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I will praise thee; for I am fearfully [and] wonderfully made: marvellous [are] thy works;
and [that] my soul knoweth right well. Psalms 139:1
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Table of Contents
ANATOMY & PHYSIOLOGY
Table of Contents
Intro to Human Anatomy and Physiology
Levels of Organization
Homeostasis
Organization of the Body
Membrane
Anatomical Terminology
Cells
Plasma membranes
Cytoplasm
Nucleus (Control center)
Cell Life Cycle
Tissue
Tissue type
Cell types
The Integumentary System
Functions of the Integumentary
Tissue of the Skin
Skin Color
Skin Cells
Hair
Sweet Glands
Skin Cancer
Dermis
Bed Sores
The Skeletal System
Parts of the longs bones
Parts of flat, irregular, short Bones
Functions of the bones
Structure of the Compact bone
Trabecula
Osteogenesis (Ossification) - The beginning of a bone
Stage of life
Bone remodeling
Hormones
Muscular System
Smooth
Skeletal
Cardial
Muscular
Sliding filament theory
Nervous System
Organs
Information
Characteristics of neurons
Axon
The Synapse
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Parts of a Synapse
Plexus
The Brain
Somatic and Special Senses
Somatic (soma body)
Special Sense
Sensory Receptor
Sensory Adaptation
Classification of Sensory Receptors
Sense of Pain
Classification of Pain
Headaches
Sense of Smell
Olfactory Pathway
Sense of Taste
Primary taste
Taste pathway
Sense of hearing
Hearing Disorders
Sense of Equilibrium
Path way of Static Equilibrium
Dynamic Equilibrium
Sense of Sight
Eyes disorders
The Lacrimal Apparatus
Endocrine System
Glands
Two types of glands
Major Endocrine Glands with one function
Major Endocrine Glands with Dual functions
Minor Endocrines Tissues
Functions of the Endocrine System
What are hormones?
Control of hormonal secretions
Hypothalamus Control
Thyroid
Parathyroid Glands
Abnormal Secretion of PTH
Adrenal Glands
Corticosteroids
Cushings Syndrome
Hormones Secreted by the Adrenal Medulla
The Pancreas A dual glad
Abnormalities of Pancreas
Thymus Glad
Reproductive Glands
Other hormone Producing Structure
The Blood System
Three functions of the blood
Formed Elements
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Percentage of RBCs
Hematopoiesis before Birth
Hematopoiesis
Primary Nutrients Needs for Erythropoiesis
Types of Anemia
Sickle Cell Anemia
Thalassemia
Iron Deficiency Anemia
Vegan Sources of Iron
Vegan Sources of B12
Best Sources of Folate
What happens when RBC dies?
Leukocytes or White Blood Cells
Diapedesis - Chemotaxis
Leukemia
Platelets
Hemostasis
Hemophilia
Three Steps to Homeostasis
The Cardiovascular System
Introduction
Anatomy of the Heart
Heart chambers and valves
Valvular Incompetence
The fetal heart
Pathway of blood
Blood supply to the heart (Coronary Circulation)
Coronary Occlusion
Congestive Heart Failure
Heart Actions
Factors that contribute to venous return
S-A Node
Blood Vessels
Arteries
Capillaries
Venules
Veins
Blood Pressure
Hypertension = persistent high blood pressure.
Hypertension can lead to left heart failure.
Blood pressure homeostasis
Atherosclerosis
The Digestive System
Definition
Digestive Processes
Components of the Gastric Juice
Structure of the Wall of the GI Tract
Six Sphincters of the GI Tract
Organs of the Digestive System
Salivary glands
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Pharynx
Esophagus
Stomach
Gastric emptying
Pancreas
Liver
Gallbladder
Regulation of bile secretion:
Small Intestine
Peristaltic
Large intestine
Normal Flora
The Lymphatic System
General Functions
What is the Lymphatic system?
Lymphoid Organs
Lymph Nodes
Clusters of lymph nodes
Structure of the lymph Node
Non-specific defense system
Inflammation
Fever
Specific Defenses
Cells of the Immune System
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Levels of Organization
Atom
Molecule
Macromolecule
Organelle
Cell
Tissue
Organ
Organ system
Organism
We have 11 systems
Integumentary
Skeletal
Muscular
Nervous
Endocrine
Cardiovascular
Lymphatic
Digestive
Respiratory
Urinary
Reproduction
Reproduction (1) division of cells (2) making a whole new organism (endocrine,
reproduction)
Digestion (the breakdown of foods into particles that can be absorbed into the blood)
(digestive system)
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respiratory
digestive
Water
o
Transportation
Food
o
Provides nutrients
Lipids (fat)
Used to release of energy from the nutrients. All the nutrients in the world are
useless if the oxygen is not available to release the energy from them.
A from of energy. Energy is the power required to make something happen. Most of
our energy is used for homeostasis relatively stable system (p5).
Pressure
o
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Atmospheric pressure is the force outside of the body due to the weight of the air
around it. Breathing depends on appropriate atmospheric pressure.
Hydrostatic pressure
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Homeostasis
The five external environmental factors are able to changes therefore the body must be able to
maintain the internal environmental.
Homeostasis - Maintenance of a retaliative stable internal environment.
The three main elements
Receptors
o Sense changes (eg. temperature, thermal sensor > brain, hypothalamus)
Control centre (brain, hypothalamus)
Effectors (always muscles and glands)
Example: Blood pressure
Good range 100 120. The arteries have sensors called baroreceptors for blood pressure. It sends
the message to the control center, the heart. Then in one of the chambers there is a node that will
then either increases or decreases the rate of the cardiac muscle to control the flow rate of the
blood.
LEARN Example: Temperature (p6)
Set point for temperature is 37C 98.6F
If temperature is rising then:
If temperature is falling then:
Sensory input to the hypothalamus
Hypothalamus will analyse
1) effectors blood cells (smooth muscles) restrict, sweet glands restrict
2) effectors muscles (skeletal) active to create heat (shivers)
There are two types of Homeostasis
Negative feedback most common, if getting cold then get hot
Positive feedback very few, when the change goes in the same direction; 1) labour pain,
when its felt it does not stop it increases it. 2) Bleeding, the body will continue to form clots
till its healed.
Axial portion
o Dorsal cavity
Cranial cavity
Vertebral canal
o Ventral cavity
Thoracic cavity
Left/Right Pleural cavity
Mediastinum
o Superior mediastinum
Trackea
o Pericardial cavity
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heart
Adomino-pelvic cavity
Abdominal cavity
o Stomach
o Kidneys
Pelvic cavity
o Large Intestine
o Reproductive organs
o Bladder
Appendicular portion
Small portions
o Oral cavity
o Nasal cavity
Frontal sinus
o Orbital cavity
o Middle ear cavity (ossicles)
o Sphenoidal sinus cavity
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Membrane
Membrane - a thin layer of tissue
(Sheet 4)
The two type of membranes
1. Serous membrane
a. (secretes serous fluid) a double (2) layer membrane that lines the walls and covers
the viscera of a cavity that does not open to the exterior
2. Mucous membrane
a. (secretes mucus) a thick layer of tissue that lines cavities and canals that open to
the outside of the body
3. Synovial membrane
a. (secrete synovial fluid)
Most membranes are formed from epithelium and the connective tissue on which it rests.
Visceral Serosa covers the organ
Parietal Serosa lines the wall of the cavity
1. Body Covering
a. Integumentary System
2. Support and Movement
a. Skeletal System
b. Muscular System
i. Cartilage
3. Integration and Coordination
a. Nervous System
i. Brain
ii. Spinal Cord
iii. Sense Organs
b. Endocrine System
i. Endocrine Glands
4. Transport
a. Cardiovascular System
i. Heart Blood Vessels
b. Lymphatic System
i. Lymphatic vessels
ii. Lymph nodes
iii. Spleen
5. Absorption and Excretion
a. Digestive System
b. Respiratory System
c. Urinary System
6. Reproduction
a. Reproductive System
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Anatomical Terminology
Established to have a common language between doctors
This means that the body is standing erect, face forward, with upper limbs at the sides and the
palms forward. Note that the terms right and left refer to the right and left of a body in anatomical
position.
(Sheet 5)
Superior
Inferior
Anterior (ventral)
Posterior (dorsal)
Medial
Lateral
Intermediate
Proximal
Distal
Superficial
Deep
Top
Bottom
Front
Back
Towards
Away
Closer to the body part
Farther from body part
Toward the surface of the body
Away from the body surface
Cutting Planes
Coronal Plane (frontal plane) Anterior / Posterior
Transverse Plane (horizontal plane) Superior / Inferior
Sagittal Plane (median plane)
Four Abdominal Quadrants
Abdominal is divided into 4 sections, from the naval
1. Right upper quadrants
2. Left upper quadrants
3. Right lower quadrants
4. Left lower quadrants
Cells
We have about 75 trillion cells in the body. In the 1800s the first discovered that the human body
was mad of cells. We have about 200 different types of cells in the body. The activity of the cell is
determined by the make of the organelle. The cell is divided into three main parts, the plasma
membranes, cytoplasm, and the nucleus.
Plasma membranes
Bi-layer of Phospholipid molecules, very thin and flexible, contains protein, carbohydrates,
cholesterol. Function: (1) To maintenance the integrity of the cell, by inclosing it like an envelope.
(2) Controls the passage of molecules in and out of the cell (Selective permeability). Head
(Phospholipid) is Hydrophilic; Tail (lipid) is Hydrophobic. Contains protein channels and carriers.
Some Plasma membranes contain Microvilli (The little fingers, to increase the surface area.)
Cytoplasm
Is everything inside the cell and outside of the nucleus. The protein is received and processed here
by the organelles.
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Ribosomes
Peroxisomes
o Sacs that contain detoxifying enzymes
o Found in liver
o Destroys free-radicals, brakes them down to Hydrochloric-acid
Centrosome
o Very active in the function the division of the cell (mitosis)
Vesicles
Eg. Keratin
Haemoglobin
Melanin
Lipid droplets
(Uni-nucleated) but some have that have more then one Nucleus (Multi-nucleated) (skeletal
muscle fibre), and one that is A-nucleated.
Three main parts
1. Nuclear Envelope Has nuclear pores
2. Nucleolus Synthesises, ribosome precursors, and RNA
3. Chromatin Fibres of DNA loosely coiled around clusters of protein molecules. 1)
Maintains the structure. 2) Change their own structure when it is needed expose the DNA.
Will divide into 46 chromosomes.
Movement through Cell membranes (sheet)
Passive Processes
o Passive Processes Diffusion Move down there concentration gradient
Simple Diffusion Movement of lipid soluble particles from higher
concentration to lower concentration
Osmosis Its only water, through the membrane.
Facilitated Diffusion Particles that are water soluble molecules that
cannot pass the lipid bi-layer and molecules that are too big to pass
through the pores. The need carries.
o Passive Process of Filtration hydrostatic pressure, from higher to lower
pressure gradient.
Active Processes These are going from low to high pressure. Need of a pump.
o Active Transport ATP (cellular energy)
o Vesicular Transport Transported by Organelles
Exocytosis Exit from Cell via a vesical organelle
Endocytosis Enter into the Cell
Phagocytosis Cell eating - particles
Pinocytosis Cell drinking - droplets
Receptor-mediated endocytosis requires a receptor, an
element to unlock and a the element that is required by the cell.
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Tissue
Tissue type
Cell types
Pseud stratified Columnar Combination of different cell sizes gives the false
impression that there is more then one layer. (Has lots of goblet cells)
Chondroblast: Cartilage
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Binding
Binding
o Tendons: (Dense Regular Connective Tissue) Muscles to bones
o Ligaments (Dense Regular Connective Tissue) Bones to bones
Support
o Bones (osseous Tissue) Support the body in an upright position
o Dermis (Dense Irregular Connective Tissue) Supports the epidermis
Protections
o Bones: (Osseous Tissue)
o Cartilage (Cartilage Tissue)
o Adipose tissue (Protects organs)
Insulation
o Adiposes tissue under the dermis
Fill spaces
o Areolar tissue files spaces around the organs
Storage
o Adipose Tissue Stores fat
o Areolar Tissue Stores water and salts
o Osseous Tissue Stores minerals
Transportation
o Blood Transports gases, nutrients, hormones
Production of Blood Cells
o Bone Marrow (Reticular Connective Tissue)
Immune Protection
o Areolar Tissue Houses macrophages and mast cells
o Blood Contains leukocytes
3. Muscle
4. Nervous Conducts electrical impulses
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Skin Color
1. Melanin
o Yellow to reddish brown to black
o Increases or decreases based on sunlight
o Protects DNA
2. Haemoglobin
o RBC Erythrocytes Transport O2 Haemoglobin red in colour
o Cyanosis when blood is lacking O2 it turns to red colour and skin turns blue
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3. Carotene
o Yellow to orange colour found in food like carrots
o Accumulates in the stratum coronum
4. Bilirubin
o Yellow pigment RB are destroyed
o Skin can turn yellowish because of the liver not working
o Newborn Jaundice
Amount of melanin and colour melanin > DNA
o
Skin Cells
Hair
1. Shaft
2. Root
3. Bulb Around it is the Root Hair Plexus (nerve endings around the hair bulb)
4. Colour Trichosiderin
5. Growth is based on the hormone - Androgen
Sweet Glands
Apocrine sweet glands have fatty compounds, bacteria decomposing which leads to body odour.
Ceruminous gland = ear wax, cerumen sticky trap
Skin Cancer
1. Cutaneous Carcinoma (Common Type)
o Basal carcinoma
Stratum Basale/spinosum Cuboidal / Column
Rarely metastasize (slow growing)
Better chance of full cure 80%-90%
Starts from wounds that wont heal
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Squamous carcinoma
Stratum spinosum
2. Cutaneous Melanoma
o Melanocytes
o Fast metastasis
o Begins as a mole (nevus)
o 50% chance of survive
o there are four types
o
Dermis
Second layer of the skin, full of collagen fibre, elastic, nerve fibbers, blood vessels, lymphatic vessels,
hair, oil, sweet glands, squmsus glads, major cell if the FibroBlast , WBC, mast cells, two layers
ritcular, and papularir layer
Bed Sores
There are four types of bed sores
1. Skin still intact
2. Skin is broken the first few layers of skin
3. Skin is broken to all the way
4. The Bone or muscle is exposed
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1. Bone - 206
2. Cartilage - Connective tissue, Hyaline, Elastic, Fibrocartilage
3. Ligaments - Connects bones to bones, Dense regular connective tissue
4. Joints - the junctions between bones, Fibrous, cartilaginous, synovial
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Trabecula
Stage of life
1. Embryo - Fatal Stages - Bony skeleton formation
2. Birth - Early adulthood - bone growth (females end around 18, male around 21, by 25 bone
growth is ended)
3. Adult - No more bone growth - Bone remodeling / Repair
Bone remodeling
1. Bone deposit - by osteoblast > osteoid (controlled by a hormone call calcitonin - secreted by
thyroid gland) This is determined by good nutrition, protein, vitamin C, A, D, B12, calcium,
phosphorus
2. Takes place in bone injury or required strength
3. Bone resorption - Osteoclast > Lysozyme, Controlled by the Parathyroid hormone
4. Ensures the bone is not to thick/heavy
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5. When a person has fracture site if the do electrical stimulation then it heals faster
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Hormones
Calcitonin (thyroid gland) Secreted when:
1. Blood calcium level increased
2. Brain sends message to thyroid gland to secrete calcitonin
3. Osteoblast activity increases
4. Blood calcium level drops
Parathormone (PR gland) secreted when:
1. Blood ca level decreases
2. Brain sends message to PT gland
3. PT hormone secreted
4. Stimulates osteoclasts activity
5. Blood calcium level increases
Growth hormone
1. stimulates epiphyseal plate activity
2. Pituitary gland
3. Hypersecretion growth hormone = gigantism - during childhood
4. = acromegaly - after growth has ended
5. Hyposecretion growth hormone = pituitary dwarfism
Examples of those who have stronger bones
Tennis
Ballerina
Weightlifter
runners
Osteoclast is more active then Osteoblast = Osteoporosis
Factor that increase the risk
1. Age - bone resorption dominates
2. Decrease in blood oestrogen / testosterone hormones (inhibit osteoclast activity)
3. Insufficient exercise (mechanical stress)
4. Speed walking
5. Weight lifting
6. Too much sodium - increases the excretion of calcium in the urine
7. Too much protein - increases the excretion of calcium in the urine
8. Too much phosphorus - increases the excretion of calcium in the urine
9. Deficient intake of protein, calcium, magnesium, Vit C, D, A, B12
10. Smoking - decrease estrogens levels
11. Alcohol
12. Certain drugs (corticosteroids)
READ THIS ONE Joint pg 158 - Synovial Joints
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Muscular System
Three types: smooth, skeletal, and cardial.
Smooth
Non-striated
Controlled by the Autonomic division of the nervous system
Visceral muscular
Uni-nucleated
Found in the walls of hollow organs, iris of the eye
Involuntary control
Skeletal
Striated
Controlled by Somatic division of the nervous system
Of voluntary control
Multi-nucleated
Transportation and movement
Functions
o Allow for body movement, and expression
o Maintain body posture
o Produce heat
Tissue
o Skeletal
o Nervous
o Blood
o Connective
Each muscle fibres are surrounded by Endomysium, all these form a fascicle
which are surrounded by Perimysium. On top of all the fascicles is the
Epimysium and on top of that there is the Fascia (separates one muscle from
another)
Tendon - fascia in a cordlike fashion
Aponeurosis - Flat/broad fashion
Tendon - muscle to bones
Aponeurosis - muscles to muscles
Sarcolemma - (Plasma membrane)
Sarcoplasm - (Cytoplasm)
Inclusions - Myoglobin - red pigment that carries oxygen
Inclusions - Glycogen - storage of glucose
Organelles - Sarcoplasmic reticulum - smooth (regulate the calcium)
Organelles - Cisternae of sarcoplasmic reticulum - Play major role in muscle
constriction
Organelles -Myofibrils - Play major role in muscle constriction
Muscles are connected to neurons
Motor neuron connect from the CNS to the muscle
Motor neuron > motor terminals > motor units
Neuro muscular junction is where the terminal meets the muscle
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Motor endplate
Cardial
Striated
Uni-nucleated
Found in the walls of the heart
Involuntary control
Controlled by the Autonomic division of the nervous system
Cardiac
Muscular
p176
Fibres in a single unit are not clustered in one place but are spread through out the muscle, there
for a single weak contraction will effect the entire muscle.
Myosin = thick, two tail and heads intertwined
Cross bridge = the head of a myosin molecule
The red dot is the myosin binding site
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Nervous System
Function - Integrations and coordination (makes the body act as one system)
Organs
1. Brain
2. Spinal Cord
3. Nervous
Information
The system works using electrical signals and produce immediate responses.
Two main divisions
Central Nervous System
Brain
Spinal Cord
Perferial Nervous System
Cranial + Spinal Nerves
Nerves are bundles of Axons
Spinal Nerves
Cranial Tissue
Characteristics of neurons
Extreme Longevity over 100 years
Amitotic - can not me replaced is destroyed
Cannot survive with our oxygen and glucose.
p220 - structure of nervous
Axon
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The Synapse
The junction between to communicating neurones
Axosomatic synapse axon to soma
Axodendritic synapse axon to dendrites
Axoaxonic synapse axon to axon
Dendrodenditric synapse dendrites to dendrites
Parts of a Synapse
Synaptic knob - pre
Synaptic Vesicles - pre
Synaptic cleft microscopic gap 1 millionth of an inch
Presynaptic and Postsynaptic from and to
Neuron transmitter receptors on the postsynaptic
What is action potential?
Depolarization
Repolarization
Nerve impulse = is a wave of action potential of moving down the axon to the end of it.
Na+ = Sodium
K + = Potassium
Inside has more (-) negative then outside
Resting potential = when the inside is (-) outside (+) (The membrane is polarised)
There are two factors that maintain the resting potential
1. The membrane of the resting neuron is slightly more permeable to potassium.
2. Sodium / potassium pump. Two molecules of potassium are brought into the cell, and three
of sodium is taken out side. Per pump.
Neurons are highly excitable MS Multiple sclerous of the myelin sheath = demyelination of the white matter causing
neurological disorders
Read p216 Table 9.1
All-or-none response
This is a law that states that whenever a stimulus of threshold potential is applied to a nerve fibre
(axon) nerve impulses is conducted.
Protection of the CNS
Bones
Meninges membranes of connective tissues deep to the bone.
o Skin
o Bone
o Dura mater
Periosteal
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Meningeal
Arachnoid mater looks like a spider
Subarachnoid - CSF
o Pia mater (gentle matter) connective tissue connects to the bran itself (p223)
Cerobrospinal fluid
o Found in and around the brain and spinal fluid
o Made in the ventricles
o Occupies the brain ventricles
o Produced by the epidianly cells
o Liquid cushion, floating, reduces the weight of the brain 97%
o CSF protects from trauma
o CSF nourishes the brain
o
Plexus
What is a plexus? A Plexus is a network or nerves or capillaries
Hydrocephalus occurs when there is blocking of the CSF
Spinal Cord
Begins at the magman foraman
Consist of grey and white matter
Functions:
o Conducts nerve impulses up and down the descending and ascending tracts (nerves
in the CNS)
o Its divide into 31 segments each segment has two sets nerves.
o Grey matter in the spinal cord is within the white matter
Ten Nerves that come out of the brain
1. Olfactory = sense of smell
2. Optic = vision
3. Oculomotor = movement of eye
4. Troclear = eye movement
5. Trigeminal = sensory / motor, lips, tongue, teeth
6. Abducens = eye movement
7. Facial = facial expression
8. Vestibulocochlear = ear
9. Glossopharyngeal = movement of tongue
10. Vagus = heart, lung, digestive system etc.
11. Accessory = movement of the sternocleidomastoid
12. Hypoglossal = movement of the tongue
Neural stem cells
Approx 100 billion neural cells in the brain, multi-polar type
The Brain
The brain has four major regions
1. Cerebrum
2. Diencephalon
3. Cerebellum
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4. Brain stem
Connected by the corpus callosum are axons of neurons that are the right and left hemispheres.
Cerebrum cortex the grey matter
The gyri = convolutions of the cerebrum
Sulci = Shallow grooves
Fissura = deep grooves
Areas of the Cerebrum
Motor
sensory
association = from memory makes decision based on sensory
The follow effect he frontal lobe
Alcohol
TV
Rock and roll music
The Diencephalon
Consist of mainly grey matter
It is sub divided
o Thalamus has the Pineal gland melatonin=sleep/mood, and serotonin=Neuro
transmitter/sleep/appetite/moods
Deals more with sensory functions
Called the relay centre
o Hypothalamus from this hangs the pituitary gland, it makes 9 hormones.
Control centre for temp
Water balance
Sleep cycle
Appetite
Pleasure, anger, pain, sexual arousal, fear
It controls more motor functions
o Epithalamus
Cerebellum small brain
Deals with movement
Provides precise movement
Equilibrium is controlled
Two hemispheres
Brain Steam
Divides into three parts
Medulla oblongata
o Cardiac centre - controls the heart rate
o Vasomotor control blood pressure
o Respiratory centre
o Contains tracks boundless of axons
Ponds
Midbrain
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Frontal Lobe prefrontal lobotomy 1930-1940 this made things worse then better.
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Meissners corpuscle
Pacinian corpuscle
The merkel disc light pressure
Root hair plexus
Special Sense
1. Taste
2. Smell
3. Sight
4. Hearing
5. Equilibrium
This are involved with complex receptors
Olfactory organ
Taste bud
Organ of corti
Eyes
Organs of eubilibrium (crista ampullaris and maculae)
All of these are all found in the head.
Sensory Receptor
Sensory Receptor - A structure that responds to stimuli
A cell
A Collection of cells
The nerve ending o a sensory neuron
Stimuli - are chang4es in the internal or external environment.
Sensation
A feeling that occurs when the cerebral cortex interprets a sensory input this happens in
with in the gray matter on the outside of the brain.
The result of the simulation of a sensory receptor
NOTE: Damage to the cerebral cortex (gray matter) can result in lost of sensation.
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Sensory Adaptation
When a receptors stops sending signals because it adjusts to a continual, unchanging
stimulus.
An adapted receptor can respond only if the threshold of the stimulus is increased.
Sensory Adaptation Receptor of pressure, touch, and smell adapt rapidly. That is why we
adapt of the feel of our clothing against our skin.
Classification of Sensory Receptors
1. Location
o Exteroreceptors (near bodys surface)
o Interoreceptors (on smooth muscles or the viscera)
o Propioceptors (our own movement skeletal muscles)
(Cartridge is devoid of nerve fibers)
2. Type of stimulus
o Mechanoreceptors (mechanical)
o Thermoreceptors (Heat)
o Photoreceptors (Light)
o Chemoreceptors (Chemical)
o Pain receptors or nociceptors
Noxious stimuli harmful stimuli
3. Structural complexity
o Simple receptor one cell or few cells together
o Complex receptors eye, ear organs
Sense of Pain
Free Nerve Endings
Pain Receptors are widely distributed except in the nervous tissue of the brain.
Pain is a response to noxious stimuli
Pain protects from tissue damage
Pain receptors adapt poorly
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chew well and to move the food around in the mouth otherwise there is very little taste
Primary taste
Sweet - Front
Sour - Side
Salt - Tip
Biter - Back
Taste pathway
1. Taste hairs
2. Taste cell (gystatory cell)
3. Facial nerve and glossopharyngeal nerve
4. Medulla oblongata
5. Thalamus
6. Gustatory cortex (parietal lobe)
Sense of hearing
Organ of Corti is the organ for hearing
1. The external ear
a. (auricle)
b. External auditory meatus
i. Sebaceous glands
ii. Ceruminous glands
iii. Sticky traps for foreign
bodies
iv. Repels insects
v. Ceruminous
impactation (impairs
hearing)
2. The middle ear
a. The tympanic membrane (Ear drum)
i. A barrier to protect the inner and middle ear
b. The tympanic cavity
c. Auditory ossicles
3. The inner ear (labyrinth)
a. Osseous labyrinth
b. Membranous labyrinth
The Labyrinth of made up of two parts Osseous which is filled with Perilymph which comes from
the CSF. The membranous contains Endolymph which also comes from the CSF which is produced
by the choroids plexus.
Hearing Disorders
1. Conduction Deafness (Person tends to speak softly)
a. Ostosclerosis or damage to ossicles
b. A perforated or hardned eardrum
c. Impacted cerumen (or plugged meatus) (Wax)
2. Sensorineural Deafness (Talk loud)
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e. inner muscle around the pupil - circular muscle when they contract it closes the
pupil
f. outer are called the radial muscle
when they contract it opens the
pupil
3. Sensory tunic = retina The innermost
layer
a. Pigmented layer epithelial cells
1. Epithelial cells act as
phagocytes
b. Neural layer Rods and Cones
1. has about 250 million
rods and cones
2. There are more rods
then cones
c. This as all the blood cells, also the neurons
d. Rods and Cones are the Receptor cells
e. Stores vitamin A for the Rods if you are lacking in this you will have night
blindness
f. Rods are for night vision Cannot see color
g. Cones are for day vision For color, for detail
h. Macula Iutea a yellow spot with a depression know as the fovea centralis. Contains
only cones which is the area for the sharpest color vision.
Eyes disorders
Cataracts lens becomes cloudy {page 270}
o Smoking, diabetes, intense sunlight
Glaucoma Increased pressure in the eye
(page 271}
o The large space in the eye filled with
liquid has too much pressure from a
build up
Night Blindness vitamin A deficiency {page
274}
Retina Detachment Pigmented and
nervous layers separate and vitreous humor
seeps between them
Myopia (nearsightedness) distant objects
are blurred, Eye is too long or lens is too
strong
Hyperopia (farsightedness) close objects
are blurred. Eyes is too short and lens is
lazy.
Macular Degeneration Tissue of the macula
lutea deteriorates. Loss of central vision, not
peripheral vision.
Floaters Clumps of gels in the vitreous humor that cast a shadow in the retina producing
moving specks in the field of vision
Conjunctivitis inflammation of the conjunctiva, a membrane that lines the eyelid.
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o
o
Pinkeye, may be caused by allergic reactions or bacteria last about two weeks
Epidemic or viral conjunctivitis highly contagious. Last 2 to 3 weeks.
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Endocrine System
Glands
A system made of glands, all the organs are glands that secret hormones. The two regulatory
systems Endocrine and nervous.
The nervous system provides rapid, brief control by fast traveling nerve impulses through
neurons.
The endocrine system provides slower but longer lasting control by hormones secreted into
the blood by glandular epithelium.
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increased
Parathyroid Glands
Parathormone is stimulated by low levels of calcium
Thyroid glands
Parathyroid glands
It affects three things
o Bones PTH Calcium
o Kidneys PTH Vit D increase
absorption of calcium
o Small intestine PTH calcium
absorption, vit D is needed for
this.
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All of this to increases the level of calcium level in the blood. When this happens the negative
feedback system will stop the release of this hormone.
Abnormal Secretion of PTH
Hyperparathyroidism
o Results in increased osteoclast activity (bones resorption) soften, deform and
fracture spontaneously.
o Excess calcium in the blood can be deposit in the kidneys and the endothelium
causing kidney stones or atherosclerosis.
Hypoprathyroidism
o Reduced osteoclast activity
o Bones remain strong, but blood
calcium concentration
decreases, which affects
transmission of electrical
impulses and muscular
contraction.
Osteoporosis when osteoclasts activity
outpaces osteoblasts activity. Normal, Thinning,
Osteoporotic
Adrenal Glands
Hormones Secreted by the Adrenal Cortex.
Stimulated by hormones.
Corticosteroids
Mineralocorticoids
o Aldosterone it regulates the
metabolism, potassium
Glucocorticoids
o Regulates glucose
o Cortisol increased during
stress
Gonadocorticoids
o Sex hormone control
o Androgens
Cushings Syndrome
Excess glucose production caused by hypersecretion of cortisol, and glucocorticoid.
Gluconeogenesis the body is making glucose from protein, from the muscles and collagen.
Hormones Secreted by the Adrenal Medulla
Stimulated by neural transmitters
Ephinephrine
Norepinephrine
Addisons Disease Hyposecretion of adrenal cortex hormones,
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especially cortisole. The pigmentation of the skin and oral mucosa due to over stimulation of the
melanocytes by ACTH, which has melanostimulating properties.
The Pancreas A dual glad
Islet of Langerhans
Is apart of the endocrine gland
Alpha cells Secrete glucagons When it goes down
Beta cells secrete insulin When it goes up
Abnormalities of Pancreas
Hypersecretion of insulin, results in hypoglycemia
o Need whole fiber
Hypersecretion of glucagons results in hyperglycemia.
o Diabeties Type 1 or 2 (normally type 2)
Hyposecretion of insulin results in hyperglycemia
o Diabetes mellitus
Diabetes Type 1 person does not produce insulin or enough of it.
Diabetes Type 2 starts with reception insufficient (insulin resistance)
What to do: Exercise improves diabetes by increasing the number of insulin receptors
and by increasing receptors and by increasing utilization of glucose by the skeletal
muscles.
Pineal Gland
Production of the melanoma
Thymus Glad
Secretes thymosins this is used for the production of anti-bodies
Reproductive Glands
Ovaries estrogen and progesterone
Placenta estrogen, progesterone and gonadoropin
Testes - testosterone
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3. Spleen
4. Lymph nodes
5. Read bond marrow (all bones)
After Birth: Read bone marrow of bones in the axial skeleton, in the girdles, and in the
epiphyses of the humerus and femur.
All formed elements are derived from a stem cell: the hemocytoblasts. These are in the red bone
marrow of adults.
Hematopoiesis
Erythrocytes (RBC)
o Anuclated
o 120 days of life
o Biconcave disk
o Confined blood stream
o RBC count
1. Women 4.3-5.2 million / mm3
2. Men 5.1 5.8 /mm3
o Content: 97% hemoglobin oxygen carrying protein
o Erythropoises creation of red cell production
o Erythropoietin (kidneys, liver)
o Production of more then 2 million cells per second
o Kidney failure low RBC count which leads to Anemia = lack of blood
o Hypoxia - lack of oxygen at the cellular level this is the result of lack of RBC
o Hypoxia triggers secretion of erythropoietin
1. Target cell is bone marrow
2. Starts the production of RBC
3. When there is more the negative feedback will stop the release of
erythropoietin
Erythropoieses
o This process takes from 3-5 days
o They start in the bone marrow until the loss
the nucleus
Hypoxia the result of..
o Loss of RBCs
1. Hemorrhage / destruction)
o Decrease of Oxygen
1. High altitude, low temperature,
vasoconstriction, etc)
o High demand for Oxygen
Polycythemia (too many
RBCs) can result as the body
tries to compensate for the
lack of Oxygen
Cyanosis
o Children with Tetralogy turn blue and are
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Signs of Problems
Numbness of the fingers tingling
Bad coordination
Bad memory
Best Sources of Folate
Legumes
Green leafy vegetables
What happens when RBC dies?
After about 120 days, a macrophage will eat the RBC keep the hemoglobin and then a few days after
it will through it out destroyed into two groups, Heme and Globin.
Globin > broken down into amino acids which are recycled.
Heme > decomposes into Iron and bilirubin (green part)
Iron > sent to the liver and stored
Biliverdin > sent to liver to be broken down into bilirubin
Bilirubin > sent to the intestine this is what gives the stool the brown color.
New Born Jaundiec
The child looks yellow because their liver is not getting rid of the bilirubin. They need
to be placed in the sun daily. Protect their eyes, feed them with breast milk to help them
to get rid of the bilirubin. Also charcoal water is good for them.
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9. Granulocytes, which are larger than erythrocytes include neutrophils, eosinophils and
basophils. Their nuclei are lobes shaped in many ways (polymorphonuclear). They have a
short life span (hours to a few days). All granulocytes can do phagocytosis. Why? The
granules are strong digestive enzymes. Remember: lysosomes are known as the garbage
disposals of the cells.
a. Neutrophils more abundant of all the leukocytes (62%), engulf bacteria and fungi
b. Eosinophils 2.3% of all the leukocytes, destroy parasitic worms by releasing
digestive enzymes on the worm surface.
c. Basophils rarest leukocytes, 0.5% of all the leukocyte population, release
(1) Histamine - an inflammatory chemical that acts as a vasodilator, increases
blood flow and makes blood vessels leaky
(2) Heparin - inhibits blood clotting
10. Agranulocytes include monocytes and lymphocytes. They lack cytoplasmic granules, and
their nuclei are spherical. Live longer than granulocytes (months to years).
a. Lymphocytes about 30% of all the leukocytes, but a small amount is found in the
bloodstream, found mostly in the lymphoid tissues (lymph nodes, spleen, tonsils,
etc.), produce antibodies (antibodies destroy foreign particles), may live 100 to 300
days of even years.
(1) T lymphocytes (T cells) attack virus infected cells and tumor cells. Differentiate in
the thymus.
(2) B lymphocytes (B cells) secrete antibodies that destroy foreign substances.
Differentiate in the bone marrow.
b. Monocytes 5% of all the leukocytes, may live from weeks to months or even years,
very phagocytic. When monocytes enter the site of attack, they begin to grow in size
(5X) and develop into macrophages, which can engulf very large objects.
c. We have macrophages in all routes by which invading organisms frequently enter the
body.
1) The skin (broken skin)
2) The alveolar walls
3) In the liver (for the portal blood circulation). They are
known as the Kupffer cells.
4) The lymph nodes (For the lymph, because it does not
enter the liver.)
The skin (langerhans cells)
The alveoli (Alveolar macroghpages)
The liver (Kupffer cells)
The lymph nodes (lymph nodes macrophages)
11. To remember the leukocytes in order from most abundant to
least abundant: Never let monkeys eat bananas.
Of the blood cells 98% is RBC and 2% is WBC
Diapedesis - Chemotaxis
WBCs follow chemical trails left by damaged cells or by other leukocytes.
Leukemia
A cancerous growth of nonfunctional leukocytes that overcrowds the RBSs and causes anemia.
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Platelets
1. Sometimes called thrombocytes (thrombo = clot). Contain chemicals that act in the clotting
process. (Basophils are the antagonist to the platelets. Basophils are anticlotting agents.
They secrete heparin.)
2. Not a real cell, but cytoplasmic fragments of the disintegrating megakaryocytes.
3. Half the size of an erythrocyte.
4. Capable of amoeboid movement.
5. Life span is about 10 days.
6. Thrombocytopenia - A condition in which the number of circulating platelets is deficient,
causes spontaneous bleeding from small blood vessels all over the body.
7. Platelets count per cubic millimeter is 130,000 to 360,000.
Hemostasis
8. Play a key role in hemostasis (stoppage of bleeding) of a ruptured vessel. (See Overhead.)
Three steps of hemostasis:
a. Vascular spasm (vasoconstriction) vessel contracts and blood flow is reduced.
Vasocontraction is also caused by serotonin, which is secreted by the platelets to
contract the smooth muscles of the walls. The spasm lasts long enough (20-30
minutes) to allow for the formation of
a platelet plug.
b. Platelet plug (by platelets
aggregation) Platelets contact the
exposed collagen fibers of the ruptured
blood vessel and begin to release the
platelet factor (makes them sticky and
attract other platelets. They swell,
become sticky and adhere to each other
and to the exposed collagen fiber to
form a platelet plug. Platelet plugs
control the blood loss from small
breaks. Larger ones may need a blood
clot.
c. Blood clot formation. (See overhead
and handout with illustration. p320)
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Platelet factors and collagen factors released, combine with calcium in the plasma and
form an enzyme known as prothrombin activator. The prothombin activator plus the
calcium in the blood combine to stimulate the conversion of prothombin (an inactive
coagulating factor present in the blood) into thrombin (an active enzyme). Thrombin
converts fibrinogen (a soluble protein in the blood) into fibrin threads within 10 to 15
seconds. These threads form a mesh that traps RBCs and plasma to form a clot. It must
be in the presence of calcium.
d. Vitamin K is required by the liver for production of clotting factors. Vitamin K is fat
soluble. Vitamin K deficiency can occur if fat absorption is impaired and also if dietary
fat is severely restricted.
Sources of vitamin K: green leafy vegetables, broccoli, cabbage, etc. Vitamin K is also
the product of bacterial digestion in the colon.
e. Vitamin E is a potent anticoagulant. A vitamin K antagonist.
Sources of vitamin E: nuts, seeds especially sunflower seeds, whole grains, avocados,
olives, vegetable oils, wheat germ, green leafy vegetables, unrefined vegetable oils, etc.
Heparin is secreted by Basophils
f. Fibrinolysis - When vessel is repaired, clot is digested within two days.
g. Undesirable blood clots Abnormal blood clot formation can occur due to changes in
the lining of vessels (Simple Squamous Epithelium). For example: atherosclerosis,
smoking, high blood pressure, are factors that may damage the lining of vessels. Those
changes initiate undesirable blood clots. Can lead to complete occlusion.
1) Thrombus is a nonmoving clot.
2) Embolus is a clot that broke loose and is circulating in the blood. Emboli can reach
narrow places in the vessels and interfere with blood flow. This is very dangerous.
Hemophilia
h. Hemophilia a bleeding disorder due to a deficiency of coagulating factors.
1) Hemophilia affects mostly men.
2) Symptoms: Severe bleeding episodes throughout lifetime. First episode before the
age of 18 months. IV injections can cause large hematomas (masses of blood
confined to an organ, tissue or space due to tissue hemorrhage). Even a light blow to
the head may cause intracranial bleeding.
3) Dental extractions or surgeries can precipitate severe bleeding episodes that could
be fatal.
4) No cure.
5) Life expectancy of a hemophilic depends on the deficiency level of the coagulating
factor.
(a) Severe deficiencies with severe bleeding episodes = early death.
(b) Mild deficiencies with mild bleeding episodes = possible normal life span if
properly managed.
6) Treatment: Replacement therapy (blood or plasma transfusion, which contain the
lacking factor) and oral administration of coagulating factors. These therapies
provide relief for several days only.
7) Recommendations: Avoid trauma and the use of aspirin, which has an anticoagulant
effect. Carry identification as a hemophiliac in case of an accident.
Three Steps to Homeostasis
The arrest of bleeding or circulation of the blood
1. Vascular Spasm injured smooth muscles
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2. Platelet Plug
3. Blood Clot Formation
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Heart valves
open and close
in response to
difference in
blood pressure
on either side.
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trunk. Its closure also begins immediately after birth. Only a remnant is left, which is
known as the ligamentum arteriosum.
c. 70% of the fetal blood goes through these bypasses. The other 30% may go through the
pulmonary trunk but will not be for gas exchange (fetal lungs are collapsed), only for
tissue nourishment.
d. The umbilical arteries and umbilical vein of the umbilical cord provide gas exchange for
the fetus.
e. Congenital heart failure If any of these bypasses fail to close, it results in a congenital
heart failure.
5. Heart Skeleton Rings of fibrous connective tissue surround the semilunar and AV valves
to provide attachment for the valves and to prevent AV valves dilation during contraction of
the myocardium. Dense fibrous connective tissue is present also in the septum.
Pathway of blood
a. Ventricles and atria are sometimes referred to as the right heart and the left heart.
b. They are two pumps, each serving a separate circuit:
1) The pulmonary circuit is served by the right heart.
Pathway: Oxygen-poor/carbon dioxide rich blood goes from the right ventricle
through pulmonary semilunar valve pulmonary trunk right and left
pulmonary arteries lungs pulmonary veins left atrium through
atrioventricular bicuspid valve left ventricle.)
2) The systemic circuit is served by the left heart.
Pathway: Oxygen-rich blood goes from the left ventricle through the aortic
semilunar valve aorta smaller arteries systemic capillaries small veins
venae cavae to the right atrium through the tricuspid atrioventricular valve
right ventricle.
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Note: It takes around 60 seconds for one drop of blood to go around the whole system.
Blood supply to the heart (Coronary Circulation)
a. It is part of the systemic circulation.
b. The heart is beating constantly to supply blood to all the body tissues, so the cells of the
cardiac muscle (the myocardium) require a constant supply of oxygen.
c. The first two branches of the aorta supply blood to the heart.
1) The right coronary artery and the left coronary artery, which subdivide into
anterior and posterior interventricular arteries and the marginal artery, etc.
2) The openings to the right and left coronary arteries are just beyond the semilunar
aortic valve.
d. After passing through capillary beds of the myocardium, venous blood is collected by
the cardiac veins to be returned to the heart.
e. In the posterior side of the heart all the cardiac veins join to form a very large vessel
known as the coronary sinus or great cardiac vein, which drains the blood into the
right atrium.
f. IMPORTANT: Any blockage to the coronary arteries can be very serious or even
fatal.
1) Partial obstruction results in reduced oxygen supply to myocardial cells (ischemia
= lack of blood), which in turn results in angina pectoris (thoracic pain). Cells are
weakened, but they do not die.
2) However, in complete obstruction
(coronary thrombosis or blot clot
obstruction) cells die and it results
in a myocardial infarction (heart
attack). Whether a person survives a
myocardial infarction depends on the
extent and location of the damage.
3) Contraction of the myocardium
shortly blocks the coronary arteries.
The myocardium receives blood only
during diastole. If the heart rate is
high, plus there is atherosclerosis in
the coronary arteries, the blood supply to the myocardium is seriously decreased,
which results in damage to the cardiac muscle.
Coronary Occlusion
CHD Coronary heart disease
Partial or complete blocking of coronary artery.
Angina pectoris.
Complete obstruction of coronary arteries - heart
attack.
Atherosclerosis Congestive Heart Failure
CHF the heart is not pumping efficiently. It is the
result of other cardiac conditions.
Because there is less blood being pumped the heart has to work more, this enlarges the
heart.
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Heart Actions
1. Cardiac cycle
a. Cardiac cycle is all the events associated
with the flow of blood through the heart
during one complete heartbeat. In other
words, a cardiac cycle is atrial systole and
diastole followed by ventricle systole and
diastole.
b. The term systole and diastole refer to the
contraction and relaxation period of heart
activity.
c. Each chamber goes through a systole and diastole period.
1) When the atria relax (diastole), blood flows into them from the large venae cavae,
the coronary sinus, and the pulmonary veins. As pressure increases in those
chambers, the A-V valves open and allow 70% of the blood to flow passively into the
ventricles. As blood is flowing into the ventricles the atria contract (systole) and
force the rest of the
(1) .
(2) Begins the chemical digestion of carbohydrates with amylase (a digestive
enzyme).
2) Dissolves food blood (30%) into the ventricles.
3) Due to increased pressure in the ventricles, the A-V valves close, the ventricles
contract (systole) and the semilunar valves are forced open. Blood is ejected into
the large arteries (pulmonary trunk and aorta). Pressure in the ventricles drop and
they relax (diastole). Blood in the arteries begin to back flow, which causes the
semilunar valves to close.
4) The cardiac cycle includes all the events associated with the flow of blood through
the heart during one complete heartbeat - that is, atrial systole and diastole
followed by ventricular systole and diastole.
5) One heartbeat equals a cardiac cycle.
6) Heart rate is the total heartbeats in a minute. The average heart rate is 70 to 80
heartbeats per minute.
7) Sinoatrial (SA) node, AV node, atrioventricular bundle The SA node is also
known as the heart pacemaker. It is a mass of conducting cells located in the right
atrium (below the superior vena cava). It generates impulses that cause contraction
of cardiac muscle (70 to 80 per minute). Impulses from SA node travel to the AV
node (near the tricuspid valve) and down the septum on the atrioventricular
bundle.
8) Tachycardia heart rate >100.
9) Bradycardia heart rate <60
10) LUBB-DUPP is the sound of the opening and closing of the valves. This is one heart
beat.
2. Cardiac Output is the quantity of blood pumped into the aorta each minute by the heart. a.
Cardiac output = Stroke Volume (SV) x Heart Rate (HR)
c. Stroke volume = the volume of blood pumped by a ventricle with each heartbeat.
d. CO = SV X HR
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e.
f.
g.
h.
i.
j.
3. Venous return is the quantity of blood flowing from the veins into the right atrium each
minute.
a. The venous return and the cardiac output are most of the time equal to each other.
b. Blood in the veins is under low pressure. The venous return is aided by four factors
known as the muscular pump, the venous valve
c. Comes from the venae cavae and the coronary sinus into the right atrium each minute.
Factors that contribute to venous return
Respiratory Pump
o Main organ is the diaphragm
Muscular Pump
Venous Valves one way valves that help the blood
to move one way up back to the heart.
Large Lumen the hollow space inside the vain
Venous Constriction nervous impulse to vain to
pump
S-A Node
The nature pace maker for the heart
Sometimes controlled by the medulla oblongata.
A-V Node controls the rate of the heart.
A-V bundles this is the fibers that send the impulses.
4. Heart sounds
a. A heartbeat sounds like lub-dub.
b. It is due to vibration in the heart
tissues during the opening and
closing of the valves.
c. The lub occurs when the A-V valves
close, during ventricular contraction
(systole)
d. The dub occurs when the semilunar
valves snap shut, during ventricular
relaxation (diastole).
e. Heart murmurs are abnormal or
unusual heart sounds that often
indicate valve problems (leaking or
incompetent valves that allow blood
backflow). Such backflow is known as
regurgitation. Regurgitation
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produces the sounds known as murmurs. However, the thin heart walls in old people or
young children may vibrate with the rushing blood and produce heart murmurs also.
5. Cardiac muscle fibers (See Overhead.).
a. Cardiac muscle fibers, like skeletal muscle fibers, are striated.
b. Contraction is accomplished by the sliding filament mechanism.
c. Cardiac muscle fibers are short, branched, and interconnected by the intercalated discs,
whereas skeletal muscle fibers are independent of one another.
d. Because of this interconnection of the cardiac fibers, the entire myocardium functions as
a single unit
6. Electrocardiogram - This is the recording of the electrical changes in the myocardium
during a cardiac cycle.
Blood Vessels
1. The blood vessels of the body form a closed delivery system that begins and ends at the
heart. Function: blood transport
2. There are three major types of blood vessels: arteries, capillaries, and veins.
3. The walls of blood vessels, except for the very small capillaries, are composed of three
layers or tunics that surround the central opening known as lumen.
a. Tunica interna or intima (in intimate contact with the blood) contains the
endothelium (very smooth simple squamous epithelium) and a subendothelial layer of
loose connective tissue that supports the endothelium. Very thin in both arteries and
veins.
b. Tunica media a layer of smooth muscle cells that contract (vasoconstriction) and
relax (vasodilation) depending on the needs of the body. Vasoconstriction and
vasodilation are actions regulated by the autonomic nervous system to control blood
pressure. This layer is thicker in arteries. It contains elastic fibers and elastin sheets.
c. Tunica externa or adventitia (coming from outside) Composed mainly of collagen
fibers that protects the blood vessels. Has nerve fibers and very tiny blood vessels
(nourish the external tissues of the blood vessel walls).
Blood pressure in
vessels decreases as
Arteries
distance from the left
(BP =120 to 70 mm Hg)
ventricle increases.
a. Carry oxygenated blood (except for the pulmonary arteries) away from the heart
under high pressure.
b. There are three groups of arteries that branch down. (Not in the book.)
1) Elastic arteries (aorta and major branches)
(a) Thick arteries near the heart that conduct the blood from the heart to mediumsized arteries. Know as conductive arteries.
(b) Largest in diameter and the most elastic.
(c) Have a large lumen.
Arteriosclerosis
(a) Are very distensible (capacity to stretch) because they contain elastin in all
is hardening of
three tunics, which allows arteries to expand and recoil adjusting to changes
the blood vessel.
in blood volume. The tunica media of the elastic arteries contains most of the
Arteriosclerosis
elastin (elastic membrane. (See Overhead)
results in increased
peripheral resistance,
which leads to HBP.
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(b) If blood pressure is constantly high, arteries weaken and may balloon out
(aneurysm) and even burst. It is the same as a hernia.
2) Muscular (distributing) arteries
(a) Deliver blood to organs (kidneys, heart, liver, etc.) Known as distributing arteries
(b) Contain less elastin than elastic arteries.
(c) Their tunica media is thicker (more smooth muscle fiber) because these arteries
are more active in vasoconstriction.
3) Arterioles (a) The smallest of the arteries.
(b) Contain very little elastin.
(c) Larger arterioles have the three tunics (each very thin).
(d) The smaller arterioles have no tunica externa. They are merely a very thin
layer of smooth muscle cells (tunica media) around the endothelial lining
Capillaries
(BP = 40 to 20 mm Hg. 40 in the beginning and 20 at the end of the capillary bed)
a. Microscopic blood vessels.
b. Consist of tunica interna only (very thin endothelium). So thin that RBCs have to flow
through in single file.
c. Semipermeable vessels, through which substances are exchanged between blood and
tissue fluids (interstitial fluid).
d. Function: allow for exchange of material (gases, nutrients, hormones, ions, etc.)
between blood and interstitial fluid. The exchange is done by diffusion (from higher
concentration to lower concentration- oxygen and nutrients), filtration (molecules are
forced through the membrane by pressure) and osmosis (diffusion of water).
e. Capillaries do not function independently. They form a network called capillary beds.
f. Smooth muscle fibers (precapillary sphincters) encircle capillary entrances and
regulate blood distribution in the capillaries. If cells are low in oxygen or nutrients,
sphincters relax and blood flows in.
g. Vasoconstriction and vasodilation of arterioles and the precapillary sphincters
determine the route of blood flow. Example: during exercise blood flow is
increased to capillary beds of the skeletal muscles, while blood flow to capillary
network of the digestive tract is reduced.
h. Most tissue have a rich capillary supply (tendons and ligaments are poorly
vascularized). Tissues that require large quantities of oxygen and nutrients (muscle and
nerve) have more capillaries than tissues that require less oxygen and nutrients.
Cartilage and epidermis lack capillaries.
i. The blood that flows from arterioles to venules through capillary beds is called
microcirculation.
Venules
(drain blood from capillaries) (BP in all veins = aprox. 20 mm Hg)
a. Blood is carried from the capillaries to the heart by veins that merge.
b. Capillaries join/merge to form venules.
c. Smaller venules = only endothelium (tunica interna).
d. Larger venules = may have the three tunics (interna, media and externa) but each is
very thin.
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Veins
a. Venules join/merge to form veins.
b. Veins have three tunics; but they are thinner. As a result veins have thinner walls than
arteries, and they collapse.
c. Large lumen.
d. Carry blood under low pressure (about 20 mm Hg).
e. Low pressure condition demands some special adaptation to help return blood to the
heart. There are five factors aiding venous return:
(1) Respiratory pump abdominal pressure increases, which forces blood to the
thoracic cavity
(2) Muscular pump Skeletal muscles around deep veins contract and squeeze or milk
the blood.
Skeletal muscle inactivity during prolonged period of standing may result in
swollen ankles because blood poolins in the feet.
(3) Large lumen The larger the lumen the lower the peripheral resistance.
(4) Venous valves (formed from folds of the tunica intima) Only open upward,
preventing backflow of blood.
(5) Venous Constriction - low venous pressure stimulates SNS, which stimulates
smooth muscle in the walls of veins to contract.
f. Venous valves are abundant in veins of the limbs. They are absent in veins of the ventral
cavity.
g. Varicose veins are veins that have become tortuous and dilated because of
incompetent venous valves. Causes: prolong standing, obesity, pregnancy and
constipation. The belly of an obese person or a pregnant lady exerts pressure on vessels
of the groin. This restricts return of blood to the heart. Blood pools in the legs and, with
time, the valves weaken and the venous walls stretch and become floppy.
h. Venous sinuses are large flattened veins with extremely thin walls that are supported
by the tissues around them. Example: coronary sinus supported by the pericardium,
the dural sinus in the dural space.
Blood Pressure
1. Blood pressure is the force the blood exerts against the inner walls of blood vessels.
2. The direct cause of blood pressure is the volume of blood in the vessels. The larger the
blood volume, the more pressure the blood exerts on the walls of the arteries.
3. Prolonged hypertension causes the myocardium to thicken and the heart enlarges. If
coronary heart vessels cannot supply all myocardium, heart muscle fibers die and heart
weakens.
4. Blood pressure changes with age. In a newborn baby BP is 90/55. This tends to increase
with age, due to arteriosclerosis (hardening of the vessels). Elastin in blood vessels
deteriorates and walls are not so distensible.
5. This force occurs throughout the whole vascular system, but it is highest in the arteries and
lowest in the veins. The term blood pressure usually refers to pressure in the larger
arteries (elastic arteries) near the heart.
6. Ventricular systole forces blood into the pulmonary trunk and aorta, which increases the
pressure in these arteries. Since the pumping of the heart is intermittent, the arterial
pressure fluctuates between a systolic pressure of 120 and a diastolic pressure of 80. The
maximum pressure during ventricular systole is called systolic pressure. During
ventricular diastole the arterial pressure drops, and the lowest pressure before the
next ventricular systole is diastolic pressure.
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(5) Intestinal enzymes - maltase, sucrase, lactase, lipases, proteases Secreted by the
brush border (secretory cells of the small intestine)
b. Enzymatic breakdown or chemical digestion of food begins in the mouth and is
completed in the small intestine.
5. Absorption the passage of digested end products (monosaccharides, amino acids, fatty
acids) plus vitamins, minerals, water, etc., from the lumen of the GI tract into the blood or
lymph. Most of the absorption takes place in the small intestine.
6. Defecation Elimination of indigestible substances from the body via the anus in the form
of feces. (Only the large intestine defecates.)
Components of the Gastric Juice
Pepsin formed by the activation of pepsinogen in the presence of HCl. Pespsinogen is
secreted by the chief cells of the gastric glands.
HCl activates pepsinogen, lowers the pH in the stomach. Secreted by the parietal cells.
Intrinsic Factor Binds to B12 and protects it from the low pH. Necessary for B12
absorption in the ileum. Secreted by the parietal cells.
Mucus Lubricaton and compacting of the chime. Secreated by surface mucus cells, mucus
neck cells and goblet cells.
All these cells are found in the gastric glad.
Structure of the Wall of the GI Tract
1. The GI tract in a cadaver is
approximately 9 meters long
(about 30 feet). Shorter in a
living person because of muscle
tone.
2. Food material within this tube
is technically outside the body
because the canal is open to
external environment at both
ends.
3. Most of the alimentary tract
resides in the abdominopelvic
cavity (esophagus is in the
thoracic cavity). Remember
that the ventral body cavities
contain a slippery serous
membrane. In the
abdominopelvic cavity this
membrane is call the
peritoneum the visceral
peritoneum and the parietal
peritoneum. Between the two
peritoneum is the peritoneal
cavity filled with serous fluid that protects the organs as they carry out their digestive
activities.
4. From the esophagus to the anal canal, the walls of every organ of the alimentary canal are
made up of the same four basic layers:
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a. The mucosa
1) Most inner layer around the lumen.
2) An endothelium made mostly of simple columnar epithelium (from the stomach
and down) rich in mucus-secreting goblet cells. Mouth, pharynx, and esophagus are
nonkeratinized stratified squamous epithelium.
3) May have folds (like rugae in the stomach), projections (like vili in the large
intestine), or circular folds (like folds in the small intestine).
4) Functions of the mucosa are:
(a) Secretion the mucosa is a serous membrane that secretes a serous fluid. It also
secretes hormones and enzymes.
(b) Protection Protects against infectious diseases with bactericidal secretions,
and mucus secreted by goblet cells protects some organs from being digested by
the strong digestive enzymes.
(c) Absorption Vitamins, minerals, and water are absorbed into the blood.
b. The Submucosa
c. - Loose (areolar) connective tissue containing blood vessels, lymphatic vessels,
lymph nodes, and nerve fibers. The vessels nourish surrounding tissues and carry
away absorbed material.
d. The muscular layer
1) Consists of two layers of smooth
muscle tissue and nerve plexus (a
network of nerve fibers). The
muscular layer of the stomach has
three layers of muscle fibers circular, longitudinal, and the
oblique.
2) Responsible for peristalsis,
churning, and segmentation.
When circular fibers contract, the
diameter of the tube decreases.
When the longitudinal fibers
contracts, the length of the tube
shortens.
3) In several places along the GI tract
the circular layer thickens to form
sphincters that act as valves to
prevent backflow and control food
passage from one organ to the next.
(a) upper esophageal sphincter
(b) lower esophageal sphincter
(c) pyloric sphincter
(d) ileocecal valve
(e) external anal sphincter (of voluntary control)
(f) internal anal sphincter
4) A peristalsis wave occurs when a ring of smooth muscle fibers contracts at the
same time that the muscular wall just ahead of the ring relaxes.
e. The Serosa
1) Also known as the visceral peritoneum.
2) Made of loose areolar connective tissue and simple squamous epithelium.
3) It is a moist outer covering that protects the GI tract. Secretes serous fluid which
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moistens and lubricates the tube so that organs of abdominal cavity slide freely
against one another.
Six Sphincters of the GI Tract
1. Upper esophageal sphincter
2. Lower esophageal sphincter ( Cardiac sphincter)
3. Pyloric sphincter
4. Ileocecal valve
5. Internal anal sphincters
6. External anal sphincters
Organs of the Digestive System
(organs of the GI tract: oral cavity, pharynx, esophagus, stomach, small intestine, and large
intestine; accessory organs: teeth, tongue, salivary gland, liver, gallbladder, pancreas)
1. Mouth or oral cavity (See Overhead)
a. Digestive function
1) Ingestion
2) Mechanical digestion (chewing and mixing food)
3) Chemical digestion of starches (a complex carbohydrate)
4) Propulsion (initiated by the tongue)
b. A chamber known as the oral cavity, and a space known as the vestibule between the
teeth, cheeks and lips.
c. Boundaries are the lips anteriorly, the cheeks laterally, the palate superiorly, and the
tongue inferiorly. Lips are made of skeletal muscles and sensory receptors helpful in
judging the temperature and texture of food.
d. Openings are: oral orifice anteriorly, and the fauces posteriorly.
e. Functions:
f. Begins ingestion and
g. mechanical digestion by reducing the size of solid particles and
h. mixing them with saliva (beginning of chemical digestion). Only of the complex
carbohydrates
i. Tongue mixes the food with enzymes and mucuse, forms a bolus (propulsion)
j.
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mechanisms may be interrupted and food may enter the respiratory tract. This triggers
the cough reflex in an attempt to expel the food.
m. Palatine tonsils are located on either side of the fauces (back opening of the mouth).
These lymphatic organs are common sites of infections (tonsillitis) (tonsillectomy =
surgical extraction).
n. Pharyngeal tonsils another lymphatic organ on the posterior wall of the pharynx.
Also known as adenoids. They may become infected and enlarged blocking the
nasopharynx.
o. Lingual tonsils (posterior surface of the tongue)
p. Tubal tonsils (around the opening of the auditory tube)
q. Pharangeal tonsils
r. Lingual tonsils
s. Palatine tonsils
t.
Salivary glands
(See Overhead (accessory organs of the digestive system)
a. Functions of saliva:
Salivary centers
(3) Cleanses the mouth.
are in the pons
(4) Protects against microorganisms with
and medulla
(a) antibodies - immunoglobulin A (Ig A)
(b) bactericidal lysozyme (enzyme that inhibits bacterial growth in the mouth and
protects against tooth decay)
(c) antibiotics - defensins, which function as cytokines to call defensive cell
(lymphocytes and phagocytes) into the mouth for battle
(5) Aids in propulsion (mucin) - Moistens and binds food particles, making a bolus
that is easy to swallowmolecules so they can be sensed by the gustatory cells in the
taste buds (97% water)
b. Extrinsic salivary glands - found outside the oral cavity and empty their secretions
into the mouth through ducts.
c. Intrinsic salivary glands - known as buccal glands that are found throughout the
mucosa of the oral cavity. These secrete saliva continuously.
d. There are 3 pairs of extrinsic salivary glands, which are major exocrine glands that
secrete saliva (not hormones) through ducts when food enters the mouth.
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e. Salivary glands are composed of serous (watery secretion containing enzymes) cells,
and mucous (sticky secretion) cells. These cells are present in varying proportions
within different glands.
(1) Parotid glands Largest of the salivary glands. Secrete a serous fluid that contains
amylase, which begins the digestion of carbohydrates. Mumps is an inflammation
of the parotid gland caused by a virus that spreads from person to person in the
saliva.
(2) Submandibular glands Secrete serous fluid and mucus, which bind food
particles to make a bolus and to lubricate during swallowing.
(3) Sublingual glands Smallest of the major salivary glands. More mucus than serous
fluid.
f. Major components of saliva:
(1) Water 97%
(2) Digestive enzymes - Most significant is amylase
(3) Mucus - Mucin
(4) Bactericidals - Ex: lysozyme
(5) Antibodies - Ex: Immunoglobulin A
(6) Antibiotics - Ex: defensins
g. Smelling, tasting, or thinking of food stimulates parasympathetic nerve impulses to
elicit secretion of large volumes of saliva.
h. Halitosis may be the result of a dried mouth because decomposing food particles are
allowed to accumulate in the mouth and bacteria can grow. Drinking water increases
secretion of saliva.
Pharynx
(Connects the nasal and oral cavity with the larynx and the esophagus.)
a. A passageway for food from the mouth to the esophagus (oropharynx and
laryngopharynx).
b. Digestive function: food propulsion The muscular wall of the pharynx propels food
into the esophagus.
c. Mucosa membrane consists of non-keratinized stratified squamous epithelium.
d. Muscular layer is skeletal muscle. (Remember that first part of swallowing is a
voluntary action.)
e. Pharingitis Inflammation of the pharynx.
Esophagus
a. A food passage, approximately 10 inches long, from the pharynx to the stomach.
b. Mucosa is non-keratinized stratified squamous epithelium.
c. Muscular layer is
(1) First third = skeletal muscle fibers
(2) Second third = a mixture of skeletal muscle fibers and smooth muscle fibers
(3) Inferior third = only smooth muscle fibers
d. Glands in the mucosa secrete lubricating mucus that aids in food propulsion.
e. Begins at the base of the pharynx and descends behind the trachea, passing through
the mediastinum and penetrating the diaphragm through an opening called the
esophageal hiatus where it enters the abdomen to join the stomach. The esophageal
hiatus surrounds the cardiac sphincter of the stomach and helps keep it closed when
food is not being swallowed.
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and some drugs, like aspirin. (alcohol and aspiring absorption cause gastric
bleeding.)
(4) Propulsion Food moves from the body region to the pyloric region aided by
stomach contractions (peristaltic waves), and as the pyloric region fills up, the
pyloric sphincter relaxes, allowing small
portions of the chyme to move to the
duodenum of the small intestine for further
digestion.
(5) Stomach emptying takes approximately 4
hours (depending on the quantity and quality
of food).
(6) Another function of the stomach: A holding
tank. Holds chyme until duodenum is ready to
receive it.
c. Anatomy of the stomach: (See Overhead)
(1) Cardiac region small regions that surrounds
the cardiac orifice.
(2) Fundus the dome-shaped part of the
stomach.
(3) Body the main part of the stomach where most of the chemical digestion occurs.
(4) Pyloric region a funnel shaped region that continues to narrow and become the
(5) Pylorus This is the opening to the duodenum.
(6) Pyloric sphincter - where the muscular wall of the stomach thickens to form a
valve, which controls gastric emptying.
d. Gastric secretions
(1) The lining of the stomach mucosa is a simple columnar epithelium composed
entirely of goblet cells (tiny glands), which produce a protective coat of mucus
(protects the mucosa from being digested by its own highly acidic enzymes).
(2) Gastric glands Found in the gastric
pits of the stomach wall. Made of three
types of secretory cells that collectively
produce the gastric juice.
(a) Mucous neck cells mucus (not
the same as the goblet cells mucus)
Its about 1mm thick.
(b) Chief cells - pepsinogen (the
inactive form of pepsin) Pepsinogen
is activated by hydrochloric acid.
(c) Parietal cells - hydrochloric acid
(HCl) and intrinsic factor (necessary
for B12 absorption in the small
intestine). HCl is very acid (pH 1.53.5), harsh enough to kill many of
the bacteria ingested with foods.
(d) The mixture of the mucus, the
hydrochloric acid and the digestive
enzymes is called gastric juice
(3) Pyloric Glands - Found in the pyloric region
(a) Similar to the gastric glands but less parietal and chief cells.
(b) Mostly mucous cells that secrete a thin mucus that lubricate chyme movement
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(4)
(5)
(6)
(7)
(8)
(9)
Gastric emptying
1. The stomach usually empties completely
within four hours 4-6 after a meal.
2. Liquid meals pass quickly through the stomach.
3. Carbohydrates usually pass through rapidly.
4. Proteins take longer than carbohydrates. It is
digested in the stomach.
5. However, the rate of gastric emptying depends
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also on what is happening in the duodenum. When the chyme entering the duodenum is
fatty, food may remain in the stomach six hours or more. (high fat diet = longer digestion,
high carbohydrates diet = shorter digestion)
6. Fatty foods may remain in the stomach from 5-6 hours. That is because portions of a fatty
chyme are digested slowly by the enzymes in the small intestine, and that causes the rest of
the chyme to stay longer in the stomach. If food is too long in the stomach, fermentation
begins.
f. Gastritis An inflammation of the underlying
layers of the stomach wall due to a breach in the
mucosal barrier. Persistent gastritis can lead to a
stomach ulcer (erosion of the stomach wall).
Pancreas
(an accessory organ of the digestive system)
a. The pancreas has two functions
endocrine and exocrine functions.
b. Structure of the pancreas
(1) It joins the C-shaped curve of the
duodenum
(2) Exocrine cells are the pancreatic
acinar cells. They make the bulk
of the pancreas. (Endocrine cells <alpha and beta cells> are found only in the islets
of Langerhans. Alpha cells secrete glucagon and beta cells secrete insulin.)
(3) Acinar cells release their secretion into tiny tubes that join the pancreatic duct.
(4) The pancreatic duct extends the length of the pancreas and fuses with the bile
duct just before it enters the duodenum. (The bile duct transport bile from the liver
and gallbladder.)
(5) The secretion of the acinar cells is called the pancreatic juice, which contains
different enzymes: pH8 alkaline (The stomach is pH2 acid)
(a) Pancreatic amylase breaks down carbohydrate molecules (starch and
glycogen)
(b) Pancreatic lipase breaks down fat molecules into fatty acids.
(c) Pancreatic protease breaks down protein molecules into amino acids. This
enzyme is secreted in an inactive form and is activated in the duodenum. This is
to prevent the pancreas from self-digestion.
(d) Pancreatic nuclease breaks down nucleic acids into nucleotides.
(e) Bicarbonate makes the juice alkaline.
c. Pancreatitis: Inflammation of the pancreas that could be the cause of a gallstone within
the sphincter of Oddi (hepatopancreatic sphincter) blocking the pancreatic juice
resulting in a build up that could digest part of the pancreas. Alcohol intake, traumatic
injuries, certain drugs can also cause pancreatitis.
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Hepatopancreatic Sphincter - the one out let for the Liver, Gallbladder and Pancreas
Liver
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i.
Gallbladder
(an accessory organ of the digestive system)
a. A small, green muscular sac with a duct (the cystic
duct) that is seen in the inferior part of the liver.
b. Function of the gallbladder: Stores bile that is not
immediately needed for digestion and concentrates it
by absorbing some of its water.
c. Function of the bile: Emulsification of fat molecules
(large fat globules are broken down into millions of
small droplets so that the fat splitting enzymes can
digest fat more effectively).
d. When its muscular wall contracts, bile is expelled into
the cystic duct. Bile then flows into the common bile
duct to be released into the duodenum through the
hepatopancreatic sphincter.
Regulation of bile secretion:
a. When fatty chyme enters the duodenum, minor endocrine glands in the intestine release
cholecystokinin, a hormone that
stimulates the gallbladder contractions.
(Bile is not release unless gallbladder
contracts).
b. Cholecystokinin also stimulates secretion
of the pancreatic juice, which contains
lipase.
c. Gallstones - Bile salts keep the
cholesterol dissolved within the bile. Too
much cholesterol or too few bile salts can
lead to crystallization of cholesterol,
forming gallstones. When the gallbladder
or its duct contract, the sharp crystals
cause agonizing pain. Treatment: drugs
that dissolve the crystals, ultrasound vibration to pulverize the crystals, vaporizing with
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Small Intestine
We can eat the bread of life, but if the
General characteristics
heart does not absorb it, we will
(1) Extends from the pyloric sphincter to the ileocecal valve. experience spiritual deficiencies. We
need to be doers, not only hearers.
(2) Occupies most of the abdominal cavity.
(3) Longest part of the GI tract (about 20 feet long).
(4) Receives secretions from pancreas and liver. (Chemical digestion)
(5) Completes digestion of nutrients in chyme (3-6 hours journey). (Chemical digestion)
(6) Segmentation movements ringlike contractions that divide chyme into segments and
move it back and forth. (Mechanical digestion)
(7) Absorbs the end products of digestion. (Absorption)
(8) Transports the residues to the large intestine with peristalsis. (Propulsion) (After most
nutrients have been absorbed peristalsis gets stronger and segmenting movements
wane.)
8) Diarrhea - The chyme in the small intestine moves slowly. If the intestinal wall
becomes irritated by toxins and bacteria the chyme is rushed (peristaltic rush) into
the large intestine so quickly that water, nutrients, and electrolytes are not
absorbed through the wall of the small intestine. This causes a watery stool
(diarrhea) and a lost of electrolytes (vitamin and mineral deficiencies) and water
(dehydration).
a. Anatomy of the small intestine
(1) Three portions: duodenum, jejunum, and ileum
Treatment for
(a) Duodenum a short C-shape section about 10 inches long, from the pyloric
Diarrhea:
sphincter to the jejunum.
Carob powder,
(b) Jejunum (8 feet) - about 8 feet long
Slurry water for
(c) Ileum about 12 feet long, joins the large intestine at the ileocecal valve. This
babies,
is where B12 is digested.
1-2 Tbsp charcoal
in one large glass
H2O for adults.
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(3) Rectum begins at the end of the sigmoid colon. Hemorrhoids: dilated veins of the
anorectal area. Internal and external. Major causes: straining to have a bowel
movement (constipation) and childbirth.
(4) Anal canal Last segment of the large intestine. It has two sphincters, the internal anal
sphincter of smooth muscle, and the external anal sphincter of skeletal muscle.
d. The mucosa is made of simple columnar epithelium except in the anal canal, which is
non-keratinized stratified squamous epithelium.
e. The mucosa contains lots of mucus producing goblet cells. The mucus eases the passage of
feces and protects the intestinal wall.
f. Content of the large intestine has 12 to 24 hours more to spend there.
g. Digestive processes occurring in the large intestine:
(1) No chemical digestion occurs in the large intestine (just bacterial digestion)
(2) Some water absorption takes place in the large intestine, but it is not a major
function of this organ.
(3) Propulsion and defecation are the primary functions of the large intestine.
(4) Propulsion is accomplished by mass peristalsis or mass movement (powerful
but slow contraction waves that force the contents toward the rectum). Mass
peristalsis only occurs three or four times a day (during or after eating).
(5) Constipation: When food remains in the colon for extended periods too much
water is absorbed and the stool becomes dry, hard, and difficult to pass.
Constipation may result from a lack of fiber in the diet, improper bowel habits
(failing to heed the call), lack of exercise, emotional upset (anxiety, fear, and
stress), laxative abuse, or lack of water.
h. Inflammatory bowel diseases (Ulcerative Colitis, Chrons Disease)
Normal Flora
At birth the entire intestinal tract is sterile, but bacteria enters the first feed
Some bacteria that enter the cecum are still alive.
These bacteria ferment some of the indigestible carbohydrates
Bacterial digestion produces gases, vit K, and come vit B
If you dont have good Flora then you while have a lot of gas (this can come from lost of
enemies)
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Inflammation
1. It is a tissue response to injury or infection.
2. It inhibits the spread of pathogens and toxic substances by enclosing the injured or infected
area in a sac of fibrous connective tissue. Produces:
(a) Redness caused by increased blood volume to the area as a result of blood vessel
dilation caused by prostaglandins (tissue hormones that induce vasodilation).
(b) Swelling Increased capillary permeability as a result of histamine (a strong
vasodilator secreted by the basophils), which increases fluid leakage, resulting in
edema (swelling). The increased amount of blood to the area adds to the swelling.
(c) Heat Produced by the warmer blood that comes from deeper body parts.
(d) Pain the edema (increased volume of interstitial fluid) presses on the nearby nerve
endings (pain receptors or nociceptors) causing pain and limiting movement, which in
turn aids in the healing process. Pain also results from bacterial toxins, lack of nutrition
to cells in the area, etc.
(e) Leukocytosis - Leukocytes are attracted to the area to clear it of debris and pathogens.
(f) Fribrin and other fibers - form a capsule that prevents the spread of toxins and
pathogens to other areas.
(g) Four cardinal signs of inflammation are redness, heat, swelling, and pain
Fever
1. Bacteria require large amounts of iron and zinc. High body temperature causes iron and
zinc to go to liver and spleen, which stops the replication of fungi and bacteria.
2. Phagocytes become more active in higher temperature.
3. Fever also increases the metabolic rate of the tissue cells, speeding up defensive actions.
Specific Defenses
The third line of defense
Known as immunity
Provides resistance to specific antigens that resisted the first and second line defense
(surface and chemical barrier)
Provided by lymphocytes
Lymphocytes attack nonself molecules, known as antigens (proteins)
Substances that can mobilize the immune system and provoke an immune response.
A contraction of antibody generating anti-gens
If the immune system fails, devastating diseases like cancer, lupus, AIDS develop.
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Artificial
o Active Vaccination with antigen to stimulate an immune
response
o Passive Injection pf antibody-rich plasma from a donor. No
immune response.
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