KLASIFIKASI ANTIHISTAMIN

Generatio
n
1st
Sedasi

Class
Alkilamin

Etanolamin

nd

2
Non Sedasi

Piperazine
Alkylamines
Piperazine

piperidine

Drug

Children dose (day)

Chlorpheniramine

0,15 mg/kg

Clemastine
Cyproheptadine

0,5 ml/kg
0,125 mg/kg

Diphenhydramine HCl
Doxepine
Hydroxyzine
Acrivastine
Ketotifen
Cetirizine

5 mg/kg + 3 to 4x
Not used
1-2 mg/kg
U
0,05 mg/kg
2,6 yrs: 2,5 mg. 2x/day
6-12 yrs: 5 mg. 2x/day
>6 yrs (5mg/day)
2-6 yrs, 2.5 mg
6-12 yrs: 5 mg. 1x/day
6 mos-2yrs: 2,5 ml (15mg) 2x/day
2-11 yrs: 5 ml (30mg)
>12 yrs: 60 mg. 2x/day
U
2-6 yrs, 2.5 mg
6-12 yrs: 5 mg. 1x/day
6 mos-1 yr: 1 mg/day
1-6 yrs: 1,25 mg/day
6-12 yrs: 2,5 mg/ day
Nao tem

Levocetirizine
Ebastine/ carebastine
Fexofenadine
Mizolastine
Loratadine/
Decarboetoxilaratadine
Desloratadine
Rupatadine

Adult dose
(day)

Duration of
action
(hours)
24

Yes

U
U

Yes
Yes

U
H1

10-100 mg
10-200 mg
Unavailable
1-2 mg
10 mg

12
U
24
8
12
24

Yes
Yes
Yes
< 50%
Yes (?)
< 40%

H1
H1
H1
U
H1 and R1
H1 and R1

5 mg
10 mg

24
24

< 15%
Yes

1H e 1R
H1 and R1

120 mg
180 mg

24

< 8%
Yes

R1

10 mg
10 mg

24
24

Yes
Yes

H1
H1 and R1

5 mg

24

Yes

H1 and R1

10 mg

13

Yes

H1 and R1

2-8 mg/kg + 3
doses
2 mg
2-8 mg
50 to 400mg

Hepatic
metabolism

Marisa O. Luhukay
2015-84-011

Dose
adjustment