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of Infectious Diseases
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Mongoose Rabies
C 0. R. Everard and J. D. Everard From the Medical Research Council, Leptospira Laboratory,
Bridgetown, Barbados
Mongooses are indigenous to Africa and Asia and have been introduced elsewhere. In
Cuba, Puerto Rico, Grenada, and South Africa they are the major reservoir and vector
of rabies. Elsewhere, sporadic cases of mongoose rabies are reported, but dog rabies can
mask their importance. Population density probably determines the importance of the
mongoose as a reservoir of rabies. In Grenada during a 4-year period, nearly 30% (and
in some areas >50%) of mongooses were found to have rabies serum neutralizing antibodies. The annual proportions of mongooses that were serum antibody-positive and
virus-positive, respectively, were inversely related. Natural immunity in mongooses prob-
ably lasts for life. In contrast with foxes, in mongooses immunity is an important factor
in the epizootiology of rabies. Inoculation of mongooses with Evelyn-Rokitnicki-Abelseth
(ERA) vaccine induced a good immunologic response and augurs well for the success
of vaccination in the field. The effects of wildlife vaccination on animal populations with
high levels of natural immunity need to be investigated before costly campaigns are started.
The Viverridae are a family of small- to mediumance [5]. The implications of this for the epidemiology36
of rabies are disturbing.
sized carnivores comprising civets, genets, and
species of mongoose. They are distributed throughout Asia and Africa and are the tropical equivalents
Mongooses as Hosts of Rabies
of the weasels and martens, which are found mainly
Mongooses are important reservoirs and vectors of
in cooler regions. One or another species of monrabies; where they are free of the disease, as in som
goose can be found in all types of habitat - dry scrub,
of the islands to which they were introduced, they
marsh, open forest, or thick jungle [1]. Introductions
are an incipient threat. The importance of the mon
of mongooses to various areas have also taken place.
In Europe the Egyptian mongoose (Herpestesgoose
ich- is seen in Grenada, an island with an area o
S610
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Mongoose
Table
1.
Rabies
Rabies
Area
S611
in
the
Total
Puerto Rico [8] 3,459 1984 60 37 (61.7) 12 (20.0) 5 (8.3) 5 (8.3) 1 (1.7)
Cuba [7] 44,178 1983 131 51(38.9) 17 (13.0) 23 (17.6) 40 (30.5) . ..
* Includes apparently healthy mongooses that were captured in a trapping program and found to be virus-positive by fluo
cent antibody microscopy.
Transmission of Virus
Information reported to the World Health OrgaIn South Africa cases of rabies have been recorded
nization (WHO) concerning mongoose rabies in Asia
in mongoose species other than Cynictis, namely
and most parts of Africa is skimpy and unreliable.
since the 1920s, when rabies was first confirmed in nies that are close to each other, conditions that perthat country [10]. Rabies is enzootic in the Viverri- mit ready transmission of the virus from one colony
dae, principally in the yellow mongoose (Cynictis to another [1]. Herpestes, on the other hand, is an
penicillata). This species accounted for 69% of all essentially solitary species, yet the large proportion
rabies cases in South Africa between 1977 and 1981, of these animals in Grenada that have serum neuwhereas the Canis species accounted for 7%. Because tralizing antibodies suggests a high rate of in-
jackals are predators of sheep, the jackal popula- traspecific contact. It is therefore unlikely that
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S612
Everard
and
Everard
of
No.
No.
No.
Natural Immunity
9%-55% in some areas)- of naturally infected mongooses can develop serum neutralizing antibodies to
rabies virus [6, 12]. The annual figures for serum neuNOTE. Data are from [12].
tralizing antibody-positive mongooses were inversely
proportional to the figures for virus-positive mongooses in the same year (see table 2), a finding that
gregariousness in mongooses is an important factor suggests immunity can build up in a population and
in the transmission of rabies. Meredith believes that inhibit the spread of rabies [6, 12]. The rabies cycle
the reason for the preeminence of Cynictis is its highwould then follow the sequence of high antibody/low
population density, which is determined by its low rabies prevalence-low antibody/high rabies prevahabitat specificity relative to other species [10]. Theselence, because after the dispersal or death of the imfactors are probably also responsible for the impor-mune individuals in the population there are more
tance of H. auropunctatus in the epizootiology ofsusceptible individuals available to promote a resur-
rabies in Grenada. Everard and Everard [6] state: gence of the disease. As an immune population
tations, even scavenging near dustbins and on rub- before rabies disappears from the population, even
bish heaps in urban areas. Their great adaptability, though extrapolation from four data groups is unfew parasites and pathogens, and their near omniv- wise; the figure is almost 60%. Conversely, 13.5%
orous habit mean that mongooses can build up very
dense populations.
gooses, a much lower population density was re- nity probably lasts for the lifetime of the animal [12].
corded (0.3-2.2 per acre, mean 0.8), with populationsWe have no information on levels of rabies serum
confined to the savannahs and flat agricultural areas. neutralizing antibodies in mongoose populations
It is possible that the lower population density inwhere only sporadic cases are reported. However,
Trinidad has kept mongooses free of rabies [6]. MacLean found serum neutralizing antibodies in sera
The titers of virus in salivary gland material fromfrom 2.6% of raccoons that were trapped in areas
eight naturally infected mongooses ranged fromreporting only sporadic cases of rabies; prevalence
undetectable (in three animals) to 105-6 MICLDsoof the antibody in raccoons collected from enzootic
(mouse intracerebral 50% lethal dose)/0.03 mL [12]. areas varied from 3% to 12%. Figures as high as 27%
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Mongoose
were
Rabies
S613
recorded
during
sibilities and should give
new impetus to the
[14].
This
trend
is
prob
epidemiologic study of mongoose
rabies.
since
in
areas
of
low
p
Several questions
must be answered
before costly
transmission,
few
anim
control campaigns
are started. Is vaccination
useful
antibodies.
Induced Immunity
Seven mongooses with and seven without naturally sity? Should vaccination be undertaken during an
acquired rabies serum neutralizing antibodies were epizootic or when the disease is enzootic? How ofinoculated im in the thigh with 1.0 mL of ERAten should vaccination be repeated? Is it more feasi-
(Evelyn-Rokitnicki-Abelseth) vaccine [12]. All 14 ble (and desirable) to cull the population to a denmongooses showed a substantial increase in serumsity below the threshold level for harboring the
naturally acquired antibodies tended to show a animals in the wild to ensure that the proportion of
immune animals inhibits the transmission of rabies?
greater response than those without antibodies. The
highest antibody titer recorded was 1:34,800; most The alternatives of culling and vaccinating the anianimals had titers >1:1,100 1 month after vaccina- mal population are daunting prospects on an island
tion and maintained high titers for several months.where there may be more than three mongooses per
This ready immune response augurs well for the ef- acre and the terrain is often steep and rugged. It
should be remembered, however, that mongoose rafectiveness of vaccination in the field.
bies can put a considerable strain on a small island
2. Chinery M. The natural history of Britain and Europe. Lonon the incidence of rabies [3, 6]. The object of popudon: Kingfisher Books, 1982
lation reduction is to inhibit the transmission of the
disease by reducing rates of animal contact. How- the Caribbean. Studies on the fauna of Curacao and other
ever, in the mongoose a high rate of transmission
consists largely of susceptible animals, control cam- Herpestes auropunctatus. Journal of Mammology 1974;
paigns may defeat their own purpose [6]. In the early 55:645-7
6. Everard COR, Everard JD. Mongoose rabies in Grenada. In:
1970s the development of an oral rabies vaccine for
Bacon PJ, ed. Population dynamics of rabies in wildlife.
wildlife looked promising, and the Medical Research
demiologic data relevant to the control of mongooses years 1982/83). Geneva: WHO, 1984
8. Centers for Disease Control. Rabies surveillance. Annual
by this method. Unfortunately, technical problems
encountered in producing an oral (or enteric) vac- summary- 1984. Atlanta: U.S. Department of Health and
Human Services, 1985
cine for mongooses were insurmountable at that
9. Beran WB. Rabies and infections by rabies-related viruses.
time, and work on it ceased. Recent advances in ra- In: Steele JH, Beran WB, eds. CRC handbook series in
bies technology, especially in the development of ge- zoonoses. Viral zoonoses. Vol 2. Boca Raton, Fla: CRC
netically engineered vaccines, offer exciting new pos- Press, 1981
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S614
Everard
and
Everard
10.
Meredith
CD.
Wildlif
13.
Steck
F,
W
Africa.
South
African
Jo
rope.
Epidem
World
Health
Organizat
14.
McLean
R
years
1980/81).
Geneva:
history
of
ra
53-77
12.
Everard
COR,
Baer
GM
11.
neutralizing
Soc
Trop
antibody
Med
Hyg
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in
19