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PROLIFERATION OF IMMATURE
WHITE BLOOD CELLS (BLASTS)
WBC's
(decreased
immune
function)
RBC's
(decreased O2
carrying
capacity)
Platelets
(decreased
clotting
capacity)
Weight Loss
Bones
Fever, infection
(especially
pulmonary,
urinary, rectal
blood)
Weakness,
Malaise, Pallor
11/28/2016
Pathophysiology of Acute Lymphocytic Leukemia
Increased
bruising/
petechiae,
Nose bleeds,
Bleeding from
gums
Bone pain,
Migratory joint
pain
ENLARGEMENT OF ORGANS
INFILTRATED BY BLAST CELLS
Spleen
Splenomegaly,
Abdominal
fullness
Liver
Hepatomegaly
Glands
Lymphadenopathy, Local
tenderness
Kidney