Question Bank for Pharmacolgy-II T.Y.B.

Pharm

(Sem-IV )

Q.1: a) Answer the following :-

70 Mks

12

1.
2.
3.
4.

Enlist the various mechanisms for development of microbial resistance(Summer-2015)

Give mechanism of action of aminoglycosides(Summer-2015)
CD4 cell count gets depleted in HIV infection.Justify(Summer-2015)
Name the hormones secreted by thyroid gland.Give the physiological role of one of the thyroid hormone(Summer2015)
5. Give mechanism of action of DPP-IV inhibitors(Summer-2015)
6. Enlist factors affecting iron absorption(Summer-2015)
7. Explain cross resistance in bacteria with suitable example(Winter-2015)
8. Give mechanism of action of tetracycline(Winter-2015)
9. Enlist the disorders in which immunosuppressants are prescribed(Winter-2015)
10. Give any two physiological role of thyroid hormones(Winter-2015)
11. Discuss clinical uses of oxytocin(Winter-2015)
12. Suggest any two conditions where parenteral iron therapy is recommended(Winter-2015)
13. Methicillin can be used in pencillinase producing staphylococcal infections.Justify(Winter-2014)
14. Patients given sulphonamides are advised to drink plenty of water.Justify(Winter-2014)
15. Why do cancer cells evoke a weak immune response and go undetected(Winter-2014)
16. Explain mechanism of action of iodides as anti-thyroid agents(Winter-2014)
17. Enlist the different types of oral contraceptives(Winter-2014)
18. Enlist factors affecting iron absorption from gastro-intestinal tract(Winter-2014)
a)

Fill in the blanks:-

1. __________produces gray baby syndrome. (Summer-2015)

2. Active form of Vitamin D is ____________(Summer-2015)
3. Aspirin inhibits ___________enzyme to produce its analgesic and anti-inflammatory action. (Summer-2015)
4. _________antibiotics are known to cause ototoxicity. (Winter-2015)
5. Acarbose is a complex oligosaccharide which reversible inhibits_______enzyme. (Winter-2015)
6. Deficiency of _________is the main reason for anaemia in patients with kidney failure. (Winter-2015)
7. Match the Following:- (Winter-2014)
Drugs
a) Tacrolimus

Adverse effects
(i)Ototoxicity

b) Tetracyclins

(ii)Nephrotoxicity

c) Heparin

(iii)Haemochromatosis
(iv)Thrombocytopenia

Q. 2: a) Answer any TWO of the following:

1. Explain the cycle of malarial parasite indicating various targets for anti-malarial drug action(Summer-2015)

2. Classify anti-cancer drugs. Explain pharmacology of any one class(Summer-2015)

3. Give classification, mechanism of action and therapeutic uses of penicillin(Summer-2015)
4. Classify chemotherapeutic agents on the basis of their mechanism of action. Justify combination of trimethoprim
with sulphamethoxazole in antimicrobial therapy. (Winter-2015)
5. Explain diagrammatically the various targets of anti-malarial therapy. (Winter-2015)
6. Brief on the general principles of cytotoxic anti-cancer therapy. Provide a note on 5-flurouracil. (Winter-2015)
7. Short note on:-(Winter-2014)
a)First line drugs in treatment of TB
b)Agents used to treat herpes infection
c)Extended spectrum penicillin's.
b) Answer any ONE of the following:

Short note on:-(Summer-2015)

a)Tetracyclines
b)Albendazole
Give a brief note on mechanism of action and indications of primaquine.
Elaborate on combination therapy used in treatment of TB
Justify the combination of trimethoprim and sulphamethoxazole
Write a short note on alkylating agent
Q. 3:a) Answer any TWO of the following

Classify anti-diabetic drugs . Explain MOA and unwanted effects of sulphonylureas. (Summer-2015)
Write a short note on antithyroid drugs(Summer-2015)
Explain pharmacological action, adverse effects and clinical uses of oxytocin(Summer-2015)
Enlist different forms of vitamin D. Add a note on its pharmacological action and clinical uses. (Winter-2015)
Classify oral hypoglycemic drugs. Discuss in brief pharmacology of DPP-IV inhibitors. (Winter-2015)
Give an account on drugs used as oxytosis. Discuss clinical uses of oxytocin. (Witer-2015)
Explain the process of bone remodelling. Add a note on bisphonates. (Winter-2014)
Explain mechanism of action of insulin. Discuss in brief the action of insulin on liver. (Winter-2014)
Write a short note on Oxytocics. (Winter-2014)
b) Answer any ONE of the following
What arethe different types of oral contraceptives. Explain MOA of combined pill(Summer-2015)
Explain the role of parathyroid hormones in the treatment of osteoporosis(Summer-2015)
Write a short note on oral contraceptives. (Winter-2015)
Elaborate on anti-thyroid drugs. (Winter-2015)

Explain rationale of using vitamin D with calcium supplements. (Winter-2014)

Write note on propylthiouracil. (Winter-2014)

Q. 4:a) Answer any TWO of the following

Explain MOA, Adverse effects and clinical uses of any two drugs:(Summer-2015)
a)heparin
b)aspirin
c)folic acid
Discuss in a brief about the pharmacology of heparin. (Winter-2015)
Write a note on use of clopidogrel in treating ischemic heart disease. (Winter-2015)
Discuss the role of tissue plasminogen activators in treatment of stoke. (Winter-2015)
Classify anticoagulants. Write a short note on mechanism of action and uses of heparin. (Winter-2014)
Discuss the physiological role of folic acid and its role in treatment of anaemia. (Winter-2014)
Classify anti-platelets. Add a note on clopidogrel. (Winter-2014)
b) Answer any ONE of the following
Write a short note on any one of the following:(Summer-2015)
a)Vitamin-K
b)thrombolytic drugs
Write a short note on folic acid. (Winter-2015)
Compare and contrast pharmacological action of vitamin-K and warfarin. (Winter-2015)
Explain mechanism of action and role of vitamin K(Winter-2014)
Write a brief note on fibrinoltics. (Winter-2014)
Q.5: a) Answer any TWO of the following :
Sulphonamides are not very effective in prensence of pus justufy. Explain MOA of trimethoprim(Summer-2015)
Write a short note on chemotherapy of AIDs(Summer-2015)
Classify anthelmentic drugs. Write a short note on metronidazole(Summer-2015)
Classify anti-viral drugs. Add a note on protease inhibitors. (Winter-2015)
Give a detailed account of Azole antifungals(Winter-2015)
Classify cephalosporins. Give an account about their mechanism of action. (Winter-2015)

Write a short note on any two of the following:(Winter-2multidrua)Azole antifungals

b)Drugs used in leprosy
c)Macrolide antibiotics
b) Answer any ONE of the following:
Classify antifungal drugs on the basis of MOA(Summer-2015)
Classify anti-tubercular drugs. Add a note on MOA of Rifampin(Summer-2015)
Elaborate on pharmacology of mixed amoiebicidal drugs. (Winter-2015)
Write a short note on multidrug therapy in leprosy(Winter-2015)
Discuss combination therapy of antimicrobials.(Winter-2014)
Classify antimalarials and and write a note on primaquine(Winter-2014)
Q.6 a) Answer any TWO of the following:
Write a short note on immunosuppressant. (Summer-2015)
Give MOA and complications of insulin(Summer-2015)
Classify the drugs used for treatment of osteoporosis. Elaborate on pharmacological actions of vitamin-D. (Summer2015)
Enlist immunosuppressant drugs. Add a note on tacrolimus(Winter-2015)
Give mechanism of action, indications and adverse effects of insulin(Winter-2015)
Discuss the role of biphosphate in the treatment of osteoporosis. (Winter-2015)
Write a short note on glucocorticoids as immunosuppressant agents(Winter-2014)
Classify oral anti-diabetic drugs. Explain mechanism of action and uses of sulphonylureas. (Winter-2014)
Describe treatment of hypothyroidism. (Winter-2014)
b) Answer any ONE of the following:
Give MOA of Amphotericin-B and Azole antifungal (Summer-2015)
Write a short note on Dapsones

(Summer-2015)

Discuss the role of piperazine as an anthelmentic. (Winter-2015)

Give the mechanism of action and adverse effects of chloramphenicol. (Winter-2015)
Write short notes on any ine of the following:(Winter-2014)
a)Vinca alkaloids in cancer
b)Metronidazole