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Environmental Protection
Agency
Prevention, Pesticides
And Toxic Substances
(7504C)
EPA-738-F-95-020
June 1995
R.E.D. FACTS
Agrobacterium
radiobacter
Pesticide
Reregistration
Use Profile
Weeping Cherry
Regulatory
History
Human Health
Assessment
Toxicity
In studies using laboratory animals, A. radiobacter generally has been
shown to be of very low acute toxicity. It's primary eye irritation/infection
toxicity places it in Toxicity Category III (the second lowest of four
categories). Agrobacterium radiobacter's oral toxicity is LD50 > 5g/Kg,
which places it in Toxicity Category IV (the lowest of four categories).
Likewise, A. radiobacter's acute dermal toxicity is in Toxicity Category IV.
Dietary Exposure
Although A. radiobacter is applied to certain fruit and nut crops, the
Agency considers these applications to be non-food uses because they are
made only to non-bearing nursery stock. Thus, neither a tolerance nor an
exemption from a tolerance is required. Additionally, the Agency has
concluded that dietary exposure from consuming commodities which were
treated with A. radiobacter as nursery stock not expected.
Occupational and Residential Exposure
Based on the application methods (dipping of plants by hand and
spraying with a hand-held sprayer) listed on the product label, the potential
for eye, dermal and inhalation exposure to handlers and post application
nursery workers exists. Because of a lack of human toxicity concern, worker
exposure data are not required. Moreover, it is the Agency's opinion that these
occupational exposures and subsequent risks are negligible because: (1) the
proposed precautionary product labeling stipulated in the RED for A.
radiobacter will adequately mitigate the risks to applicators and related
nursery workers; and (2) the organism has been determined not to be
pathogenic to humans and animals.
Environmental
Assessment
Additional Data
Required
Product Labeling
Changes Required
Regulatory
Conclusion
For More
Information