Clinical Biochemistry II

CLINICAL BIOCHEMISTRY
Multiple Choice Practice Questions II

Author email: sidharta123@yahoo.com
Total time for test = 30 minutes
Total Marks: 50
QUESTION 1. Choose the SINGLE MOST CORRECT option (A-E) listed below.
Correct about glycosidic linkages of carbohydrates:
A) D-glucose units in amylose are linked with alpha (1,4) glycosidic linkage in addition to alpha
(1,6) glycosidic linkage
B) bond in sucrose is Beta(1,4) glycosidic linkage
C) D-glucose units in amylopectin are linked with alpha (1,4) glycosidic linkage in addition to
alpha (1,6) glycosidic linkage
D) lactose consists of alpha(1)-->Beta(2) glycosidic linkage
E) maltose consists of alpha (1,6) glycosidic linkage
Normal serum Ceruloplasmin level in females
A) 75.0 4.6 mg/dl
B) 40.9 6.8 mg/dl
C) 30.9 7.6 mg/dl
D) 50.9 5.4 mg/dl
E) 36.0 5.6 mg/dl
pH of venous blood is
A) 7.32-7.45
B) 7.35-7.45
C) 7.32-7.42
D) 7.35-7.42
E) 7.45-7.32
The dissociable group in side chain of amino acid histidine is:
A) Sulphydryl
B) Carboxyl beta
C) Amino eta
D) Phenolic hydroxyl
E) Imidazole N
'Swan neck' deformity is seen generally in
A) Rheumatoud arthritis
B) Rheumatic fever
C) Psoriatic arthropathy
D) Gout
E) Osteoarthritis
A) 1, 2, & 3 correct
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Regarding blood supply of the breast correct is:
1. inter costal arteries
2. inter costal vein
3. branches of the axillary artery
4. branches of the subclavian artery
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Strongest buffers in the body is
1. plasma bicarbonate
2. Plasma proteins
3. hemoglobin and oxyhemoglobin
4. RBC bicarbonate
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Serum electrolytes normal values:
1. Sodium 129-145 mEq/L
2. Potassium 2.5-3.5 mEq/L
3. Calcium 6-9 mg/dl
4. Phosphorus 1.1-2.2 mEq/L
Spot the correct statements about carbohydrates:
A) Heparin is a sulphated polysaccharide
B) Hyaluronic acid is a product of pyruvic acid and mannosamine
C) Chondroitin sulphates are acid mucopolysaccharide

D) Dextrin is a partial hydrolytic product of starch
E) Neuraminic acid is an unbranched polymer of D-glucoronic acid and N-acetyl-D-glucosamine
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the following is true about Rheumatoid arthritis?
1. Glucose concentration is markedly reduced during inflammation of the synovium
2. Glucose concentration is markedly increased during inflammation of the synovium
3. synovial membrane cell Type B is increased in RA
4. synovial membrane cell Type A is increased in RA
Oxygen saturation of venous blood
A) 70-96%
B) 25-40%
C) 80-100%
D) 96-97%
E) 40-70%
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Which of the following statements regarding routine blood tests are correct?
1. normal bilirubin level of newborn is 0.4-4.0 mg/dl
2. normal serum amylase level is 5-9 Wohlgemuth units/dl
3. plasma copper level is 75-160 microgm/dl
4. normal prostatic acid phosphatase level is 3.5-10 IU/L
QUESTION 13. Choose the CORRECT options (A-E) listed below, MULTIPLE options may be
correct.
Mark the statements True or False about carbohydrates:
A) Lactose is a polysaccharide
B) Glycogen is an oligosaccharide
C) Amylose is an oligosaccharide
D) Amylopectin is a polysaccharide
E) Maltose is an oligosaccharide
Regarding rheumatoid arthritis (RA) which of the following statements is correct?

A) most common pattern of onset is acute oligoarticular (70%)
B) rheumatoid factor forms immune complexes with Ig M
C) synovial fluid is rich in polymorphonuclear leucocytes (PMNL)
D) Extra-articular respiratory involvement in RA include Sicca syndrome
E) Cytokines IL-2, IL-8 are involved
Osteoarthritis (OA) is characterized by all of the following except:
A) proliferation of new bone and cartilage
B) decreased collagen and proteoglycan synthesis
C) occurs in acromegaly
D) Paget's disease prediposes to secondary OA
E) degenerative joint changes
Rheumatoid factor is associated with which of the following immunoglobulins?
A) Ig G
B) Ig E
C) Ig M
D) Ig D
E) Ig A
Heberden's nodes are characteristic of which disease?
A) Systemic lupus erthematosus
B) Osteoarthritis
C) Focal nodular hyperplasia of the liver
D) Hyperparathyroidism
E) Rheumatoid arthritis
Drug of choice for long-term prophylaxis for Gout:
A) Sulphinpyrazone
B) Probenecid
C) Chloroquine phosphate
D) Allopurinol
E) Colchicine
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
'Livedo reticularis' is specific to:

1. Progressive systemic sclerosis
2. Systemic lupus erythematosus
3. Rheumatoid arthritis
4. Polyarteritis nodosa
Actual bicarbonate of arterial blood
A) 22-24 mmol/L plama
B) 24-28 mmol/L plama
C) 26-28 mmol/L plama
D) 22-26 mmol/L plama
E) 22-28 mmol/L plama
pH of CSF is
A) 7.35-7.43
B) 7.32-7.43
C) 7.34-7.43
D) 7.32-7.42
E) 7.35-7.45
Average pH value of human milk is
A) 6.0
B) 7.2
C) 6.8
D) 7.1
E) 7.4
correct.
Mark the following statements true or false:
A) D-mannose is an aldohexose
B) Dihydroxy-acetone is a ketopentose
C) D-fructose is a ketopentose
D) D-Glyceraldehyde is an aldotriose
E) D-deoxyribose is an aldohexose
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Developmental causes of secondary osteoarthritis:
1. Slipped capital femoral epiphysis

2. Intra-articular acetabular labrum
3. Perthes disease
4. Tabes dorsalis
Which of the following statements are correct regarding creatinine phosphokinase isoenzymes?
A) MB fraction is 94-95%
B) total CPK 0-1.4 micromoles/dl
C) Creatinine 1.4-4.0 mg/dl
D) BB fraction is 0-2%
E) MM fraction is 0-2%
Normal PCO2 of arterial blood
A) 41-45 mm Hg
B) 45-51 mm Hg
C) 41-51 mm Hg
D) 35-45 mm Hg
E) 35-41 mm Hg
correct.
Mark the following statements 'True' or 'False':
A) Reiter's disease is an example of seronagative spondyloarthropathy
B) Ankylosing spondylitis is an example of reactive arthritis
C) fibromyalgia is an example of seronagative spondyloarthropathy
D) fibromyalgia is an example of soft tissue rheumatism
E) polymyositis-dermatomyositis is an example of soft tissue rheumatism
Not true about Vitamin D (1,25-dihydroxycholecalciferol)
A) promotes absorption of phosphorus from the intestine
B) promotes resorption of bone
C) increases excretion of phosphate by the kidney
D) promotes absorption of calcium from the intestine
E) fat soluble lipid substance
Which of the following statements regarding Colloids and Crystalloids is/are true?
A) colloids pass through parchment membrane
B) colloids possess net charge
C) size of cystalloids are large compared to colloids
D) colloids do no possess net charge
E) colloids do not exhibit Brownian motion or Tyndall effect
Suspensory ligaments of Cooper are found in
A) fallopian tubes
B) vagina
C) uterus
D) ovary
E) breasts
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Spot the correct statements:
1. hyaluronic acid is found in synovial fluid
2. chondroitin sulphate serve as a structural material of vitreous fluid
3. chondroitin sulphate serve as a structural material of tendons and cartilage
4. hyaluronic acid is found in cartilage and tendons
correct.
Which of the following statements are correct?
A) Gamma-globulin content of CSF is 9%
B) Alkaline phosphate level of child is 1.4-4 Bodansky units/dl
C) Normal blood alpha-1 antitrypsin level is 60-200 mg/dl
D) Beta-globulin content of CSF is 8%
E) Normal blood aldolase level is 1.0-6.0 IU/L
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
A buffer is a
1. pair of strong acid and its salt with a strong base
2. pair of weak base and its salt with a strong acid
3. pair of strong base and its salt with a strong acid
4. pair of weak acid and its salt with a strong base
Which of the following statements about the nipple is correct?
A) behind the nipple is ampulla where milk is formed
B) muscular projection
C) surrounded by striped muscles

D) has 20-100 lactiferous ducts
E) is avascular
The second most abundant immunoglobulin molecule found in mother's first milk (colostrum):
A) Ig E
B) Ig M
C) Ig D
D) Ig G
E) Ig A
Normal levels of delta-amino laevulinic acid:
A) 300 microgm/dl
B) 140 microgm/dl
C) 200 microgm/dl
D) 350 microgm/dl
E) 570 microgm/dl
Normal blood ascorbic acid level is
A) 0.4-1.5 mg/dl
B) 1.8-3.6 mg/dl
C) 0.3-1.1 mg/dl
D) 0.2-4.0 mg/dl
E) 0.2-2.0 mg/dl
correct.
Mark the following statements True or False:
A) albumin content of CSF is 58%
B) Normal cisternal protein content of CSF is 15-25 mg/dl
C) Oxygen tension PO2 of arterial blood is 96-97 mm Hg
D) normal pressure of CSF is 50-120 mm Hg
E) Normal acetoacetate content of blood is 0.2-4 mg/dl
Chloride content of normal CSF
A) 200-500 mg/dl
B) 140-220 mg/dl
C) 250-450 mg/dl
D) 600-700 mg/dl
E) 150-350 mg/dl
Leg ulcers are commonly found in:

A) Systemic lupus erythematosus
B) Weber-Christian disease
C) Still's disease
D) Felty's syndrome
E) Reiter's disease
Baker's cysts are associated with which of the following diseases?
A) Cystic fibrosis
B) Osteoarthritis
C) Rheumatoid arthritis
D) Polycystic ovarian syndrome
E) Deep vein thrombosis
Total CO2 of venous blood
A) 23-30 mmol/L plasma
B) 23-27 mmol/L plasma
C) 27-30 mmol/L plasma
D) 23-26 mmol/L plasma
E) 26-30 mmol/L plasma
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
All of the following are traumatic causes of secondary osteoarthritis except:
1. Ehlers-Danlos syndrome
2. Perthes' disease
3. Menisectomy
4. Syringomyelia
B) 1, & 3 correct
C) 2, & 4 correct
D) 4 only correct
E) All correct
Regarding immunoglobulin G, which of the following statements is/are correct?
1. largest and first Ig to be secreted by plasma cells
2. activates B-cells
3. available in colostrum
4. involved in opsonization that increases phagocytosis
Which of the following carbohydrates is a Pentose?
A) D-Glucose
B) D-Ribose
C) D-Erythrose
D) D-Fructose
E) D-Xylulose
Which of the following do not reduce Benedict's Reagent?
A) Maltose
B) Sucrose
C) Fructose
D) Glucose
E) Lactose
Glucose content of normal CSF
A) 45-60 mg/dl
B) 60-85 mg/dl
C) 45-75 mg/dl
D) 60-75 mg/dl
E) 60-100 mg/dl
Collagen is produced by
A) osteocytes
B) fibroblasts
C) synovial cells
D) osteoblasts
E) chondrocytes
Regarding rancidity of fats, all of the following statements are correct except:
A) results in the formation of short chain ketones and aldehydes
B) vitamin E prevents rancidity
C) rancidity is due to hydrolytic and oxidative change
D) takes place at the double bonds of unsaturated fatty acids
E) takes place at the double bonds of saturated fatty acids
Commonest form of inflammatory joint disease:
A) Ankylosing spondilytis
B) Osteoarthritis
C) Psoriatic arthritis
D) Rheumatoid arthritis
E) Gout
ANSWERS
QUESTION 1. Correct answer = C
QUESTION 2. Correct answer = B
QUESTION 4. Correct answer = E
QUESTION 5. Correct answer = A
QUESTION 8. Correct answer = D
QUESTION 13. Correct answers: A= F, B = F, C = F, D = T, E = T.
QUESTION 23. Correct answers: A= T, B = F, C = F, D = T, E = F.
QUESTION 27. Correct answers: A= T, B = F, C = F, D = T, E = F.
QUESTION 32. Correct answers: A= F, B = F, C = F, D = F, E = T.

QUESTION 38. Correct answers: A= T, B = T, C = F, D = F, E = F.

Clinical Biochemistry II

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CLINICAL BIOCHEMISTRY

Multiple Choice Practice Questions II

C) Chondroitin sulphates are acid mucopolysaccharide

Regarding rheumatoid arthritis (RA) which of the following statements is correct?

'Livedo reticularis' is specific to:

1. Slipped capital femoral epiphysis

C) surrounded by striped muscles

Leg ulcers are commonly found in:

QUESTION 37. Correct answer = A

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