a
n
,
C
.
;
M
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H
a
18-09-2016 09:55
983 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
e
m
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P
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s
18-09-2016 09:55
984 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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.
R
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s
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]
18-09-2016 09:55
985 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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S
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,
S
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;
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18-09-2016 09:55
986 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
s
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18-09-2016 09:55
987 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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e
p
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s
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A
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P
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18-09-2016 09:55
988 of 1060
[
C
Abstract
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o
s
Introduction
Metabolites
s
R
e
Metabolites as
Directions
Acknowledgments
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;
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18-09-2016 09:55
989 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
a
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A
18-09-2016 09:55
990 of 1060
d
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Abstract
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Introduction
Metabolites
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18-09-2016 09:55
991 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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C
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.
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18-09-2016 09:55
992 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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18-09-2016 09:55
993 of 1060
n
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Abstract
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Introduction
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18-09-2016 09:55
994 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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h
o
w
d
h
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r
y
,
N
.
;
B
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;
L
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.
;
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,
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.
E
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y
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18-09-2016 09:55
995 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
f
S
o
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18-09-2016 09:55
996 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
n
t
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a
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.
T
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k
.
18-09-2016 09:55
997 of 1060
J
.
Abstract
Z
o
o
Introduction
Metabolites
.
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0
7
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;
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j
18-09-2016 09:55
998 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
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e
,
S
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;
L
a
s
k
a
r
,
S
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;
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s
18-09-2016 09:55
999 of 1060
Abstract
Introduction
Metabolites
Metabolites as
Directions
Acknowledgments
References
u
m
M
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l
l
.
(
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s
G
r
a
s
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1000 of 1060
Acknowledgments
References
s
i
(
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18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1001 of 1060
Acknowledgments
References
d
a
t
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s
K
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f
f
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18-09-2016 09:55

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Introduction
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1002 of 1060
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e
153.
f
]
M
a
h
e
s
h
K
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,
P
.
;
M
u
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u
g
a
n
,
K
.
;
K
o
v
e
n
d
a
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1003 of 1060
Acknowledgments
References
n
,
K
.
;
P
a
n
n
e
e
r
s
e
l
v
a
m
,
C
.
;
P
r
a
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a
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n
a
K
u
m
a
r
,
K
.
;
A
m
e
r
a
s
a
n
,
D
.
;
S
u
b
r
a
m
a
n
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1004 of 1060
Acknowledgments
References
i
a
m
,
J
.
;
K
a
l
i
m
u
t
h
u
,
K
.
;
N
a
t
a
r
a
j
,
T
.
M
o
s
q
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d
a
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a
c
t
i
v
i
t
y
o
f
S
o
l
a
n
u
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1005 of 1060
Acknowledgments
References
m
x
a
n
t
h
o
c
a
r
p
u
m
f
r
u
i
t
e
x
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a
n
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c
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p
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d
M
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l
o
p
s
t
h
e
r
m
o
c
y
c
l
o
p
o
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1006 of 1060
Acknowledgments
References
i
d
e
s
f
o
r
t
h
e
c
o
n
t
r
o
l
o
f
d
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s
a
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y
p
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i
.
P
a
r
a
s
i
t
o
l
.
R
e
s
.
2
18-09-2016 09:55

0
1
Abstract
2
,
1
Introduction
Metabolites
1
1
,
Metabolites as
Directions
1007 of 1060
6
0
9
Acknowledgments
6
1
References
8
.
[
G
o
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P
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b
M
e
154.
d
]
M
a
h
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s
h
K
u
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1008 of 1060
Acknowledgments
References
a
r
,
P
.
;
M
u
r
u
g
a
n
,
K
.
;
K
o
v
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d
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n
,
K
.
;
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a
m
,
J
.
;
A
m
a
r
e
s
a
n
,
D
.
M
o
s
q
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1009 of 1060
Acknowledgments
References
u
i
t
o
l
a
r
v
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c
i
d
a
l
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r
p
u
m
(
f
a
m
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1010 of 1060
Acknowledgments
References
i
l
y
:
S
o
l
a
n
a
c
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e
)
l
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a
f
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c
t
i
c
i
d
e
,
B
a
c
i
l
l
u
s
t
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1011 of 1060
Acknowledgments
References
h
u
r
i
n
g
i
e
n
s
i
s
,
a
g
a
i
n
s
t
C
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q
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a
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a
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S
a
y
(
D
i
p
t
e
r
a
:
C
u
l
i
c
i
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1012 of 1060
Acknowledgments
References
d
a
e
)
.
P
a
r
a
s
i
t
o
l
.
R
e
s
.
2
0
1
2
,
1
1
0
,
2
5
4
1
2
5
5
0
.
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G
o
o
g
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e
S
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h
o
l
a
r
]
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C
r
o
s
s
18-09-2016 09:55

R
e
Abstract
f
]
[
Introduction
Metabolites
P
u
b
Metabolites as
Directions
1013 of 1060
M
e
d
Acknowledgments
References
155.
G
a
u
r
,
R
.
;
K
u
m
a
r
,
K
.
I
n
s
e
c
t
g
r
o
w
t
h
r
e
g
u
l
a
t
i
n
g
e
f
f
e
c
t
s
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1014 of 1060
Acknowledgments
References
o
f
W
i
t
h
a
n
i
a
s
o
m
n
i
f
e
r
a
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n
a
p
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l
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t
,
S
p
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l
i
t
u
r
a
.
P
h
y
t
18-09-2016 09:55

o
p
Abstract
a
r
a
Introduction
Metabolites
s
i
t
Metabolites as
Directions
1015 of 1060
i
c
a
Acknowledgments
2
0
1
References
0
,
3
8
,
2
3
7
2
4
1
.
[
G
o
o
g
l
e
S
c
h
o
l
a
r
]
[
C
r
o
s
s
R
e
156.
f
]
A
b
d
e
l
-
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1016 of 1060
Acknowledgments
References
S
a
t
t
a
r
,
E
.
;
E
l
S
a
y
e
d
,
A
.
M
.
;
Z
a
i
t
o
o
n
,
A
.
;
B
a
k
h
a
s
h
w
a
i
n
,
A
.
A
.
E
v
a
l
u
a
t
i
o
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1017 of 1060
Acknowledgments
References
n
o
f
s
o
m
e
m
e
d
i
c
i
n
a
l
p
l
a
n
t
s
f
o
r
c
o
n
t
r
o
l
o
f
C
u
l
e
x
p
i
p
i
e
n
s
m
o
s
q
u
i
t
o
e
s
.
R
e
18-09-2016 09:55

s
.
Abstract
J
.
P
Introduction
Metabolites
h
a
r
Metabolites as
Directions
1018 of 1060
m
.
B
Acknowledgments
i
o
l
References
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C
h
e
m
.
S
c
i
.
2
0
1
5
,
6
,
8
9
8
9
0
5
.
[
G
o
o
g
l
e
S
c
h
o
l
a
r
157.
S
m
i
t
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1019 of 1060
Acknowledgments
References
h
,
D
.
B
.
;
R
o
d
d
i
c
k
,
J
.
G
.
;
J
o
n
e
s
,
J
.
L
.
S
y
n
e
r
g
i
s
m
b
e
t
w
e
e
n
t
h
e
p
o
t
a
t
o
g
l
y
c
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1020 of 1060
Acknowledgments
References
o
a
l
k
a
l
o
i
d
s
a
l
p
h
a
c
h
a
c
o
n
i
n
e
a
n
d
a
l
p
h
a
s
o
l
a
n
i
n
e
i
n
i
n
h
i
b
i
t
i
o
n
o
f
s
n
a
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1021 of 1060
Acknowledgments
References
i
l
f
e
e
d
i
n
g
.
P
h
y
t
o
c
h
e
m
i
s
t
r
y
2
0
0
1
,
5
7
,
2
2
9
2
3
4
.
[
G
o
o
g
l
e
S
c
h
o
l
a
r
]
[
C
r
o
18-09-2016 09:55

s
s
Abstract
R
e
f
Introduction
Metabolites
Metabolites as
Directions
1022 of 1060
Acknowledgments
References
158.
T
a
k
,
J
.
H
.
;
J
o
v
e
l
,
E
.
;
I
s
m
a
n
,
M
.
B
.
C
o
m
p
a
r
a
t
i
v
e
a
n
d
s
y
n
e
r
g
i
s
t
i
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1023 of 1060
Acknowledgments
References
c
a
c
t
i
v
i
t
y
o
f
r
o
s
m
a
r
i
n
u
s
o
f
f
i
c
i
n
a
l
i
s
l
.
E
s
s
e
n
t
i
a
l
o
i
l
c
o
n
s
t
i
t
u
e
n
t
s
a
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1024 of 1060
Acknowledgments
References
g
a
i
n
s
t
t
h
e
l
a
r
v
a
e
a
n
d
a
n
o
v
a
r
i
a
n
c
e
l
l
l
i
n
e
o
f
t
h
e
c
a
b
b
a
g
e
l
o
o
p
e
r
,
T
r
i
c
h
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1025 of 1060
Acknowledgments
References
o
p
l
u
s
i
a
n
i
(
L
e
p
i
d
o
p
t
e
r
a
:
N
o
c
t
u
i
d
a
e
)
.
P
e
s
t
M
a
n
a
g
e
.
S
c
i
.
2
0
1
5
.
[
G
o
o
g
l
18-09-2016 09:55

e
S
Abstract
c
h
o
Introduction
Metabolites
l
a
r
Metabolites as
Directions
1026 of 1060
]
[
C
Acknowledgments
r
o
s
References
s
R
e
159.
f
]
A
k
h
t
a
r
,
Y
.
;
P
a
g
e
s
,
E
.
;
S
t
e
v
e
n
s
,
A
.
;
B
r
a
d
b
u
r
y
,
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1027 of 1060
Acknowledgments
References
R
.
;
d
a
C
a
m
a
r
a
,
C
.
A
.
G
.
;
I
s
m
a
n
,
M
.
B
.
E
f
f
e
c
t
o
f
c
h
e
m
i
c
a
l
c
o
m
p
l
e
x
i
t
y
o
f
e
s
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1028 of 1060
Acknowledgments
References
s
e
n
t
i
a
l
o
i
l
s
o
n
f
e
e
d
i
n
g
d
e
t
e
r
r
e
n
c
e
i
n
l
a
r
v
a
e
o
f
t
h
e
c
a
b
b
a
g
e
l
o
o
p
e
r
.
P
h
18-09-2016 09:55

y
s
Abstract
i
o
l
Introduction
Metabolites
.
E
n
Metabolites as
Directions
1029 of 1060
t
o
m
Acknowledgments
o
l
.
References
2
0
1
2
,
3
7
,
8
1
9
1
.
[
G
o
o
g
l
e
S
c
h
o
l
a
r
]
[
C
r
o
s
s
R
160.
e
f
]
M
u
l
l
i
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1030 of 1060
Acknowledgments
References
n
,
C
.
;
G
o
n
z
a
l
e
z
-
C
o
l
o
m
a
,
A
.
;
G
u
t
i
e
r
r
e
z
,
C
.
;
R
e
i
n
a
,
M
.
;
E
i
c
h
e
n
s
e
e
r
,
H
.
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1031 of 1060
Acknowledgments
References
;
H
o
l
l
i
s
t
e
r
,
B
.
;
C
h
y
b
,
S
.
A
n
t
i
f
e
e
d
a
n
t
e
f
f
e
c
t
s
o
f
s
o
m
e
n
o
v
e
l
t
e
r
p
e
n
o
i
d
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1032 of 1060
Acknowledgments
References
s
o
n
c
h
r
y
s
o
m
e
l
i
d
a
e
b
e
e
l
t
e
s
:
C
o
m
p
a
r
i
s
o
n
s
w
i
t
h
a
l
k
a
l
o
i
d
s
o
n
a
n
a
l
k
a
l
o
i
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1033 of 1060
Acknowledgments
References
d
a
d
a
p
t
e
d
a
n
d
n
o
n
a
d
a
p
t
e
r
d
s
p
e
c
i
e
s
.
J
.
C
h
e
m
.
E
c
o
l
.
1
9
9
7
,
2
3
,
1
8
5
1
1
8
6
18-09-2016 09:55

6
.
Abstract
[
G
o
Introduction
Metabolites
o
g
l
Metabolites as
Directions
1034 of 1060
e
S
c
Acknowledgments
h
o
l
References
a
r
]
[
C
r
o
s
s
R
e
f
161.
P
i
n
o
,
O
.
;
S
n
c
h
e
z
,
Y
.
;
R
o
j
a
s
,
M
.
M
.
P
l
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1035 of 1060
Acknowledgments
References
a
n
t
s
e
c
o
n
d
a
r
y
m
e
t
a
b
o
l
i
t
e
s
a
s
a
n
a
l
t
e
r
n
a
t
i
v
e
i
n
p
e
s
t
m
a
n
a
g
e
m
e
n
t
.
I
:
B
a
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1036 of 1060
Acknowledgments
References
c
k
g
r
o
u
n
d
,
r
e
s
e
a
r
c
h
a
p
p
r
o
a
c
h
e
s
a
n
d
t
r
e
n
d
s
.
R
e
v
i
s
t
a
d
e
P
r
o
t
e
c
c
V
e
g
18-09-2016 09:55

e
t
Abstract
a
l
2
Introduction
Metabolites
0
1
3
Metabolites as
Directions
1037 of 1060
,
2
8
Acknowledgments
,
8
1
References
9
4
.
[
G
o
o
g
l
e
S
c
h
o
l
a
r
162.
M
a
n
n
,
R
.
S
.
;
K
a
u
f
m
a
n
,
P
.
E
.
N
a
t
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1038 of 1060
Acknowledgments
References
u
r
a
l
p
r
o
d
u
c
t
p
e
s
t
i
c
i
d
e
s
:
T
h
e
i
r
d
e
v
e
l
o
p
m
e
n
t
,
d
e
l
i
v
e
r
y
a
n
d
u
s
e
a
g
a
i
n
s
18-09-2016 09:55
Abstract
Introduction
Metabolites
Metabolites as
Directions
1039 of 1060
Acknowledgments
References
t
i
n
s
e
c
t
v
e
c
t
o
r
s
.
M
i
n
i
-
R
e
v
.
O
r
g
.
C
h
e
m
.
2
0
1
2
,
9
,
1
8
5
2
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Toxins
1060 of 1060
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Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

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Toxins 2016, 8(3), 60; doi:10.3390/toxins8030060

A Review of Bioinsecticidal Activity of Solanaceae Alkaloids

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Department of Animal Physiology and Development, Faculty of Biology, Adam Mickiewicz

* Correspondence: Tel.: +48-8295-925 (S.C.); +48-8295-646 (Z.A.)

Received: 29 November 2015 / Accepted: 24 February 2016 / Published: 1 March 2016

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Humanity faces many problems that arise from its rapidly

increasing population and one is the provision of the population

only a small percentage of insects, they cause significant losses to

pests of Brassicaceae crop plants, causes annual losses of between

the natural environment [6]. These compounds have a wide

(poisoning as well as water and food contamination) [9,10] as well

nonselective pesticides are primarily used in developing countries

protection strategies with an emphasis on a variety of biological

of highly toxic insecticides must be limited, so substances with

compounds are produced by a variety of plant species in

these substances is very wide and covers metabolic pathways,

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

functioning of entire organism

countries, effective biological controls

in benefits for every dollar invested in

secondary metabolites in plant organs

to insects, make a plant unpalatable

short half-life of natural insecticides

due to pleiotropy and their broad

of the reasons is that biopesticides

reproduction and can be acquired and

produced by plants have a wide

organismal level. In general, their

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...

Toxins | Free Full-Text | A Review of Bioinsecticidal Activity of Solanac...