Assignment Introduction to epidemiology in health economics

Dr. Annette Gerritsen, Epi Result

Critical appraisal of a RCT
Instructions:
Read the following article:
Gerritsen AA, de Vet HC, Scholten RJ, Bertelsmann FW, de Krom MC, Bouter LM. Splinting
versus surgery in the treatment of carpal tunnel syndrome. A randomized controlled trial. JAMA
2002;288:1245-1251.
Then answer the questions underneath with Yes, No or Dont know [with the latter is meant
that there is no information in the article regarding the question.]
After answering all 8 questions, explain in your own words each answer, i.e. refer to the
information in the text that provides evidence regarding the question and explain this evidence in
your own words.
Please send the answers to the questions, as well as the explanation per question, before 14 May
2013 to: annette.gerritsen@epiresult.com
Questions:
1. Treatment allocation
a) Was a method of randomisation performed?

Yes / No / Dont know

b) Was the treatment allocation concealed?

Yes / No / Dont know

2. Were the groups similar at baseline regarding the most

important prognostic indicators?

Yes / No / Dont know

3. Were the eligibility criteria specified?

Yes / No / Dont know

4. Was the outcome assessor blinded?

Yes / No / Dont know

5. Was the care provider blinded?

Yes / No / Dont know

6. Was the patient blinded?

Yes / No / Dont know

7. Were point estimates and measures of variability presented for

the primary outcome measures?

Yes / No / Dont know

8. Did the analysis include an intention-to-treat analysis?

Yes / No / Dont know